CL:0002328bronchial epithelial cellD000236AdenomaD002277CarcinomaCL:0000158Clara cellGO:0008219cell deathGO:0050673epithelial cell proliferationD006965hyperplasia1increased10090Mus musculusIncrease, Necrosis (terminal bronchiolar cells)Increase, Necrosis (terminal bronchiolar cells)CellularCL:0002328bronchial epithelial cell2016-11-29T18:41:262017-09-16T10:16:05Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)Cellular2016-11-29T18:41:262016-12-03T16:37:51Increase, Hyperplasia (terminal bronchiolar cells)Increase, Hyperplasia (terminal bronchiolar cells)CellularUBERON:0001958terminal bronchiole epitheliumCL:0002328bronchial epithelial cell2016-11-29T18:41:262017-09-16T10:16:06Increase, Adenomas/carcinomas (bronchioloalveolar)Increase, Adenomas/carcinomas (bronchioloalveolar)TissueUBERON:0002048lung2016-11-29T18:41:262017-09-16T10:16:06Increase, Cytotoxicity (club cells)Increase, Cytotoxicity (club cells)Cellular<p>This key event can be associated with Cyp2f2 bioactivation.
</p>CL:0000158Clara cell2016-11-29T18:41:262017-09-16T10:16:060444267d-3f87-44ae-b0af-3ed618378d25c2dc2d3e-b5a3-4db7-ac63-f186add13a042016-11-29T18:41:352016-12-03T16:37:59c2dc2d3e-b5a3-4db7-ac63-f186add13a049a01277b-39df-478c-86e5-f4ab58d1f7fd2016-11-29T18:41:352016-12-03T16:37:599a01277b-39df-478c-86e5-f4ab58d1f7fde327633d-e92a-457e-b88d-5336b0a226de2016-11-29T18:41:352016-12-03T16:37:5980677fd8-a63c-4831-bd33-47883e9a5c800444267d-3f87-44ae-b0af-3ed618378d252016-11-29T18:41:352016-12-03T16:38:00Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)Cytotoxicity- bronchiolar adenoma/carcinoma<p>Cancer AOP group. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p>
Under Development: Contributions and Comments WelcomeUnder Development1.29<p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p>
adjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedNot SpecifiedMaleNot SpecifiedFemaleNot Specified2016-11-29T18:41:162023-04-29T13:02:12