67-66-3HEDRZPFGACZZDS-UHFFFAOYSA-NHEDRZPFGACZZDS-UHFFFAOYSA-N
ChloroformTrichloromethane
Methane, trichloro-
CARBON TRICHLORIDE
Chloroforme
cloroformo
Formyl trichloride
Methane trichloride
Methane,trichloro-
NSC 77361
Trichloroform
UN 1888
DTXSID1020306CL:1000494nephron tubule epithelial cellCL:1000507kidney tubule cellD000236AdenomaD002277CarcinomaGO:0008219cell deathGO:0050673epithelial cell proliferationMP:0004968kidney epithelium hyperplasiaD002292Carcinoma, Renal Cell1increasedChloroform2016-11-29T18:42:272016-11-29T18:42:2710116Rattus norvegicusIncrease, Cytotoxicity (tubular epithelial cells)Increase, Cytotoxicity (tubular epithelial cells)Cellular<p>This key event can be associated with Cyp2e1-mediated bioactivation.
</p>CL:1000494nephron tubule epithelial cell2016-11-29T18:41:272017-09-16T10:16:15Increase, Regenerative cell proliferation (tubular epithelial cells)Increase, Regenerative cell proliferation (tubular epithelial cells)CellularCL:1000494nephron tubule epithelial cell2016-11-29T18:41:262017-09-16T10:16:00Increase, Hyperplasia (tubular epithelial cells)Increase, Hyperplasia (tubular epithelial cells)CellularCL:1000494nephron tubule epithelial cell2016-11-29T18:41:272017-09-16T10:16:15Increase, Adenomas/carcinomas (renal tubular)Increase, Adenomas/carcinomas (renal tubular)TissueUBERON:0009773renal tubule2016-11-29T18:41:262017-09-16T10:16:00b6756105-9af9-4f45-9d40-824a0f50c5c4a1c248df-f629-4f7a-b3e8-6428fd4ab84f2016-11-29T18:41:352016-12-03T16:38:00a1c248df-f629-4f7a-b3e8-6428fd4ab84f7ceb14e8-22cd-4478-9c63-c8d055ee4bdd<p>Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia.
</p>2016-11-29T18:41:352016-12-03T16:38:007ceb14e8-22cd-4478-9c63-c8d055ee4bdd855d517c-9b5b-4890-9835-24572e43dee72016-11-29T18:41:352016-12-03T16:38:00Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Cytotoxicity- renal tubular adenoma/carcinoma<p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p>
Under Development: Contributions and Comments WelcomeUnder Development1.29<p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p>
adjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedNot SpecifiedMaleNot Specified<p>Golden, R. J., Holm, S. E., Robinson, D. E., Julkunen, P. H., & Reese, E. A. (1997). Chloroform mode of action: implications for cancer risk assessment. Regul Toxicol Pharmacol, 26(2), 142-155. doi: 10.1006/rtph.1997.1161</p>
2016-11-29T18:41:162023-04-29T13:02:12