Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol

112809-51-5

HPJKCIUCZWXJDR-UHFFFAOYSA-N

Letrozole

Femera Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-

DTXSID4023202

102676-47-1

CLPFFLWZZBQMAO-UHFFFAOYNA-N

CLPFFLWZZBQMAO-UHFFFAOYSA-N

Fadrozole

DTXSID5034141

PR:000006100

PR aromatase

CHEBI:16469

CHEBI 17beta-estradiol

CHEBI:50114

CHEBI estrogen

PR:Q7TSB7

PR metastasis-suppressor KiSS-1 (rat)

D007987

MESH Gonadotropin Releasing Hormone

CHEBI:81568

CHEBI Luteinizing hormone

GO:0023052

GO signaling

GO:0006703

GO estrogen biosynthetic process

GO:0007269

GO neurotransmitter secretion

GO:0046879

GO hormone secretion

GO:0032275

GO luteinizing hormone secretion

GO:0042698

GO ovulation cycle

VT:1000294

VT egg quantity

WIKI decreased

WIKI abnormal

Letrozole

2016-11-29T18:42:17

Fadrozole

2016-11-29T18:42:17

1,2,4-triazole

2016-11-29T18:42:27

Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol

Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle b

Molecular

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells

reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic producti

Cellular

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation

Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulos

Tissue

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus

Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation de

Organ

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response

Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces

Cellular

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons

Cellular

CL:0011111

CL gonadotropin releasing neuron

AOPWiki 2016-11-29T18:41:28

2017-09-16T10:16:51

Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs

Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituit

Cellular

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation

Reduced Ovulation of oocytes

Individual

AOPWiki 2016-11-29T18:41:28

2020-05-19T16:39:16

Decreased fertility, Reduced number of oocytes ovulated

Individual

AOPWiki 2016-11-29T18:41:28

2016-12-03T16:37:52

Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats

Aromatase Inhibition in Female Rats

Evgeniia Kazymova

BY-SA

1.29

1.0

Not Specified

AOPWiki 2016-11-29T18:41:17

2024-05-26T20:39:52