
This AOP is licensed under a Creative Commons Attribution 4.0 International License.
Aop: 162
Title
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
Short name
Graphical Representation
Point of Contact
Contributors
- Charles Wood
- Lucia Vergauwen
- Arthur Author
Status
Author status | OECD status | OECD project | SAAOP status |
---|---|---|---|
Under Development: Contributions and Comments Welcome | 1.29 | Under Development |
This AOP was last modified on July 16, 2022 18:37
Revision dates for related pages
Page | Revision Date/Time |
---|---|
Increased, Thyroid-stimulating hormone (TSH) | September 16, 2017 10:17 |
Thyroxine (T4) in serum, Decreased | July 08, 2022 06:52 |
Increase, Adenomas/carcinomas (follicular cell) | September 16, 2017 10:16 |
Increase, Hyperplasia (follicular cells) | September 16, 2017 10:16 |
Increase, Hypertrophy and proliferation (follicular cell) | September 16, 2017 10:16 |
Induction, Upregulation of glucuronyltransferase activity | September 16, 2017 10:14 |
Increased, Clearance of thyroxine from serum | January 26, 2021 10:41 |
Induction, Upregulation of glucuronyltransferase activity leads to Increased, Clearance of thyroxine from serum | September 10, 2021 08:32 |
Increased, Clearance of thyroxine from serum leads to T4 in serum, Decreased | January 26, 2021 10:42 |
T4 in serum, Decreased leads to Increased, Thyroid-stimulating hormone (TSH) | July 07, 2021 09:49 |
Increased, Thyroid-stimulating hormone (TSH) leads to Increase, Hypertrophy and proliferation (follicular cell) | July 07, 2021 10:17 |
Increase, Hypertrophy and proliferation (follicular cell) leads to Increase, Hyperplasia (follicular cells) | December 03, 2016 16:38 |
Increase, Hyperplasia (follicular cells) leads to Increase, Adenomas/carcinomas (follicular cell) | December 03, 2016 16:38 |
Phenobarbital | November 29, 2016 18:42 |
thiazopyr | November 29, 2016 18:42 |
Pyrethrins and Pyrethroids | November 29, 2016 18:42 |
Abstract
This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.
AOP Development Strategy
Context
Strategy
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Type | Event ID | Title | Short name |
---|
KE | 295 | Induction, Upregulation of glucuronyltransferase activity | Induction, Upregulation of glucuronyltransferase activity |
KE | 961 | Increased, Clearance of thyroxine from serum | Increased, Clearance of thyroxine from serum |
KE | 281 | Thyroxine (T4) in serum, Decreased | T4 in serum, Decreased |
KE | 1023 | Increased, Thyroid-stimulating hormone (TSH) | Increased, Thyroid-stimulating hormone (TSH) |
KE | 739 | Increase, Hypertrophy and proliferation (follicular cell) | Increase, Hypertrophy and proliferation (follicular cell) |
KE | 740 | Increase, Hyperplasia (follicular cells) | Increase, Hyperplasia (follicular cells) |
AO | 741 | Increase, Adenomas/carcinomas (follicular cell) | Increase, Adenomas/carcinomas (follicular cell) |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
---|
Network View
Prototypical Stressors
Life Stage Applicability
Taxonomic Applicability
Sex Applicability
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Known Modulating Factors
Quantitative Understanding
Considerations for Potential Applications of the AOP (optional)
References
1. Dellarco, V. L., McGregor, D., Berry, S. C., Cohen, S. M., and Boobis, A. R. (2006). Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Critical reviews in toxicology 36(10), 793-801, 10.1080/10408440600975242.
2. Finch, J. M., Osimitz, T. G., Gabriel, K. L., Martin, T., Henderson, W. J., Capen, C. C., Butler, W. H., and Lake, B. G. (2006). A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. Toxicology and applied pharmacology 214(3), 253-62, 10.1016/j.taap.2006.01.009.
3. Hurley, P. M. (1998). Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environmental health perspectives 106(8), 437-45.