1912-24-9MXWJVTOOROXGIU-UHFFFAOYSA-NMXWJVTOOROXGIU-UHFFFAOYSA-N
Atrazine1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N'-(1-methylethyl)-
1,3,5-Triazine-2,4-diamine, 6-chloro-N2-ethyl-N4-(1-methylethyl)-
1-Chloro-3-ethylamino-5-isopropylamino-2,4,6-triazine
2-Chloro-4-(ethylamino)-6-(2-propylamino)-s-triazine
2-Chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine
2-Chloro-4-(ethylamino)-6-(isopropylamino)triazine
2-Chloro-4-ethylamineisopropylamine-s-triazine
2-Chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine
2-Chloro-4-ethylamino-6-isopropylamino-s-triazine
2-Ethylamino-4-isopropylamino-6-chloro-s-triazine
6-Chloro-4-(ethylamino)-2-(isopropylamino)-s-triazine
6-Chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine
AAtrex Nine-O
Akticon
Aktikon
Aktikon PK
Aktinit A
Aktinit PK
Argezin
Atragranz
Atranex
Atranex 80WP
Atraphyt
Atrataf
Atrazin
atrazina
Azoprim
Chromozin
Farmozine
Gesamprim
Gesaprim
Gesaprim 50
Gesaprim 500
Gesaprim L
Herbatoxol
Hungazin
Hungazin PK
NSC 163046
Nu-Trazine
Oleogesaprim
Oleogesaprim 200
Primatol A
Primoleo
Radazin
Radazin T
s-Triazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-
Triazine A 1294
Zealin L
Zeazine
DTXSID9020112D007987Gonadotropin Releasing HormoneCHEBI:81568Luteinizing hormoneCHEBI:50114estrogenCL:0000439prolactin secreting cellD000236AdenomaGO:0046879hormone secretionGO:0060209estrusMP:0001928abnormal ovulationD006965hyperplasiaD006984hypertrophyHP:0002893Pituitary adenoma2decreased5delayed9disrupted1increasedatrazine2016-11-29T18:42:272016-11-29T18:42:2710116SD ratDecreased, GnRH pulsatility/release in hypothalamusDecreased, GnRH pulsatility/release in hypothalamusCellularCL:0011111gonadotropin releasing neuron2016-11-29T18:41:292017-09-16T10:17:11Decreased, LH Surge from anterior pituitaryDecreased, LH Surge from anterior pituitaryCellular2016-11-29T18:41:292016-12-03T16:37:53prolonged, estrusprolonged, estrusIndividual2016-11-29T18:41:292016-12-03T16:37:53interruption, Ovulationinterruption, OvulationIndividual2016-11-29T18:41:292016-12-03T16:37:53Increased, circulating estrogen levelsIncreased, circulating estrogen levelsOrgan2016-11-29T18:41:292016-12-03T16:37:53Increased, lactotroph hyperplasia and hypertrophyIncreased, lactotroph hyperplasia and hypertrophyCellularCL:0000439prolactin secreting cell2016-11-29T18:41:292017-09-16T10:17:13Increased, adenomas (pituitary)Increased, adenomas (pituitary)TissueUBERON:0000007pituitary gland2016-11-29T18:41:292017-09-16T10:17:1453c1d1ed-dbcc-46f6-bba2-4462fe8cba67b70e8128-f6f0-478c-9440-0fa551b91d142016-11-29T18:41:362016-12-03T16:38:03b70e8128-f6f0-478c-9440-0fa551b91d14b225c6b7-7e4f-44aa-a5e0-c8e8af1b09ae2016-11-29T18:41:362016-12-03T16:38:03b70e8128-f6f0-478c-9440-0fa551b91d14bf8151b0-3114-4e29-87a0-310ce1643cfa2016-11-29T18:41:362016-12-03T16:38:03b225c6b7-7e4f-44aa-a5e0-c8e8af1b09ae82d54774-1273-47e4-aed4-11309644acd52016-11-29T18:41:362016-12-03T16:38:03bf8151b0-3114-4e29-87a0-310ce1643cfa82d54774-1273-47e4-aed4-11309644acd52016-11-29T18:41:362016-12-03T16:38:0382d54774-1273-47e4-aed4-11309644acd5f189c58b-5ccd-4990-b077-e2c58a459b572016-11-29T18:41:362016-12-03T16:38:03f189c58b-5ccd-4990-b077-e2c58a459b5704ca66af-212a-42a0-8ac9-2529723fa7702016-11-29T18:41:362016-12-03T16:38:03GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.GnRH pulse disruption and pituitary tumors<p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p>
Under Development: Contributions and Comments WelcomeUnder Development1.29<p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p>
adjacentNot SpecifiedHighadjacentNot SpecifiedHighadjacentNot SpecifiedHighadjacentNot SpecifiedHighnon-adjacentNot SpecifiedHighnon-adjacentNot SpecifiedHighnon-adjacentNot SpecifiedHighHighFemaleHighNot Specified<p>1. O'Connor, J. C., Davis, L. G., Frame, S. R., and Cook, J. C. (2000). Detection of dopaminergic modulators in a tier I screening battery for identifying endocrine-active compounds (EACs). Reproductive toxicology 14(3), 193-205.</p>
2016-11-29T18:41:172023-04-29T13:02:13