PR:000021564sterol regulatory element-binding protein 2 proteolytic cleavage productCHEBI:27208unsaturated fatty acidPR:000008293glutathione synthetasePR:000029945glutathione S-transferaseCHEBI:16856glutathionePR:0000087743-hydroxyacyl-CoA dehydrogenase type-2CHEBI:16113cholesterolGO:0010467gene expressionGO:0006636unsaturated fatty acid biosynthetic processGO:0004363glutathione synthase activityGO:0004364glutathione transferase activityGO:0006750glutathione biosynthetic processGO:00038573-hydroxyacyl-CoA dehydrogenase activity1increased2decreased4abnormalSilica nanoparticles2017-02-15T04:01:162017-02-15T04:01:16Up Regulation, SREBF2Up Regulation, SREBF2CellularCL:0000182hepatocyte2017-02-15T04:03:082017-09-16T10:17:46Up Regulation, Unsaturated fatty acidUp Regulation, Unsaturated fatty acidCellularCL:0000182hepatocyte2017-02-15T04:04:252017-09-16T10:17:46Down Regulation, GSS and GSTs geneDown Regulation, GSS and GSTs geneCellularCL:0000182hepatocyte2017-02-15T04:06:042017-09-16T10:17:46Glutathione synthesisGlutathione synthesisCellularCL:0000182hepatocyte2017-02-15T04:06:562017-09-16T10:17:46Activation, 3-hydroxy-3-methylglutaryl-CoA reductase geneActivation, 3-hydroxy-3-methylglutaryl-CoA reductase geneCellularCL:0000182hepatocyte2017-02-15T04:09:152017-09-16T10:17:47Perturbation of cholesterolPerturbation of cholesterolCellularCL:0000182hepatocyte2017-02-15T04:10:442017-09-16T10:17:47Glutathione homeostasisGlutathione homeostasisCellularCL:0000182hepatocyte2017-02-15T04:11:092017-09-16T10:17:47HepatotoxicityHepatotoxicityCellular2017-02-15T04:11:362017-02-15T04:11:365791d832-7810-456c-a49b-3ba01157b14c3e07bed3-7a6c-4a92-8779-8f31f1dedaa72017-02-15T04:11:492017-02-15T04:11:493e07bed3-7a6c-4a92-8779-8f31f1dedaa7f3ec8906-6917-4ce0-890c-3c3c02269b0e2017-02-15T04:12:102017-02-15T04:12:1095fa78d5-8163-43ea-85a1-44ed2d64f0547e1bd154-79d8-4760-960c-56ed5db455b72017-02-15T04:12:352017-02-15T04:12:357e1bd154-79d8-4760-960c-56ed5db455b7e1ed348c-7f4c-44b6-a2f8-6671dc49ec3b2017-02-15T04:12:442017-02-15T04:12:44e1ed348c-7f4c-44b6-a2f8-6671dc49ec3bf3ec8906-6917-4ce0-890c-3c3c02269b0e2017-02-15T04:13:022017-02-15T04:13:0295fa78d5-8163-43ea-85a1-44ed2d64f0549cdf296d-08b5-4379-a835-103de32ea3ac2017-02-15T04:13:182017-02-15T04:13:18f3ec8906-6917-4ce0-890c-3c3c02269b0ecfbd0c2e-cd9e-40a4-82a6-16bb30e1a1372017-02-15T04:13:292017-02-15T04:13:299cdf296d-08b5-4379-a835-103de32ea3accfbd0c2e-cd9e-40a4-82a6-16bb30e1a1372017-02-15T04:13:392017-02-15T04:13:39Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Cholesterol and glutathione leading to hepatotoxicity: Multi-OMICS approach<p>Jinhee Choi, University of Seoul, Republic of Korea</p>
<p>Nivedita Chatterjee, University of Seoul, India</p>
<p>Jaeseong Jeong, University of Seoul, Republic of Korea</p>
Under development: Not open for comment. Do not citeUnder Development<p style="text-align: justify;">The system toxicology approach using ‘multi-OMICS-profiling-techniques’ (transcriptomics, proteomics and metabolomics) have proven to be robust tool for unraveling complex molecular machinery underlying various physiological, as well as, pathophysiological processes and have been successfully utilized in various fields including stress biology and toxicology. The application of multi-OMICS approaches are gaining acceptance in the regulatory community to provide information on a chemical’s hazard and risks though their mode-of-action (MOA), however, its utility in a AOP building context are still limited. This AOP is constituted the MIE as sterol regulatory element binding transcription factor 2 (SREBF2) gene activation and repressions of glutathione synthetase (GSS) and glutathione S-transferases (GSTA1, GSTA2, GSTA3, GSTA5) genes and the KEs as perturbation of cholesterol, though up regulated unsaturated fatty acid concentration, and glutathione homeostasis leading to oxidative stress, DNA damage and AO as hepatotoxicity (HepG2 cell death).</p>
adjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedNot SpecifiedUnspecificNot SpecifiedAll life stagesNot Specified2017-02-15T03:56:472023-04-29T13:02:14