{"id":497,"title":"ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome","short_name":"ERa inactivation leads to insulin resistance in skeletal muscle and metabolic syndrome","created_at":"2023-05-25T08:44:03.000-04:00","updated_at":"2024-05-26T20:39:59.000-04:00","corresponding_author":{"id":18942,"created_at":"2024-05-26T20:39:48.000-04:00","updated_at":"2024-05-26T20:39:48.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2126,"event":"Estrogen receptor alpha inactivation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":179,"event":"Decreased, Mitochondrial fatty acid beta-oxidation","event_type":"KeyEvent"},{"event_id":1115,"event":"Increased, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":177,"event":"Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":1088,"event":"Increased, Oxidative Stress","event_type":"KeyEvent"},{"event_id":2144,"event":"Impaired insulin signaling","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2119,"event":"Insulin resistance, increased","event_type":"AdverseOutcome"},{"event_id":2145,"event":"Metabolic syndrome","event_type":"AdverseOutcome"}],"relationships":[{"relation":3477,"upstream_event_id":2126,"upstream_event":"Estrogen receptor alpha inactivation","downstream_event_id":179,"downstream_event":"Decreased, Mitochondrial fatty acid beta-oxidation"},{"relation":3478,"upstream_event_id":2126,"upstream_event":"Estrogen receptor alpha inactivation","downstream_event_id":1115,"downstream_event":"Increased, Reactive oxygen species"},{"relation":3780,"upstream_event_id":179,"upstream_event":"Decreased, Mitochondrial fatty acid beta-oxidation","downstream_event_id":177,"downstream_event":"Mitochondrial dysfunction"},{"relation":3480,"upstream_event_id":1115,"upstream_event":"Increased, Reactive oxygen species","downstream_event_id":1088,"downstream_event":"Increased, Oxidative Stress"},{"relation":3782,"upstream_event_id":177,"upstream_event":"Mitochondrial dysfunction","downstream_event_id":2144,"downstream_event":"Impaired insulin signaling"},{"relation":3482,"upstream_event_id":1088,"upstream_event":"Increased, Oxidative Stress","downstream_event_id":2144,"downstream_event":"Impaired insulin signaling"},{"relation":3804,"upstream_event_id":2144,"upstream_event":"Impaired insulin signaling","downstream_event_id":2119,"downstream_event":"Insulin resistance, increased"},{"relation":3805,"upstream_event_id":2119,"upstream_event":"Insulin resistance, increased","downstream_event_id":2145,"downstream_event":"Metabolic syndrome"},{"relation":3781,"upstream_event_id":1088,"upstream_event":"Increased, Oxidative Stress","downstream_event_id":177,"downstream_event":"Mitochondrial dysfunction"}]}