{"id":507,"title":"Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway","short_name":"Vascular disrupting effects","created_at":"2023-08-19T19:52:00.000-04:00","updated_at":"2024-05-26T20:39:59.000-04:00","corresponding_author":{"id":18938,"created_at":"2024-05-26T20:39:48.000-04:00","updated_at":"2024-05-26T20:39:48.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1417,"event":"NFE2/Nrf2 repression","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1969,"event":"Increase, Oxidative Stress","event_type":"KeyEvent"},{"event_id":2009,"event":"Activation of inflammation pathway","event_type":"KeyEvent"},{"event_id":1928,"event":"increased, Vascular endothelial dysfunction","event_type":"KeyEvent"},{"event_id":2181,"event":"Angiogenesis dysfunction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2161,"event":"Increase, Vascular disrupting effects","event_type":"AdverseOutcome"}],"relationships":[{"relation":3539,"upstream_event_id":1417,"upstream_event":"NFE2/Nrf2 repression","downstream_event_id":1969,"downstream_event":"Increase, Oxidative Stress"},{"relation":3619,"upstream_event_id":1417,"upstream_event":"NFE2/Nrf2 repression","downstream_event_id":2009,"downstream_event":"Activation of inflammation pathway"},{"relation":3540,"upstream_event_id":1969,"upstream_event":"Increase, Oxidative Stress","downstream_event_id":2009,"downstream_event":"Activation of inflammation pathway"},{"relation":3541,"upstream_event_id":2009,"upstream_event":"Activation of inflammation pathway","downstream_event_id":1928,"downstream_event":"increased, Vascular endothelial dysfunction"},{"relation":3615,"upstream_event_id":1928,"upstream_event":"increased, Vascular endothelial dysfunction","downstream_event_id":2181,"downstream_event":"Angiogenesis dysfunction"},{"relation":3616,"upstream_event_id":2181,"upstream_event":"Angiogenesis dysfunction","downstream_event_id":2161,"downstream_event":"Increase, Vascular disrupting effects"}]}