{"id":518,"title":"Liver X Receptor (LXR) activation leads to liver steatosis","short_name":"LXR activation leads to liver steatosis","created_at":"2023-12-07T14:47:29.000-05:00","updated_at":"2024-05-26T20:40:00.000-04:00","corresponding_author":{"id":18937,"created_at":"2024-05-26T20:39:48.000-04:00","updated_at":"2024-05-26T20:39:48.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":167,"event":"Activation, LXR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2199,"event":"Increased, Expression of LXR activated genes","event_type":"KeyEvent"},{"event_id":89,"event":"Synthesis, De Novo Fatty Acid (FA)","event_type":"KeyEvent"},{"event_id":291,"event":"Accumulation, Triglyceride","event_type":"KeyEvent"}],"aop_aos":[{"event_id":459,"event":"Increased, Liver Steatosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":3705,"upstream_event_id":167,"upstream_event":"Activation, LXR","downstream_event_id":2199,"downstream_event":"Increased, Expression of LXR activated genes"},{"relation":3706,"upstream_event_id":2199,"upstream_event":"Increased, Expression of LXR activated genes","downstream_event_id":89,"downstream_event":"Synthesis, De Novo Fatty Acid (FA)"},{"relation":3707,"upstream_event_id":89,"upstream_event":"Synthesis, De Novo Fatty Acid (FA)","downstream_event_id":291,"downstream_event":"Accumulation, Triglyceride"},{"relation":3742,"upstream_event_id":291,"upstream_event":"Accumulation, Triglyceride","downstream_event_id":459,"downstream_event":"Increased, Liver Steatosis"}]}