{"id":527,"title":"Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased","short_name":"Decreased COUP-TFII in Leydig cells leads to Hypospadias, increased","created_at":"2024-03-19T11:10:58.000-04:00","updated_at":"2024-05-26T20:40:00.000-04:00","corresponding_author":{"id":18942,"created_at":"2024-05-26T20:39:48.000-04:00","updated_at":"2024-05-26T20:39:48.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[],"aop_kes":[{"event_id":656,"event":"Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII)","event_type":"KeyEvent"},{"event_id":647,"event":"Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells","event_type":"KeyEvent"},{"event_id":1613,"event":"Decrease, dihydrotestosterone (DHT) level","event_type":"KeyEvent"},{"event_id":2213,"event":"Impaired, urethral tube closure ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2082,"event":"Hypospadias, increased","event_type":"AdverseOutcome"}],"relationships":[{"relation":3794,"upstream_event_id":656,"upstream_event":"Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII)","downstream_event_id":647,"downstream_event":"Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells"},{"relation":3795,"upstream_event_id":647,"upstream_event":"Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells","downstream_event_id":1613,"downstream_event":"Decrease, dihydrotestosterone (DHT) level"},{"relation":3796,"upstream_event_id":1613,"upstream_event":"Decrease, dihydrotestosterone (DHT) level","downstream_event_id":2213,"downstream_event":"Impaired, urethral tube closure "},{"relation":3797,"upstream_event_id":2213,"upstream_event":"Impaired, urethral tube closure ","downstream_event_id":2082,"downstream_event":"Hypospadias, increased"}]}