{"id":532,"title":"CYP450 upregulation leads to Chronic kidney disease  ","short_name":"CYP450 upregulation leads to Chronic kidney disease  ","created_at":"2024-06-03T02:08:56.000-04:00","updated_at":"2024-06-20T20:48:02.000-04:00","corresponding_author":{"id":18939,"created_at":"2024-05-26T20:39:48.000-04:00","updated_at":"2026-06-05T15:04:12.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":774,"stressor_name":"Cyclophosphamide"},{"stressor_id":319,"stressor_name":"Acrolein"},{"stressor_id":777,"stressor_name":"Ifosfamide"}],"aop_mies":[{"event_id":2228,"event":"CYP450 Upregulation  ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1445,"event":"Increased, Lipid peroxidation","event_type":"KeyEvent"},{"event_id":2229,"event":"Acrolein accumulation ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1603,"event":"Chronic kidney disease","event_type":"AdverseOutcome"}],"relationships":[{"relation":3871,"upstream_event_id":2228,"upstream_event":"CYP450 Upregulation  ","downstream_event_id":1392,"downstream_event":"Oxidative Stress "},{"relation":3875,"upstream_event_id":1392,"upstream_event":"Oxidative Stress ","downstream_event_id":1603,"downstream_event":"Chronic kidney disease"},{"relation":3872,"upstream_event_id":1392,"upstream_event":"Oxidative Stress ","downstream_event_id":1445,"downstream_event":"Increased, Lipid peroxidation"},{"relation":3873,"upstream_event_id":1445,"upstream_event":"Increased, Lipid peroxidation","downstream_event_id":2229,"downstream_event":"Acrolein accumulation "},{"relation":3874,"upstream_event_id":2229,"upstream_event":"Acrolein accumulation ","downstream_event_id":1603,"downstream_event":"Chronic kidney disease"}]}