D005298fertilityCL:0000019spermCHEBI:16827corticosteronePR:000011406glucocorticoid receptorPR:000011405COUP transcription factor 2GO:0004883glucocorticoid receptor activityGO:0035624receptor transactivationMP:0013604abnormal adult Leydig cell differentiationMP:0013603abnormal fetal Leydig cell differentiationHP:0008715Testicular dysgenesis2decreased1increased10116Rattus norvegicusDecreased sperm quantity / quality in the adult, Decreased fertility Decreased sperm quantity / quality in the adult, Decreased fertility Individual2016-11-29T18:41:252016-12-03T16:37:50Decreased testosterone by the fetal Leydig cells, Increased corticosteroneDecreased testosterone by the fetal Leydig cells, Increased corticosteroneCellularCL:0000178Leydig cell2016-11-29T18:41:262017-09-16T10:15:26Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonistsDecreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptCellular2016-11-29T18:41:262016-12-03T16:37:51Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cellsDecreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cellsCellular2016-11-29T18:41:262016-12-03T16:37:51Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cellsDecreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cellsCellular2016-11-29T18:41:262016-12-03T16:37:51Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cellsDecreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cellsOrgan2016-11-29T18:41:262016-12-03T16:37:51Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal TestisDecreased Fetal Testosterone 1<p>Gary Klinefelter and Susan Laws</p>
Under Development: Contributions and Comments WelcomeUnder Development1.29HighMaleHighFoetalModerateAdult, reproductively matureHigh2016-11-29T18:41:162023-04-29T13:02:11