API

AOPs

ID Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Parkinsonian motor deficits
WPHA/WNT Endorsed 1.33
6 Antagonist binding to PPARα leading to body-weight loss Agnes Aggy Open for citation & comment Included in OECD Work Plan
  • Binding of antagonist, PPAR alpha
  • Decreased, Body Weight
WPHA/WNT Endorsed 2.3
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Binding at picrotoxin site, iGABAR chloride channel
  • Occurrence, Epileptic seizure
WPHA/WNT Endorsed 1.15
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Arthur Author Open for citation & comment Included in OECD Work Plan
  • Binding of antagonist, NMDA receptors
  • N/A, Neurodegeneration
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Agnes Aggy Open for citation & comment Included in OECD Work Plan
  • Binding of antagonist, NMDA receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan
  • Alkylation, DNA
  • Increase, Heritable mutations in offspring
WPHA/WNT Endorsed 1.11
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Allie Always Open for citation & comment Included in OECD Work Plan
  • Activation, AhR
WPHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Inhibition, Aromatase
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
38 Protein Alkylation leading to Liver Fibrosis Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan
  • Alkylation, Protein
  • N/A, Liver fibrosis
WPHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Agnes Aggy Open for citation & comment Included in OECD Work Plan
  • Covalent Binding, Protein
  • sensitisation, skin
WPHA/WNT Endorsed 1.1
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Cognitive Function, Decreased
WPHA/WNT Endorsed 1.10
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Allie Always Open for citation & comment Included in OECD Work Plan
  • Binding of agonist, Ionotropic glutamate receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Arthur Author Open for citation & comment Included in OECD Work Plan
  • Inhibition, Na+/I- symporter (NIS)
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.28
131 Aryl hydrocarbon receptor activation leading to uroporphyria Allie Always Open for citation & comment Included in OECD Work Plan
  • Activation, AhR
  • Uroporphyria
WPHA/WNT Endorsed 1.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Arthur Author Open for citation & comment Included in OECD Work Plan
  • Activation, AhR
  • Increase, Early Life Stage Mortality
WPHA/WNT Endorsed 1.7
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Cataia Ives Open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Calcineurin Activity
  • Impairment, T-cell dependent antibody response
WPHA/WNT Endorsed 1.38
212 Histone deacetylase inhibition leading to testicular atrophy Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan
  • Histone deacetylase inhibition
  • Testicular atrophy
WPHA/WNT Endorsed 1.52
220 Cyp2E1 Activation Leading to Liver Cancer Agnes Aggy Open for citation & comment Included in OECD Work Plan
  • Activation of Cyp2E1
  • Liver Cancer
WPHA/WNT Endorsed 1.24
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation Allie Always Open for citation & comment Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
WPHA/WNT Endorsed 1.92
360 Chitin synthase 1 inhibition leading to mortality Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
WPHA/WNT Endorsed 1.94
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Impairment, Learning and memory
EAGMST Approved 1.13
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Approved 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Approved 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Approved 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Allie Always Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Approved 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Approved 1.35
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan
  • Binding to (interferes with) topoisomerase II enzyme
  • Infant leukaemia
EAGMST Approved 1.53
272 Deposition of energy leading to lung cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Deposition of Energy
  • Increase, lung cancer
EAGMST Approved 1.56
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Brendan Ferreri-Hanberry Open for comment. Do not cite Included in OECD Work Plan
  • Increase, Oxidative damage to DNA
  • Increase, Mutations
  • Increase, Chromosomal aberrations
EAGMST Approved 1.76
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Allie Always Open for citation & comment Included in OECD Work Plan
  • reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
  • impaired, Fertility
  • irregularities, ovarian cycle
EAGMST Under Review 1.21
18 PPARα activation in utero leading to impaired fertility in males Arthur Author Open for citation & comment Included in OECD Work Plan
  • Activation, PPARα
  • impaired, Fertility
  • Malformation, Male reproductive tract
EAGMST Under Review 1.21
30 Estrogen receptor antagonism leading to reproductive dysfunction Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan
  • Antagonism, Estrogen receptor
  • Decrease, Population growth rate
EAGMST Under Review 1.12
41 Sustained AhR Activation leading to Rodent Liver Tumours Allie Always Open for citation & comment Included in OECD Work Plan
  • Activation, Long term AHR receptor driven direct and indirect gene expression changes
  • Formation, Hepatocellular and Bile duct tumors
EAGMST Under Review 1.7
43 Disruption of VEGFR Signaling Leading to Developmental Defects Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Inhibition, VegfR2
  • Increased, Developmental Defects
EAGMST Under Review 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Agnes Aggy Open for citation & comment Included in OECD Work Plan
  • Formation, Pro-mutagenic DNA Adducts
  • Tumorigenesis, Hepatocellular carcinoma
EAGMST Under Review 1.8
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Binding, Tubulin
  • Increase, Aneuploid offspring
EAGMST Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan
  • Activation, Constitutive androstane receptor
  • Increase, hepatocellular adenomas and carcinomas
EAGMST Under Review 1.17
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Decrease, Intracellular pH
  • Increase, Site of Contact Nasal Tumors
EAGMST Under Review 2.7
144 Endocytic lysosomal uptake leading to liver fibrosis Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Endocytotic lysosomal uptake
  • N/A, Liver fibrosis
EAGMST Under Review 1.47
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Substance interaction with the lung resident cell membrane components
  • Pulmonary fibrosis
EAGMST Under Review 1.32
277 Impaired IL-1R1 signaling leading to increased susceptibility to infection Cataia Ives Open for citation & comment Included in OECD Work Plan
  • Impaired IL-1R1 signaling
  • Increase, Increased susceptibility to infection
EAGMST Under Review 1.48
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • ROS generation from photoactivated chemicals
  • Inflamatory events in light-exposed tissues
EAGMST Under Review 1.49
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan
  • Chronic reactive oxygen species
  • Treatment-resistant gastric cancer
EAGMST Under Review 1.58
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality Allie Always Open for citation & comment Included in OECD Work Plan
  • Acetylcholinesterase (AchE) Inhibition
  • Sensory axonal peripheral neuropathy
  • Increased Mortality
EAGMST Under Review 1.2
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Open for adoption Included in OECD Work Plan
  • Activation, Pregnane-X receptor, NR1l2
  • Loss, Cochlear function
Under Development 1.9
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan
  • Activation, PXR/SXR
Under Development 2.5
16 Acetylcholinesterase inhibition leading to acute mortality Cataia Ives Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.3
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Bile Salt Export Pump (ABCB11)
  • Cholestasis, Pathology
Under Development 1.19
31 Oxidation of iron in hemoglobin leading to hematotoxicity Cataia Ives Open for adoption Included in OECD Work Plan
  • N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
  • N/A, Cyanosis occurs
Under Development 1.16
35 Narcosis leading to respiratory failure Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Accumulation, Biological membranes
Under Development 1.2
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Activation, PPARα
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.17
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Covalent Binding, Protein
  • Increase, Allergic Respiratory Hypersensitivity Response
Under Development 1.20
51 PPARα activation leading to impaired fertility in adult male rodents Evgeniia Kazymova Not under active development Included in OECD Work Plan
  • Activation, PPARα
  • impaired, Fertility
Under Development 1.21
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Evgeniia Kazymova Open for adoption Included in OECD Work Plan
  • Activation, Androgen receptor
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.26
128 Kidney dysfunction by decreased thyroid hormone Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Thyroid hormone synthesis, Decreased
  • Occurrence, Kidney toxicity
Under Development 1.40
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Inhibition, Phospholipase A
  • Formation, Liver fibrosis
Under Development 1.39
148 EGFR Activation Leading to Decreased Lung Function Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Activation, EGFR
  • Decrease, Lung function
Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan
  • Peptide Oxidation
  • Hypertension
Under Development 1.50
151 AhR activation leading to preeclampsia Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Activation, AhR
  • increase, Preeclampsia
Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Allie Always Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Binding, Transthyretin in serum
  • Cognitive Function, Decreased
Under Development 1.41
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan
  • Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
  • Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
  • Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
  • Impaired recruitment , Population trajectory
Under Development 1.31
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inactivation of PPARγ
  • Lung fibrosis
Under Development 1.54
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Sensing of the stressor by pulmonary cells
  • Plaque progression in arteries
Under Development 1.55
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
  • Occurrence, Kidney toxicity
Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding of substrate, endocytic receptor
  • Occurrence, Kidney toxicity
Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Evgeniia Kazymova Not under active development Included in OECD Work Plan
  • Alkylation, Protein
  • Occurrence, Kidney toxicity
Under Development 1.43
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Blockade, L-Type Calcium Channels
  • Heart failure
Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
Under Development 1.45
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cell death Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased lipid storage Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via oxidative DNA damage Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased lipid peroxidation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased protein oxidation Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish Cataia Ives Open for comment. Do not cite Included in OECD Work Plan
  • Thyroperoxidase, Inhibition
  • Reduction, Cumulative fecundity and spawning
Under Development 1.59
283 L-type calcium channel blockade leading to hypotension Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
Under Development 1.45
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Cataia Ives Open for citation & comment Included in OECD Work Plan
  • 5α-reductase, inhibition
  • Decrease, Population growth rate
Under Development 1.81
292 Inhibition of tyrosinase leads to decreased population in fish Agnes Aggy Open for citation & comment Included in OECD Work Plan
  • Inhibition of tyrosinase
  • Decrease, Population growth rate
Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
Under Development 1.79
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan
  • Retinaldehyde dehydrogenase inhibition
  • Decrease, Population growth rate
Under Development 1.77
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Antagonism, Thyroid Receptor
  • Cognitive Function, Decreased
Under Development 1.84
302 Lung surfactant function inhibition leading to decreased lung function Brendan Ferreri-Hanberry Open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of lung surfactant function
  • Decrease, Lung function
Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Frustrated phagoytosis
  • Lung cancer
Under Development 1.86
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • 5α-reductase, inhibition
  • decrease, male anogenital distance
Under Development 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Antagonism, Androgen receptor
  • decrease, male anogenital distance
Under Development 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • decrease, male anogenital distance
Under Development 1.90
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Stimulation, TLR7/8
  • Psoriatic skin disease
Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to estrogen receptor (ER)-α in immune cells
  • Exacerbation of systemic lupus erythematosus (SLE)
Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of JAK3
  • Impairment of T-cell dependent antibody response
Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Trypsin inhibition
  • Pancreatic acinar cell tumors
Under Development 1.60
319 Binding to ACE2 leading to lung fibrosis Allie Always Open for comment. Do not cite Included in OECD Work Plan
  • Induced dysregulation of ACE2
  • Lung fibrosis
Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Evgeniia Kazymova Open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Increased Mortality
Under Development 1.96
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of 11β-HSD
  • Decrease, Population growth rate
Under Development 1.93
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • 11β-hydroxylase inhibition
  • Decrease, Population growth rate
Under Development 1.93
358 Chitinase inhibition leading to mortality Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Chitinase
  • Increase, Mortality
Under Development 1.94
359 Chitobiase inhibition leading to mortality Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition, Chitobiase
  • Increase, Mortality
Under Development 1.94
361 Sulfonylureareceptor binding leading to mortality Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
Under Development 1.94
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Encephalitis
Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • SARS-CoV-2 cell entry
  • Increased SARS-CoV-2 production
  • Thrombosis and Disseminated Intravascular Coagulation
Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • dysgeusia
Under Development 1.96
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
  • Lung fibrosis
Under Development 1.96
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Induced dysregulation of ACE2
  • N/A, Liver fibrosis
Under Development 1.96
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Fibrinolysis, decreased
  • Bradykinin system, hyperactivated
  • Hyperinflammation
Under Development 1.96
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • impaired olfactory function (anosmia)
Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Cerebrovascular disease (stroke)
Under Development 1.96
397 Bulky DNA adducts leading to mutations Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Bulky DNA adducts, increase
  • Increase, Mutations
Under Development 1.11
398 Inhibition of ALDH1A (RALDH) causing reduced all-trans retinoic acid levels leading to impaired fertility, females Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Inhibition of ALDH1A (RALDH)
  • impaired, Fertility
Under Development 1.97
412 Endothelial cell dysfunction leading to thromboinflammation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Thromboinflammation, Increased
Under Development 1.96
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
Under Development 1.96
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
Under Development 1.96
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan
  • Binding to ACE2
  • Viral infection and host-to-host transmission, proliferated
Under Development 1.96