3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) |
896: Parkinsonian motor deficits |
WPHA/WNT Endorsed |
1.33 |
6 |
Antagonist binding to PPARα leading to body-weight loss |
Agnes Aggy |
Open for citation & comment |
Included in OECD Work Plan |
998: Binding of antagonist, PPAR alpha |
864: Decreased, Body Weight |
WPHA/WNT Endorsed |
2.3 |
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Allie Always |
Open for citation & comment |
Included in OECD Work Plan |
408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) |
406: impaired, Fertility and 405: irregularities, ovarian cycle |
EAGMST Under Review |
1.21 |
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Evgeniia Kazymova |
Open for adoption |
Included in OECD Work Plan |
239: Activation, Pregnane-X receptor, NR1l2 |
319: Loss, Cochlear function |
Under Development |
1.9 |
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
667: Binding at picrotoxin site, iGABAR chloride channel |
613: Occurrence, Epileptic seizure |
WPHA/WNT Endorsed |
1.15 |
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Brendan Ferreri-Hanberry |
Not under active development |
Included in OECD Work Plan |
245: Activation, PXR/SXR |
|
Under Development |
2.5 |
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Arthur Author |
Open for citation & comment |
Included in OECD Work Plan |
201: Binding of antagonist, NMDA receptors |
352: N/A, Neurodegeneration and 341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.13 |
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Agnes Aggy |
Open for citation & comment |
Included in OECD Work Plan |
201: Binding of antagonist, NMDA receptors |
341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.22 |
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Evgeniia Kazymova |
Open for citation & comment |
Included in OECD Work Plan |
97: Alkylation, DNA |
336: Increase, Heritable mutations in offspring |
WPHA/WNT Endorsed |
1.11 |
16 |
Acetylcholinesterase inhibition leading to acute mortality |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
12: Acetylcholinesterase (AchE) Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
Under Development |
1.3 |
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress |
341: Impairment, Learning and memory |
EAGMST Approved |
1.13 |
18 |
PPARα activation in utero leading to impaired fertility in males |
Arthur Author |
Open for citation & comment |
Included in OECD Work Plan |
227: Activation, PPARα |
406: impaired, Fertility and 348: Malformation, Male reproductive tract |
EAGMST Under Review |
1.21 |
21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Allie Always |
Open for citation & comment |
Included in OECD Work Plan |
18: Activation, AhR |
947: Increase, early life stage mortality |
WPHA/WNT Endorsed |
1.27 |
23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Evgeniia Kazymova |
Open for citation & comment |
Included in OECD Work Plan |
25: Agonism, Androgen receptor |
360: Decrease, Population trajectory |
WPHA/WNT Endorsed |
1.12 |
25 |
Aromatase inhibition leading to reproductive dysfunction |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
36: Inhibition, Aromatase |
360: Decrease, Population trajectory |
WPHA/WNT Endorsed |
1.12 |
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
41: Inhibition, Bile Salt Export Pump (ABCB11) |
357: Cholestasis, Pathology |
Under Development |
1.19 |
30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Evgeniia Kazymova |
Open for citation & comment |
Included in OECD Work Plan |
112: Antagonism, Estrogen receptor |
360: Decrease, Population trajectory |
EAGMST Under Review |
1.12 |
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Cataia Ives |
Open for adoption |
Included in OECD Work Plan |
213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) |
321: N/A, Cyanosis occurs |
Under Development |
1.16 |
35 |
Narcosis leading to respiratory failure |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
46: Accumulation, Biological membranes |
|
Under Development |
1.2 |
37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
227: Activation, PPARα |
719: Increase, hepatocellular adenomas and carcinomas |
Under Development |
1.17 |
38 |
Protein Alkylation leading to Liver Fibrosis |
Brendan Ferreri-Hanberry |
Open for citation & comment |
Included in OECD Work Plan |
244: Alkylation, Protein |
344: N/A, Liver fibrosis |
WPHA/WNT Endorsed |
1.14 |
39 |
Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
396: Covalent Binding, Protein |
313: Increase, Allergic Respiratory Hypersensitivity Response |
Under Development |
1.20 |
40 |
Covalent Protein binding leading to Skin Sensitisation |
Agnes Aggy |
Open for citation & comment |
Included in OECD Work Plan |
396: Covalent Binding, Protein |
827: sensitisation, skin |
WPHA/WNT Endorsed |
1.1 |
41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Allie Always |
Open for citation & comment |
Included in OECD Work Plan |
165: Activation, Long term AHR receptor driven direct and indirect gene expression changes |
856: Formation, Hepatocellular and Bile duct tumors |
EAGMST Under Review |
1.7 |
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Evgeniia Kazymova |
Open for citation & comment |
Included in OECD Work Plan |
279: Thyroperoxidase, Inhibition |
402: Cognitive Function, Decreased |
WPHA/WNT Endorsed |
1.10 |
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
305: Inhibition, VegfR2 |
1001: Increased, Developmental Defects |
EAGMST Under Review |
1.6 |
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Agnes Aggy |
Open for citation & comment |
Included in OECD Work Plan |
373: Formation, Pro-mutagenic DNA Adducts |
378: Tumorigenesis, Hepatocellular carcinoma |
EAGMST Under Review |
1.8 |
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Allie Always |
Open for citation & comment |
Included in OECD Work Plan |
875: Binding of agonist, Ionotropic glutamate receptors |
341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.23 |
51 |
PPARα activation leading to impaired fertility in adult male rodents |
Evgeniia Kazymova |
Not under active development |
Included in OECD Work Plan |
227: Activation, PPARα |
406: impaired, Fertility |
Under Development |
1.21 |
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Arthur Author |
Open for citation & comment |
Included in OECD Work Plan |
424: Inhibition, Na+/I- symporter (NIS) |
341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.28 |
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
718: Binding, Tubulin |
728: Increase, Aneuploid offspring |
EAGMST Under Review |
1.11 |
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Brendan Ferreri-Hanberry |
Open for citation & comment |
Included in OECD Work Plan |
715: Activation, Constitutive androstane receptor |
719: Increase, hepatocellular adenomas and carcinomas |
EAGMST Under Review |
1.17 |
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Evgeniia Kazymova |
Open for adoption |
Included in OECD Work Plan |
785: Activation, Androgen receptor |
719: Increase, hepatocellular adenomas and carcinomas |
Under Development |
1.26 |
128 |
Kidney dysfunction by decreased thyroid hormone |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
277: Thyroid hormone synthesis, Decreased |
814: Occurrence, Kidney toxicity |
Under Development |
1.40 |
130 |
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
828: Inhibition, Phospholipase A |
840: Formation, Liver fibrosis |
Under Development |
1.39 |
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Allie Always |
Open for citation & comment |
Included in OECD Work Plan |
18: Activation, AhR |
369: Uroporphyria |
WPHA/WNT Endorsed |
1.7 |
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
867: Decrease, Intracellular pH |
872: Increase, Site of Contact Nasal Tumors |
EAGMST Under Review |
2.7 |
144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1539: Endocytotic lysosomal uptake |
344: N/A, Liver fibrosis |
EAGMST Under Review |
1.47 |
148 |
EGFR Activation Leading to Decreased Lung Function |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
941: Activation, EGFR |
1250: Decrease, Lung function |
Under Development |
1.51 |
149 |
Peptide Oxidation Leading to Hypertension |
Brendan Ferreri-Hanberry |
Not under active development |
Included in OECD Work Plan |
209: Peptide Oxidation |
952: Hypertension |
Under Development |
1.50 |
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Arthur Author |
Open for citation & comment |
Included in OECD Work Plan |
18: Activation, AhR |
947: Increase, Early Life Stage Mortality |
WPHA/WNT Endorsed |
1.7 |
151 |
AhR activation leading to preeclampsia |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
18: Activation, AhR |
1893: increase, Preeclampsia |
Under Development |
1.42 |
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Allie Always |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
957: Binding, Transthyretin in serum |
402: Cognitive Function, Decreased |
Under Development |
1.41 |
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Cataia Ives |
Open for comment. Do not cite |
Included in OECD Work Plan |
980: Inhibition, Calcineurin Activity |
984: Impairment, T-cell dependent antibody response |
WPHA/WNT Endorsed |
1.38 |
155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1002: Inhibition, Deiodinase 2 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1002: Inhibition, Deiodinase 2 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1009: Inhibition, Deiodinase 1 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Allie Always |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1009: Inhibition, Deiodinase 1 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
173 |
Substance interaction with the lung resident cell membrane components leading to lung fibrosis |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1495: Interaction with the lung resident cell membrane components |
1458: Pulmonary fibrosis |
EAGMST Under Review |
1.32 |
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Brendan Ferreri-Hanberry |
Not under active development |
Included in OECD Work Plan |
1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone and 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP and 1169: |
1136: Impaired recruitment , Population trajectory |
Under Development |
1.31 |
202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Agnes Aggy |
Open for comment. Do not cite |
Included in OECD Work Plan |
1252: Binding to (interferes with) topoisomerase II enzyme |
1254: Infant leukaemia |
EAGMST Approved |
1.53 |
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1270: Inactivation of PPARγ |
1276: Lung fibrosis |
Under Development |
1.54 |
212 |
Histone deacetylase inhibition leading to testicular atrophy |
Brendan Ferreri-Hanberry |
Open for citation & comment |
Included in OECD Work Plan |
1502: Histone deacetylase inhibition |
1506: Testicular atrophy |
WPHA/WNT Endorsed |
1.52 |
220 |
Cyp2E1 Activation Leading to Liver Cancer |
Agnes Aggy |
Open for citation & comment |
Included in OECD Work Plan |
1391: Activation of Cyp2E1 |
1395: Liver Cancer |
WPHA/WNT Endorsed |
1.24 |
237 |
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1437: Sensing of the stressor by pulmonary cells |
1443: Plaque progression in arteries |
Under Development |
1.55 |
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) |
814: Occurrence, Kidney toxicity |
Under Development |
1.43 |
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1486: Binding of substrate, endocytic receptor |
814: Occurrence, Kidney toxicity |
Under Development |
1.43 |
258 |
Renal protein alkylation leading to kidney toxicity |
Evgeniia Kazymova |
Not under active development |
Included in OECD Work Plan |
244: Alkylation, Protein |
814: Occurrence, Kidney toxicity |
Under Development |
1.43 |
261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1529: Blockade, L-Type Calcium Channels |
1535: Heart failure |
Under Development |
1.45 |
262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation |
Allie Always |
Open for citation & comment |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
EAGMST Approved |
1.92 |
264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cell death |
Evgeniia Kazymova |
Open for citation & comment |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased lipid storage |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via oxidative DNA damage |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased lipid peroxidation |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased protein oxidation |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
Cataia Ives |
Open for comment. Do not cite |
Included in OECD Work Plan |
279: Thyroperoxidase, Inhibition |
78: Reduction, Cumulative fecundity and spawning |
Under Development |
1.59 |
272 |
Deposition of energy leading to lung cancer |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1686: Direct Deposition of Energy |
1556: Increase, lung cancer |
EAGMST Approved |
1.56 |
277 |
Impaired IL-1R1 signaling leading to increased susceptibility to infection |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
1700: Impaired IL-1R1 signaling |
986: Increase, Increased susceptibility to infection |
EAGMST Under Review |
1.48 |
282 |
Adverse outcome pathway on photochemical toxicity initiated by light exposure |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1592: ROS generation from photoactivated chemicals |
1599: Inflamatory events in light-exposed tissues |
EAGMST Under Review |
1.49 |
283 |
L-type calcium channel blockade leading to hypotension |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Cataia Ives |
Open for citation & comment |
Included in OECD Work Plan |
1617: 5α-reductase, inhibition |
360: Decrease, Population trajectory |
Under Development |
1.81 |
292 |
Inhibition of tyrosinase leads to decreased population in fish |
Agnes Aggy |
Open for citation & comment |
Included in OECD Work Plan |
1627: Inhibition of tyrosinase |
360: Decrease, Population trajectory |
Under Development |
1.78 |
293 |
Increased DNA damage leading to increased risk of breast cancer |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1194: Increase, DNA damage |
185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer |
Under Development |
1.80 |
294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1632: Increase in reactive oxygen and nitrogen species (RONS) |
1194: Increase, DNA damage and 185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer |
Under Development |
1.80 |
295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.79 |
296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Brendan Ferreri-Hanberry |
Open for comment. Do not cite |
Included in OECD Work Plan |
1634: Increase, Oxidative damage to DNA |
185: Increase, Mutations and 1636: Increase, Chromosomal aberrations |
EAGMST Under Review |
1.76 |
297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1637: Retinaldehyde dehydrogenase inhibition |
360: Decrease, Population trajectory |
Under Development |
1.77 |
298 |
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Agnes Aggy |
Open for comment. Do not cite |
Included in OECD Work Plan |
1753: Chronic reactive oxygen species |
1651: Treatment-resistant gastric cancer |
EAGMST Under Review |
1.58 |
300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1656: Antagonism, Thyroid Receptor |
402: Cognitive Function, Decreased |
Under Development |
1.84 |
302 |
Lung surfactant function inhibition leading to decreased lung function |
Brendan Ferreri-Hanberry |
Open for comment. Do not cite |
Included in OECD Work Plan |
1672: Inhibition of lung surfactant function |
1250: Decrease, Lung function |
Under Development |
1.87 |
303 |
Frustrated phagocytosis-induced lung cancer |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1668: Frustrated phagoytosis |
1670: Lung cancer |
Under Development |
1.86 |
305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1617: 5α-reductase, inhibition |
1688: decrease, male anogenital distance |
Under Development |
1.90 |
306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
26: Antagonism, Androgen receptor |
1688: decrease, male anogenital distance |
Under Development |
1.90 |
307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
1688: decrease, male anogenital distance |
Under Development |
1.90 |
313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1706: Stimulation, TLR7/8 |
1709: Psoriatic skin disease |
Under Development |
1.75 |
314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1710: Binding to estrogen receptor (ER)-α in immune cells |
1714: Exacerbation of systemic lupus erythematosus (SLE) |
Under Development |
1.73 |
315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1715: Inhibition of JAK3 |
1719: Impairment of T-cell dependent antibody response |
Under Development |
1.74 |
316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1720: Trypsin inhibition |
1725: Pancreatic acinar cell tumors |
Under Development |
1.60 |
319 |
Induced dysregulation of Angiotensin-converting enzyme 2 leading to lung fibrosis |
Allie Always |
Open for comment. Do not cite |
Included in OECD Work Plan |
1740: ACE2 inhibition |
1276: Lung fibrosis |
Under Development |
1.96 |
320 |
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality |
Evgeniia Kazymova |
Open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
351: Increased Mortality |
Under Development |
1.96 |
348 |
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1799: Inhibition of 11β-HSD |
360: Decrease, Population trajectory |
Under Development |
1.93 |
349 |
Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1796: 11β-hydroxylase inhibition |
360: Decrease, Population trajectory |
Under Development |
1.93 |
358 |
Chitinase inhibition leading to mortality |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1806: Increase, Chitinase inhibition |
350: Increase, Mortality |
Under Development |
1.94 |
359 |
Chitobiase inhibition leading to mortality |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1807: Increase, Chitobiase inhibition |
350: Increase, Mortality |
Under Development |
1.94 |
360 |
Chitin synthase 1 inhibition leading to mortality |
Brendan Ferreri-Hanberry |
Open for citation & comment |
Included in OECD Work Plan |
1522: Inhibition, Chitin synthase 1 |
350: Increase, Mortality |
EAGMST Approved |
1.94 |
361 |
Sulfonylureareceptor binding leading to mortality |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1525: Increase, Sulfonylurea receptor binding |
350: Increase, Mortality |
Under Development |
1.94 |
374 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1841: Encephalitis |
Under Development |
1.96 |
379 |
Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1738: Increased susceptibility to viral entry |
1847: Increased coronavirus production and 1846: Thrombosis and Disseminated Intravascular Coagulation |
Under Development |
1.96 |
381 |
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1850: dysgeusia |
Under Development |
1.96 |
382 |
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Allie Always |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) |
1276: Lung fibrosis |
Under Development |
1.96 |
383 |
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1740: ACE2 inhibition |
344: N/A, Liver fibrosis |
Under Development |
1.96 |
392 |
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1866: Fibrinolysis, decreased and 1867: Bradykinin system, hyperactivated |
1868: Hyperinflammation |
Under Development |
1.96 |
394 |
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1873: impaired olfactory function (anosmia) |
Under Development |
1.96 |
395 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1875: Cerebrovascular disease (stroke) |
Under Development |
1.96 |
398 |
Inhibition of ALDH1A (RALDH) causing reduced all-trans retinoic acid levels leading to impaired fertility, females |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1880: Inhibition of ALDH1A2 (RALDH2) |
972: Decreased fertility, Reduced number of oocytes ovulated |
Under Development |
1.97 |
412 |
SARS-CoV-2 infection leading to thromboinflammation |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1916: Thromboinflammation, Increased |
Under Development |
1.96 |
422 |
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to increased intestinal permeability |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1932: Gastrointestinal disorders |
Under Development |
1.96 |
428 |
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
|
Under Development |
1.96 |
430 |
Sars-CoV-2 Interferon-I antiviral response antagonism and increased viral production leading to viral infection proliferation |
Arthur Author |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1939: Viral infection and host-to-host transmission, proliferated |
Under Development |
1.96 |
4 |
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality |
Brendan Ferreri-Hanberry |
Open for citation & comment |
Under Development |
103: Increase, Ecdysone receptor agonism |
|
|
|
19 |
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) |
Agnes Aggy |
Open for adoption |
Under Development |
27: N/A, Androgen receptor, Antagonism |
337: N/A, Impairment of reproductive capacity |
|
|
26 |
Calcium-mediated neuronal ROS production and energy imbalance |
Brendan Ferreri-Hanberry |
Open for adoption |
Under Development |
51: Inhibition, Ca++ ATPase |
356: Increased, Oxidative damage |
|
|
28 |
Cyclooxygenase inhibition leading reproductive failure |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
79: Inhibition, Cyclooxygenase activity |
253: N/A, Reproductive failure |
|
1.29 |
29 |
Estrogen receptor agonism leading to reproductive dysfunction |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
111: Agonism, Estrogen receptor |
360: Decrease, Population trajectory and 363: Altered, Reproductive behaviour and 339: Altered, Larval development and 364: Impaired development of, Reproductive organs |
|
1.29 |
32 |
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors |
Brendan Ferreri-Hanberry |
Not under active development |
Under Development |
|
|
|
|
33 |
Kidney toxicity induced by activation of 5HT2C |
Arthur Author |
Open for adoption |
Under Development |
9: Activation, 5HT2c |
759: Increased, Kidney Failure |
|
|
34 |
LXR activation leading to hepatic steatosis |
Agnes Aggy |
Not under active development |
Under Development |
167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation |
345: N/A, Liver Steatosis |
|
|
36 |
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
231: Decreased, PPAR-alpha activation and 232: Decreased, PPAR-beta activation and 233: Decreased, PPAR-gamma activation |
459: Increased, Liver Steatosis |
|
1.29 |
52 |
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
111: Agonism, Estrogen receptor |
417: skewed, sex ratio |
|
1.29 |
53 |
ER agonism leading to reduced survival due to renal failure |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
111: Agonism, Estrogen receptor |
|
|
1.29 |
57 |
AhR activation leading to hepatic steatosis |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
18: Activation, AhR |
455: Accumulation, Liver lipid |
|
1.29 |
58 |
NR1I3 (CAR) suppression leading to hepatic steatosis |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
456: Suppression, Constitutive androstane receptor, NR1l3 and 468: Inhibition, PPAR alpha and 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation |
459: Increased, Liver Steatosis |
|
1.29 |
59 |
HNF4alpha suppression leading to hepatic steatosis |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
461: Suppression, HNF4alpha |
|
|
1.29 |
60 |
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
245: Activation, PXR/SXR |
459: Increased, Liver Steatosis |
|
1.29 |
61 |
NFE2L2/FXR activation leading to hepatic steatosis |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
478: Activation, NRF2 and 479: Activation, NR1H4 |
459: Increased, Liver Steatosis |
|
1.29 |
62 |
AKT2 activation leading to hepatic steatosis |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
486: systemic inflammation leading to hepatic steatosis |
459: Increased, Liver Steatosis |
|
1.29 |
63 |
Cyclooxygenase inhibition leading to reproductive dysfunction |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
|
1.29 |
64 |
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
494: Glucocorticoid Receptor Agonist, Activation |
406: impaired, Fertility |
|
1.29 |
66 |
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone and 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists |
505: Decreased sperm quantity / quality in the adult, Decreased fertility |
|
1.29 |
67 |
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
658: Decreased testosterone by the fetal Leydig cells, Increased estradiol and 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists |
505: Decreased sperm quantity / quality in the adult, Decreased fertility |
|
1.29 |
68 |
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome |
505: Decreased sperm quantity / quality in the adult, Decreased fertility |
|
1.29 |
69 |
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol and 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins and 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane |
646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis |
|
1.29 |
70 |
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell |
520: Decreased sperm quantity or quality in the adult, Decreased fertility |
|
1.29 |
71 |
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid |
520: Decreased sperm quantity or quality in the adult, Decreased fertility |
|
1.29 |
72 |
Epigenetic modification of PPARG leading to adipogenesis |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
228: peroxisome proliferator activated receptor promoter demethylation and 1454: chronic high fat diet |
1447: obesity |
|
1.29 |
73 |
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
526: Inhibition, Inhibition of Dopamine-beta-hydroxylase |
527: Decreased, Decreased fecundity |
|
1.29 |
74 |
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis |
543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis |
|
1.29 |
77 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 |
Agnes Aggy |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
|
1.29 |
78 |
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 |
Allie Always |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
566: impaired, Larval development and 563: Death/Failure, Colony |
|
1.29 |
79 |
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure |
Evgeniia Kazymova |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
|
1.29 |
80 |
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure |
Cataia Ives |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony |
|
1.29 |
81 |
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure |
Brendan Ferreri-Hanberry |
Open for comment. Do not cite |
Under Development |
|
572: Decrease, Number of worker bees and 563: Death/Failure, Colony |
|
1.29 |
82 |
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure |
Arthur Author |
Open for comment. Do not cite |
Under Development |
|
566: impaired, Larval development and 563: Death/Failure, Colony |
|
1.29 |
84 |
Suppression of immune system contributes to impaired development and leads to colony loss/failure |
Agnes Aggy |
Open for comment. Do not cite |
Under Development |
|
572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony |
|
1.29 |
85 |
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure |
Allie Always |
Open for comment. Do not cite |
Under Development |
|
572: Decrease, Number of worker bees and 563: Death/Failure, Colony |
|
1.29 |
86 |
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure |
Evgeniia Kazymova |
Open for comment. Do not cite |
Under Development |
|
566: impaired, Larval development and 563: Death/Failure, Colony |
|
1.29 |
87 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure |
Cataia Ives |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
|
1.29 |
88 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste |
Brendan Ferreri-Hanberry |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
|
1.29 |
89 |
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure |
Arthur Author |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
|
1.29 |
90 |
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 |
Agnes Aggy |
Open for comment. Do not cite |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
566: impaired, Larval development and 563: Death/Failure, Colony |
|
1.29 |
91 |
Sodium channel inhibition leading to reduced survival |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
584: Inhibition, sodium channel |
587: Reduced, feeding 1 and 588: Increased, predation and 592: Reduced, survival |
|
1.29 |
93 |
sodium channel inhibition leading to increased predation |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
584: Inhibition, sodium channel |
588: Increased, predation |
|
1.29 |
94 |
Sodium channel inhibition leading to congenital malformations |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
584: Inhibition, sodium channel |
591: Increased, amputations |
|
1.29 |
95 |
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel |
592: Reduced, survival |
|
1.29 |
96 |
Axonal sodium channel modulation leading to acute mortality |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
598: modulation, sodium channel |
351: Increased Mortality |
|
1.29 |
97 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
623: Increase, predation and 360: Decrease, Population growth rate |
|
1.29 |
99 |
Histamine (H2) receptor antagonism leading to reduced survival |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
638: Antagonism, Histamine Receptor (H2) |
636: Decreased, survival and 588: Increased, predation |
|
1.29 |
100 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
|
1.29 |
101 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
|
1.29 |
102 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
|
1.29 |
103 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
79: Inhibition, Cyclooxygenase activity |
675: Reduced, Reproductive Success and 360: Decrease, Population trajectory |
|
1.29 |
104 |
Altered ion channel activity leading impaired heart function |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
697: impaired, ion channels |
351: Increased Mortality |
|
1.29 |
105 |
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
714: Increased, Binding of chemicals to 2u (serum) |
713: Increase, Adenomas/carcinomas (renal tubular) |
|
1.29 |
108 |
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme |
719: Increase, hepatocellular adenomas and carcinomas |
|
1.29 |
109 |
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
770: Increase, Cytotoxicity (club cells) |
736: Increase, Adenomas/carcinomas (bronchioloalveolar) |
|
1.29 |
110 |
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
737: Decreased, Uptake of inorganic iodide |
741: Increase, Adenomas/carcinomas (follicular cell) |
|
1.29 |
111 |
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
742: Decreased, Androgen receptor activity |
745: Increase, Leydig cell tumors |
|
1.29 |
112 |
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
746: Increase, Dopaminergic activity |
773: Increase, Endometrial adenocarcinomas |
|
1.29 |
113 |
Glutamate-gated chloride channel activation leading to acute mortality |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
760: Activation, Glutamate-gated chloride channel |
351: Increased Mortality and 765: Decreased, population 1 |
|
1.29 |
114 |
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme |
779: Increase, Papillomas/carcinomas (squamous cells) |
|
1.29 |
115 |
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
780: Increase, Cytotoxicity (epithelial cells) |
779: Increase, Papillomas/carcinomas (squamous cells) |
|
1.29 |
116 |
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
783: Increase, Cytotoxicity (tubular epithelial cells) |
713: Increase, Adenomas/carcinomas (renal tubular) |
|
1.29 |
118 |
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
786: Increase, Cytotoxicity (hepatocytes) |
719: Increase, hepatocellular adenomas and carcinomas |
|
1.29 |
119 |
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
279: Thyroperoxidase, Inhibition |
741: Increase, Adenomas/carcinomas (follicular cell) |
|
1.29 |
120 |
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
790: Inhibition, 5α-reductase activity |
745: Increase, Leydig cell tumors |
|
1.29 |
121 |
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
793: Increase, Urinary bladder calculi |
797: Increase, Adenomas/carcinomas (urothelial) |
|
1.29 |
122 |
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
798: Inhibition, Prolyl hydroxylases |
78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory |
|
1.29 |
123 |
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
801: modulation, Unknown |
78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory |
|
1.29 |
124 |
HMG-CoA reductase inhibition leading to decreased fertility |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
804: Inhibition, HMG-CoA reductase |
330: Decrease, Fertility |
|
1.29 |
126 |
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
849: Inhibition, Antgonism of NE receptor |
527: Decreased, Decreased fecundity |
|
1.29 |
134 |
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
424: Inhibition, Na+/I- symporter (NIS) |
402: Cognitive Function, Decreased |
|
1.29 |
138 |
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
877: Inhibition, organic anion transporter 1 (OAT1) |
351: Increased Mortality and 360: Decrease, Population growth rate |
|
1.29 |
139 |
Alkylation of DNA leading to cancer 1 |
Arthur Author |
Open for adoption |
Under Development |
97: Alkylation, DNA |
885: Increase, Cancer |
|
|
146 |
Estrogen Receptor Activation and Female Precocious Puberty |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
153 |
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol |
972: Decreased fertility, Reduced number of oocytes ovulated |
|
1.29 |
160 |
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Under Development |
762: Activation, ionotropic GABA Receptor chloride channel |
351: Increased Mortality |
|
|
161 |
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Under Development |
1018: Activation, Glutamate-gated chloride channels |
351: Increased Mortality |
|
|
162 |
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) |
|
1.29 |
163 |
PPARgamma activation leading to sarcomas in rats, mice, and hamsters |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
1028: Activation of specific nuclear receptors, PPAR-gamma activation |
|
|
1.29 |
164 |
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
1038: Activation, beta-2 adrenergic receptor |
1044: Promotion, mesovarian leiomyomas |
|
1.29 |
165 |
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1053: Promotion, ovarian adenomas and 1054: Promotion, ovarian granular cell tumors |
|
1.29 |
166 |
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1063: Increased, Pancreatic acinar tumors |
|
1.29 |
167 |
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
1064: prepubertal increase, Estrogen receptor (ER) activity |
1070: Increased, adenosquamous carcinomas of endometrium |
|
1.29 |
168 |
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1079: Increased, Adenomas/carcinomas (mammary) |
|
1.29 |
169 |
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1082: Increased, adenomas (pituitary) |
|
1.29 |
170 |
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1079: Increased, Adenomas/carcinomas (mammary) |
|
1.29 |
171 |
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
|
1090: Increased, mesotheliomas |
|
1.29 |
175 |
Thyroperoxidase inhibition leading to altered amphibian metamorphosis |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
279: Thyroperoxidase, Inhibition |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
176 |
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
424: Inhibition, Na+/I- symporter (NIS) |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
177 |
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
1103: Inhibition, Cyclooxygenase 1 activity |
351: Increased Mortality and 360: Decrease, Population growth rate |
|
1.29 |
178 |
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
559: Activation, Nicotinic acetylcholine receptor |
563: Death/Failure, Colony |
|
1.29 |
179 |
Varroa mite infestation increases virus levels leading to colony loss/failure |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
180 |
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
181 |
Weather event contributes to colony loss/failure |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
182 |
Weather event contributes abnormal foraging leading to colony loss/failure |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
183 |
Nosema infection increases energetic demands leading to colony loss/failure |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
184 |
Nosema infection causes abnormal role change that leads to colony loss/failure |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
185 |
Queen egg-laying decrease leads to colony loss/failure |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
|
563: Death/Failure, Colony |
|
1.29 |
186 |
unknown MIE leading to renal failure and mortality |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
1114: Unknown, MIE |
351: Increased Mortality |
|
1.29 |
188 |
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
1152: Inhibition, Iodotyrosine deiodinase (IYD) |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
189 |
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
1009: Inhibition, Deiodinase 1 |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
190 |
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
1002: Inhibition, Deiodinase 2 |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
191 |
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
1153: Inhibition, Deiodinase 3 |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
192 |
Pendrin inhibition leading to altered amphibian metamorphosis |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
1155: Inhibition, Pendrin |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
193 |
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
1156: Inhibition, Dual oxidase |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
194 |
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
1157: Activation, Hepatic nuclear receptor(s) |
1101: Altered, Amphibian metamorphosis |
|
1.29 |
195 |
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
1164: Increased, Population |
|
1.29 |
196 |
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation |
Allie Always |
Under development: Not open for comment. Do not cite |
Under Development |
1215: TRPA1 activation, TRPA1 Receptor |
1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea and 1434: Irritation of nasal mucosa inducing sneeze reflex and 1226: Increased Respiratory irritability and Chronic Cough, |
|
|
197 |
Sodium channel (Nav1.1) inhibition leading to population decline |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
584: Inhibition, sodium channel |
|
|
1.29 |
199 |
ER mediated breast cancer AOP |
Cataia Ives |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
200 |
Estrogen receptor activation leading to breast cancer |
Brendan Ferreri-Hanberry |
Open for adoption |
Under Development |
1181: Activation, Estrogen receptor |
1193: N/A, Breast Cancer |
|
|
201 |
Juvenile hormone receptor agonism leading to male offspring induction associated population decline |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
1205: Activation, Juvenile hormone receptor |
1208: Increased, Male offspring and 361: Decline, Population and 1210: Alteration, Food-web structures |
|
|
203 |
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
1141: Decreased, Reproductive Success and 360: Decrease, Population growth rate |
|
1.29 |
204 |
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase |
Evgeniia Kazymova |
Under Development: Contributions and Comments Welcome |
Under Development |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
1163: Increased, Reproductive Success and 1164: Increased, Population |
|
1.29 |
205 |
AOP from chemical insult to cell death |
Cataia Ives |
Open for comment. Do not cite |
Under Development |
1258: Decompartmentalization and 1260: Direct mitochondrial inhibition and 1259: narcosis |
1262: Apoptosis and 1263: Necrosis |
|
|
207 |
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans |
Arthur Author |
Under development: Not open for comment. Do not cite |
Under Development |
1174: Activation, NADPH Oxidase |
1277: Reproductive failure |
|
|
208 |
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Under Development |
|
1277: Reproductive failure |
|
|
209 |
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP |
Allie Always |
Under development: Not open for comment. Do not cite |
Under Development |
|
1291: Hepatotoxicity |
|
|
210 |
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Under Development |
|
1277: Reproductive failure |
|
|
211 |
Handbook development AOP |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
213 |
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) |
Arthur Author |
Open for adoption |
Under Development |
1490: Inhibition, Fatty Acid Beta Oxidation |
1489: N/A, Steatohepatisis |
|
|
214 |
Network of SSRIs (selective serotonin reuptake inhibitors) |
Agnes Aggy |
Open for adoption |
Under Development |
|
1344: Increased, seizure and 1345: Increased, agitation and 1346: Increased, depression and 1343: Increase, hypertension |
|
|
215 |
Molecular events lead to epilepsy |
Allie Always |
Open for adoption |
Under Development |
|
1348: Increase, seizure and 1362: Increased, hippocampal hyperdepolarization and 1363: Increased, epilepsy |
|
|
216 |
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Under Development |
257: Increase, Reactive Oxygen Species production |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
|
|
217 |
Gastric ulcer formation |
Cataia Ives |
Open for adoption |
Under Development |
|
1367: Inhibit, gastric ulcer formation and 1385: Activated, gastric ulcer formation |
|
|
218 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity |
Brendan Ferreri-Hanberry |
Not under active development |
Under Development |
1386: CYP7B activity, inhibition |
360: Decrease, Population growth rate |
|
|
219 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior |
Arthur Author |
Not under active development |
Under Development |
1386: CYP7B activity, inhibition |
360: Decrease, Population growth rate |
|
|
221 |
Mental stress to depression |
Allie Always |
Open for adoption |
Under Development |
1396: Increased, glucocorticoid receptor activity |
1346: Increased, depression |
|
|
222 |
Mental stress to agitation |
Evgeniia Kazymova |
Open for adoption |
Under Development |
1396: Increased, glucocorticoid receptor activity |
1345: Increased, agitation |
|
|
223 |
Serotonin transporter activation to seizure |
Cataia Ives |
Open for adoption |
Under Development |
1397: Increased, serotonin transporter activity |
1344: Increased, seizure |
|
|
224 |
Serotonin transporter activation to depression |
Brendan Ferreri-Hanberry |
Open for adoption |
Under Development |
1397: Increased, serotonin transporter activity |
1346: Increased, depression |
|
|
225 |
Serotonin transporter activation to agitation |
Arthur Author |
Open for adoption |
Under Development |
|
1345: Increased, agitation |
|
|
226 |
SSRI (Selective serotonin reuptake inhibitor) to hypertension |
Agnes Aggy |
Open for adoption |
Under Development |
1317: Decreased, serotonin transporter activity |
1343: Increase, hypertension |
|
|
227 |
NSAID induced PTGS1 inactivation to gastric ulcer |
Allie Always |
Open for adoption |
Under Development |
1402: Reduced, PTGS1 function |
1385: Activated, gastric ulcer formation |
|
|
228 |
NSAID induced PTGS2 inactivation to gastric ulcer |
Evgeniia Kazymova |
Open for adoption |
Under Development |
1408: Reduced, PTGS2 function |
1385: Activated, gastric ulcer formation |
|
|
229 |
Helicobacter pylori to gastric ulcer |
Cataia Ives |
Open for adoption |
Under Development |
1412: Helicobacter pylori infection |
1385: Activated, gastric ulcer formation |
|
|
230 |
presynaptic neuron 1 activation to epilepsy |
Brendan Ferreri-Hanberry |
Open for adoption |
Under Development |
1349: Activated, presynaptic neuron 1 |
1363: Increased, epilepsy |
|
|
231 |
presynaptic neuron 2 repression to epilepsy |
Arthur Author |
Open for adoption |
Under Development |
1413: Reduced, presynaptic neuron 2 activity |
1363: Increased, epilepsy |
|
|
232 |
NFE2/Nrf2 repression to steatosis |
Agnes Aggy |
Open for adoption |
Under Development |
1417: NFE2/Nrf2 repression |
1418: Increased, steatosis |
|
|
233 |
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening |
Allie Always |
Not under active development |
Under Development |
1425: Mu Opioid Receptor Agonism |
1428: Analgesia |
|
|
234 |
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition |
Evgeniia Kazymova |
Not under active development |
Under Development |
1425: Mu Opioid Receptor Agonism |
1428: Analgesia |
|
|
235 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening |
Cataia Ives |
Not under active development |
Under Development |
1431: Serotonin 1A Receptor Agonism |
1432: Anti-depressant Activity |
|
|
236 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition |
Brendan Ferreri-Hanberry |
Not under active development |
Under Development |
1431: Serotonin 1A Receptor Agonism |
1432: Anti-depressant Activity |
|
|
239 |
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling |
Allie Always |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
240 |
DNA Adducts Leading to Liver Hemangiosarcoma |
Evgeniia Kazymova |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
286 |
Mitochondrial complex III antagonism leading to growth inhibition (1) |
Agnes Aggy |
Under development: Not open for comment. Do not cite |
Under Development |
1542: Increase, Mitochondrial complex III antagonism |
1521: Decrease, Growth |
|
|
287 |
Mitochondrial complex III antagonism leading to growth inhibition (2) |
Allie Always |
Under development: Not open for comment. Do not cite |
Under Development |
1542: Increase, Mitochondrial complex III antagonism |
1521: Decrease, Growth |
|
|
290 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) |
Brendan Ferreri-Hanberry |
Under development: Not open for comment. Do not cite |
Under Development |
1785: Increase, Mitochondrial ATP synthase antagonism |
1521: Decrease, Growth |
|
|
291 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) |
Arthur Author |
Under development: Not open for comment. Do not cite |
Under Development |
1785: Increase, Mitochondrial ATP synthase antagonism |
1521: Decrease, Growth |
|
|
299 |
Deposition of energy leading to population decline via DNA oxidation and follicular atresia |
Allie Always |
Under development: Not open for comment. Do not cite |
Under Development |
257: Increase, Reactive Oxygen Species production |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
|
|
336 |
DNA methyltransferase inhibition leading to population decline (1) |
Agnes Aggy |
Under Development: Contributions and Comments Welcome |
Under Development |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
|
|
337 |
DNA methyltransferase inhibition leading to population decline (2) |
Allie Always |
Under Development: Contributions and Comments Welcome |
Under Development |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
|
|
339 |
DNA methyltransferase inhibition leading to population decline (4) |
Cataia Ives |
Under Development: Contributions and Comments Welcome |
Under Development |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
|
|
340 |
DNA methyltransferase inhibition leading to transgenerational effects (1) |
Brendan Ferreri-Hanberry |
Under Development: Contributions and Comments Welcome |
Under Development |
1619: Increase, DNA methyltransferase inhibition |
1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory |
|
|
341 |
DNA methyltransferase inhibition leading to transgenerational effects (2) |
Arthur Author |
Under Development: Contributions and Comments Welcome |
Under Development |
1619: Increase, DNA methyltransferase inhibition |
1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory |
|
|