API

AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Cataia Ives Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired TFHA/WNT Endorsed 1.33
6 Antagonist binding to PPARα leading to body-weight loss Agnes Aggy Open for citation & comment Included in OECD Work Plan PPAR starvation-like body-weight loss TFHA/WNT Endorsed 2.3
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Allie Always Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Not under active development Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Cataia Ives Open for citation & comment Included in OECD Work Plan GABA epileptic seizures TFHA/WNT Endorsed 1.15
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan case study Under Development 2.5
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Arthur Author Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration TFHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Agnes Aggy Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
16 Acetylcholinesterase inhibition leading to acute mortality Cataia Ives Under Development: Contributions and Comments Welcome Included in OECD Work Plan AChE acute mortality Under Development 1.3
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration EAGMST Under Review 1.13
18 PPARα activation in utero leading to impaired fertility in males Arthur Author Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Allie Always Open for citation & comment Included in OECD Work Plan AhR embryo toxicity TFHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction TFHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Cataia Ives Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
30 Estrogen receptor antagonism leading to reproductive dysfunction Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
31 Oxidation of iron in hemoglobin leading to hematotoxicity Cataia Ives Open for adoption Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
35 Narcosis leading to respiratory failure Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
38 Protein Alkylation leading to Liver Fibrosis Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
40 Covalent Protein binding leading to Skin Sensitisation Agnes Aggy Open for citation & comment Included in OECD Work Plan Covalent Binding, Protein sensitisation, skin TFHA/WNT Endorsed 1.1
41 Sustained AhR Activation leading to Rodent Liver Tumours Allie Always Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes TFHA/WNT Endorsed 1.10
43 Disruption of VEGFR Signaling Leading to Developmental Defects Cataia Ives Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Agnes Aggy Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Allie Always Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
51 PPARα activation leading to impaired fertility in adult male rodents Evgeniia Kazymova Not under active development Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Arthur Author Open for citation & comment Included in OECD Work Plan NIS learning and memory deficits in children TFHA/WNT Endorsed 1.28
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Cataia Ives Open for citation & comment Included in OECD Work Plan tubulin? aneuploid offspring EAGMST Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.17
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Evgeniia Kazymova Open for adoption Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
128 Kidney dysfunction by decreased thyroid hormone Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
130 Phospholipase A inhibitors lead to hepatotoxicity Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
131 Aryl hydrocarbon receptor activation leading to uroporphyria Allie Always Open for citation & comment Included in OECD Work Plan AhR uroporphyria TFHA/WNT Endorsed 1.7
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Cataia Ives Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
144 Endocytic lysosomal uptake leading to liver fibrosis Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation EAGMST Under Review 1.47
148 EGFR Activation Leading to Decreased Lung Function Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan Under Development 1.50
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Arthur Author Open for citation & comment Included in OECD Work Plan Activation, AhR Increase, Early Life Stage Mortality TFHA/WNT Endorsed 1.7
151 AhR activation leading to preeclampsia Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Allie Always Open for adoption Included in OECD Work Plan Transthyretin Under Development 1.41
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Cataia Ives Open for comment. Do not cite Included in OECD Work Plan Calcineurin Activity, Inhibition EAGMST Under Review 1.38
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Brendan Ferreri-Hanberry Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Arthur Author Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Agnes Aggy Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Allie Always Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Evgeniia Kazymova Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.32
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan Under Development 1.31
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
212 Histone deacetylase inhibition leading to testicular atrophy Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan Histone deacetylase, inhibition testicular toxicity EAGMST Under Review 1.52
220 Cyp2E1 Activation Leading to Liver Cancer Agnes Aggy Open for citation & comment Included in OECD Work Plan Activation of Cyp2E1 liver cancer EAGMST Under Review 1.24
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.55
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Evgeniia Kazymova Not under active development Included in OECD Work Plan Under Development 1.43
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
263 Uncoupling of oxidative phosphorylation leading to growth inhibition (1) Allie Always Open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition (2) Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition (3) Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition (4) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition (5) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition (6) Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish Cataia Ives Open for comment. Do not cite Included in OECD Work Plan Under Development 1.59
272 Direct deposition of ionizing energy leading to lung cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.56
277 Impaired IL-1R1 signaling leading to increased susceptibility to infection Cataia Ives Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.48
282 Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.49
283 L-type calcium channel blockade leading to hypotension Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Cataia Ives Open for citation & comment Included in OECD Work Plan Under Development 1.81
292 Inhibition of tyrosinase leads to decreased population in fish Agnes Aggy Open for citation & comment Included in OECD Work Plan Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.79
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Brendan Ferreri-Hanberry Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.76
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan Under Development 1.77
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan EAGMST Under Review 1.58
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Thyroid Receptor Antagonism Cognitve function, Decreased Under Development 1.84
302 Lung surfactant function inhibition leading to impaired lung function Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.86
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.60
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Brendan Ferreri-Hanberry Open for citation & comment Under Development EcR mortality
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Agnes Aggy Open for adoption Under Development AR adverse effects in the male foetus
26 Calcium-mediated neuronal ROS production and energy imbalance Brendan Ferreri-Hanberry Open for adoption Under Development unclear energy imbalance
28 Cyclooxygenase inhibition leading reproductive failure Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive failure 1.29
29 Estrogen receptor agonism leading to reproductive dysfunction Allie Always Under Development: Contributions and Comments Welcome Under Development ER reproductive dysfunction 1.29
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry Not under active development Under Development nitric oxide liver tumors
33 Kidney toxicity induced by activation of 5HT2C Arthur Author Open for adoption Under Development 5-HTT2c kidney toxicity
34 LXR activation leading to hepatic steatosis Agnes Aggy Not under active development Under Development LXR liver steatosis
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development b-oxidation fatty acid steatosis 1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Cataia Ives Under Development: Contributions and Comments Welcome Under Development ER altered sexual differentiation 1.29
53 ER agonism leading to reduced survival due to renal failure Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development ER reduced survival 1.29
57 AhR activation leading to hepatic steatosis Agnes Aggy Under Development: Contributions and Comments Welcome Under Development AhR hepatic steatosis 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Allie Always Under Development: Contributions and Comments Welcome Under Development CAR hepatic steatosis 1.29
59 HNF4alpha suppression leading to hepatic steatosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development HNF4alpha hepatic steatosis 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Cataia Ives Under Development: Contributions and Comments Welcome Under Development PXR hepatic steatosis 1.29
61 NFE2L2/FXR activation leading to hepatic steatosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development multiple hepatic steatosis 1.29
62 AKT2 activation leading to hepatic steatosis Arthur Author Under Development: Contributions and Comments Welcome Under Development AKT2 hepatic steatosis 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Allie Always Under Development: Contributions and Comments Welcome Under Development GR decreased male fertitlity 1.29
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Cataia Ives Under Development: Contributions and Comments Welcome Under Development GR modulation of leydig cell function 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development estradiol modulation of leydig cell function 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author Under Development: Contributions and Comments Welcome Under Development proteins - undefined modulation of leydig cell function 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy Under Development: Contributions and Comments Welcome Under Development multiple modulation of leydig cell function 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always Under Development: Contributions and Comments Welcome Under Development modulation of leydig cell function 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development GR modulation of leydig cell function 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Cataia Ives Under Development: Contributions and Comments Welcome Under Development PPARg adipogenesis 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development DBH reduced fecundity 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Arthur Author Under Development: Contributions and Comments Welcome Under Development unk modulation of leydig cell function 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Agnes Aggy Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Allie Always Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Evgeniia Kazymova Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Cataia Ives Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry Open for comment. Do not cite Under Development metabolic stress is not MIE colony loss/failure 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Arthur Author Open for comment. Do not cite Under Development unk colony loss/failure 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Agnes Aggy Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Allie Always Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Evgeniia Kazymova Open for comment. Do not cite Under Development glucose oxidase colony loss/failure 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Cataia Ives Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Brendan Ferreri-Hanberry Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Arthur Author Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Agnes Aggy Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
91 Sodium channel inhibition leading to reduced survival Allie Always Under Development: Contributions and Comments Welcome Under Development sodium channel reduced survival 1.29
93 sodium channel inhibition leading to increased predation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development sodium channel increased predation 1.29
94 Sodium channel inhibition leading to congenital malformations Cataia Ives Under Development: Contributions and Comments Welcome Under Development sodium channel congenital malformations 1.29
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development ERG reduced survival 1.29
96 Axonal sodium channel modulation leading to acute mortality Arthur Author Under Development: Contributions and Comments Welcome Under Development sodium channel acute mortality 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 5-HTT increased predation 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development H2 reduced survival 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cataia Ives Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
104 Altered ion channel activity leading impaired heart function Allie Always Under Development: Contributions and Comments Welcome Under Development multiple impaired heart function 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development Alpha2u adenomas and carcinomas 1.29
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development pyruvate dehydrogenase hepatocellular carcinoma 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always Under Development: Contributions and Comments Welcome Under Development NIS follicular cell adenomas and carcinomas 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development AR leydig cell tumors 1.29
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Cataia Ives Under Development: Contributions and Comments Welcome Under Development dopamine?? endometrial adenocarcinomas 1.29
113 Glutamate-gated chloride channel activation leading to acute mortality Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development GluCl Channel acute mortality 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development HPPD corneal papillomas and carcinomas 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cytotox not MIE forestomach tumors 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Allie Always Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE renal tubular adenomas and carcinomas 1.29
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Cataia Ives Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development TPO follicular cell adenomas and carcinomas 1.29
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development 5α-reductase leydig cell tumors 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development unclear urothelial papillomas and carcinomas 1.29
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Allie Always Under Development: Contributions and Comments Welcome Under Development Prolyl hydroxylase reproductive dysfunction 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development Unknown reproductive dysfunction 1.29
124 HMG-CoA reductase inhibition leading to decreased fertility Cataia Ives Under Development: Contributions and Comments Welcome Under Development HMG-CoA reductase decreased fertility 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development alpha Norad Receptors delayed ovulation 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development NIS neurodevelopmental outcomes 1.29
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development p-amino hippuric acid renal failure and mortality 1.29
139 Alkylation of DNA leading to cancer 1 Arthur Author Open for adoption Under Development DNA alkylation cancer
146 Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development ER 1.29
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Cataia Ives Under development: Not open for comment. Do not cite Under Development
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
181 Weather event contributes to colony loss/failure Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
185 Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
186 unknown MIE leading to renal failure and mortality Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Allie Always Under development: Not open for comment. Do not cite Under Development
197 Sodium channel (Nav1.1) inhibition leading to population decline Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
199 ER mediated breast cancer AOP Cataia Ives Under development: Not open for comment. Do not cite Under Development
200 Estrogen receptor activation leading to breast cancer Brendan Ferreri-Hanberry Open for adoption Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Arthur Author Under development: Not open for comment. Do not cite Under Development
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
205 AOP from chemical insult to cell death Cataia Ives Open for comment. Do not cite Under Development
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always Under development: Not open for comment. Do not cite Under Development
211 Handbook development AOP Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Arthur Author Open for adoption Under Development
214 Network of SSRIs (selective serotonin reuptake inhibitors) Agnes Aggy Open for adoption Under Development
215 Molecular events lead to epilepsy Allie Always Open for adoption Under Development
216 Excessive reactive oxygen species production leading to population decline via follicular atresia Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
217 Gastric ulcer formation Cataia Ives Open for adoption Under Development
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Brendan Ferreri-Hanberry Not under active development Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Arthur Author Not under active development Under Development
221 Mental stress to depression Allie Always Open for adoption Under Development
222 Mental stress to agitation Evgeniia Kazymova Open for adoption Under Development
223 Serotonin transporter activation to seizure Cataia Ives Open for adoption Under Development
224 Serotonin transporter activation to depression Brendan Ferreri-Hanberry Open for adoption Under Development
225 Serotonin transporter activation to agitation Arthur Author Open for adoption Under Development
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Agnes Aggy Open for adoption Under Development
227 NSAID induced PTGS1 inactivation to gastric ulcer Allie Always Open for adoption Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Evgeniia Kazymova Open for adoption Under Development
229 Helicobacter pylori to gastric ulcer Cataia Ives Open for adoption Under Development
230 presynaptic neuron 1 activation to epilepsy Brendan Ferreri-Hanberry Open for adoption Under Development
231 presynaptic neuron 2 repression to epilepsy Arthur Author Open for adoption Under Development
232 NFE2/Nrf2 repression to steatosis Agnes Aggy Open for adoption Under Development
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Allie Always Not under active development Under Development
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Evgeniia Kazymova Not under active development Under Development
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Cataia Ives Not under active development Under Development
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Brendan Ferreri-Hanberry Not under active development Under Development
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always Under development: Not open for comment. Do not cite Under Development
240 DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
286 Mitochondrial complex III antagonism leading to growth inhibition (1) Agnes Aggy Under development: Not open for comment. Do not cite Under Development
287 Mitochondrial complex III antagonism leading to growth inhibition (2) Allie Always Under development: Not open for comment. Do not cite Under Development
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) Arthur Author Under development: Not open for comment. Do not cite Under Development
299 Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation Allie Always Under development: Not open for comment. Do not cite Under Development
336 DNA methyltransferase inhibition leading to population decline (1) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development
337 DNA methyltransferase inhibition leading to population decline (2) Allie Always Under Development: Contributions and Comments Welcome Under Development
339 DNA methyltransferase inhibition leading to population decline (4) Cataia Ives Under Development: Contributions and Comments Welcome Under Development
340 DNA methyltransferase inhibition leading to transgenerational effects (1) Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development
341 DNA methyltransferase inhibition leading to transgenerational effects (2) Arthur Author Under Development: Contributions and Comments Welcome Under Development