API

AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
259 Sensitization induction of the intestinal tract by food proteins Cataia Ives Under development: Not open for comment. Do not cite
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan case study Under Development 2.5
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Allie Always Under development: Not open for comment. Do not cite
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Evgeniia Kazymova Under development: Not open for comment. Do not cite
273 Mitochondrial complex inhibition leading to liver injury Arthur Author Under development: Not open for comment. Do not cite
274 Histone deacetylase inhibition leads to impeded craniofacial development Agnes Aggy Under development: Not open for comment. Do not cite
275 Histone deacetylase inhibition leads to neural tube defects Allie Always Under development: Not open for comment. Do not cite
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Evgeniia Kazymova Under development: Not open for comment. Do not cite
278 IKK complex inhibition leading to liver injury Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
279 Microtubule interacting drugs lead to peripheral neuropathy Arthur Author Under development: Not open for comment. Do not cite
280 α-diketone-induced bronchiolitis obliterans Agnes Aggy Under development: Not open for comment. Do not cite
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Allie Always Under development: Not open for comment. Do not cite
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
285 Inhibition of N-linked glycosylation leads to liver injury Arthur Author Under development: Not open for comment. Do not cite
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Evgeniia Kazymova Open for citation & comment
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Cataia Ives Under development: Not open for comment. Do not cite
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Agnes Aggy Under development: Not open for comment. Do not cite
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Arthur Author Under development: Not open for comment. Do not cite
311 Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction Agnes Aggy Under development: Not open for comment. Do not cite
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Allie Always Under development: Not open for comment. Do not cite
318 Glucocorticoid Receptor activation leading to hepatic steatosis Agnes Aggy Under Development: Contributions and Comments Welcome
319 Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis Allie Always Open for comment. Do not cite
320 Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Evgeniia Kazymova Open for comment. Do not cite
321 Reduced environmental pH leading to thinner shells in Mytilus edulis Cataia Ives Under development: Not open for comment. Do not cite
322 Alkylation of DNA leading to reduced sperm count Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
323 PPARalpha Agonism Impairs Fish Reproduction Arthur Author Under development: Not open for comment. Do not cite
324 Thermal stress leading to population decline (1) Agnes Aggy Under development: Not open for comment. Do not cite
325 Thermal stress leading to population decline (2) Allie Always Under development: Not open for comment. Do not cite
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always Under Development: Contributions and Comments Welcome Under Development modulation of leydig cell function 1.29
326 Thermal stress leading to population decline (3) Evgeniia Kazymova Under development: Not open for comment. Do not cite
327 Excessive reactive oxygen species production leading to mortality (1) Cataia Ives Under development: Not open for comment. Do not cite
328 Excessive reactive oxygen species production leading to mortality (2) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
329 Excessive reactive oxygen species production leading to mortality (3) Arthur Author Under development: Not open for comment. Do not cite
330 Excessive reactive oxygen species production leading to mortality (4) Agnes Aggy Under development: Not open for comment. Do not cite
331 Formation of DNA photoproducts leading to growth inhibition (1) Allie Always Under development: Not open for comment. Do not cite
332 Formation of DNA photoproducts leading to growth inhibition (2) Evgeniia Kazymova Under development: Not open for comment. Do not cite
333 Formation of DNA photoproducts leading to growth inhibition (3) Cataia Ives Under development: Not open for comment. Do not cite
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Arthur Author Under development: Not open for comment. Do not cite
338 DNA methyltransferase inhibition leading to population decline (3) Evgeniia Kazymova Under Development: Contributions and Comments Welcome
342 S-adenosylmethionine depletion leading to population decline (1) Agnes Aggy Under development: Not open for comment. Do not cite
343 S-adenosylmethionine depletion leading to population decline (2) Allie Always Under development: Not open for comment. Do not cite
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Evgeniia Kazymova Under development: Not open for comment. Do not cite
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Cataia Ives Under development: Not open for comment. Do not cite
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Arthur Author Under development: Not open for comment. Do not cite
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased trajectory in fish Agnes Aggy Under development: Not open for comment. Do not cite
349 Inhibition of 11β-hydroxylase leading to decresed trajectory in fish Allie Always Under development: Not open for comment. Do not cite
358 Chitinase inhibition leading to mortality Evgeniia Kazymova Under development: Not open for comment. Do not cite
359 Chitobiase inhibition leading to mortality Cataia Ives Under development: Not open for comment. Do not cite
360 Chitin synthase 1 inhibition leading to mortality Brendan Ferreri-Hanberry Open for comment. Do not cite
361 Sulfonylureareceptor binding leading to mortality Arthur Author Under development: Not open for comment. Do not cite
362 Immune mediated hepatitis Agnes Aggy Under development: Not open for comment. Do not cite
363 Thyroperoxidase inhibition leading to increased mortality via altered eye structure Allie Always Under development: Not open for comment. Do not cite
364 Thyroperoxidase inhibition leading to increased mortality via decreased eye size Evgeniia Kazymova Under development: Not open for comment. Do not cite
365 Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning Cataia Ives Under development: Not open for comment. Do not cite
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Arthur Author Under development: Not open for comment. Do not cite
368 Cytochrome oxidase inhibition leading to olfactory nasal lesions Agnes Aggy Under development: Not open for comment. Do not cite
369 Photosystem II antagonism leading to growth inhibition via oxidative damage Allie Always Under development: Not open for comment. Do not cite
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis Evgeniia Kazymova Under development: Not open for comment. Do not cite
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone Cataia Ives Under development: Not open for comment. Do not cite
372 Androgen receptor antagonism leading to testicular cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
373 Mitochondrial dysfunction to metabolic diseases Arthur Author Under Development: Contributions and Comments Welcome
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Agnes Aggy Under development: Not open for comment. Do not cite
375 test AOP Allie Always Under development: Not open for comment. Do not cite
376 Androgen receptor agonism leading to male-biased sex ratio Evgeniia Kazymova Under development: Not open for comment. Do not cite
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) Cataia Ives Under development: Not open for comment. Do not cite
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
379 Coronaviral replication / RNA genome transcription leading to thrombosis Arthur Author Under development: Not open for comment. Do not cite
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Agnes Aggy Under development: Not open for comment. Do not cite
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Allie Always Under development: Not open for comment. Do not cite
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Evgeniia Kazymova Under development: Not open for comment. Do not cite
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Cataia Ives Under development: Not open for comment. Do not cite
385 ACE2 dysregulation leading to microvascular disfunction Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
386 CIAO Molecular Initiating Event leading to CIAO Adverse Outcome Arthur Author Under development: Not open for comment. Do not cite
387 Decreased fibrinolytic and activated bradykinin systems leading to hyperinflammation Arthur Author Under development: Not open for comment. Do not cite
388 Increased susceptibility to viral entry and coronavirus production leading to hyperinflammation Hasmik Yepiskoposyan Under development: Not open for comment. Do not cite
389 Carole Yauk test AOP Arthur Author Under development: Not open for comment. Do not cite
390 leading to white blood cell cancer Arthur Author Under development: Not open for comment. Do not cite
391 Inhibition of Proline/Asparagine Hydroxylation Leads to Breast Cancer Arthur Author Under development: Not open for comment. Do not cite
392 Cyclooxygenase inhibition leading to acute kidney injury Arthur Author Under development: Not open for comment. Do not cite
393 Acetylcholine esterase inhibition leading to type 2 diabetes Arthur Author Under development: Not open for comment. Do not cite
394 Bulky DNA adducts leading to low birth weight Arthur Author Under development: Not open for comment. Do not cite
395 Jason's Test AOP Arthur Author Under development: Not open for comment. Do not cite
396 Multi-walled carbon nanotubes induce malignant mesothelioma Arthur Author Under development: Not open for comment. Do not cite
397 CIAO-related Test AOP Clemens Wittwehr Under development: Not open for comment. Do not cite
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
205 AOP from chemical insult to cell death Cataia Ives Open for comment. Do not cite Under Development
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always Under development: Not open for comment. Do not cite Under Development
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite
211 Handbook development AOP Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Arthur Author Open for adoption Under Development
214 Network of SSRIs (selective serotonin reuptake inhibitors) Agnes Aggy Open for adoption Under Development
215 Molecular events lead to epilepsy Allie Always Open for adoption Under Development
216 Excessive reactive oxygen species production leading to population decline via follicular atresia Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
217 Gastric ulcer formation Cataia Ives Open for adoption Under Development
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Brendan Ferreri-Hanberry Not under active development Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Arthur Author Not under active development Under Development
221 Mental stress to depression Allie Always Open for adoption Under Development
222 Mental stress to agitation Evgeniia Kazymova Open for adoption Under Development
223 Serotonin transporter activation to seizure Cataia Ives Open for adoption Under Development
224 Serotonin transporter activation to depression Brendan Ferreri-Hanberry Open for adoption Under Development
225 Serotonin transporter activation to agitation Arthur Author Open for adoption Under Development
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Agnes Aggy Open for adoption Under Development
227 NSAID induced PTGS1 inactivation to gastric ulcer Allie Always Open for adoption Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Evgeniia Kazymova Open for adoption Under Development
229 Helicobacter pylori to gastric ulcer Cataia Ives Open for adoption Under Development
230 presynaptic neuron 1 activation to epilepsy Brendan Ferreri-Hanberry Open for adoption Under Development
231 presynaptic neuron 2 repression to epilepsy Arthur Author Open for adoption Under Development
232 NFE2/Nrf2 repression to steatosis Agnes Aggy Open for adoption Under Development
238 Excessive reactive oxygen species production leading to population decline via lipid peroxidation Agnes Aggy Under development: Not open for comment. Do not cite
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Cataia Ives Under development: Not open for comment. Do not cite
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Brendan Ferreri-Hanberry Open for adoption
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Arthur Author Under development: Not open for comment. Do not cite
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Evgeniia Kazymova Not under active development Included in OECD Work Plan Under Development 1.43
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
263 Uncoupling of oxidative phosphorylation leading to growth inhibition (1) Allie Always Open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition (2) Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition (3) Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition (4) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition (5) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition (6) Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish Cataia Ives Open for comment. Do not cite Included in OECD Work Plan Under Development 1.59
272 Direct deposition of ionizing energy leading to lung cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.56
277 Impaired IL-1R1 signaling leading to increased susceptibility to infection Cataia Ives Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.48
282 Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.49
283 L-type calcium channel blockade leading to hypotension Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
286 Mitochondrial complex III antagonism leading to growth inhibition (1) Agnes Aggy Under development: Not open for comment. Do not cite Under Development
287 Mitochondrial complex III antagonism leading to growth inhibition (2) Allie Always Under development: Not open for comment. Do not cite Under Development
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Cataia Ives Open for citation & comment Included in OECD Work Plan Under Development 1.81
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) Arthur Author Under development: Not open for comment. Do not cite Under Development
292 Inhibition of tyrosinase leads to decreased population in fish Agnes Aggy Open for citation & comment Included in OECD Work Plan Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.79
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Brendan Ferreri-Hanberry Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.76
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan Under Development 1.77
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan EAGMST Under Review 1.58
299 Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation Allie Always Under development: Not open for comment. Do not cite Under Development
302 Lung surfactant function inhibition leading to impaired lung function Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.86
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.60
336 DNA methyltransferase inhibition leading to population decline (1) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development
337 DNA methyltransferase inhibition leading to population decline (2) Allie Always Under Development: Contributions and Comments Welcome Under Development
339 DNA methyltransferase inhibition leading to population decline (4) Cataia Ives Under Development: Contributions and Comments Welcome Under Development
340 DNA methyltransferase inhibition leading to transgenerational effects (1) Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development
341 DNA methyltransferase inhibition leading to transgenerational effects (2) Arthur Author Under Development: Contributions and Comments Welcome Under Development
144 Endocytic lysosomal uptake leading to liver fibrosis Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation EAGMST Under Review 1.47
149 Peptide Oxidation Leading to Hypertension Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan Under Development 1.50
151 AhR activation leading to preeclampsia Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Brendan Ferreri-Hanberry Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Arthur Author Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Agnes Aggy Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Allie Always Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Evgeniia Kazymova Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Cataia Ives Under development: Not open for comment. Do not cite Under Development
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.32
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
181 Weather event contributes to colony loss/failure Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
185 Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
186 unknown MIE leading to renal failure and mortality Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan Under Development 1.31
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Allie Always Under Development: Contributions and Comments Welcome Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Allie Always Under development: Not open for comment. Do not cite Under Development
197 Sodium channel (Nav1.1) inhibition leading to population decline Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
199 ER mediated breast cancer AOP Cataia Ives Under development: Not open for comment. Do not cite Under Development
200 Estrogen receptor activation leading to breast cancer Brendan Ferreri-Hanberry Open for adoption Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Arthur Author Under development: Not open for comment. Do not cite Under Development
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Allie Always Not under active development Under Development
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Evgeniia Kazymova Not under active development Under Development
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Cataia Ives Not under active development Under Development
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Brendan Ferreri-Hanberry Not under active development Under Development
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.55
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always Under development: Not open for comment. Do not cite Under Development
240 DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan 1252 1254 EAGMST Under Review 1.53
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 5-HTT increased predation 1.29
33 Kidney toxicity induced by activation of 5HT2C Arthur Author Open for adoption Under Development 5-HTT2c kidney toxicity
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development 5α-reductase leydig cell tumors 1.29
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Allie Always Under Development: Contributions and Comments Welcome 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation 1.29
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
16 Acetylcholinesterase inhibition leading to acute mortality Cataia Ives Under Development: Contributions and Comments Welcome Included in OECD Work Plan AChE acute mortality Under Development 1.3
220 Cyp2E1 Activation Leading to Liver Cancer Agnes Aggy Open for citation & comment Included in OECD Work Plan Activation of Cyp2E1 liver cancer EAGMST Under Review 1.24
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Arthur Author Open for citation & comment Included in OECD Work Plan Activation, AhR Increase, Early Life Stage Mortality TFHA/WNT Endorsed 1.7
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Agnes Aggy Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Allie Always Open for citation & comment Included in OECD Work Plan AhR embryo toxicity TFHA/WNT Endorsed 1.27
41 Sustained AhR Activation leading to Rodent Liver Tumours Allie Always Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
57 AhR activation leading to hepatic steatosis Agnes Aggy Under Development: Contributions and Comments Welcome Under Development AhR hepatic steatosis 1.29
131 Aryl hydrocarbon receptor activation leading to uroporphyria Allie Always Open for citation & comment Included in OECD Work Plan AhR uroporphyria TFHA/WNT Endorsed 1.7
62 AKT2 activation leading to hepatic steatosis Arthur Author Under Development: Contributions and Comments Welcome Under Development AKT2 hepatic steatosis 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development alpha Norad Receptors delayed ovulation 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development Alpha2u adenomas and carcinomas 1.29
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Agnes Aggy Open for adoption Under Development AR adverse effects in the male foetus
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction TFHA/WNT Endorsed 1.12
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development AR leydig cell tumors 1.29
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Evgeniia Kazymova Open for adoption Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
25 Aromatase inhibition leading to reproductive dysfunction Cataia Ives Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development b-oxidation fatty acid steatosis 1.29
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Cataia Ives Open for comment. Do not cite Included in OECD Work Plan Calcineurin Activity, Inhibition EAGMST Under Review 1.38
58 NR1I3 (CAR) suppression leading to hepatic steatosis Allie Always Under Development: Contributions and Comments Welcome Under Development CAR hepatic steatosis 1.29
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.17
40 Covalent Protein binding leading to Skin Sensitisation Agnes Aggy Open for citation & comment Included in OECD Work Plan Covalent Binding, Protein sensitisation, skin TFHA/WNT Endorsed 1.1
28 Cyclooxygenase inhibition leading reproductive failure Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive failure 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cataia Ives Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Allie Always Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE renal tubular adenomas and carcinomas 1.29
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Cataia Ives Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development cytotox not MIE forestomach tumors 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development DBH reduced fecundity 1.29
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
139 Alkylation of DNA leading to cancer 1 Arthur Author Open for adoption Under Development DNA alkylation cancer
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Cataia Ives Under Development: Contributions and Comments Welcome Under Development dopamine?? endometrial adenocarcinomas 1.29
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Brendan Ferreri-Hanberry Open for citation & comment Under Development EcR mortality
148 EGFR Activation Leading to Decreased Lung Function Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
29 Estrogen receptor agonism leading to reproductive dysfunction Allie Always Under Development: Contributions and Comments Welcome Under Development ER reproductive dysfunction 1.29
30 Estrogen receptor antagonism leading to reproductive dysfunction Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Cataia Ives Under Development: Contributions and Comments Welcome Under Development ER altered sexual differentiation 1.29
53 ER agonism leading to reduced survival due to renal failure Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development ER reduced survival 1.29
146 Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development ER 1.29
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development ERG reduced survival 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development estradiol modulation of leydig cell function 1.29
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Cataia Ives Open for citation & comment Included in OECD Work Plan GABA epileptic seizures TFHA/WNT Endorsed 1.15
113 Glutamate-gated chloride channel activation leading to acute mortality Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development GluCl Channel acute mortality 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Evgeniia Kazymova Open for comment. Do not cite Under Development glucose oxidase colony loss/failure 1.29
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Allie Always Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Allie Always Open for comment. Do not cite GR increased disease susceptibility 1.29
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Allie Always Under Development: Contributions and Comments Welcome Under Development GR decreased male fertitlity 1.29
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Cataia Ives Under Development: Contributions and Comments Welcome Under Development GR modulation of leydig cell function 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development GR modulation of leydig cell function 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development H2 reduced survival 1.29
31 Oxidation of iron in hemoglobin leading to hematotoxicity Cataia Ives Open for adoption Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
212 Histone deacetylase inhibition leading to testicular atrophy Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan Histone deacetylase, inhibition testicular toxicity EAGMST Under Review 1.52
124 HMG-CoA reductase inhibition leading to decreased fertility Cataia Ives Under Development: Contributions and Comments Welcome Under Development HMG-CoA reductase decreased fertility 1.29
59 HNF4alpha suppression leading to hepatic steatosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development HNF4alpha hepatic steatosis 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development HPPD corneal papillomas and carcinomas 1.29
34 LXR activation leading to hepatic steatosis Agnes Aggy Not under active development Under Development LXR liver steatosis
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry Open for comment. Do not cite Under Development metabolic stress is not MIE colony loss/failure 1.29
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Not under active development Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration EAGMST Under Review 1.13
61 NFE2L2/FXR activation leading to hepatic steatosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development multiple hepatic steatosis 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy Under Development: Contributions and Comments Welcome Under Development multiple modulation of leydig cell function 1.29
104 Altered ion channel activity leading impaired heart function Allie Always Under Development: Contributions and Comments Welcome Under Development multiple impaired heart function 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Agnes Aggy Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Allie Always Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Evgeniia Kazymova Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Cataia Ives Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Cataia Ives Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Brendan Ferreri-Hanberry Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Arthur Author Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Agnes Aggy Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Cataia Ives Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired TFHA/WNT Endorsed 1.33
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Arthur Author Open for citation & comment Included in OECD Work Plan NIS learning and memory deficits in children TFHA/WNT Endorsed 1.28
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always Under Development: Contributions and Comments Welcome Under Development NIS follicular cell adenomas and carcinomas 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development NIS neurodevelopmental outcomes 1.29
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry Not under active development Under Development nitric oxide liver tumors
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Arthur Author Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration TFHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Agnes Aggy Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development p-amino hippuric acid renal failure and mortality 1.29
130 Phospholipase A inhibitors lead to hepatotoxicity Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
6 Antagonist binding to PPARα leading to body-weight loss Agnes Aggy Open for citation & comment Included in OECD Work Plan PPAR starvation-like body-weight loss TFHA/WNT Endorsed 2.3
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Allie Always Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
18 PPARα activation in utero leading to impaired fertility in males Arthur Author Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
51 PPARα activation leading to impaired fertility in adult male rodents Evgeniia Kazymova Not under active development Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
72 Epigenetic modification of PPARG leading to adipogenesis Cataia Ives Under Development: Contributions and Comments Welcome Under Development PPARg adipogenesis 1.29
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Allie Always Under Development: Contributions and Comments Welcome Under Development Prolyl hydroxylase reproductive dysfunction 1.29
38 Protein Alkylation leading to Liver Fibrosis Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author Under Development: Contributions and Comments Welcome Under Development proteins - undefined modulation of leydig cell function 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Cataia Ives Under Development: Contributions and Comments Welcome Under Development PXR hepatic steatosis 1.29
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development pyruvate dehydrogenase hepatocellular carcinoma 1.29
91 Sodium channel inhibition leading to reduced survival Allie Always Under Development: Contributions and Comments Welcome Under Development sodium channel reduced survival 1.29
93 sodium channel inhibition leading to increased predation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development sodium channel increased predation 1.29
94 Sodium channel inhibition leading to congenital malformations Cataia Ives Under Development: Contributions and Comments Welcome Under Development sodium channel congenital malformations 1.29
96 Axonal sodium channel modulation leading to acute mortality Arthur Author Under Development: Contributions and Comments Welcome Under Development sodium channel acute mortality 1.29
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Thyroid Receptor Antagonism Cognitve function, Decreased Under Development 1.84
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes TFHA/WNT Endorsed 1.10
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development TPO follicular cell adenomas and carcinomas 1.29
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Allie Always Open for adoption Included in OECD Work Plan Transthyretin Under Development 1.41
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Cataia Ives Open for citation & comment Included in OECD Work Plan tubulin? aneuploid offspring EAGMST Under Review 1.11
26 Calcium-mediated neuronal ROS production and energy imbalance Brendan Ferreri-Hanberry Open for adoption Under Development unclear energy imbalance
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Agnes Aggy Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Allie Always Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development unclear urothelial papillomas and carcinomas 1.29
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Cataia Ives Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
128 Kidney dysfunction by decreased thyroid hormone Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
35 Narcosis leading to respiratory failure Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Arthur Author Under Development: Contributions and Comments Welcome Under Development unk modulation of leydig cell function 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Arthur Author Open for comment. Do not cite Under Development unk colony loss/failure 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development Unknown reproductive dysfunction 1.29
43 Disruption of VEGFR Signaling Leading to Developmental Defects Cataia Ives Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6