API

AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
280 α-diketone-induced bronchiolitis obliterans Agnes Aggy Under development: Not open for comment. Do not cite 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity 1.29
181 Weather event contributes to colony loss/failure Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Arthur Author Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Allie Always Under development: Not open for comment. Do not cite Under Development 1215: TRPA1 activation, TRPA1 Receptor 1223: Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea and 1434: Irritation of nasal mucosa inducing sneeze reflex and 1226: Increased Respiratory irritability and Chronic Cough,
179 Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Cataia Ives Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial) 1.29
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Open for adoption Included in OECD Work Plan 239: Activation, Pregnane-X receptor, NR1l2 319: Loss, Cochlear function Under Development 1.9
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 801: modulation, Unknown 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory 1.29
186 unknown MIE leading to renal failure and mortality Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1114: Unknown, MIE 351: Increased Mortality 1.29
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via oxidative DNA damage Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased protein oxidation Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased lipid peroxidation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cell death Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased lipid storage Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation Allie Always Open for citation & comment Included in OECD Work Plan 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth EAGMST Approved 1.92
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Allie Always Under Development: Contributions and Comments Welcome Under Development 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis 1.29
316 Trypsin inhibition leading to pancreatic acinar cell tumors Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Arthur Author Under development: Not open for comment. Do not cite 1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ 1458: Pulmonary fibrosis
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Included in OECD Work Plan 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Approved 1.35
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Evgeniia Kazymova Under development: Not open for comment. Do not cite 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Allie Always Open for comment. Do not cite 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Cataia Ives Under development: Not open for comment. Do not cite 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 279: Thyroperoxidase, Inhibition 1101: Altered, Amphibian metamorphosis 1.29
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 1656: Antagonism, Thyroid Receptor 402: Cognitive Function, Decreased Under Development 1.84
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Allie Always Under development: Not open for comment. Do not cite
326 Thermal stress leading to population decline (3) Evgeniia Kazymova Under development: Not open for comment. Do not cite 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
325 Thermal stress leading to population decline (2) Allie Always Under development: Not open for comment. Do not cite 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
324 Thermal stress leading to population decline (1) Agnes Aggy Under development: Not open for comment. Do not cite 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
375 test AOP Allie Always Under development: Not open for comment. Do not cite
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Agnes Aggy Under development: Not open for comment. Do not cite 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
41 Sustained AhR Activation leading to Rodent Liver Tumours Allie Always Open for citation & comment Included in OECD Work Plan 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors EAGMST Under Review 1.7
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Agnes Aggy Open for comment. Do not cite Under Development 572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Allie Always Open for comment. Do not cite Under Development 572: Decrease, Number of worker bees and 563: Death/Failure, Colony 1.29
361 Sulfonylureareceptor binding leading to mortality Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality Under Development 1.94
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1495: Interaction with the lung resident cell membrane components 1458: Pulmonary fibrosis EAGMST Under Review 1.32
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Agnes Aggy Open for adoption Under Development 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive Function, Decreased 1.29
91 Sodium channel inhibition leading to reduced survival Allie Always Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 587: Reduced, feeding 1 and 588: Increased, predation and 592: Reduced, survival 1.29
93 sodium channel inhibition leading to increased predation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 588: Increased, predation 1.29
94 Sodium channel inhibition leading to congenital malformations Cataia Ives Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 591: Increased, amputations 1.29
197 Sodium channel (Nav1.1) inhibition leading to population decline Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 584: Inhibition, sodium channel 1.29
223 Serotonin transporter activation to seizure Cataia Ives Open for adoption Under Development 1397: Increased, serotonin transporter activity 1344: Increased, seizure
224 Serotonin transporter activation to depression Brendan Ferreri-Hanberry Open for adoption Under Development 1397: Increased, serotonin transporter activity 1346: Increased, depression
225 Serotonin transporter activation to agitation Arthur Author Open for adoption Under Development 1345: Increased, agitation
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Cataia Ives Not under active development Under Development 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Brendan Ferreri-Hanberry Not under active development Under Development 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
259 Sensitization induction of the intestinal tract by food proteins Cataia Ives Under development: Not open for comment. Do not cite
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1437: Sensing of the stressor by pulmonary cells 1443: Plaque progression in arteries Under Development 1.55
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Allie Always Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1934: Myocardial Infarction
430 Sars-CoV-2 Interferon-I antiviral response antagonism and increased viral production leading to viral infection proliferation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1939: Viral infection and host-to-host transmission, proliferated Under Development 1.96
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1873: impaired olfactory function (anosmia) Under Development 1.96
412 SARS-CoV-2 infection leading to thromboinflammation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1916: Thromboinflammation, Increased Under Development 1.96
407 SARS-CoV-2 infection leading to pyroptosis Agnes Aggy Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1967: Pyroptosis
406 SARS-CoV-2 infection leading to hyperinflammation Arthur Author Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1868: Hyperinflammation
343 S-adenosylmethionine depletion leading to population decline (2) Allie Always Under development: Not open for comment. Do not cite 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
342 S-adenosylmethionine depletion leading to population decline (1) Agnes Aggy Under development: Not open for comment. Do not cite 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality
258 Renal protein alkylation leading to kidney toxicity Evgeniia Kazymova Not under active development Included in OECD Work Plan 244: Alkylation, Protein 814: Occurrence, Kidney toxicity Under Development 1.43
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Arthur Author Under development: Not open for comment. Do not cite 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
321 Reduced environmental pH leading to thinner shells in Mytilus edulis Cataia Ives Under development: Not open for comment. Do not cite
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 1486: Binding of substrate, endocytic receptor 814: Occurrence, Kidney toxicity Under Development 1.43
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Allie Always Under development: Not open for comment. Do not cite
185 Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
38 Protein Alkylation leading to Liver Fibrosis Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan 244: Alkylation, Protein 344: N/A, Liver fibrosis WPHA/WNT Endorsed 1.14
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Allie Always Under Development: Contributions and Comments Welcome Under Development 798: Inhibition, Prolyl hydroxylases 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory 1.29
231 presynaptic neuron 2 repression to epilepsy Arthur Author Open for adoption Under Development 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
230 presynaptic neuron 1 activation to epilepsy Brendan Ferreri-Hanberry Open for adoption Under Development 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
51 PPARα activation leading to impaired fertility in adult male rodents Evgeniia Kazymova Not under active development Included in OECD Work Plan 227: Activation, PPARα 406: impaired, Fertility Under Development 1.21
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
18 PPARα activation in utero leading to impaired fertility in males Arthur Author Open for citation & comment Included in OECD Work Plan 227: Activation, PPARα 406: impaired, Fertility and 348: Malformation, Male reproductive tract EAGMST Under Review 1.21
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1028: Activation of specific nuclear receptors, PPAR-gamma activation 1.29
421 PPARG activation leading to intrahepatic cholestasis Evgeniia Kazymova Under development: Not open for comment. Do not cite
323 PPARalpha Agonism Impairs Fish Reproduction Arthur Author Open for citation & comment 227: Activation, PPARα
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1063: Increased, Pancreatic acinar tumors 1.29
446 PM-related Adverse outcome pathway frameworks on various systems Cataia Ives Under development: Not open for comment. Do not cite
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis Evgeniia Kazymova Under development: Not open for comment. Do not cite
369 Photosystem II antagonism leading to growth inhibition via oxidative damage Allie Always Under development: Not open for comment. Do not cite
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone Cataia Ives Under development: Not open for comment. Do not cite
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan 828: Inhibition, Phospholipase A 840: Formation, Liver fibrosis Under Development 1.39
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always Under development: Not open for comment. Do not cite Under Development 1291: Hepatotoxicity
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 231: Decreased, PPAR-alpha activation and 232: Decreased, PPAR-beta activation and 233: Decreased, PPAR-gamma activation 459: Increased, Liver Steatosis 1.29
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan 245: Activation, PXR/SXR Under Development 2.5
149 Peptide Oxidation Leading to Hypertension Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan 209: Peptide Oxidation 952: Hypertension Under Development 1.50
192 Pendrin inhibition leading to altered amphibian metamorphosis Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis 1.29
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always Under development: Not open for comment. Do not cite Under Development
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Agnes Aggy Open for comment. Do not cite 1392: Oxidative Stress 1250: Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Arthur Author Open for comment. Do not cite 1392: Oxidative Stress 1250: Decrease, Lung function
411 Oxidative stress Leading to Decreased Lung Function Brendan Ferreri-Hanberry Open for comment. Do not cite 1392: Oxidative Stress 1250: Decrease, Lung function
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Brendan Ferreri-Hanberry Open for comment. Do not cite Included in OECD Work Plan 1634: Increase, Oxidative damage to DNA 185: Increase, Mutations and 1636: Increase, Chromosomal aberrations EAGMST Under Review 1.76
31 Oxidation of iron in hemoglobin leading to hematotoxicity Cataia Ives Open for adoption Included in OECD Work Plan 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) 321: N/A, Cyanosis occurs Under Development 1.16
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Agnes Aggy Open for citation & comment 351: Increased Mortality
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive Function, Decreased
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 877: Inhibition, organic anion transporter 1 (OAT1) 351: Increased Mortality and 360: Decrease, Population growth rate 1.29
228 NSAID induced PTGS2 inactivation to gastric ulcer Evgeniia Kazymova Open for adoption Under Development 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
227 NSAID induced PTGS1 inactivation to gastric ulcer Allie Always Open for adoption Under Development 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
58 NR1I3 (CAR) suppression leading to hepatic steatosis Allie Always Under Development: Contributions and Comments Welcome Under Development 456: Suppression, Constitutive androstane receptor, NR1l3 and 468: Inhibition, PPAR alpha and 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation 459: Increased, Liver Steatosis 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Cataia Ives Under Development: Contributions and Comments Welcome Under Development 245: Activation, PXR/SXR 459: Increased, Liver Steatosis 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Allie Always Under Development: Contributions and Comments Welcome Under Development 563: Death/Failure, Colony 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Arthur Author Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always Under Development: Contributions and Comments Welcome Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Evgeniia Kazymova Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Cataia Ives Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 572: Decrease, Number of worker bees and 568: impaired, Hive thermoregulation and 563: Death/Failure, Colony 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Agnes Aggy Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Allie Always Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Brendan Ferreri-Hanberry Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Cataia Ives Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Agnes Aggy Open for comment. Do not cite Under Development 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony 1.29
61 NFE2L2/FXR activation leading to hepatic steatosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 478: Activation, NRF2 and 479: Activation, NR1H4 459: Increased, Liver Steatosis 1.29
232 NFE2/Nrf2 repression to steatosis Agnes Aggy Open for adoption Under Development 1417: NFE2/Nrf2 repression 1418: Increased, steatosis
214 Network of SSRIs (selective serotonin reuptake inhibitors) Agnes Aggy Open for adoption Under Development 1344: Increased, seizure and 1345: Increased, agitation and 1346: Increased, depression and 1343: Increase, hypertension
35 Narcosis leading to respiratory failure Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 46: Accumulation, Biological membranes Under Development 1.2
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author Under development: Not open for comment. Do not cite Under Development 1174: Activation, NADPH Oxidase 1277: Reproductive failure
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Allie Always Not under active development Under Development 1425: Mu Opioid Receptor Agonism 1428: Analgesia
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Evgeniia Kazymova Not under active development Under Development 1425: Mu Opioid Receptor Agonism 1428: Analgesia
215 Molecular events lead to epilepsy Allie Always Open for adoption Under Development 1348: Increase, seizure and 1362: Increased, hippocampal hyperdepolarization and 1363: Increased, epilepsy
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always Under Development: Contributions and Comments Welcome Under Development 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Arthur Author Under Development: Contributions and Comments Welcome Under Development 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 658: Decreased testosterone by the fetal Leydig cells, Increased estradiol and 659: Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists 505: Decreased sperm quantity / quality in the adult, Decreased fertility 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 642: Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol and 643: Decreased Cholesterol, Decreased Uptake of Lipoproteins and 644: Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author Under Development: Contributions and Comments Welcome Under Development 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility 1.29
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Cataia Ives Under Development: Contributions and Comments Welcome Under Development 653: Decreased testosterone by the fetal Leydig cells, Increased corticosterone and 654: Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists 505: Decreased sperm quantity / quality in the adult, Decreased fertility 1.29
373 Mitochondrial dysfunction to metabolic diseases Arthur Author Under Development: Contributions and Comments Welcome
273 Mitochondrial complex inhibition leading to liver injury Arthur Author Under development: Not open for comment. Do not cite 1542, 1543, 1544, 888, 887, 1653, 1654, 1655 1548: Necrotic Tissue and 1549: Liver Injury
287 Mitochondrial complex III antagonism leading to growth inhibition (2) Allie Always Under development: Not open for comment. Do not cite Under Development 1542: Increase, Mitochondrial complex III antagonism 1521: Decrease, Growth
286 Mitochondrial complex III antagonism leading to growth inhibition (1) Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1542: Increase, Mitochondrial complex III antagonism 1521: Decrease, Growth
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) Arthur Author Under development: Not open for comment. Do not cite Under Development 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
279 Microtubule interacting drugs lead to peripheral neuropathy Arthur Author Under development: Not open for comment. Do not cite 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Cataia Ives Under development: Not open for comment. Do not cite
221 Mental stress to depression Allie Always Open for adoption Under Development 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
222 Mental stress to agitation Evgeniia Kazymova Open for adoption Under Development 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
34 LXR activation leading to hepatic steatosis Agnes Aggy Not under active development Under Development 167: Activation, LXR and 228: peroxisome proliferator activated receptor promoter demethylation 345: N/A, Liver Steatosis
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome 1691: Antagonism,LH receptor 679: Decline, Population trajectory
302 Lung surfactant function inhibition leading to decreased lung function Brendan Ferreri-Hanberry Open for comment. Do not cite Included in OECD Work Plan 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Cataia Ives Under development: Not open for comment. Do not cite 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
283 L-type calcium channel blockade leading to hypotension Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
33 Kidney toxicity induced by activation of 5HT2C Arthur Author Open for adoption Under Development 9: Activation, 5HT2c 759: Increased, Kidney Failure
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
128 Kidney dysfunction by decreased thyroid hormone Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 277: Thyroid hormone synthesis, Decreased 814: Occurrence, Kidney toxicity Under Development 1.40
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Arthur Author Under Development: Contributions and Comments Welcome Under Development 1205: Activation, Juvenile hormone receptor 1208: Increased, Male offspring and 361: Decline, Population and 1210: Alteration, Food-web structures
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1277: Reproductive failure
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Cataia Ives Under development: Not open for comment. Do not cite Under Development 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Allie Always Under development: Not open for comment. Do not cite
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis 1.29
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Cataia Ives Open for citation & comment Included in OECD Work Plan 867: Decrease, Intracellular pH 872: Increase, Site of Contact Nasal Tumors EAGMST Under Review 2.7
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Allie Always Under Development: Contributions and Comments Welcome Included in OECD Work Plan 957: Binding, Transthyretin in serum 402: Cognitive Function, Decreased Under Development 1.41
442 Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development Arthur Author Under development: Not open for comment. Do not cite
292 Inhibition of tyrosinase leads to decreased population in fish Agnes Aggy Open for citation & comment Included in OECD Work Plan 1627: Inhibition of tyrosinase 360: Decrease, Population trajectory Under Development 1.78
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan 279: Thyroperoxidase, Inhibition 402: Cognitive Function, Decreased WPHA/WNT Endorsed 1.10
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish Cataia Ives Open for comment. Do not cite Included in OECD Work Plan 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell) 1.29
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Cataia Ives Open for citation & comment Included in OECD Work Plan 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population trajectory Under Development 1.77
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Arthur Author Open for comment. Do not cite
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas 1.29
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Arthur Author Open for citation & comment Included in OECD Work Plan 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.28
285 Inhibition of N-linked glycosylation leads to liver injury Arthur Author Under development: Not open for comment. Do not cite 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Agnes Aggy Under development: Not open for comment. Do not cite
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) 814: Occurrence, Kidney toxicity Under Development 1.43
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Brendan Ferreri-Hanberry Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts 1467: Growth, reduction and 636: Decreased, survival
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always Under Development: Contributions and Comments Welcome Under Development 737: Decreased, Uptake of inorganic iodide 741: Increase, Adenomas/carcinomas (follicular cell) 1.29
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry Not under active development Under Development
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Brendan Ferreri-Hanberry Open for citation & comment 1884: Inhibition of Fyna 351: Increased Mortality and 360: Decrease, Population trajectory
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Arthur Author Open for adoption Under Development 1490: Inhibition, Fatty Acid Beta Oxidation 1489: N/A, Steatohepatisis
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Cataia Ives Under development: Not open for comment. Do not cite 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Arthur Author Not under active development Under Development 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Brendan Ferreri-Hanberry Not under active development Under Development 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Evgeniia Kazymova Under development: Not open for comment. Do not cite 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Cataia Ives Open for comment. Do not cite Included in OECD Work Plan 980: Inhibition, Calcineurin Activity 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.38
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 1740: ACE2 inhibition 344: N/A, Liver fibrosis Under Development 1.96
398 Inhibition of ALDH1A (RALDH) causing reduced all-trans retinoic acid levels leading to impaired fertility, females Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1880: Inhibition of ALDH1A2 (RALDH2) 972: Decreased fertility, Reduced number of oocytes ovulated Under Development 1.97
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development 790: Inhibition, 5α-reductase activity 745: Increase, Leydig cell tumors 1.29
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Cataia Ives Open for citation & comment Included in OECD Work Plan 1617: 5α-reductase, inhibition 360: Decrease, Population trajectory Under Development 1.81
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Evgeniia Kazymova Open for citation & comment 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 1799: Inhibition of 11β-HSD 360: Decrease, Population trajectory Under Development 1.93
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 1796: 11β-hydroxylase inhibition 360: Decrease, Population trajectory Under Development 1.93
319 Induced dysregulation of Angiotensin-converting enzyme 2 leading to lung fibrosis Allie Always Open for comment. Do not cite Included in OECD Work Plan 1740: ACE2 inhibition 1276: Lung fibrosis Under Development 1.96
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Agnes Aggy Under Development: Contributions and Comments Welcome 1950: Increase, TNF 1953: Gestational diabetes mellitus
379 Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1738: Increased susceptibility to viral entry 1847: Increased coronavirus production and 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 1632: Increase in reactive oxygen and nitrogen species (RONS) 1194: Increase, DNA damage and 185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer Under Development 1.80
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry Open for comment. Do not cite Under Development 572: Decrease, Number of worker bees and 563: Death/Failure, Colony 1.29
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Cataia Ives Under Development: Contributions and Comments Welcome Under Development 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas 1.29
293 Increased DNA damage leading to increased risk of breast cancer Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 1194: Increase, DNA damage 185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer Under Development 1.80
400 Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Arthur Author Under development: Not open for comment. Do not cite 1888: Increased (ectopic) all-trans retinoic acid concentration 1757: Reduce, Sperm count
277 Impaired IL-1R1 signaling leading to increased susceptibility to infection Cataia Ives Open for citation & comment Included in OECD Work Plan 1700: Impaired IL-1R1 signaling 986: Increase, Increased susceptibility to infection EAGMST Under Review 1.48
362 Immune mediated hepatitis Agnes Aggy Under development: Not open for comment. Do not cite 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
408 Imbalance in redox homeostasis leading to structural damage to tissues Allie Always Under development: Not open for comment. Do not cite
278 IKK complex inhibition leading to liver injury Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1574: Inhibition, IKK complex 1548: Necrotic Tissue and 1549: Liver Injury
440 Hypothalamic estrogen receptors inhibition leading to ovarian cancer Cataia Ives Under development: Not open for comment. Do not cite
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Cataia Ives Under development: Not open for comment. Do not cite 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Arthur Author Under Development: Contributions and Comments Welcome Under Development 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells) 1.29
59 HNF4alpha suppression leading to hepatic steatosis Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 461: Suppression, HNF4alpha 1.29
124 HMG-CoA reductase inhibition leading to decreased fertility Cataia Ives Under Development: Contributions and Comments Welcome Under Development 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility 1.29
275 Histone deacetylase inhibition leads to neural tube defects Allie Always Under Development: Contributions and Comments Welcome 1502: Histone deacetylase inhibition 1561: Neural tube defects
274 Histone deacetylase inhibition leads to impeded craniofacial development Agnes Aggy Under Development: Contributions and Comments Welcome 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
212 Histone deacetylase inhibition leading to testicular atrophy Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan 1502: Histone deacetylase inhibition 1506: Testicular atrophy WPHA/WNT Endorsed 1.52
99 Histamine (H2) receptor antagonism leading to reduced survival Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 638: Antagonism, Histamine Receptor (H2) 636: Decreased, survival and 588: Increased, predation 1.29
433 hERG inhibition leading to cardiac toxicity Evgeniia Kazymova Under development: Not open for comment. Do not cite 1956: Binding to hERG channel and 1957: hERG channel biogenesis interference 1964: Sudden cardiac death
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis 1.29
229 Helicobacter pylori to gastric ulcer Cataia Ives Open for adoption Under Development 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
211 Handbook development AOP Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1.29
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Cataia Ives Open for citation & comment 1647: GSK3beta inactivation 351: Increased Mortality and 360: Decrease, Population trajectory
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1082: Increased, adenomas (pituitary) 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Arthur Author Under Development: Contributions and Comments Welcome Under Development 1079: Increased, Adenomas/carcinomas (mammary) 1.29
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
113 Glutamate-gated chloride channel activation leading to acute mortality Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 760: Activation, Glutamate-gated chloride channel 351: Increased Mortality and 765: Decreased, population 1 1.29
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Brendan Ferreri-Hanberry Open for citation & comment 122: Activation, Glucocorticoid Receptor 360: Decrease, Population trajectory
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Allie Always Open for comment. Do not cite 122: Activation, Glucocorticoid Receptor 323: Increased, Disease susceptibility 1.29
318 Glucocorticoid Receptor activation leading to hepatic steatosis Agnes Aggy Under Development: Contributions and Comments Welcome 122: Activation, Glucocorticoid Receptor 459: Increased, Liver Steatosis
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Allie Always Under Development: Contributions and Comments Welcome Under Development 494: Glucocorticoid Receptor Agonist, Activation 406: impaired, Fertility 1.29
217 Gastric ulcer formation Cataia Ives Open for adoption Under Development 1367: Inhibit, gastric ulcer formation and 1385: Activated, gastric ulcer formation
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Agnes Aggy Under development: Not open for comment. Do not cite
303 Frustrated phagocytosis-induced lung cancer Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 1668: Frustrated phagoytosis 1670: Lung cancer Under Development 1.86
409 Frustrated phagocytosis leads to malignant mesothelioma Evgeniia Kazymova Under development: Not open for comment. Do not cite 1668: Frustrated phagoytosis 1090: Increased, mesotheliomas
439 From activation of the AhR leading to breast cancer related death Evgeniia Kazymova Under development: Not open for comment. Do not cite
333 Formation of DNA photoproducts leading to growth inhibition (3) Cataia Ives Under development: Not open for comment. Do not cite
332 Formation of DNA photoproducts leading to growth inhibition (2) Evgeniia Kazymova Under development: Not open for comment. Do not cite
331 Formation of DNA photoproducts leading to growth inhibition (1) Allie Always Under development: Not open for comment. Do not cite 1765: Increase, Formation of DNA photoproducts 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) Agnes Aggy Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) Arthur Author Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
327 Excessive reactive oxygen species production leading to mortality (1) Cataia Ives Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 592: Reduced, survival 1.29
30 Estrogen receptor antagonism leading to reproductive dysfunction Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan 112: Antagonism, Estrogen receptor 360: Decrease, Population trajectory EAGMST Under Review 1.12
445 Estrogen Receptor Alpha(α) Agonism leads to Impaired Reproduction Evgeniia Kazymova Under development: Not open for comment. Do not cite
29 Estrogen receptor agonism leading to reproductive dysfunction Allie Always Under Development: Contributions and Comments Welcome Under Development 111: Agonism, Estrogen receptor 360: Decrease, Population trajectory and 363: Altered, Reproductive behaviour and 339: Altered, Larval development and 364: Impaired development of, Reproductive organs 1.29
200 Estrogen receptor activation leading to breast cancer Brendan Ferreri-Hanberry Open for adoption Under Development 1181: Activation, Estrogen receptor 1193: N/A, Breast Cancer
146 Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1.29
199 ER mediated breast cancer AOP Cataia Ives Under development: Not open for comment. Do not cite Under Development
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Cataia Ives Under Development: Contributions and Comments Welcome Under Development 111: Agonism, Estrogen receptor 417: skewed, sex ratio 1.29
53 ER agonism leading to reduced survival due to renal failure Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 111: Agonism, Estrogen receptor 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells) 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Cataia Ives Under Development: Contributions and Comments Welcome Under Development 228: peroxisome proliferator activated receptor promoter demethylation and 1454: chronic high fat diet 1447: obesity 1.29
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Arthur Author Under Development: Contributions and Comments Welcome Under Development 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) 1.29
144 Endocytic lysosomal uptake leading to liver fibrosis Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 1539: Endocytotic lysosomal uptake 344: N/A, Liver fibrosis EAGMST Under Review 1.47
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Arthur Author Under development: Not open for comment. Do not cite 18: Activation, AhR 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Evgeniia Kazymova Under development: Not open for comment. Do not cite
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Allie Always Under development: Not open for comment. Do not cite
148 EGFR Activation Leading to Decreased Lung Function Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Brendan Ferreri-Hanberry Open for citation & comment Under Development 103: Increase, Ecdysone receptor agonism
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.79
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1064: prepubertal increase, Estrogen receptor (ER) activity 1070: Increased, adenosquamous carcinomas of endometrium 1.29
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1848: Toll Like Receptor (TLR) Dysregulation
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Cataia Ives Under development: Not open for comment. Do not cite 1842: Prolonged TLR9 activation 1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis 1.29
341 DNA methyltransferase inhibition leading to transgenerational effects (2) Arthur Author Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory
340 DNA methyltransferase inhibition leading to transgenerational effects (1) Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 1781: Decrease, Fecundity (F3) and 360: Decrease, Population trajectory
339 DNA methyltransferase inhibition leading to population decline (4) Cataia Ives Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
338 DNA methyltransferase inhibition leading to population decline (3) Evgeniia Kazymova Under Development: Contributions and Comments Welcome 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
337 DNA methyltransferase inhibition leading to population decline (2) Allie Always Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
336 DNA methyltransferase inhibition leading to population decline (1) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
443 DNA damage and mutations leading to Metastatic Breast Cancer Agnes Aggy Under development: Not open for comment. Do not cite
240 DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
43 Disruption of VEGFR Signaling Leading to Developmental Defects Cataia Ives Open for citation & comment Included in OECD Work Plan 305: Inhibition, VegfR2 1001: Increased, Developmental Defects EAGMST Under Review 1.6
396 Deposition of ionizing energy leads to population decline via impaired meiosis Allie Always Under development: Not open for comment. Do not cite 1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage 1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size
386 Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis Arthur Author Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
435 Deposition of ionising energy leads to population decline via pollen abnormal Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1686: Deposition of Energy 1863: Decrease, Reproduction and 442: Decreased, Population trajectory
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Agnes Aggy Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
388 Deposition of ionising energy leading to population decline via programmed cell death Allie Always Under development: Not open for comment. Do not cite 1194: Increase, DNA damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
238 Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Agnes Aggy Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis Agnes Aggy Under development: Not open for comment. Do not cite 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
299 Deposition of energy leading to population decline via DNA oxidation and follicular atresia Allie Always Under development: Not open for comment. Do not cite Under Development 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
272 Deposition of energy leading to lung cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan 1686: Direct Deposition of Energy 1556: Increase, lung cancer EAGMST Approved 1.56
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Allie Always Under development: Not open for comment. Do not cite 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Included in OECD Work Plan 1002: Inhibition, Deiodinase 2 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Approved 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan 1002: Inhibition, Deiodinase 2 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Approved 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Agnes Aggy Under Development: Contributions and Comments Welcome Included in OECD Work Plan 1009: Inhibition, Deiodinase 1 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Approved 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Allie Always Under Development: Contributions and Comments Welcome Included in OECD Work Plan 1009: Inhibition, Deiodinase 1 351: Increased Mortality and 360: Decrease, Population trajectory EAGMST Approved 1.35
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1688: decrease, male anogenital distance Under Development 1.90
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1866: Fibrinolysis, decreased and 1867: Bradykinin system, hyperactivated 1868: Hyperinflammation Under Development 1.96
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 742: Decreased, Androgen receptor activity 745: Increase, Leydig cell tumors 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Evgeniia Kazymova Open for comment. Do not cite Under Development 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Allie Always Under Development: Contributions and Comments Welcome Under Development 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular) 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar) 1.29
368 Cytochrome oxidase inhibition leading to olfactory nasal lesions Agnes Aggy Under development: Not open for comment. Do not cite 1840: Inhibition, cytochrome oxidase 872: Increase, Site of Contact Nasal Tumors
220 Cyp2E1 Activation Leading to Liver Cancer Agnes Aggy Open for citation & comment Included in OECD Work Plan 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1508: CYP2E1 Activation and 1509: Protein Adduct Formation 1514: Neurodegeneration
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Cataia Ives Under development: Not open for comment. Do not cite
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cataia Ives Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 675: Reduced, Reproductive Success and 360: Decrease, Population trajectory 1.29
28 Cyclooxygenase inhibition leading reproductive failure Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 1103: Inhibition, Cyclooxygenase 1 activity 351: Increased Mortality and 360: Decrease, Population growth rate 1.29
40 Covalent Protein binding leading to Skin Sensitisation Agnes Aggy Open for citation & comment Included in OECD Work Plan 396: Covalent Binding, Protein 827: sensitisation, skin WPHA/WNT Endorsed 1.1
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Arthur Author Under Development: Contributions and Comments Welcome Included in OECD Work Plan 396: Covalent Binding, Protein 313: Increase, Allergic Respiratory Hypersensitivity Response Under Development 1.20
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas EAGMST Under Review 1.17
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Arthur Author Under development: Not open for comment. Do not cite 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
403 combined unhealthy lifestyle factors leading to metabolic syndrome Evgeniia Kazymova Under development: Not open for comment. Do not cite
448 Cigarette smoke-related adverse outcome pathway frameworks on cardiovascular system Arthur Author Under development: Not open for comment. Do not cite
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan 1753: Chronic reactive oxygen species 1651: Treatment-resistant gastric cancer EAGMST Under Review 1.58
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1090: Increased, mesotheliomas 1.29
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Cataia Ives Under Development: Contributions and Comments Welcome Under Development 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas 1.29
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Arthur Author Open for citation & comment Included in OECD Work Plan 201: Binding of antagonist, NMDA receptors 352: N/A, Neurodegeneration and 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Agnes Aggy Open for citation & comment Included in OECD Work Plan 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan 41: Inhibition, Bile Salt Export Pump (ABCB11) 357: Cholestasis, Pathology Under Development 1.19
359 Chitobiase inhibition leading to mortality Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1807: Increase, Chitobiase inhibition 350: Increase, Mortality Under Development 1.94
358 Chitinase inhibition leading to mortality Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 1806: Increase, Chitinase inhibition 350: Increase, Mortality Under Development 1.94
360 Chitin synthase 1 inhibition leading to mortality Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality EAGMST Approved 1.94
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Cataia Ives Open for citation & comment Included in OECD Work Plan 718: Binding, Tubulin 728: Increase, Aneuploid offspring EAGMST Under Review 1.11
449 Ceramide synthase inhibition leading to neural tube defects Agnes Aggy Under development: Not open for comment. Do not cite
26 Calcium-mediated neuronal ROS production and energy imbalance Brendan Ferreri-Hanberry Open for adoption Under Development 51: Inhibition, Ca++ ATPase 356: Increased, Oxidative damage
397 Bulky DNA adducts leading to mutations Evgeniia Kazymova Under development: Not open for comment. Do not cite 1879: Bulky DNA adducts, increase 185: Increase, Mutations
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Cataia Ives Open for citation & comment Included in OECD Work Plan 667: Binding at picrotoxin site, iGABAR chloride channel 613: Occurrence, Epileptic seizure WPHA/WNT Endorsed 1.15
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1850: dysgeusia Under Development 1.96
320 Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Evgeniia Kazymova Open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 351: Increased Mortality Under Development 1.96
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to increased intestinal permeability Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1932: Gastrointestinal disorders Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1875: Cerebrovascular disease (stroke) Under Development 1.96
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein 1841: Encephalitis Under Development 1.96
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Cataia Ives Under development: Not open for comment. Do not cite Included in OECD Work Plan 1739: ACE2 binding to viral S-protein Under Development 1.96
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory EAGMST Approved 1.13
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Allie Always Open for citation & comment Included in OECD Work Plan 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.23
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Allie Always Under Development: Contributions and Comments Welcome Under Development 1038: Activation, beta-2 adrenergic receptor 1044: Promotion, mesovarian leiomyomas 1.29
96 Axonal sodium channel modulation leading to acute mortality Arthur Author Under Development: Contributions and Comments Welcome Under Development 598: modulation, sodium channel 351: Increased Mortality 1.29
131 Aryl hydrocarbon receptor activation leading to uroporphyria Allie Always Open for citation & comment Included in OECD Work Plan 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Allie Always Under development: Not open for comment. Do not cite 18: Activation, AhR
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Evgeniia Kazymova Under development: Not open for comment. Do not cite 18: Activation, AhR 1276: Lung fibrosis
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Allie Always Under development: Not open for comment. Do not cite 18: Activation, AhR 1670: Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Cataia Ives Under development: Not open for comment. Do not cite 18: Activation, AhR 1670: Lung cancer
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 18: Activation, AhR 1670: Lung cancer
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Agnes Aggy Under development: Not open for comment. Do not cite 18: Activation, AhR 1250: Decrease, Lung function
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Arthur Author Under development: Not open for comment. Do not cite 18: Activation, AhR 1250: Decrease, lung function
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Arthur Author Open for citation & comment Included in OECD Work Plan 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Allie Always Open for citation & comment Included in OECD Work Plan 18: Activation, AhR 947: Increase, early life stage mortality WPHA/WNT Endorsed 1.27
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome 36: Inhibition, Aromatase 360: Decrease, Population trajectory
25 Aromatase inhibition leading to reproductive dysfunction Cataia Ives Open for citation & comment Included in OECD Work Plan 36: Inhibition, Aromatase 360: Decrease, Population trajectory WPHA/WNT Endorsed 1.12
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated 1.29
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Allie Always Open for citation & comment Included in OECD Work Plan 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 406: impaired, Fertility and 405: irregularities, ovarian cycle EAGMST Under Review 1.21
205 AOP from chemical insult to cell death Cataia Ives Open for comment. Do not cite Under Development 1258: Decompartmentalization and 1260: Direct mitochondrial inhibition and 1259: narcosis 1262: Apoptosis and 1263: Necrosis
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Arthur Author Under development: Not open for comment. Do not cite 1261: Mitochondrial impairment 1763: Urothelial Tumor
393 AOP for thyroid disorder caused by triphenyl phosphate Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 1053: Promotion, ovarian adenomas and 1054: Promotion, ovarian granular cell tumors 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Brendan Ferreri-Hanberry Not under active development Included in OECD Work Plan 1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone and 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP and 1169: 1136: Impaired recruitment , Population trajectory Under Development 1.31
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Allie Always Under Development: Contributions and Comments Welcome Under Development 1079: Increased, Adenomas/carcinomas (mammary) 1.29
6 Antagonist binding to PPARα leading to body-weight loss Agnes Aggy Open for citation & comment Included in OECD Work Plan 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight WPHA/WNT Endorsed 2.3
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) 1276: Lung fibrosis Under Development 1.96
372 Androgen receptor antagonism leading to testicular cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 26: Antagonism, Androgen receptor 1839: Testicular Cancer
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Agnes Aggy Open for adoption Under Development 27: N/A, Androgen receptor, Antagonism 337: N/A, Impairment of reproductive capacity
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan 25: Agonism, Androgen receptor 360: Decrease, Population trajectory WPHA/WNT Endorsed 1.12
376 Androgen receptor agonism leading to male-biased sex ratio Evgeniia Kazymova Open for citation & comment 25: Agonism, Androgen receptor 360: Decrease, Population trajectory
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Evgeniia Kazymova Open for adoption Included in OECD Work Plan 785: Activation, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 26: Antagonism, Androgen receptor 1688: decrease, male anogenital distance Under Development 1.90
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Evgeniia Kazymova Under development: Not open for comment. Do not cite 26: Antagonism, Androgen receptor 1786: increase, retained nipples in males
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Cataia Ives Under development: Not open for comment. Do not cite 26: Antagonism, Androgen receptor 972: Decreased fertility, Reduced number of oocytes ovulated
104 Altered ion channel activity leading impaired heart function Allie Always Under Development: Contributions and Comments Welcome Under Development 697: impaired, ion channels 351: Increased Mortality 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular) 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Brendan Ferreri-Hanberry Under Development: Contributions and Comments Welcome Under Development 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity 1.29
322 Alkylation of DNA leading to reduced sperm count Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 97: Alkylation, DNA 1757: Reduce, Sperm count
139 Alkylation of DNA leading to cancer 1 Arthur Author Open for adoption Under Development 97: Alkylation, DNA 885: Increase, Cancer
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
62 AKT2 activation leading to hepatic steatosis Arthur Author Under Development: Contributions and Comments Welcome Under Development 486: systemic inflammation leading to hepatic steatosis 459: Increased, Liver Steatosis 1.29
151 AhR activation leading to preeclampsia Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan 18: Activation, AhR 1893: increase, Preeclampsia Under Development 1.42
57 AhR activation leading to hepatic steatosis Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 18: Activation, AhR 455: Accumulation, Liver lipid 1.29
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Agnes Aggy Open for citation & comment Included in OECD Work Plan 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma EAGMST Under Review 1.8
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan 1592: ROS generation from photoactivated chemicals 1599: Inflamatory events in light-exposed tissues EAGMST Under Review 1.49
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1277: Reproductive failure
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Allie Always Under development: Not open for comment. Do not cite 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Allie Always Under development: Not open for comment. Do not cite 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
16 Acetylcholinesterase inhibition leading to acute mortality Cataia Ives Under Development: Contributions and Comments Welcome Included in OECD Work Plan 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory Under Development 1.3
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evgeniia Kazymova Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein 1535: Heart failure
385 ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1739: ACE2 binding to viral S-protein
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Arthur Author Open for comment. Do not cite Under Development 566: impaired, Larval development and 563: Death/Failure, Colony 1.29
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite 1941: Memory loss
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan 1617: 5α-reductase, inhibition 1688: decrease, male anogenital distance Under Development 1.90
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Evgeniia Kazymova Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1163: Increased, Reproductive Success and 1164: Increased, Population 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Allie Always Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1141: Decreased, Reproductive Success and 360: Decrease, Population growth rate 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Agnes Aggy Under Development: Contributions and Comments Welcome Under Development 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 623: Increase, predation and 360: Decrease, Population growth rate 1.29
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Allie Always Under Development: Contributions and Comments Welcome 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation 1.29
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Evgeniia Kazymova Under development: Not open for comment. Do not cite 1865: Increase, Oxygen-evolving complex damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia EAGMST Approved 1.53