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Event: 1115
Key Event Title
Increased, Reactive oxygen species
Short name
Biological Context
Level of Biological Organization |
---|
Cellular |
Cell term
Organ term
Key Event Components
Process | Object | Action |
---|---|---|
reactive oxygen species biosynthetic process | reactive oxygen species | increased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
unknown MIE renal failure | KeyEvent | Cataia Ives (send email) | Under Development: Contributions and Comments Welcome | |
Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH) | KeyEvent | Arthur Author (send email) | Open for adoption | |
Frustrated phagocytosis-induced lung cancer | KeyEvent | Arthur Author (send email) | Under development: Not open for comment. Do not cite | Under Development |
ACE2 inhibition, liver fibrosis | KeyEvent | Evgeniia Kazymova (send email) | Under development: Not open for comment. Do not cite | Under Development |
AT1R, lung fibrosis | KeyEvent | Allie Always (send email) | Under development: Not open for comment. Do not cite | Under Development |
ACE/Ang-II/AT1R axis, chronic kidney disease (CKD) | KeyEvent | Cataia Ives (send email) | Under development: Not open for comment. Do not cite | |
Deposition of ionizing energy leads to population decline via impaired meiosis | KeyEvent | Allie Always (send email) | Under development: Not open for comment. Do not cite | |
Frustrated phagocytosis leads to malignant mesothelioma | KeyEvent | Evgeniia Kazymova (send email) | Under development: Not open for comment. Do not cite | |
Oxidation of Reduced Glutathione Leading to Mortality | KeyEvent | Agnes Aggy (send email) | Open for citation & comment | |
AHR activation leading to lung cancer via IL-6 tox path | KeyEvent | Cataia Ives (send email) | Under development: Not open for comment. Do not cite | |
AHR activation decreasing lung function via AHR-ARNT tox path | KeyEvent | Arthur Author (send email) | Under development: Not open for comment. Do not cite | |
ROS production leading to population decline via photosynthesis inhibition | KeyEvent | Arthur Author (send email) | Under development: Not open for comment. Do not cite | |
ROS production leading to population decline via mitochondrial dysfunction | KeyEvent | Agnes Aggy (send email) | Under development: Not open for comment. Do not cite | |
Binding to ACE2 leads to lung fibrosis | KeyEvent | Allie Always (send email) | Open for comment. Do not cite | Under Development |
Interaction with lung cells leads to lung cancer | KeyEvent | Evgeniia Kazymova (send email) | Under development: Not open for comment. Do not cite | |
Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity | MolecularInitiatingEvent | Cataia Ives (send email) | Under development: Not open for comment. Do not cite | |
Glutathione conjugation leading to reproductive dysfunction | KeyEvent | Allie Always (send email) | Under Development: Contributions and Comments Welcome | |
ERa inactivation leads to insulin resistance in skeletal muscle and metabolic syndrome | KeyEvent | Arthur Author (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
Vertebrates | Vertebrates | High | NCBI |
Life Stages
Life stage | Evidence |
---|---|
All life stages | High |
Sex Applicability
Term | Evidence |
---|---|
Unspecific | High |
Key Event Description
Biological State: increased reactive oxygen species (ROS)
Biological compartment: an entire cell -- may be cytosolic, may also enter organelles.
Reactive oxygen species (ROS) are O2- derived molecules that can be both free radicals (e.g. superoxide, hydroxyl, peroxyl, alcoxyl) and non-radicals (hypochlorous acid, ozone and singlet oxygen) (Bedard and Krause 2007; Ozcan and Ogun 2015). ROS production occurs naturally in all kinds of tissues inside various cellular compartments, such as mitochondria and peroxisomes (Drew and Leeuwenburgh 2002; Ozcan and Ogun 2015). Furthermore, these molecules have an important function in the regulation of several biological processes – they might act as antimicrobial agents or triggers of animal gamete activation and capacitation (Goud et al. 2008; Parrish 2010; Bisht et al. 2017). However, in environmental stress situations (exposure to radiation, chemicals, high temperatures) these molecules have its levels drastically increased, and overly interact with macromolecules, namely nucleic acids, proteins, carbohydrates and lipids, causing cell and tissue damage (Brieger et al. 2012; Ozcan and Ogun 2015).
How It Is Measured or Detected
Photocolorimetric assays (Sharma et al. 2017; Griendling et al. 2016) or through commercial kits purchased from specialized companies.
Domain of Applicability
ROS is a normal constituent found in all organisms.
References
Bedard, Karen, and Karl-Heinz Krause. 2007. “The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology.” Physiological Reviews 87 (1): 245–313.
Ozcan, Ayla, and Metin Ogun. 2015. “Biochemistry of Reactive Oxygen and Nitrogen Species.” In Basic Principles and Clinical Significance of Oxidative Stress, edited by Sivakumar Joghi Thatha Gowder. Rijeka: IntechOpen.
Drew, Barry, and Christiaan Leeuwenburgh. 2002. “Aging and the Role of Reactive Nitrogen Species.” Annals of the New York Academy of Sciences 959 (April): 66–81.
Goud, Anuradha P., Pravin T. Goud, Michael P. Diamond, Bernard Gonik, and Husam M. Abu-Soud. 2008. “Reactive Oxygen Species and Oocyte Aging: Role of Superoxide, Hydrogen Peroxide, and Hypochlorous Acid.” Free Radical Biology & Medicine 44 (7): 1295–1304.
Parrish, A. R. 2010. “2.27 - Hypoxia/Ischemia Signaling.” In Comprehensive Toxicology (Second Edition), edited by Charlene A. McQueen, 529–42. Oxford: Elsevier.
Bisht, Shilpa, Muneeb Faiq, Madhuri Tolahunase, and Rima Dada. 2017. “Oxidative Stress and Male Infertility.” Nature Reviews. Urology 14 (8): 470–85.
Brieger, K., S. Schiavone, F. J. Miller Jr, and K-H Krause. 2012. “Reactive Oxygen Species: From Health to Disease.” Swiss Medical Weekly 142 (August): w13659.
Sharma, Gunjan, Nishant Kumar Rana, Priya Singh, Pradeep Dubey, Daya Shankar Pandey, and Biplob Koch. 2017. “p53 Dependent Apoptosis and Cell Cycle Delay Induced by Heteroleptic Complexes in Human Cervical Cancer Cells.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 88 (April): 218–31.
Griendling, Kathy K., Rhian M. Touyz, Jay L. Zweier, Sergey Dikalov, William Chilian, Yeong-Renn Chen, David G. Harrison, Aruni Bhatnagar, and American Heart Association Council on Basic Cardiovascular Sciences. 2016. “Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.” Circulation Research 119 (5): e39–75.