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Event: 563

Key Event Title

A descriptive phrase which defines a discrete biological change that can be measured. More help

Death/Failure, Colony

Short name
The KE short name should be a reasonable abbreviation of the KE title and is used in labelling this object throughout the AOP-Wiki. More help
Death/Failure, Colony
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Biological Context

Structured terms, selected from a drop-down menu, are used to identify the level of biological organization for each KE. More help
Level of Biological Organization
Population

Key Event Components

The KE, as defined by a set structured ontology terms consisting of a biological process, object, and action with each term originating from one of 14 biological ontologies (Ives, et al., 2017; https://aopwiki.org/info_pages/2/info_linked_pages/7#List). Biological process describes dynamics of the underlying biological system (e.g., receptor signalling).Biological process describes dynamics of the underlying biological system (e.g., receptor signaling).  The biological object is the subject of the perturbation (e.g., a specific biological receptor that is activated or inhibited). Action represents the direction of perturbation of this system (generally increased or decreased; e.g., ‘decreased’ in the case of a receptor that is inhibited to indicate a decrease in the signaling by that receptor).  Note that when editing Event Components, clicking an existing Event Component from the Suggestions menu will autopopulate these fields, along with their source ID and description.  To clear any fields before submitting the event component, use the 'Clear process,' 'Clear object,' or 'Clear action' buttons.  If a desired term does not exist, a new term request may be made via Term Requests.  Event components may not be edited; to edit an event component, remove the existing event component and create a new one using the terms that you wish to add.  Further information on Event Components and Biological Context may be viewed on the attached pdf. More help
Process Object Action
colony collapse increased

Key Event Overview

AOPs Including This Key Event

All of the AOPs that are linked to this KE will automatically be listed in this subsection. This table can be particularly useful for derivation of AOP networks including the KE. Clicking on the name of the AOP will bring you to the individual page for that AOP. More help
AOP Name Role of event in AOP Point of Contact Author Status OECD Status
nAChR activation - colony death/failure2 AdverseOutcome Allie Always (send email) Open for comment. Do not cite
nAChR activation - colony loss 3 AdverseOutcome Evgeniia Kazymova (send email) Open for comment. Do not cite
nAChR activation - colony loss 4 AdverseOutcome Cataia Ives (send email) Open for comment. Do not cite
Chane in caste - Colony loss AdverseOutcome Arthur Author (send email) Open for comment. Do not cite
Immune system - Colony loss 1 AdverseOutcome Agnes Aggy (send email) Open for comment. Do not cite
Immune system - Colony loss 2 AdverseOutcome Allie Always (send email) Open for comment. Do not cite
Glucose oxidase - Colony loss AdverseOutcome Evgeniia Kazymova (send email) Open for comment. Do not cite
nAChR activation - colony loss 5 AdverseOutcome Cataia Ives (send email) Open for comment. Do not cite
nAChR activation - colony loss 6 AdverseOutcome Brendan Ferreri-Hanberry (send email) Open for comment. Do not cite
nAChR activation - colony loss 7 AdverseOutcome Arthur Author (send email) Open for comment. Do not cite
nAChR activation - colony loss 8 AdverseOutcome Agnes Aggy (send email) Open for comment. Do not cite
nAChR activation - colony death 1 AdverseOutcome Agnes Aggy (send email) Open for comment. Do not cite
Metabolic stress - Colony loss AdverseOutcome Brendan Ferreri-Hanberry (send email) Open for comment. Do not cite
nAChR to colony loss/failure AdverseOutcome Allie Always (send email) Under Development: Contributions and Comments Welcome
Varroa mite leads to colony loss/failure AdverseOutcome Evgeniia Kazymova (send email) Under Development: Contributions and Comments Welcome
Varroa mite and abnormal foraging leads to colony loss/failure AdverseOutcome Cataia Ives (send email) Under Development: Contributions and Comments Welcome
Weather to colony loss/failure AdverseOutcome Brendan Ferreri-Hanberry (send email) Under Development: Contributions and Comments Welcome
Weather to abnormal foraging to colony loss/failure AdverseOutcome Arthur Author (send email) Under Development: Contributions and Comments Welcome
Nosema to energy to colony loss/failure AdverseOutcome Agnes Aggy (send email) Under Development: Contributions and Comments Welcome
Nosema to role change to colony loss/failure AdverseOutcome Allie Always (send email) Under Development: Contributions and Comments Welcome
Queen egg-laying to colony loss/failure AdverseOutcome Evgeniia Kazymova (send email) Under Development: Contributions and Comments Welcome

Taxonomic Applicability

Latin or common names of a species or broader taxonomic grouping (e.g., class, order, family) that help to define the biological applicability domain of the KE.In many cases, individual species identified in these structured fields will be those for which the strongest evidence used in constructing the AOP was available in relation to this KE. More help

Life Stages

An indication of the the relevant life stage(s) for this KE. More help

Sex Applicability

An indication of the the relevant sex for this KE. More help

Key Event Description

A description of the biological state being observed or measured, the biological compartment in which it is measured, and its general role in the biology should be provided. More help

Text from LaLone et al. (2017) Weight of evidence evaluation of a network of adverse outcome pathways linking activaiton of the nicotinic acetylcholine receptor in honey bees to colony death. Science of the Total Environment 584-585, 751-775:

"Colony death/failure is defined as demise of a functional colony. Dramatic losses in the number of managed honey bee colonies have been reported across the globe (Potts et al., 2010) and efforts have been undertaken to survey and identify trends in losses over time, particularly in the US and European Union. Most recent survey results collected in the US have shown that managed honey bee colony losses are significantly higher than those deemed acceptable by beekeepers (Seitz et al., 2015). From surveying commercial (>300 colonies), sideline (25–300 colonies), and small scale <25 colonies) beekeepers, average annual colony losses (both summer and winter losses) per operation in the US during 2014–2015 were 49%, compared to 18.7% that has been identified by beekeepers as an acceptable loss rate (Seitz et al., 2015). Starvation, poor over-winter survival, and weak colonies, were among the most common perceived causes of loss reported by bee keepers (Seitz et al., 2015). Commercial beekeepers, managing thousands of colonies, self-reported colony collapse disorder and pesticides as third and fourth leading reasons for colony loss, respectively (Seitz et al., 2015)."

How It Is Measured or Detected

A description of the type(s) of measurements that can be employed to evaluate the KE and the relative level of scientific confidence in those measurements.These can range from citation of specific validated test guidelines, citation of specific methods published in the peer reviewed literature, or outlines of a general protocol or approach (e.g., a protein may be measured by ELISA). Do not provide detailed protocols. More help

Domain of Applicability

A description of the scientific basis for the indicated domains of applicability and the WoE calls (if provided).  More help

Regulatory Significance of the Adverse Outcome

An AO is a specialised KE that represents the end (an adverse outcome of regulatory significance) of an AOP. More help

References

List of the literature that was cited for this KE description. More help

LaLone, C.A., Villeneuve, D.L., Wu-Smart, J., Milsk, R.Y., Sappington, K., Garber, K.V., Housenger, J. and Ankley, G.T., 2017. Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death. STOTEN. 584-585, 751-775.

Potts, S.G., Biesmeijer, J.C., Kremen, C., Neumann, P., Schweiger, O., Kunin, W.E., 2010. Global pollinator declines: trends, impacts and drivers. Trends Ecol. Evol. 25 (6), 345–353.

Seitz, N., Traynor, K.S., Steinhauer, N., Rennich, K., Wilson, M.E., Ellis, D., Rose, R., Tarpy, D.R., Sagili, R.R., Caron, D.M., Delaplane, K.S., Rangel, J., Lee, K., Baylis, K., Wilkes, J.T., Skinner, J.A., Pettis, J.S., vanEngelsdorp, D., 2015. A national survey of managed honey bee 2014–2015 annual colony losses in the USA. J. Apic. Res. 54 (4), 1–12.