Recently added AOPs

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Allie Always 5-HTT increased predation
ACE2 dysregulation leading to microvascular disfunction Brendan Ferreri-Hanberry
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Allie Always
Acetylcholinesterase Inhibition Leading to Neurodegeneration Allie Always
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi
Alkylation of DNA leading to reduced sperm count Brendan Ferreri-Hanberry
Androgen receptor (AR) antagonism leading to decreased fertility in females Cataia Ives
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Evgeniia Kazymova
Androgen receptor agonism leading to male-biased sex ratio Evgeniia Kazymova
Androgen receptor antagonism leading to testicular cancer Brendan Ferreri-Hanberry
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Allie Always
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Arthur Author
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Brendan Ferreri-Hanberry
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Brendan Ferreri-Hanberry
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Agnes Aggy
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Evgeniia Kazymova
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Agnes Aggy
Chitin synthase 1 inhibition leading to mortality Brendan Ferreri-Hanberry
Chitinase inhibition leading to mortality Evgeniia Kazymova
Chitobiase inhibition leading to mortality Cataia Ives
CIAO Molecular Initiating Event leading to CIAO Adverse Outcome Arthur Author
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Arthur Author
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
Coronaviral replication / RNA genome transcription leading to thrombosis Arthur Author
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Brendan Ferreri-Hanberry
Cytochrome oxidase inhibition leading to olfactory nasal lesions Agnes Aggy
Decreased fibrinolytic and activated bradykinin systems leading to hyperinflammation Arthur Author
DNA methyltransferase inhibition leading to population decline (3) Evgeniia Kazymova
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) Cataia Ives
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Brendan Ferreri-Hanberry
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Allie Always
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Evgeniia Kazymova
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Arthur Author
Excessive reactive oxygen species production leading to mortality (1) Cataia Ives
Excessive reactive oxygen species production leading to mortality (2) Brendan Ferreri-Hanberry
Excessive reactive oxygen species production leading to mortality (3) Arthur Author
Excessive reactive oxygen species production leading to mortality (4) Agnes Aggy
Excessive reactive oxygen species production leading to population decline via lipid peroxidation Agnes Aggy
Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction Agnes Aggy
Formation of DNA photoproducts leading to growth inhibition (1) Allie Always
Formation of DNA photoproducts leading to growth inhibition (2) Evgeniia Kazymova
Formation of DNA photoproducts leading to growth inhibition (3) Cataia Ives
Glucocorticoid Receptor activation leading to hepatic steatosis Agnes Aggy
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Allie Always GR increased disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Brendan Ferreri-Hanberry
Histone deacetylase inhibition leads to impeded craniofacial development Agnes Aggy
Histone deacetylase inhibition leads to neural tube defects Allie Always
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Cataia Ives
IKK complex inhibition leading to liver injury Brendan Ferreri-Hanberry
Immune mediated hepatitis Agnes Aggy
Increased susceptibility to viral entry and coronavirus production leading to hyperinflammation Hasmik Yepiskoposyan
Inhibition of 11β-hydroxylase leading to decresed trajectory in fish Allie Always
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased trajectory in fish Agnes Aggy
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Evgeniia Kazymova
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Evgeniia Kazymova
Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis Allie Always
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Evgeniia Kazymova
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Cataia Ives
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Brendan Ferreri-Hanberry
Inhibition of N-linked glycosylation leads to liver injury Arthur Author
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Cataia Ives
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Brendan Ferreri-Hanberry
Microtubule interacting drugs lead to peripheral neuropathy Arthur Author
Mitochondrial complex inhibition leading to liver injury Arthur Author
Mitochondrial dysfunction to metabolic diseases Arthur Author
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone Cataia Ives
Photosystem II antagonism leading to growth inhibition via oxidative damage Allie Always
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis Evgeniia Kazymova
PPARalpha Agonism Impairs Fish Reproduction Arthur Author
Reduced environmental pH leading to thinner shells in Mytilus edulis Cataia Ives
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Arthur Author
S-adenosylmethionine depletion leading to population decline (1) Agnes Aggy
S-adenosylmethionine depletion leading to population decline (2) Allie Always
Sensitization induction of the intestinal tract by food proteins Cataia Ives
Sulfonylureareceptor binding leading to mortality Arthur Author
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Agnes Aggy
test AOP Allie Always
Thermal stress leading to population decline (1) Agnes Aggy
Thermal stress leading to population decline (2) Allie Always
Thermal stress leading to population decline (3) Evgeniia Kazymova
Thyroperoxidase inhibition leading to increased mortality via altered eye structure Allie Always
Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning Cataia Ives
Thyroperoxidase inhibition leading to increased mortality via decreased eye size Evgeniia Kazymova
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Arthur Author
α-diketone-induced bronchiolitis obliterans Agnes Aggy