Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis |
Evgeniia Kazymova |
- Increase, Oxygen-evolving complex damage
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway |
Brendan Ferreri-Hanberry |
|
|
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Allie Always |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
|
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants |
Brendan Ferreri-Hanberry |
|
|
ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation |
Brendan Ferreri-Hanberry |
|
|
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. |
Evgeniia Kazymova |
|
|
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Allie Always |
- Acetylcholinesterase (AchE) Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
|
Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Allie Always |
- Acetylcholinesterase (AchE) Inhibition
|
|
Adverse outcome pathway of PM-induced respiratory toxicity |
Cataia Ives |
- Non-coding RNA expression profile alteration
|
- Chronic obstructive pulmonary disease
|
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Cataia Ives |
|
|
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Brendan Ferreri-Hanberry |
|
|
AhR activation leads to increased diabetes risk |
Arthur Author |
|
|
Alkylation of DNA leading to reduced sperm count |
Brendan Ferreri-Hanberry |
|
|
Androgen receptor (AR) antagonism leading to decreased fertility in females |
Cataia Ives |
- Antagonism, Androgen receptor
|
- Decreased fertility, Reduced number of oocytes ovulated
|
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Evgeniia Kazymova |
- Antagonism, Androgen receptor
|
- Nipple retention in male offspring, increased
|
Androgen receptor agonism leading to male-biased sex ratio |
Evgeniia Kazymova |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
|
Androgen receptor antagonism leading to testicular cancer |
Brendan Ferreri-Hanberry |
- Antagonism, Androgen receptor
|
|
Antagonist binding to smoothened causes disruption of shh signaling resulting in orofacial clefting |
Arthur Author |
- Antagonism, Smoothened receptor
|
|
AOP for thyroid disorder caused by triphenyl phosphate |
Brendan Ferreri-Hanberry |
|
|
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Arthur Author |
|
|
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Brendan Ferreri-Hanberry |
|
- Decrease, Population growth rate
|
Aryl hydrocarbon receptor activation leading to early stage mortality via cardiovascular toxicity |
Allie Always |
|
- Increase, Early Life Stage Mortality
|
Aryl hydrocarbon receptor activation leading to early stage mortality via impeded craniofacial development |
Agnes Aggy |
|
- Increase, Early Life Stage Mortality
|
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway |
Arthur Author |
|
|
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway |
Agnes Aggy |
|
|
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway |
Brendan Ferreri-Hanberry |
|
|
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway |
Cataia Ives |
|
|
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway |
Allie Always |
|
|
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway |
Evgeniia Kazymova |
|
|
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway |
Allie Always |
|
|
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Brendan Ferreri-Hanberry |
- Binding, Thiol/seleno-proteins involved in protection against oxidative stress
|
|
Ceramide synthase inhibition leading to neural tube defects |
Agnes Aggy |
- Inhibition of Ceramide Synthase
|
|
combined unhealthy lifestyle factors leading to metabolic syndrome |
Evgeniia Kazymova |
|
|
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Arthur Author |
- Binding, Thyroid binding globulin in serum
|
- Altered, Amphibian metamorphosis
|
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Brendan Ferreri-Hanberry |
- Binding, Transthyretin in serum
|
- Altered, Amphibian metamorphosis
|
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects |
Cataia Ives |
|
|
CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Brendan Ferreri-Hanberry |
- CYP2E1 Activation
- Protein Adduct Formation
|
|
Cytochrome oxidase inhibition leading to olfactory nasal lesions |
Agnes Aggy |
- Inhibition, cytochrome oxidase
|
- Increase, Site of Contact Nasal Tumors
|
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia |
Allie Always |
|
|
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis |
Agnes Aggy |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis |
Agnes Aggy |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Deposition of ionising energy leading to population decline via programmed cell death |
Allie Always |
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Deposition of ionising energy leading to population decline via mitochondrial dysfunction |
Agnes Aggy |
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis |
Agnes Aggy |
|
|
Deposition of ionising energy leads to population decline via pollen abnormal |
Brendan Ferreri-Hanberry |
|
- Decrease, Reproduction
- Decreased, Population trajectory
|
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis |
Arthur Author |
|
- Decrease, Reproduction
- Decrease, Population growth rate
|
Deposition of ionizing energy leads to population decline via impaired meiosis |
Allie Always |
- Deposition of Ionizing Energy
- Increased, Reactive oxygen species
- Increase, DNA damage
|
- Decrease of egg production and cummulative fecundity
- Decrease, Reproduction
- Decreased, Population size
|
DNA damage and mutations leading to Metastatic Breast Cancer |
Agnes Aggy |
- Increased, DNA damage and mutation
|
|
DNA methyltransferase inhibition leading to population decline (3) |
Evgeniia Kazymova |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) |
Cataia Ives |
- Prolonged TLR9 activation
|
- Multi Organ Failure involving Acute Respiratory Distress Syndrome
- Increased Mortality
|
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load |
Brendan Ferreri-Hanberry |
- Toll Like Receptor (TLR) Dysregulation
|
|
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Allie Always |
|
|
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Evgeniia Kazymova |
|
|
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Arthur Author |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
|
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction |
Evgeniia Kazymova |
- Activation, estrogen receptor alpha
|
|
Excessive reactive oxygen species production leading to mortality (1) |
Cataia Ives |
- Increase, Reactive Oxygen Species production
|
|
Excessive reactive oxygen species production leading to mortality (2) |
Brendan Ferreri-Hanberry |
- Increase, Reactive Oxygen Species production
|
|
Excessive reactive oxygen species production leading to mortality (3) |
Arthur Author |
- Increase, Reactive Oxygen Species production
|
|
Excessive reactive oxygen species production leading to mortality (4) |
Agnes Aggy |
- Increase, Reactive Oxygen Species production
|
|
Formation of DNA photoproducts leading to growth inhibition (1) |
Allie Always |
- Increase, Formation of DNA photoproducts
|
|
Formation of DNA photoproducts leading to growth inhibition (2) |
Evgeniia Kazymova |
|
|
Formation of DNA photoproducts leading to growth inhibition (3) |
Cataia Ives |
|
|
From activation of the AhR leading to breast cancer related death |
Evgeniia Kazymova |
|
|
Frustrated phagocytosis leads to malignant mesothelioma |
Evgeniia Kazymova |
|
|
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect |
Agnes Aggy |
|
|
Glucocorticoid Receptor activation leading to hepatic steatosis |
Agnes Aggy |
- Activation, Glucocorticoid Receptor
|
- Increased, Liver Steatosis
|
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Allie Always |
- Activation, Glucocorticoid Receptor
|
- Increased, Disease susceptibility
|
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Brendan Ferreri-Hanberry |
- Activation, Glucocorticoid Receptor
|
- Decrease, Population growth rate
|
GSK3beta inactivation leading to increased mortality via defects in developing inner ear |
Cataia Ives |
|
- Increased Mortality
- Decrease, Population growth rate
|
hERG inhibition leading to cardiac toxicity |
Evgeniia Kazymova |
- Binding to hERG channel
- hERG channel biogenesis interference
|
|
Histone deacetylase inhibition leads to impeded craniofacial development |
Agnes Aggy |
- Histone deacetylase inhibition
|
- Facial cartilage structures are reduced in size and morphologically distorted
|
Histone deacetylase inhibition leads to neural tube defects |
Allie Always |
- Histone deacetylase inhibition
|
|
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease |
Cataia Ives |
- Hyperactivation of ACE/Ang-II/AT1R axis
|
|
Hypothalamic estrogen receptors inhibition leading to ovarian cancer |
Cataia Ives |
- Suppression, Estrogen receptor (ER) activity
|
- Promotion, ovarian adenomas
- Promotion, ovarian granular cell tumors
|
IKK complex inhibition leading to liver injury |
Brendan Ferreri-Hanberry |
|
- Necrotic Tissue
- Liver Injury
|
Imbalance in redox homeostasis leading to structural damage to tissues |
Allie Always |
|
|
Immune mediated hepatitis |
Agnes Aggy |
- benzoquinone imine and acylglucuronide metabolites
|
- Immune mediated hepatitis
|
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males |
Arthur Author |
- Increased (ectopic) all-trans retinoic acid concentration
|
|
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) |
Agnes Aggy |
|
- Gestational diabetes mellitus
|
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Evgeniia Kazymova |
- Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
|
- Malformation, cryptorchidism - maldescended testis
|
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Evgeniia Kazymova |
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
|
- Chemical induced Fanconi syndrome
|
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Cataia Ives |
- Inhibition of cystathionine beta-synthase
|
- Impaired,anterior-posterior axis development
|
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) |
Brendan Ferreri-Hanberry |
|
- Increased Mortality
- Decrease, Population growth rate
|
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Brendan Ferreri-Hanberry |
- Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
|
- Growth, reduction
- Decreased, survival
|
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity |
Agnes Aggy |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Occurrence, Kidney toxicity
|
Inhibition of N-linked glycosylation leads to liver injury |
Arthur Author |
- Inhibition of N-linked glycosylation
|
|
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries |
Arthur Author |
- Inhibition of ALDH1A (RALDH)
|
- transposition of the great arteries
|
Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development |
Arthur Author |
- Inhibit, voltage-gated sodium channel
|
- Impairment, Learning and memory
|
Interaction with lung resident cell membrane components leads to lung cancer |
Evgeniia Kazymova |
- Substance interaction with the lung resident cell membrane components
|
|
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability |
Allie Always |
- Deposition of Energy
- Increase in reactive oxygen and nitrogen species (RONS)
- Increase, DNA damage
|
- Decrease, Population growth rate
|
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation |
Brendan Ferreri-Hanberry |
|
- Increase risk, microcephaly
|
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways |
Brendan Ferreri-Hanberry |
|
- Increased, Kidney Failure
|
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Cataia Ives |
- Activation, Latent Transforming Growth Factor Beta 1
|
|
Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Brendan Ferreri-Hanberry |
|
- Decline, Population trajectory
|
Metabolic Syndrome leading to Toll Like Receptor dysregulation |
Cataia Ives |
|
|
Microtubule interacting drugs lead to peripheral neuropathy |
Arthur Author |
- Binding of microtubule stabilizing agents (MSA) to microtubules
|
- Sensory axonal peripheral neuropathy
|
Mitochondrial complex inhibition leading to liver injury |
Arthur Author |
- Increase, Mitochondrial complex III antagonism
- Mitochondrial Complex IV inhibition
- Mitochondrial Complex V inhibition
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
- Inhibition, NADH-ubiquinone oxidoreductase (complex I)
- Binding of inhibitor to mitochondrial complex III
- Binding of inhibitor to mitochondrial complex IV
- Binding of inhibitor to mitochondrial complex V
|
- Necrotic Tissue
- Liver Injury
|
Mitochondrial dysfunction to metabolic diseases |
Arthur Author |
|
|
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function |
Brendan Ferreri-Hanberry |
- Acetylcholinesterase (AchE) Inhibition
|
- Cognitive Function, Decreased
|
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure |
Agnes Aggy |
- Oxidation, Glutathione (To be considered with MIE)
|
|
Oxidative stress Leading to Decreased Lung Function |
Brendan Ferreri-Hanberry |
|
|
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction |
Arthur Author |
|
|
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 |
Agnes Aggy |
|
|
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone |
Cataia Ives |
|
|
Photosystem II antagonism leading to growth inhibition via oxidative damage |
Allie Always |
|
|
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis |
Evgeniia Kazymova |
|
|
PM-related Adverse outcome pathway frameworks on various systems |
Cataia Ives |
|
|
PM2.5-related AOP frameworks on liver diseases |
Arthur Author |
|
|
PPARalpha Agonism Impairs Fish Reproduction |
Arthur Author |
|
|
PPARG activation leading to intrahepatic cholestasis |
Evgeniia Kazymova |
|
|
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population |
Brendan Ferreri-Hanberry |
|
|
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality |
Allie Always |
|
|
Reduced environmental pH leading to thinner shells in Mytilus edulis |
Cataia Ives |
|
|
Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Arthur Author |
- Increase, Uncoupling of photophosphorylation
|
|
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality |
Arthur Author |
|
|
S-adenosylmethionine depletion leading to population decline (1) |
Agnes Aggy |
- Inhibition, Chitin synthase 1
|
|
S-adenosylmethionine depletion leading to population decline (2) |
Allie Always |
- Increase, Sulfonylurea receptor binding
|
|
SARS-CoV-2 infection leading to hyperinflammation |
Arthur Author |
|
|
SARS-CoV-2 infection leading to pyroptosis |
Agnes Aggy |
|
|
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. |
Allie Always |
|
|
Sensitization induction of the intestinal tract by food proteins |
Cataia Ives |
|
|
Superoxide dismutase inhibition leading to increased insulin resistance |
Evgeniia Kazymova |
|
|
TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Agnes Aggy |
|
- Anomalies, Congenital cardiac conotruncal
|
test AOP |
Allie Always |
|
|
Thermal stress leading to population decline (1) |
Agnes Aggy |
- N/A, Mitochondrial dysfunction 1
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Thermal stress leading to population decline (2) |
Allie Always |
- N/A, Mitochondrial dysfunction 1
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Thermal stress leading to population decline (3) |
Evgeniia Kazymova |
- N/A, Mitochondrial dysfunction 1
|
- Decrease, Fecundity
- Decrease, Population growth rate
|
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain |
Allie Always |
|
|
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning |
Cataia Ives |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
|
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure |
Allie Always |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
|
Thyroperoxidase inhibition leading to altered visual function via decreased eye size |
Evgeniia Kazymova |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
|
Toll-like receptor 4 (TLR4) activation leads to neurodegeneration via increase in neuroinflammation |
Arthur Author |
- Toll like receptor 4 Activation
|
- N/A, Neurodegeneration (updated)
|
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Arthur Author |
- Toll-like receptor 4 activation
- Inactivation of PPARγ
|
|
XYZ leading to ABC |
Arthur Author |
|
|
α-diketone-induced bronchiolitis obliterans |
Agnes Aggy |
- Interaction of α-diketones with arginine residues
|
|