All AOPs With OECD Status With SAAOP Status

Recently added AOPs

Title	Point of Contact	MIE	AO
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis	Evgeniia Kazymova	Increase, Oxygen-evolving complex damage	Decrease, Reproduction Decrease, Population growth rate
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway	Brendan Ferreri-Hanberry
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation	Allie Always	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, predation
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants	Brendan Ferreri-Hanberry		Memory Loss
ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation	Brendan Ferreri-Hanberry	Binding to ACE2
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.	Evgeniia Kazymova	Binding to ACE2	Heart failure
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement	Allie Always	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate
Acetylcholinesterase Inhibition Leading to Neurodegeneration	Allie Always	Acetylcholinesterase (AchE) Inhibition	N/A, Neurodegeneration
Adverse outcome pathway of PM-induced respiratory toxicity	Cataia Ives	Non-coding RNA expression profile alteration	Chronic obstructive pulmonary disease
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Cataia Ives
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Brendan Ferreri-Hanberry
AhR activation leads to increased diabetes risk	Arthur Author	Activation, AhR	Increased diabetes risk
Alkylation of DNA leading to reduced sperm count	Brendan Ferreri-Hanberry	Alkylation, DNA	Reduce, Sperm count
Androgen receptor (AR) antagonism leading to decreased fertility in females	Cataia Ives	Antagonism, Androgen receptor	Decreased fertility, Reduced number of oocytes ovulated
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring	Evgeniia Kazymova	Antagonism, Androgen receptor	Nipple retention in male offspring, increased
Androgen receptor agonism leading to male-biased sex ratio	Evgeniia Kazymova	Agonism, Androgen receptor	Decrease, Population growth rate
Androgen receptor antagonism leading to testicular cancer	Brendan Ferreri-Hanberry	Antagonism, Androgen receptor	Testicular Cancer
Antagonist binding to smoothened causes disruption of shh signaling resulting in orofacial clefting	Arthur Author	Antagonism, Smoothened receptor
AOP for thyroid disorder caused by triphenyl phosphate	Brendan Ferreri-Hanberry
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment	Arthur Author	Mitochondrial impairment	Urothelial Tumor
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation	Brendan Ferreri-Hanberry	Inhibition, Aromatase	Decrease, Population growth rate
Aryl hydrocarbon receptor activation leading to early stage mortality via cardiovascular toxicity	Allie Always	Activation, AhR	Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to early stage mortality via impeded craniofacial development	Agnes Aggy	Activation, AhR	Increase, Early Life Stage Mortality
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway	Arthur Author
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway	Agnes Aggy		Decrease, Lung function
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway	Brendan Ferreri-Hanberry	Activation, AhR	Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway	Cataia Ives	Activation, AhR	Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway	Allie Always	Activation, AhR
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway	Evgeniia Kazymova	Activation, AhR	Lung fibrosis
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway	Allie Always	Activation, AhR
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease	Brendan Ferreri-Hanberry	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Chronic kidney disease
Ceramide synthase inhibition leading to neural tube defects	Agnes Aggy	Inhibition of Ceramide Synthase
combined unhealthy lifestyle factors leading to metabolic syndrome	Evgeniia Kazymova
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis	Arthur Author	Binding, Thyroid binding globulin in serum	Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis	Brendan Ferreri-Hanberry	Binding, Transthyretin in serum	Altered, Amphibian metamorphosis
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects	Cataia Ives
CYP2E1 activation and formation of protein adducts leading to neurodegeneration	Brendan Ferreri-Hanberry	CYP2E1 Activation Protein Adduct Formation	Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions	Agnes Aggy	Inhibition, cytochrome oxidase	Increase, Site of Contact Nasal Tumors
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia	Allie Always	Deposition of Energy	Acute Myeloid Leukemia
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis	Agnes Aggy	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis	Agnes Aggy	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Deposition of ionising energy leading to population decline via programmed cell death	Allie Always	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
Deposition of ionising energy leading to population decline via mitochondrial dysfunction	Agnes Aggy	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis	Agnes Aggy
Deposition of ionising energy leads to population decline via pollen abnormal	Brendan Ferreri-Hanberry	Deposition of Energy	Decrease, Reproduction Decreased, Population trajectory
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis	Arthur Author	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
Deposition of ionizing energy leads to population decline via impaired meiosis	Allie Always	Deposition of Ionizing Energy Increased, Reactive oxygen species Increase, DNA damage	Decrease of egg production and cummulative fecundity Decrease, Reproduction Decreased, Population size
DNA damage and mutations leading to Metastatic Breast Cancer	Agnes Aggy	Increased, DNA damage and mutation	metastatic breast cancer
DNA methyltransferase inhibition leading to population decline (3)	Evgeniia Kazymova	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)	Cataia Ives	Prolonged TLR9 activation	Multi Organ Failure involving Acute Respiratory Distress Syndrome Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load	Brendan Ferreri-Hanberry	Toll Like Receptor (TLR) Dysregulation
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development	Allie Always
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity	Evgeniia Kazymova
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR	Arthur Author	Activation, AhR	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction	Evgeniia Kazymova	Activation, estrogen receptor alpha	Impaired, Reproduction
Excessive reactive oxygen species production leading to mortality (1)	Cataia Ives	Increase, Reactive Oxygen Species production	Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2)	Brendan Ferreri-Hanberry	Increase, Reactive Oxygen Species production	Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3)	Arthur Author	Increase, Reactive Oxygen Species production	Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4)	Agnes Aggy	Increase, Reactive Oxygen Species production	Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (1)	Allie Always	Increase, Formation of DNA photoproducts	Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2)	Evgeniia Kazymova
Formation of DNA photoproducts leading to growth inhibition (3)	Cataia Ives
From activation of the AhR leading to breast cancer related death	Evgeniia Kazymova	Activation, AhR	N/A, Breast Cancer
Frustrated phagocytosis leads to malignant mesothelioma	Evgeniia Kazymova	Frustrated phagoytosis	Increased, mesotheliomas
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect	Agnes Aggy
Glucocorticoid Receptor activation leading to hepatic steatosis	Agnes Aggy	Activation, Glucocorticoid Receptor	Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility	Allie Always	Activation, Glucocorticoid Receptor	Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration	Brendan Ferreri-Hanberry	Activation, Glucocorticoid Receptor	Decrease, Population growth rate
GSK3beta inactivation leading to increased mortality via defects in developing inner ear	Cataia Ives	GSK3beta inactivation	Increased Mortality Decrease, Population growth rate
hERG inhibition leading to cardiac toxicity	Evgeniia Kazymova	Binding to hERG channel hERG channel biogenesis interference	Sudden cardiac death
Histone deacetylase inhibition leads to impeded craniofacial development	Agnes Aggy	Histone deacetylase inhibition	Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects	Allie Always	Histone deacetylase inhibition	Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease	Cataia Ives	Hyperactivation of ACE/Ang-II/AT1R axis	Chronic kidney disease
Hypothalamic estrogen receptors inhibition leading to ovarian cancer	Cataia Ives	Suppression, Estrogen receptor (ER) activity	Promotion, ovarian adenomas Promotion, ovarian granular cell tumors
IKK complex inhibition leading to liver injury	Brendan Ferreri-Hanberry	Inhibition, IKK complex	Necrotic Tissue Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues	Allie Always
Immune mediated hepatitis	Agnes Aggy	benzoquinone imine and acylglucuronide metabolites	Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males	Arthur Author	Increased (ectopic) all-trans retinoic acid concentration	Reduce, Sperm count
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)	Agnes Aggy	Increase, TNF	Gestational diabetes mellitus
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)	Evgeniia Kazymova	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity	Malformation, cryptorchidism - maldescended testis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome	Evgeniia Kazymova	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis	Cataia Ives	Inhibition of cystathionine beta-synthase	Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)	Brendan Ferreri-Hanberry	Inhibition of Fyna	Increased Mortality Decrease, Population growth rate
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity	Brendan Ferreri-Hanberry	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts	Growth, reduction Decreased, survival
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity	Agnes Aggy	Inhibition, Mitochondrial Electron Transport Chain Complexes	Occurrence, Kidney toxicity
Inhibition of N-linked glycosylation leads to liver injury	Arthur Author	Inhibition of N-linked glycosylation	Liver Injury
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries	Arthur Author	Inhibition of ALDH1A (RALDH)	transposition of the great arteries
Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development	Arthur Author	Inhibit, voltage-gated sodium channel	Impairment, Learning and memory
Interaction with lung resident cell membrane components leads to lung cancer	Evgeniia Kazymova	Substance interaction with the lung resident cell membrane components	Lung cancer
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability	Allie Always	Deposition of Energy Increase in reactive oxygen and nitrogen species (RONS) Increase, DNA damage	Decrease, Population growth rate
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation	Brendan Ferreri-Hanberry	Deposition of Energy	Increase risk, microcephaly
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways	Brendan Ferreri-Hanberry		Increased, Kidney Failure
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis	Cataia Ives	Activation, Latent Transforming Growth Factor Beta 1	Pulmonary fibrosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction	Brendan Ferreri-Hanberry	Antagonism,LH receptor	Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation	Cataia Ives
Microtubule interacting drugs lead to peripheral neuropathy	Arthur Author	Binding of microtubule stabilizing agents (MSA) to microtubules	Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury	Arthur Author	Increase, Mitochondrial complex III antagonism Mitochondrial Complex IV inhibition Mitochondrial Complex V inhibition Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Inhibition, NADH-ubiquinone oxidoreductase (complex I) Binding of inhibitor to mitochondrial complex III Binding of inhibitor to mitochondrial complex IV Binding of inhibitor to mitochondrial complex V	Necrotic Tissue Liver Injury
Mitochondrial dysfunction to metabolic diseases	Arthur Author
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function	Brendan Ferreri-Hanberry	Acetylcholinesterase (AchE) Inhibition	Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure	Agnes Aggy	Oxidation, Glutathione (To be considered with MIE)	Increased Mortality
Oxidative stress Leading to Decreased Lung Function	Brendan Ferreri-Hanberry	Oxidative Stress	Decrease, Lung function
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction	Arthur Author	Oxidative Stress	Decrease, Lung function
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1	Agnes Aggy	Oxidative Stress	Decrease, Lung function
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone	Cataia Ives
Photosystem II antagonism leading to growth inhibition via oxidative damage	Allie Always
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis	Evgeniia Kazymova
PM-related Adverse outcome pathway frameworks on various systems	Cataia Ives
PM2.5-related AOP frameworks on liver diseases	Arthur Author
PPARalpha Agonism Impairs Fish Reproduction	Arthur Author	Activation, PPARα
PPARG activation leading to intrahepatic cholestasis	Evgeniia Kazymova
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population	Brendan Ferreri-Hanberry
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality	Allie Always
Reduced environmental pH leading to thinner shells in Mytilus edulis	Cataia Ives
Reduction in photophosphorylation leading to growth inhibition in aquatic plants	Arthur Author	Increase, Uncoupling of photophosphorylation	Decrease, Growth
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality	Arthur Author
S-adenosylmethionine depletion leading to population decline (1)	Agnes Aggy	Inhibition, Chitin synthase 1	Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2)	Allie Always	Increase, Sulfonylurea receptor binding	Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation	Arthur Author	Binding to ACE2	Hyperinflammation
SARS-CoV-2 infection leading to pyroptosis	Agnes Aggy	Binding to ACE2	Pyroptosis
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.	Allie Always	Binding to ACE2	Myocardial Infarction
Sensitization induction of the intestinal tract by food proteins	Cataia Ives
Superoxide dismutase inhibition leading to increased insulin resistance	Evgeniia Kazymova
TBX1 inhibition leading to congenital cardiac conotruncal anomalies	Agnes Aggy	Inhibition, TBX1	Anomalies, Congenital cardiac conotruncal
test AOP	Allie Always
Thermal stress leading to population decline (1)	Agnes Aggy	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
Thermal stress leading to population decline (2)	Allie Always	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
Thermal stress leading to population decline (3)	Evgeniia Kazymova	N/A, Mitochondrial dysfunction 1	Decrease, Fecundity Decrease, Population growth rate
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain	Allie Always
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning	Cataia Ives	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure	Allie Always	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate
Thyroperoxidase inhibition leading to altered visual function via decreased eye size	Evgeniia Kazymova	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate
Toll-like receptor 4 (TLR4) activation leads to neurodegeneration via increase in neuroinflammation	Arthur Author	Toll like receptor 4 Activation	N/A, Neurodegeneration (updated)
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis	Arthur Author	Toll-like receptor 4 activation Inactivation of PPARγ	Pulmonary fibrosis
XYZ leading to ABC	Arthur Author
α-diketone-induced bronchiolitis obliterans	Agnes Aggy	Interaction of α-diketones with arginine residues	Bronchiolitis obliterans