| 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Allie Always |
5-HTT |
increased predation |
| ACE2 dysregulation leading to microvascular disfunction |
Brendan Ferreri-Hanberry |
|
|
| Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Allie Always |
|
|
| Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Allie Always |
|
|
| Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building |
Jinhee Choi |
|
|
| Alkylation of DNA leading to reduced sperm count |
Brendan Ferreri-Hanberry |
|
|
| Androgen receptor (AR) antagonism leading to decreased fertility in females |
Cataia Ives |
|
|
| Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Evgeniia Kazymova |
|
|
| Androgen receptor agonism leading to male-biased sex ratio |
Evgeniia Kazymova |
|
|
| Androgen receptor antagonism leading to testicular cancer |
Brendan Ferreri-Hanberry |
|
|
| Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Allie Always |
|
|
| AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Arthur Author |
|
|
| Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Brendan Ferreri-Hanberry |
|
|
| Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Brendan Ferreri-Hanberry |
|
|
| Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Agnes Aggy |
|
|
| Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality |
Evgeniia Kazymova |
|
|
| Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Agnes Aggy |
|
|
| Chitin synthase 1 inhibition leading to mortality |
Brendan Ferreri-Hanberry |
|
|
| Chitinase inhibition leading to mortality |
Evgeniia Kazymova |
|
|
| Chitobiase inhibition leading to mortality |
Cataia Ives |
|
|
| CIAO Molecular Initiating Event leading to CIAO Adverse Outcome |
Arthur Author |
|
|
| Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Arthur Author |
|
|
| Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Brendan Ferreri-Hanberry |
|
|
| Coronaviral replication / RNA genome transcription leading to thrombosis |
Arthur Author |
|
|
| CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Brendan Ferreri-Hanberry |
|
|
| Cytochrome oxidase inhibition leading to olfactory nasal lesions |
Agnes Aggy |
|
|
| Decreased fibrinolytic and activated bradykinin systems leading to hyperinflammation |
Arthur Author |
|
|
| DNA methyltransferase inhibition leading to population decline (3) |
Evgeniia Kazymova |
|
|
| Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) |
Cataia Ives |
|
|
| Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load |
Brendan Ferreri-Hanberry |
|
|
| Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Allie Always |
|
|
| Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Evgeniia Kazymova |
|
|
| Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Arthur Author |
|
|
| Excessive reactive oxygen species production leading to mortality (1) |
Cataia Ives |
|
|
| Excessive reactive oxygen species production leading to mortality (2) |
Brendan Ferreri-Hanberry |
|
|
| Excessive reactive oxygen species production leading to mortality (3) |
Arthur Author |
|
|
| Excessive reactive oxygen species production leading to mortality (4) |
Agnes Aggy |
|
|
| Excessive reactive oxygen species production leading to population decline via lipid peroxidation |
Agnes Aggy |
|
|
| Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction |
Agnes Aggy |
|
|
| Formation of DNA photoproducts leading to growth inhibition (1) |
Allie Always |
|
|
| Formation of DNA photoproducts leading to growth inhibition (2) |
Evgeniia Kazymova |
|
|
| Formation of DNA photoproducts leading to growth inhibition (3) |
Cataia Ives |
|
|
| Glucocorticoid Receptor activation leading to hepatic steatosis |
Agnes Aggy |
|
|
| Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Allie Always |
GR |
increased disease susceptibility |
| Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Brendan Ferreri-Hanberry |
|
|
| Histone deacetylase inhibition leads to impeded craniofacial development |
Agnes Aggy |
|
|
| Histone deacetylase inhibition leads to neural tube defects |
Allie Always |
|
|
| Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease |
Cataia Ives |
|
|
| IKK complex inhibition leading to liver injury |
Brendan Ferreri-Hanberry |
|
|
| Immune mediated hepatitis |
Agnes Aggy |
|
|
| Increased susceptibility to viral entry and coronavirus production leading to hyperinflammation |
Hasmik Yepiskoposyan |
|
|
| Inhibition of 11β-hydroxylase leading to decresed trajectory in fish |
Allie Always |
|
|
| Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased trajectory in fish |
Agnes Aggy |
|
|
| Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Evgeniia Kazymova |
|
|
| Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Evgeniia Kazymova |
|
|
| Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis |
Allie Always |
|
|
| Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Evgeniia Kazymova |
|
|
| Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Cataia Ives |
|
|
| Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Brendan Ferreri-Hanberry |
|
|
| Inhibition of N-linked glycosylation leads to liver injury |
Arthur Author |
|
|
| Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Cataia Ives |
|
|
| Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Brendan Ferreri-Hanberry |
|
|
| Microtubule interacting drugs lead to peripheral neuropathy |
Arthur Author |
|
|
| Mitochondrial complex inhibition leading to liver injury |
Arthur Author |
|
|
| Mitochondrial dysfunction to metabolic diseases |
Arthur Author |
|
|
| Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone |
Cataia Ives |
|
|
| Photosystem II antagonism leading to growth inhibition via oxidative damage |
Allie Always |
|
|
| Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis |
Evgeniia Kazymova |
|
|
| PPARalpha Agonism Impairs Fish Reproduction |
Arthur Author |
|
|
| Reduced environmental pH leading to thinner shells in Mytilus edulis |
Cataia Ives |
|
|
| Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Arthur Author |
|
|
| S-adenosylmethionine depletion leading to population decline (1) |
Agnes Aggy |
|
|
| S-adenosylmethionine depletion leading to population decline (2) |
Allie Always |
|
|
| Sensitization induction of the intestinal tract by food proteins |
Cataia Ives |
|
|
| Sulfonylureareceptor binding leading to mortality |
Arthur Author |
|
|
| TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Agnes Aggy |
|
|
| test AOP |
Allie Always |
|
|
| Thermal stress leading to population decline (1) |
Agnes Aggy |
|
|
| Thermal stress leading to population decline (2) |
Allie Always |
|
|
| Thermal stress leading to population decline (3) |
Evgeniia Kazymova |
|
|
| Thyroperoxidase inhibition leading to increased mortality via altered eye structure |
Allie Always |
|
|
| Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning |
Cataia Ives |
|
|
| Thyroperoxidase inhibition leading to increased mortality via decreased eye size |
Evgeniia Kazymova |
|
|
| Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Arthur Author |
|
|
| α-diketone-induced bronchiolitis obliterans |
Agnes Aggy |
|
|