Recently added AOPs

Title Point of Contact MIE AO
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Evgeniia Kazymova 1865: Increase, Oxygen-evolving complex damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Brendan Ferreri-Hanberry
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Allie Always 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 588: Increased, predation
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Brendan Ferreri-Hanberry 1941: Memory loss
ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation Brendan Ferreri-Hanberry 1739: ACE2 binding to viral S-protein
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evgeniia Kazymova 1739: ACE2 binding to viral S-protein 1535: Heart failure
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Allie Always 12: Acetylcholinesterase (AchE) Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Acetylcholinesterase Inhibition Leading to Neurodegeneration Allie Always 12: Acetylcholinesterase (AchE) Inhibition 352: N/A, Neurodegeneration
Alkylation of DNA leading to reduced sperm count Brendan Ferreri-Hanberry 97: Alkylation, DNA 1757: Reduce, Sperm count
Androgen receptor (AR) antagonism leading to decreased fertility in females Cataia Ives 26: Antagonism, Androgen receptor 972: Decreased fertility, Reduced number of oocytes ovulated
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Evgeniia Kazymova 26: Antagonism, Androgen receptor 1786: increase, retained nipples in males
Androgen receptor agonism leading to male-biased sex ratio Evgeniia Kazymova 25: Agonism, Androgen receptor 360: Decrease, Population trajectory
Androgen receptor antagonism leading to testicular cancer Brendan Ferreri-Hanberry 26: Antagonism, Androgen receptor 1839: Testicular Cancer
AOP for thyroid disorder caused by triphenyl phosphate Brendan Ferreri-Hanberry
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Arthur Author 1261: Mitochondrial impairment 1763: Urothelial Tumor
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Brendan Ferreri-Hanberry 36: Inhibition, Aromatase 360: Decrease, Population trajectory
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Arthur Author 18: Activation, AhR 1250: Decrease, lung function
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Agnes Aggy 18: Activation, AhR 1250: Decrease, Lung function
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Brendan Ferreri-Hanberry 18: Activation, AhR 1670: Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Cataia Ives 18: Activation, AhR 1670: Lung cancer
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Allie Always 18: Activation, AhR 1670: Lung cancer
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Evgeniia Kazymova 18: Activation, AhR 1276: Lung fibrosis
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Allie Always 18: Activation, AhR
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Brendan Ferreri-Hanberry 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease
Bulky DNA adducts leading to mutations Evgeniia Kazymova 1879: Bulky DNA adducts, increase 185: Increase, Mutations
Ceramide synthase inhibition leading to neural tube defects Agnes Aggy
Cigarette smoke-related adverse outcome pathway frameworks on cardiovascular system Arthur Author
combined unhealthy lifestyle factors leading to metabolic syndrome Evgeniia Kazymova
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Arthur Author 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Cataia Ives
CYP2E1 activation and formation of protein adducts leading to neurodegeneration Brendan Ferreri-Hanberry 1508: CYP2E1 Activation and 1509: Protein Adduct Formation 1514: Neurodegeneration
Cytochrome oxidase inhibition leading to olfactory nasal lesions Agnes Aggy 1840: Inhibition, cytochrome oxidase 872: Increase, Site of Contact Nasal Tumors
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Allie Always 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis Agnes Aggy 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis Agnes Aggy 257: Increase, Reactive Oxygen Species production 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Deposition of ionising energy leading to population decline via programmed cell death Allie Always 1194: Increase, DNA damage 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Deposition of ionising energy leading to population decline via mitochondrial dysfunction Agnes Aggy 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Deposition of ionising energy leads to population decline via pollen abnormal Brendan Ferreri-Hanberry 1686: Deposition of Energy 1863: Decrease, Reproduction and 442: Decreased, Population trajectory
Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis Arthur Author 257: Increase, Reactive Oxygen Species production 1863: Decrease, Reproduction and 360: Decrease, Population trajectory
Deposition of ionizing energy leads to population decline via impaired meiosis Allie Always 1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage 1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size
DNA damage and mutations leading to Metastatic Breast Cancer Agnes Aggy
DNA methyltransferase inhibition leading to population decline (3) Evgeniia Kazymova 1619: Increase, DNA methyltransferase inhibition 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) Cataia Ives 1842: Prolonged TLR9 activation 1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Brendan Ferreri-Hanberry 1848: Toll Like Receptor (TLR) Dysregulation
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Allie Always
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Evgeniia Kazymova
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Arthur Author 18: Activation, AhR 78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory
Estrogen Receptor Alpha(α) Agonism leads to Impaired Reproduction Evgeniia Kazymova
Excessive reactive oxygen species production leading to mortality (1) Cataia Ives 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (2) Brendan Ferreri-Hanberry 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (3) Arthur Author 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Excessive reactive oxygen species production leading to mortality (4) Agnes Aggy 257: Increase, Reactive Oxygen Species production 350: Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (1) Allie Always 1765: Increase, Formation of DNA photoproducts 350: Increase, Mortality
Formation of DNA photoproducts leading to growth inhibition (2) Evgeniia Kazymova
Formation of DNA photoproducts leading to growth inhibition (3) Cataia Ives
From activation of the AhR leading to breast cancer related death Evgeniia Kazymova
Frustrated phagocytosis leads to malignant mesothelioma Evgeniia Kazymova 1668: Frustrated phagoytosis 1090: Increased, mesotheliomas
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect Agnes Aggy
Glucocorticoid Receptor activation leading to hepatic steatosis Agnes Aggy 122: Activation, Glucocorticoid Receptor 459: Increased, Liver Steatosis
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Allie Always 122: Activation, Glucocorticoid Receptor 323: Increased, Disease susceptibility
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Brendan Ferreri-Hanberry 122: Activation, Glucocorticoid Receptor 360: Decrease, Population trajectory
GSK3beta inactivation leading to increased mortality via defects in developing inner ear Cataia Ives 1647: GSK3beta inactivation 351: Increased Mortality and 360: Decrease, Population trajectory
hERG inhibition leading to cardiac toxicity Evgeniia Kazymova 1956: Binding to hERG channel and 1957: hERG channel biogenesis interference 1964: Sudden cardiac death
Histone deacetylase inhibition leads to impeded craniofacial development Agnes Aggy 1502: Histone deacetylase inhibition 1559: Facial cartilage structures are reduced in size and morphologically distorted
Histone deacetylase inhibition leads to neural tube defects Allie Always 1502: Histone deacetylase inhibition 1561: Neural tube defects
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Cataia Ives 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
Hypothalamic estrogen receptors inhibition leading to ovarian cancer Cataia Ives
IKK complex inhibition leading to liver injury Brendan Ferreri-Hanberry 1574: Inhibition, IKK complex 1548: Necrotic Tissue and 1549: Liver Injury
Imbalance in redox homeostasis leading to structural damage to tissues Allie Always
Immune mediated hepatitis Agnes Aggy 1814: benzoquinone imine and acylglucuronide metabolites 1820: Immune mediated hepatitis
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males Arthur Author 1888: Increased (ectopic) all-trans retinoic acid concentration 1757: Reduce, Sperm count
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Agnes Aggy 1950: Increase, TNF 1953: Gestational diabetes mellitus
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Evgeniia Kazymova 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Evgeniia Kazymova 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 1564: Chemical induced Fanconi syndrome
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Cataia Ives 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Brendan Ferreri-Hanberry 1884: Inhibition of Fyna 351: Increased Mortality and 360: Decrease, Population trajectory
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Brendan Ferreri-Hanberry 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts 1467: Growth, reduction and 636: Decreased, survival
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Agnes Aggy
Inhibition of N-linked glycosylation leads to liver injury Arthur Author 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Arthur Author
Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development Arthur Author
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Allie Always
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Brendan Ferreri-Hanberry
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Brendan Ferreri-Hanberry
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Cataia Ives 1468: Activation, Latent Transforming Growth Factor Beta 1 1458: Pulmonary fibrosis
Luteinizing hormone receptor antagonism leading to reproductive dysfunction Brendan Ferreri-Hanberry 1691: Antagonism,LH receptor 679: Decline, Population trajectory
Metabolic Syndrome leading to Toll Like Receptor dysregulation Cataia Ives
Microtubule interacting drugs lead to peripheral neuropathy Arthur Author 1580: Binding of microtubule stabilizing agents (MSA) to microtubules 1583: Sensory axonal peripheral neuropathy
Mitochondrial complex inhibition leading to liver injury Arthur Author 1542, 1543, 1544, 888, 887, 1653, 1654, 1655 1548: Necrotic Tissue and 1549: Liver Injury
Mitochondrial dysfunction to metabolic diseases Arthur Author
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function Brendan Ferreri-Hanberry 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive Function, Decreased
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Agnes Aggy 351: Increased Mortality
Oxidative stress Leading to Decreased Lung Function Brendan Ferreri-Hanberry 1392: Oxidative Stress 1250: Decrease, Lung function
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Arthur Author 1392: Oxidative Stress 1250: Decrease, Lung function
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Agnes Aggy 1392: Oxidative Stress 1250: Decrease, Lung function
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone Cataia Ives
Photosystem II antagonism leading to growth inhibition via oxidative damage Allie Always
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis Evgeniia Kazymova
PM-related Adverse outcome pathway frameworks on various systems Cataia Ives
PPARalpha Agonism Impairs Fish Reproduction Arthur Author 227: Activation, PPARα
PPARG activation leading to intrahepatic cholestasis Evgeniia Kazymova
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Allie Always
Reduced environmental pH leading to thinner shells in Mytilus edulis Cataia Ives
Reduction in photophosphorylation leading to growth inhibition in aquatic plants Arthur Author 1471: Increase, Uncoupling of photophosphorylation 1521: Decrease, Growth
S-adenosylmethionine depletion leading to population decline (1) Agnes Aggy 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality
S-adenosylmethionine depletion leading to population decline (2) Allie Always 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality
SARS-CoV-2 infection leading to hyperinflammation Arthur Author 1739: ACE2 binding to viral S-protein 1868: Hyperinflammation
SARS-CoV-2 infection leading to pyroptosis Agnes Aggy 1739: ACE2 binding to viral S-protein 1967: Pyroptosis
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Allie Always 1739: ACE2 binding to viral S-protein 1934: Myocardial Infarction
Sensitization induction of the intestinal tract by food proteins Cataia Ives
TBX1 inhibition leading to congenital cardiac conotruncal anomalies Agnes Aggy 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
test AOP Allie Always
Thermal stress leading to population decline (1) Agnes Aggy 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thermal stress leading to population decline (2) Allie Always 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thermal stress leading to population decline (3) Evgeniia Kazymova 177: N/A, Mitochondrial dysfunction 1 328: Decrease, Fecundity and 360: Decrease, Population trajectory
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Allie Always
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Cataia Ives 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Allie Always 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Thyroperoxidase inhibition leading to altered visual function via decreased eye size Evgeniia Kazymova 279: Thyroperoxidase, Inhibition 351: Increased Mortality and 360: Decrease, Population trajectory
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Arthur Author 1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ 1458: Pulmonary fibrosis
α-diketone-induced bronchiolitis obliterans Agnes Aggy 1584: Interaction of α-diketones with arginine residues 1588: Bronchiolitis obliterans