| Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis |
Evgeniia Kazymova |
1865: Increase, Oxygen-evolving complex damage |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway |
Brendan Ferreri-Hanberry |
|
|
| 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Allie Always |
619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) |
588: Increased, predation |
| A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants |
Brendan Ferreri-Hanberry |
|
1941: Memory loss |
| ACE2 binding to viral S-protein leading to microvascular disfunction via ACE2 dysregulation |
Brendan Ferreri-Hanberry |
1739: ACE2 binding to viral S-protein |
|
| ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. |
Evgeniia Kazymova |
1739: ACE2 binding to viral S-protein |
1535: Heart failure |
| Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Allie Always |
12: Acetylcholinesterase (AchE) Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Allie Always |
12: Acetylcholinesterase (AchE) Inhibition |
352: N/A, Neurodegeneration |
| Alkylation of DNA leading to reduced sperm count |
Brendan Ferreri-Hanberry |
97: Alkylation, DNA |
1757: Reduce, Sperm count |
| Androgen receptor (AR) antagonism leading to decreased fertility in females |
Cataia Ives |
26: Antagonism, Androgen receptor |
972: Decreased fertility, Reduced number of oocytes ovulated |
| Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Evgeniia Kazymova |
26: Antagonism, Androgen receptor |
1786: increase, retained nipples in males |
| Androgen receptor agonism leading to male-biased sex ratio |
Evgeniia Kazymova |
25: Agonism, Androgen receptor |
360: Decrease, Population trajectory |
| Androgen receptor antagonism leading to testicular cancer |
Brendan Ferreri-Hanberry |
26: Antagonism, Androgen receptor |
1839: Testicular Cancer |
| AOP for thyroid disorder caused by triphenyl phosphate |
Brendan Ferreri-Hanberry |
|
|
| AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Arthur Author |
1261: Mitochondrial impairment |
1763: Urothelial Tumor |
| Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Brendan Ferreri-Hanberry |
36: Inhibition, Aromatase |
360: Decrease, Population trajectory |
| Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway |
Arthur Author |
18: Activation, AhR |
1250: Decrease, lung function |
| Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway |
Agnes Aggy |
18: Activation, AhR |
1250: Decrease, Lung function |
| Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway |
Brendan Ferreri-Hanberry |
18: Activation, AhR |
1670: Lung cancer |
| Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway |
Cataia Ives |
18: Activation, AhR |
1670: Lung cancer |
| Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway |
Allie Always |
18: Activation, AhR |
1670: Lung cancer |
| Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway |
Evgeniia Kazymova |
18: Activation, AhR |
1276: Lung fibrosis |
| Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway |
Allie Always |
18: Activation, AhR |
|
| Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Brendan Ferreri-Hanberry |
1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress |
1603: Chronic kidney disease |
| Bulky DNA adducts leading to mutations |
Evgeniia Kazymova |
1879: Bulky DNA adducts, increase |
185: Increase, Mutations |
| Ceramide synthase inhibition leading to neural tube defects |
Agnes Aggy |
|
|
| Cigarette smoke-related adverse outcome pathway frameworks on cardiovascular system |
Arthur Author |
|
|
| combined unhealthy lifestyle factors leading to metabolic syndrome |
Evgeniia Kazymova |
|
|
| Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Arthur Author |
1831: Binding, Thyroid binding globulin in serum |
1101: Altered, Amphibian metamorphosis |
| Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Brendan Ferreri-Hanberry |
957: Binding, Transthyretin in serum |
1101: Altered, Amphibian metamorphosis |
| CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects |
Cataia Ives |
|
|
| CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Brendan Ferreri-Hanberry |
1508: CYP2E1 Activation and 1509: Protein Adduct Formation |
1514: Neurodegeneration |
| Cytochrome oxidase inhibition leading to olfactory nasal lesions |
Agnes Aggy |
1840: Inhibition, cytochrome oxidase |
872: Increase, Site of Contact Nasal Tumors |
| Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia |
Allie Always |
1686: Deposition of Energy |
1955: Acute Myeloid Leukemia |
| Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis |
Agnes Aggy |
257: Increase, Reactive Oxygen Species production |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis |
Agnes Aggy |
257: Increase, Reactive Oxygen Species production |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Deposition of ionising energy leading to population decline via programmed cell death |
Allie Always |
1194: Increase, DNA damage |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Deposition of ionising energy leading to population decline via mitochondrial dysfunction |
Agnes Aggy |
257: Increase, Reactive Oxygen Species production |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Deposition of ionising energy leads to population decline via pollen abnormal |
Brendan Ferreri-Hanberry |
1686: Deposition of Energy |
1863: Decrease, Reproduction and 442: Decreased, Population trajectory |
| Deposition of ionizing energy leads to leading to population decline via inhibition of photosynthesis |
Arthur Author |
257: Increase, Reactive Oxygen Species production |
1863: Decrease, Reproduction and 360: Decrease, Population trajectory |
| Deposition of ionizing energy leads to population decline via impaired meiosis |
Allie Always |
1550: Direct Deposition of Ionizing Energy and 1115: Increased, Reactive oxygen species and 1194: Increase, DNA damage |
1696: Decrease of egg production and cummulative fecundity and 997: Decreased, Population size |
| DNA damage and mutations leading to Metastatic Breast Cancer |
Agnes Aggy |
|
|
| DNA methyltransferase inhibition leading to population decline (3) |
Evgeniia Kazymova |
1619: Increase, DNA methyltransferase inhibition |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) |
Cataia Ives |
1842: Prolonged TLR9 activation |
1843: Acute Respiratory Distress Syndrome and Multiple Organ Dysfunction and 351: Increased Mortality |
| Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load |
Brendan Ferreri-Hanberry |
1848: Toll Like Receptor (TLR) Dysregulation |
|
| Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Allie Always |
|
|
| Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Evgeniia Kazymova |
|
|
| Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Arthur Author |
18: Activation, AhR |
78: Reduction, Cumulative fecundity and spawning and 360: Decrease, Population trajectory |
| Estrogen Receptor Alpha(α) Agonism leads to Impaired Reproduction |
Evgeniia Kazymova |
|
|
| Excessive reactive oxygen species production leading to mortality (1) |
Cataia Ives |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to mortality (2) |
Brendan Ferreri-Hanberry |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to mortality (3) |
Arthur Author |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Excessive reactive oxygen species production leading to mortality (4) |
Agnes Aggy |
257: Increase, Reactive Oxygen Species production |
350: Increase, Mortality |
| Formation of DNA photoproducts leading to growth inhibition (1) |
Allie Always |
1765: Increase, Formation of DNA photoproducts |
350: Increase, Mortality |
| Formation of DNA photoproducts leading to growth inhibition (2) |
Evgeniia Kazymova |
|
|
| Formation of DNA photoproducts leading to growth inhibition (3) |
Cataia Ives |
|
|
| From activation of the AhR leading to breast cancer related death |
Evgeniia Kazymova |
|
|
| Frustrated phagocytosis leads to malignant mesothelioma |
Evgeniia Kazymova |
1668: Frustrated phagoytosis |
1090: Increased, mesotheliomas |
| G protein-coupled estrogen receptor 1 (GPER) signal pathway in the endocrine disrupting effect |
Agnes Aggy |
|
|
| Glucocorticoid Receptor activation leading to hepatic steatosis |
Agnes Aggy |
122: Activation, Glucocorticoid Receptor |
459: Increased, Liver Steatosis |
| Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Allie Always |
122: Activation, Glucocorticoid Receptor |
323: Increased, Disease susceptibility |
| Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Brendan Ferreri-Hanberry |
122: Activation, Glucocorticoid Receptor |
360: Decrease, Population trajectory |
| GSK3beta inactivation leading to increased mortality via defects in developing inner ear |
Cataia Ives |
1647: GSK3beta inactivation |
351: Increased Mortality and 360: Decrease, Population trajectory |
| hERG inhibition leading to cardiac toxicity |
Evgeniia Kazymova |
1956: Binding to hERG channel and 1957: hERG channel biogenesis interference |
1964: Sudden cardiac death |
| Histone deacetylase inhibition leads to impeded craniofacial development |
Agnes Aggy |
1502: Histone deacetylase inhibition |
1559: Facial cartilage structures are reduced in size and morphologically distorted |
| Histone deacetylase inhibition leads to neural tube defects |
Allie Always |
1502: Histone deacetylase inhibition |
1561: Neural tube defects |
| Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease |
Cataia Ives |
1853: Hyperactivation of ACE/Ang-II/AT1R axis |
1603: Chronic kidney disease |
| Hypothalamic estrogen receptors inhibition leading to ovarian cancer |
Cataia Ives |
|
|
| IKK complex inhibition leading to liver injury |
Brendan Ferreri-Hanberry |
1574: Inhibition, IKK complex |
1548: Necrotic Tissue and 1549: Liver Injury |
| Imbalance in redox homeostasis leading to structural damage to tissues |
Allie Always |
|
|
| Immune mediated hepatitis |
Agnes Aggy |
1814: benzoquinone imine and acylglucuronide metabolites |
1820: Immune mediated hepatitis |
| Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males |
Arthur Author |
1888: Increased (ectopic) all-trans retinoic acid concentration |
1757: Reduce, Sperm count |
| Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) |
Agnes Aggy |
1950: Increase, TNF |
1953: Gestational diabetes mellitus |
| Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Evgeniia Kazymova |
1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity |
1616: Malformation, cryptorchidism - maldescended testis |
| Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Evgeniia Kazymova |
888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) |
1564: Chemical induced Fanconi syndrome |
| Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Cataia Ives |
1657: Inhibition of cystathionine beta-synthase |
1667: Impaired,anterior-posterior axis development |
| Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) |
Brendan Ferreri-Hanberry |
1884: Inhibition of Fyna |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Brendan Ferreri-Hanberry |
1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts |
1467: Growth, reduction and 636: Decreased, survival |
| Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity |
Agnes Aggy |
|
|
| Inhibition of N-linked glycosylation leads to liver injury |
Arthur Author |
1604: Inhibition of N-linked glycosylation |
1549: Liver Injury |
| Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries |
Arthur Author |
|
|
| Inhibition of voltage gate sodium channels leading to impairment in learning and memory during development |
Arthur Author |
|
|
| Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability |
Allie Always |
|
|
| Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation |
Brendan Ferreri-Hanberry |
|
|
| Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways |
Brendan Ferreri-Hanberry |
|
|
| Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Cataia Ives |
1468: Activation, Latent Transforming Growth Factor Beta 1 |
1458: Pulmonary fibrosis |
| Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Brendan Ferreri-Hanberry |
1691: Antagonism,LH receptor |
679: Decline, Population trajectory |
| Metabolic Syndrome leading to Toll Like Receptor dysregulation |
Cataia Ives |
|
|
| Microtubule interacting drugs lead to peripheral neuropathy |
Arthur Author |
1580: Binding of microtubule stabilizing agents (MSA) to microtubules |
1583: Sensory axonal peripheral neuropathy |
| Mitochondrial complex inhibition leading to liver injury |
Arthur Author |
1542, 1543, 1544, 888, 887, 1653, 1654, 1655 |
1548: Necrotic Tissue and 1549: Liver Injury |
| Mitochondrial dysfunction to metabolic diseases |
Arthur Author |
|
|
| Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function |
Brendan Ferreri-Hanberry |
12: Acetylcholinesterase (AchE) Inhibition |
402: Cognitive Function, Decreased |
| Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure |
Agnes Aggy |
|
351: Increased Mortality |
| Oxidative stress Leading to Decreased Lung Function |
Brendan Ferreri-Hanberry |
1392: Oxidative Stress |
1250: Decrease, Lung function |
| Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction |
Arthur Author |
1392: Oxidative Stress |
1250: Decrease, Lung function |
| Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 |
Agnes Aggy |
1392: Oxidative Stress |
1250: Decrease, Lung function |
| Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone |
Cataia Ives |
|
|
| Photosystem II antagonism leading to growth inhibition via oxidative damage |
Allie Always |
|
|
| Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis |
Evgeniia Kazymova |
|
|
| PM-related Adverse outcome pathway frameworks on various systems |
Cataia Ives |
|
|
| PPARalpha Agonism Impairs Fish Reproduction |
Arthur Author |
227: Activation, PPARα |
|
| PPARG activation leading to intrahepatic cholestasis |
Evgeniia Kazymova |
|
|
| reactive oxygen species generation leading to increased cardiovascular morbidity and mortality |
Allie Always |
|
|
| Reduced environmental pH leading to thinner shells in Mytilus edulis |
Cataia Ives |
|
|
| Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Arthur Author |
1471: Increase, Uncoupling of photophosphorylation |
1521: Decrease, Growth |
| S-adenosylmethionine depletion leading to population decline (1) |
Agnes Aggy |
1522: Inhibition, Chitin synthase 1 |
350: Increase, Mortality |
| S-adenosylmethionine depletion leading to population decline (2) |
Allie Always |
1525: Increase, Sulfonylurea receptor binding |
350: Increase, Mortality |
| SARS-CoV-2 infection leading to hyperinflammation |
Arthur Author |
1739: ACE2 binding to viral S-protein |
1868: Hyperinflammation |
| SARS-CoV-2 infection leading to pyroptosis |
Agnes Aggy |
1739: ACE2 binding to viral S-protein |
1967: Pyroptosis |
| SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. |
Allie Always |
1739: ACE2 binding to viral S-protein |
1934: Myocardial Infarction |
| Sensitization induction of the intestinal tract by food proteins |
Cataia Ives |
|
|
| TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Agnes Aggy |
1680: Inhibition, TBX1 |
1685: Anomalies, Congenital cardiac conotruncal |
| test AOP |
Allie Always |
|
|
| Thermal stress leading to population decline (1) |
Agnes Aggy |
177: N/A, Mitochondrial dysfunction 1 |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Thermal stress leading to population decline (2) |
Allie Always |
177: N/A, Mitochondrial dysfunction 1 |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Thermal stress leading to population decline (3) |
Evgeniia Kazymova |
177: N/A, Mitochondrial dysfunction 1 |
328: Decrease, Fecundity and 360: Decrease, Population trajectory |
| Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain |
Allie Always |
|
|
| Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning |
Cataia Ives |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure |
Allie Always |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Thyroperoxidase inhibition leading to altered visual function via decreased eye size |
Evgeniia Kazymova |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
| Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Arthur Author |
1792: Toll-like receptor 4 activation and 1270: Inactivation of PPARγ |
1458: Pulmonary fibrosis |
| α-diketone-induced bronchiolitis obliterans |
Agnes Aggy |
1584: Interaction of α-diketones with arginine residues |
1588: Bronchiolitis obliterans |