AOPs With SAAOP Status

Under Development

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Title Point of Contact MIE AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Brendan Ferreri-Hanberry EcR mortality

Open for comment. Do not cite

Title Point of Contact MIE AO
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Arthur Author unk colony loss/failure
AOP from chemical insult to cell death Cataia Ives
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Evgeniia Kazymova glucose oxidase colony loss/failure
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry metabolic stress is not MIE colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Agnes Aggy nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Cataia Ives nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Brendan Ferreri-Hanberry nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Allie Always nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Agnes Aggy nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Cataia Ives nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Evgeniia Kazymova nAChR colony loss/failure
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Arthur Author nAChR colony loss/failure
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Allie Always unclear colony loss/failure
Suppression of immune system contributes to impaired development and leads to colony loss/failure Agnes Aggy unclear colony loss/failure

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Not under active development

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova
ER mediated breast cancer AOP Cataia Ives
Excessive reactive oxygen species production leading to population decline via follicular atresia Evgeniia Kazymova
Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation Allie Always
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Brendan Ferreri-Hanberry
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Cataia Ives
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Arthur Author
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) Brendan Ferreri-Hanberry
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) Arthur Author
Mitochondrial complex III antagonism leading to growth inhibition (1) Agnes Aggy
Mitochondrial complex III antagonism leading to growth inhibition (2) Allie Always
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Allie Always

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Agnes Aggy 5-HTT increased predation
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Agnes Aggy
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Allie Always
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Evgeniia Kazymova
AhR activation leading to hepatic steatosis Agnes Aggy AhR hepatic steatosis
AKT2 activation leading to hepatic steatosis Arthur Author AKT2 hepatic steatosis
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Brendan Ferreri-Hanberry alpha Norad Receptors delayed ovulation
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova Alpha2u adenomas and carcinomas
Altered ion channel activity leading impaired heart function Allie Always multiple impaired heart function
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Allie Always
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Evgeniia Kazymova
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Evgeniia Kazymova
Axonal sodium channel modulation leading to acute mortality Arthur Author sodium channel acute mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Allie Always
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Cataia Ives cytotox is not MIE hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Evgeniia Kazymova
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy
Cyclooxygenase inhibition leading reproductive failure Agnes Aggy cyclooxygenase reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction Agnes Aggy cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cataia Ives cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy cyclooxygenase reproductive dysfunction
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Agnes Aggy cytotox is not MIE bronchioloalveolar adenomas and carcinomas
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Allie Always cytotox is not MIE renal tubular adenomas and carcinomas
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Evgeniia Kazymova AR leydig cell tumors
DNA methyltransferase inhibition leading to population decline (1) Agnes Aggy
DNA methyltransferase inhibition leading to population decline (2) Allie Always
DNA methyltransferase inhibition leading to population decline (4) Cataia Ives
DNA methyltransferase inhibition leading to transgenerational effects (1) Brendan Ferreri-Hanberry
DNA methyltransferase inhibition leading to transgenerational effects (2) Arthur Author
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Brendan Ferreri-Hanberry
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Arthur Author
Epigenetic modification of PPARG leading to adipogenesis Cataia Ives PPARg adipogenesis
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Agnes Aggy cytotox not MIE forestomach tumors
ER agonism leading to reduced survival due to renal failure Brendan Ferreri-Hanberry ER reduced survival
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Cataia Ives ER altered sexual differentiation
Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova ER
Estrogen receptor agonism leading to reproductive dysfunction Allie Always ER reproductive dysfunction
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Brendan Ferreri-Hanberry ERG reduced survival
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Allie Always GR decreased male fertitlity
Glutamate-gated chloride channel activation leading to acute mortality Brendan Ferreri-Hanberry GluCl Channel acute mortality
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Arthur Author
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Agnes Aggy
Handbook development AOP Cataia Ives
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Arthur Author
Histamine (H2) receptor antagonism leading to reduced survival Evgeniia Kazymova H2 reduced survival
HMG-CoA reductase inhibition leading to decreased fertility Cataia Ives HMG-CoA reductase decreased fertility
HNF4alpha suppression leading to hepatic steatosis Evgeniia Kazymova HNF4alpha hepatic steatosis
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Arthur Author HPPD corneal papillomas and carcinomas
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Cataia Ives dopamine?? endometrial adenocarcinomas
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Arthur Author 5α-reductase leydig cell tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always NIS follicular cell adenomas and carcinomas
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author pyruvate dehydrogenase hepatocellular carcinoma
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Brendan Ferreri-Hanberry TPO follicular cell adenomas and carcinomas
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Arthur Author
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Cataia Ives GR modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author proteins - undefined modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy multiple modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry estradiol modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova GR modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Arthur Author unk modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always modulation of leydig cell function
NFE2L2/FXR activation leading to hepatic steatosis Brendan Ferreri-Hanberry multiple hepatic steatosis
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always
Nosema infection causes abnormal role change that leads to colony loss/failure Allie Always
Nosema infection increases energetic demands leading to colony loss/failure Agnes Aggy
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Cataia Ives PXR hepatic steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis Allie Always CAR hepatic steatosis
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry p-amino hippuric acid renal failure and mortality
Pendrin inhibition leading to altered amphibian metamorphosis Cataia Ives
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova b-oxidation fatty acid steatosis
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Cataia Ives
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Agnes Aggy
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Allie Always Prolyl hydroxylase reproductive dysfunction
Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova
Sodium channel (Nav1.1) inhibition leading to population decline Evgeniia Kazymova
Sodium channel inhibition leading to congenital malformations Cataia Ives sodium channel congenital malformations
sodium channel inhibition leading to increased predation Evgeniia Kazymova sodium channel increased predation
Sodium channel inhibition leading to reduced survival Allie Always sodium channel reduced survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova NIS neurodevelopmental outcomes
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Agnes Aggy
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Allie Always
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova
unknown MIE leading to renal failure and mortality Cataia Ives
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Evgeniia Kazymova Unknown reproductive dysfunction
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Agnes Aggy unclear urothelial papillomas and carcinomas
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Cataia Ives
Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova
Weather event contributes abnormal foraging leading to colony loss/failure Arthur Author
Weather event contributes to colony loss/failure Brendan Ferreri-Hanberry
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Brendan Ferreri-Hanberry DBH reduced fecundity