AOPs With SAAOP Status

Under Development

Open for citation & comment

Title Point of Contact MIE AO
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Brendan Ferreri-Hanberry
  • Increase, Ecdysone receptor agonism

Open for comment. Do not cite

Title Point of Contact MIE AO
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Arthur Author
  • impaired, Larval development
  • Death/Failure, Colony
AOP from chemical insult to cell death Cataia Ives
  • Decompartmentalization
  • Direct mitochondrial inhibition
  • narcosis
  • Apoptosis
  • Necrosis
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Evgeniia Kazymova
  • impaired, Larval development
  • Death/Failure, Colony
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry
  • Decrease, Number of worker bees
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Agnes Aggy
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Cataia Ives
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Brendan Ferreri-Hanberry
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Allie Always
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Agnes Aggy
  • Activation, Nicotinic acetylcholine receptor
  • impaired, Larval development
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Cataia Ives
  • Activation, Nicotinic acetylcholine receptor
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Evgeniia Kazymova
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Arthur Author
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Allie Always
  • Decrease, Number of worker bees
  • Death/Failure, Colony
Suppression of immune system contributes to impaired development and leads to colony loss/failure Agnes Aggy
  • Decrease, Number of worker bees
  • impaired, Hive thermoregulation
  • Death/Failure, Colony

Open for adoption

Title Point of Contact MIE AO
Alkylation of DNA leading to cancer 1 Arthur Author
  • Alkylation, DNA
  • Increase, Cancer
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Agnes Aggy
  • N/A, Androgen receptor, Antagonism
  • N/A, Impairment of reproductive capacity
Calcium-mediated neuronal ROS production and energy imbalance Brendan Ferreri-Hanberry
  • Inhibition, Ca++ ATPase
  • Increased, Oxidative damage
Estrogen receptor activation leading to breast cancer Brendan Ferreri-Hanberry
  • Activation, Estrogen receptor
  • N/A, Breast Cancer
Gastric ulcer formation Cataia Ives
  • Inhibit, gastric ulcer formation
  • Activated, gastric ulcer formation
Helicobacter pylori to gastric ulcer Cataia Ives
  • Helicobacter pylori infection
  • Activated, gastric ulcer formation
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Arthur Author
  • Inhibition, Fatty Acid Beta Oxidation
  • N/A, Steatohepatisis
Kidney toxicity induced by activation of 5HT2C Arthur Author
  • Activation, 5HT2c
  • Increased, Kidney Failure
Mental stress to agitation Evgeniia Kazymova
  • Increased, glucocorticoid receptor activity
  • Increased, agitation
Mental stress to depression Allie Always
  • Increased, glucocorticoid receptor activity
  • Increased, depression
Molecular events lead to epilepsy Allie Always
  • Increase, seizure
  • Increased, hippocampal hyperdepolarization
  • Increased, epilepsy
Network of SSRIs (selective serotonin reuptake inhibitors) Agnes Aggy
  • Increased, seizure
  • Increased, agitation
  • Increased, depression
  • Increase, hypertension
NFE2/Nrf2 repression to steatosis Agnes Aggy
  • NFE2/Nrf2 repression
  • Increased, steatosis
NSAID induced PTGS1 inactivation to gastric ulcer Allie Always
  • Reduced, PTGS1 function
  • Activated, gastric ulcer formation
NSAID induced PTGS2 inactivation to gastric ulcer Evgeniia Kazymova
  • Reduced, PTGS2 function
  • Activated, gastric ulcer formation
presynaptic neuron 1 activation to epilepsy Brendan Ferreri-Hanberry
  • Activated, presynaptic neuron 1
  • Increased, epilepsy
presynaptic neuron 2 repression to epilepsy Arthur Author
  • Reduced, presynaptic neuron 2 activity
  • Increased, epilepsy
Serotonin transporter activation to agitation Arthur Author
  • Increased, agitation
Serotonin transporter activation to depression Brendan Ferreri-Hanberry
  • Increased, serotonin transporter activity
  • Increased, depression
Serotonin transporter activation to seizure Cataia Ives
  • Increased, serotonin transporter activity
  • Increased, seizure
SSRI (Selective serotonin reuptake inhibitor) to hypertension Agnes Aggy
  • Decreased, serotonin transporter activity
  • Increase, hypertension

Not under active development

Title Point of Contact MIE AO
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Brendan Ferreri-Hanberry
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Arthur Author
  • CYP7B activity, inhibition
  • Decrease, Population growth rate
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry
LXR activation leading to hepatic steatosis Agnes Aggy
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • N/A, Liver Steatosis
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Evgeniia Kazymova
  • Mu Opioid Receptor Agonism
  • Analgesia
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Allie Always
  • Mu Opioid Receptor Agonism
  • Analgesia
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Brendan Ferreri-Hanberry
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Cataia Ives
  • Serotonin 1A Receptor Agonism
  • Anti-depressant Activity

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Evgeniia Kazymova
  • Reproductive failure
Deposition of energy leading to population decline via DNA oxidation and follicular atresia Allie Always
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Evgeniia Kazymova
  • Deposition of Energy
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova
ER mediated breast cancer AOP Cataia Ives
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Brendan Ferreri-Hanberry
  • Activation, Glutamate-gated chloride channels
  • Increased Mortality
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Cataia Ives
  • Activation, ionotropic GABA Receptor chloride channel
  • Increased Mortality
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy
  • Reproductive failure
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) Brendan Ferreri-Hanberry
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) Arthur Author
  • Increase, Mitochondrial ATP synthase antagonism
  • Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (1) Agnes Aggy
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
Mitochondrial complex III antagonism leading to growth inhibition (2) Allie Always
  • Increase, Mitochondrial complex III antagonism
  • Decrease, Growth
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author
  • Activation, NADPH Oxidase
  • Reproductive failure
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always
  • Hepatotoxicity
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Allie Always
  • TRPA1 activation, TRPA1 Receptor
  • Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
  • Irritation of nasal mucosa inducing sneeze reflex
  • Increased Respiratory irritability and Chronic Cough,

Under Development: Contributions and Comments Welcome

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Agnes Aggy
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increase, predation
  • Decrease, Population growth rate
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Agnes Aggy
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Population
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Allie Always
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Decreased, Reproductive Success
  • Decrease, Population growth rate
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Evgeniia Kazymova
  • Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
  • Increased, Reproductive Success
  • Increased, Population
AhR activation leading to hepatic steatosis Agnes Aggy
  • Activation, AhR
  • Accumulation, Liver lipid
AKT2 activation leading to hepatic steatosis Arthur Author
  • systemic inflammation leading to hepatic steatosis
  • Increased, Liver Steatosis
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Brendan Ferreri-Hanberry
  • Inhibition, Antgonism of NE receptor
  • Decreased, Decreased fecundity
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova
  • Increased, Binding of chemicals to 2u (serum)
  • Increase, Adenomas/carcinomas (renal tubular)
Altered ion channel activity leading impaired heart function Allie Always
  • impaired, ion channels
  • Increased Mortality
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Allie Always
  • Increased, Adenomas/carcinomas (mammary)
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Evgeniia Kazymova
  • Promotion, ovarian adenomas
  • Promotion, ovarian granular cell tumors
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Evgeniia Kazymova
  • Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
  • Decreased fertility, Reduced number of oocytes ovulated
Axonal sodium channel modulation leading to acute mortality Arthur Author
  • modulation, sodium channel
  • Increased Mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Allie Always
  • Activation, beta-2 adrenergic receptor
  • Promotion, mesovarian leiomyomas
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Cataia Ives
  • Increase, Cytotoxicity (hepatocytes)
  • Increase, hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Evgeniia Kazymova
  • Increased, mesotheliomas
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy
  • Inhibition, Cyclooxygenase 1 activity
  • Increased Mortality
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading reproductive failure Agnes Aggy
  • Inhibition, Cyclooxygenase activity
  • N/A, Reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction Agnes Aggy
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Cataia Ives
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy
  • Inhibition, Cyclooxygenase activity
  • Reduced, Reproductive Success
  • Decrease, Population growth rate
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Agnes Aggy
  • Increase, Cytotoxicity (club cells)
  • Increase, Adenomas/carcinomas (bronchioloalveolar)
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Allie Always
  • Increase, Cytotoxicity (tubular epithelial cells)
  • Increase, Adenomas/carcinomas (renal tubular)
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Evgeniia Kazymova
  • Decreased, Androgen receptor activity
  • Increase, Leydig cell tumors
DNA methyltransferase inhibition leading to population decline (1) Agnes Aggy
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to population decline (2) Allie Always
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to population decline (4) Cataia Ives
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to transgenerational effects (1) Brendan Ferreri-Hanberry
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
DNA methyltransferase inhibition leading to transgenerational effects (2) Arthur Author
  • Increase, DNA methyltransferase inhibition
  • Decrease, Fecundity (F3)
  • Decrease, Population growth rate
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
  • Inhibition, Dual oxidase
  • Altered, Amphibian metamorphosis
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Brendan Ferreri-Hanberry
  • prepubertal increase, Estrogen receptor (ER) activity
  • Increased, adenosquamous carcinomas of endometrium
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Arthur Author
  • Increase, Adenomas/carcinomas (follicular cell)
Epigenetic modification of PPARG leading to adipogenesis Cataia Ives
  • peroxisome proliferator activated receptor promoter demethylation
  • chronic high fat diet
  • obesity
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Agnes Aggy
  • Increase, Cytotoxicity (epithelial cells)
  • Increase, Papillomas/carcinomas (squamous cells)
ER agonism leading to reduced survival due to renal failure Brendan Ferreri-Hanberry
  • Agonism, Estrogen receptor
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Cataia Ives
  • Agonism, Estrogen receptor
  • skewed, sex ratio
Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova
Estrogen receptor agonism leading to reproductive dysfunction Allie Always
  • Agonism, Estrogen receptor
  • Decrease, Population growth rate
  • Altered, Reproductive behaviour
  • Altered, Larval development
  • Impaired development of, Reproductive organs
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Brendan Ferreri-Hanberry
  • Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
  • Reduced, survival
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Allie Always
  • Glucocorticoid Receptor Agonist, Activation
  • impaired, Fertility
Glutamate-gated chloride channel activation leading to acute mortality Brendan Ferreri-Hanberry
  • Activation, Glutamate-gated chloride channel
  • Increased Mortality
  • Decreased, population 1
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Arthur Author
  • Increased, Adenomas/carcinomas (mammary)
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Agnes Aggy
  • Increased, adenomas (pituitary)
Handbook development AOP Cataia Ives
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Arthur Author
  • Activation, Hepatic nuclear receptor(s)
  • Altered, Amphibian metamorphosis
Histamine (H2) receptor antagonism leading to reduced survival Evgeniia Kazymova
  • Antagonism, Histamine Receptor (H2)
  • Decreased, survival
  • Increased, predation
HMG-CoA reductase inhibition leading to decreased fertility Cataia Ives
  • Inhibition, HMG-CoA reductase
  • Decrease, Fertility
HNF4alpha suppression leading to hepatic steatosis Evgeniia Kazymova
  • Suppression, HNF4alpha
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Arthur Author
  • Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
  • Increase, Papillomas/carcinomas (squamous cells)
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Cataia Ives
  • Increase, Dopaminergic activity
  • Increase, Endometrial adenocarcinomas
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Arthur Author
  • Inhibition, 5α-reductase activity
  • Increase, Leydig cell tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always
  • Inhibition, Na+/I- symporter (NIS)
  • Increase, Adenomas/carcinomas (follicular cell)
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author
  • Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
  • Increase, hepatocellular adenomas and carcinomas
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Brendan Ferreri-Hanberry
  • Thyroperoxidase, Inhibition
  • Increase, Adenomas/carcinomas (follicular cell)
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Arthur Author
  • Inhibition, Iodotyrosine deiodinase (IYD)
  • Altered, Amphibian metamorphosis
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Arthur Author
  • Activation, Juvenile hormone receptor
  • Increased, Male offspring
  • Decline, Population
  • Alteration, Food-web structures
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Cataia Ives
  • Decreased testosterone by the fetal Leydig cells, Increased corticosterone
  • Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author
  • Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
  • Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy
  • Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
  • Decreased Cholesterol, Decreased Uptake of Lipoproteins
  • Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
  • Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry
  • Decreased testosterone by the fetal Leydig cells, Increased estradiol
  • Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
  • Decreased sperm quantity / quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova
  • Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
  • Decreased sperm quantity or quality in the adult, Decreased fertility
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Arthur Author
  • Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
  • Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always
  • Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
  • Decreased sperm quantity or quality in the adult, Decreased fertility
NFE2L2/FXR activation leading to hepatic steatosis Brendan Ferreri-Hanberry
  • Activation, NRF2
  • Activation, NR1H4
  • Increased, Liver Steatosis
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always
  • Activation, Nicotinic acetylcholine receptor
  • Death/Failure, Colony
Nosema infection causes abnormal role change that leads to colony loss/failure Allie Always
  • Death/Failure, Colony
Nosema infection increases energetic demands leading to colony loss/failure Agnes Aggy
  • Death/Failure, Colony
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Cataia Ives
  • Activation, PXR/SXR
  • Increased, Liver Steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis Allie Always
  • Suppression, Constitutive androstane receptor, NR1l3
  • Inhibition, PPAR alpha
  • Activation, LXR
  • peroxisome proliferator activated receptor promoter demethylation
  • Increased, Liver Steatosis
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry
  • Inhibition, organic anion transporter 1 (OAT1)
  • Increased Mortality
  • Decrease, Population growth rate
Pendrin inhibition leading to altered amphibian metamorphosis Cataia Ives
  • Inhibition, Pendrin
  • Altered, Amphibian metamorphosis
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova
  • Decreased, PPAR-alpha activation
  • Decreased, PPAR-beta activation
  • Decreased, PPAR-gamma activation
  • Increased, Liver Steatosis
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Cataia Ives
  • Increased, Pancreatic acinar tumors
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Agnes Aggy
  • Activation of specific nuclear receptors, PPAR-gamma activation
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Allie Always
  • Inhibition, Prolyl hydroxylases
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Queen egg-laying decrease leads to colony loss/failure Evgeniia Kazymova
  • Death/Failure, Colony
Sodium channel (Nav1.1) inhibition leading to population decline Evgeniia Kazymova
  • Inhibition, sodium channel
Sodium channel inhibition leading to congenital malformations Cataia Ives
  • Inhibition, sodium channel
  • Increased, amputations
sodium channel inhibition leading to increased predation Evgeniia Kazymova
  • Inhibition, sodium channel
  • Increased, predation
Sodium channel inhibition leading to reduced survival Allie Always
  • Inhibition, sodium channel
  • Reduced, feeding 1
  • Increased, predation
  • Reduced, survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Evgeniia Kazymova
  • Inhibition, Na+/I- symporter (NIS)
  • Cognitive Function, Decreased
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author
  • Inhibition, Na+/I- symporter (NIS)
  • Altered, Amphibian metamorphosis
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
  • Thyroperoxidase, Inhibition
  • Altered, Amphibian metamorphosis
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Agnes Aggy
  • Inhibition, Deiodinase 1
  • Altered, Amphibian metamorphosis
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Allie Always
  • Inhibition, Deiodinase 2
  • Altered, Amphibian metamorphosis
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova
  • Inhibition, Deiodinase 3
  • Altered, Amphibian metamorphosis
unknown MIE leading to renal failure and mortality Cataia Ives
  • Unknown, MIE
  • Increased Mortality
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Evgeniia Kazymova
  • modulation, Unknown
  • Reduction, Cumulative fecundity and spawning
  • Decrease, Population growth rate
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Agnes Aggy
  • Increase, Urinary bladder calculi
  • Increase, Adenomas/carcinomas (urothelial)
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Cataia Ives
  • Death/Failure, Colony
Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova
  • Death/Failure, Colony
Weather event contributes abnormal foraging leading to colony loss/failure Arthur Author
  • Death/Failure, Colony
Weather event contributes to colony loss/failure Brendan Ferreri-Hanberry
  • Death/Failure, Colony
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Brendan Ferreri-Hanberry
  • Inhibition, Inhibition of Dopamine-beta-hydroxylase
  • Decreased, Decreased fecundity