AOPs With SAAOP Status


Proposed for OECD Work Plan

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry

Under Development

Open for citation & comment

Title Point of Contact MIE AO
Ecdysone receptor agonism leading to mortality Arthur Author EcR mortality

Open for comment. Do not cite

Title Point of Contact MIE AO
AOP from chemical insult to cell death Evgeniia Kazymova

Under development: Not open for comment. Do not cite

Title Point of Contact MIE AO
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Agnes Aggy 5-HTT increased predation
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Arthur Author 5-HTT increased predation
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Brendan Ferreri-Hanberry
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Agnes Aggy
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Allie Always
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Allie Always unk colony loss/failure
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Evgeniia Kazymova
AhR activation leading to hepatic steatosis Brendan Ferreri-Hanberry AhR hepatic steatosis
AKT2 activation leading to hepatic steatosis Brendan Ferreri-Hanberry AKT2 hepatic steatosis
Alkylation of DNA leading to cancer 1 Arthur Author DNA alkylation cancer
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Evgeniia Kazymova alpha Norad Receptors delayed ovulation
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova Alpha2u adenomas and carcinomas
Altered ion channel activity leading impaired heart function Allie Always multiple impaired heart function
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Brendan Ferreri-Hanberry AR adverse effects in the male foetus
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Agnes Aggy
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Agnes Aggy
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Brendan Ferreri-Hanberry
Axonal sodium channel modulation leading to acute mortality Brendan Ferreri-Hanberry sodium channel acute mortality
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Arthur Author
Calcium-mediated neuronal ROS production and energy imbalance Evgeniia Kazymova unclear energy imbalance
Chemical binding to tubulin in oocytes leading to aneuploid offspring Brendan Ferreri-Hanberry tubulin? aneuploid offspring
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Agnes Aggy cytotox is not MIE hepatocellular adenomas and carcinomas
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Allie Always
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy
Cyclooxygenase inhibition leading reproductive failure Arthur Author cyclooxygenase reproductive failure
Cyclooxygenase inhibition leading to reproductive dysfunction Arthur Author cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Evgeniia Kazymova cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author cyclooxygenase reproductive dysfunction
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy cyclooxygenase reproductive dysfunction
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Allie Always cytotox is not MIE bronchioloalveolar adenomas and carcinomas
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Brendan Ferreri-Hanberry cytotox is not MIE renal tubular adenomas and carcinomas
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Arthur Author glucose oxidase colony loss/failure
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Brendan Ferreri-Hanberry AR leydig cell tumors
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Allie Always
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Evgeniia Kazymova
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Evgeniia Kazymova
Epigenetic modification of PPARG leading to adipogenesis Brendan Ferreri-Hanberry PPARg adipogenesis
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Evgeniia Kazymova cytotox not MIE forestomach tumors
ER agonism leading to reduced survival due to renal failure Allie Always ER reduced survival
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Agnes Aggy ER altered sexual differentiation
ER mediated breast cancer AOP Allie Always
Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova ER
Estrogen receptor activation leading to breast cancer Evgeniia Kazymova
Estrogen receptor agonism leading to reproductive dysfunction Agnes Aggy ER reproductive dysfunction
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Evgeniia Kazymova ERG reduced survival
Excessive reactive oxygen species production leading to reproductive dysfunction Brendan Ferreri-Hanberry
Gastric ulcer formation Arthur Author
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Agnes Aggy GR decreased male fertitlity
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Brendan Ferreri-Hanberry GR increased disease susceptibility
Glutamate-gated chloride channel activation leading to acute mortality Agnes Aggy GluCl Channel acute mortality
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Allie Always
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Brendan Ferreri-Hanberry
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Arthur Author
Handbook development AOP Brendan Ferreri-Hanberry
Helicobacter pylori to gastric ulcer Allie Always
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Evgeniia Kazymova
Histamine (H2) receptor antagonism leading to reduced survival Allie Always H2 reduced survival
HMG-CoA reductase inhibition leading to decreased fertility Allie Always HMG-CoA reductase decreased fertility
HNF4alpha suppression leading to hepatic steatosis Agnes Aggy HNF4alpha hepatic steatosis
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Allie Always HPPD corneal papillomas and carcinomas
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Arthur Author dopamine?? endometrial adenocarcinomas
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Agnes Aggy metabolic stress is not MIE colony loss/failure
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Evgeniia Kazymova 5α-reductase leydig cell tumors
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Agnes Aggy
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Allie Always
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Agnes Aggy
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry nitric oxide liver tumors
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Evgeniia Kazymova NIS follicular cell adenomas and carcinomas
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Agnes Aggy pyruvate dehydrogenase hepatocellular carcinoma
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always TPO follicular cell adenomas and carcinomas
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Allie Always
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Agnes Aggy
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy
Juvenile hormone receptor agonism leading to male offspring induction associated population decline Brendan Ferreri-Hanberry
Kidney toxicity induced by activation of 5HT2C Arthur Author 5-HTT2c kidney toxicity
LXR activation leading to hepatic steatosis Agnes Aggy LXR liver steatosis
Mental stress to agitation Arthur Author
Mental stress to depression Brendan Ferreri-Hanberry
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Evgeniia Kazymova GR modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author proteins - undefined modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy multiple modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry estradiol modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova GR modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Agnes Aggy unk modulation of leydig cell function
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always modulation of leydig cell function
Molecular events lead to epilepsy Evgeniia Kazymova
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Agnes Aggy
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author
Network of SSRIs (selective serotonin reuptake inhibitors) Allie Always
NFE2/Nrf2 repression to steatosis Arthur Author
NFE2L2/FXR activation leading to hepatic steatosis Evgeniia Kazymova multiple hepatic steatosis
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Allie Always nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Agnes Aggy nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Allie Always nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Evgeniia Kazymova nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Brendan Ferreri-Hanberry nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Arthur Author nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Brendan Ferreri-Hanberry nAChR colony loss/failure
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Evgeniia Kazymova nAChR colony loss/failure
Nosema infection causes abnormal role change that leads to colony loss/failure Evgeniia Kazymova
Nosema infection increases energetic demands leading to colony loss/failure Allie Always
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Allie Always PXR hepatic steatosis
NR1I3 (CAR) suppression leading to hepatic steatosis Arthur Author CAR hepatic steatosis
NSAID induced PTGS1 inactivation to gastric ulcer Arthur Author
NSAID induced PTGS2 inactivation to gastric ulcer Agnes Aggy
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry p-amino hippuric acid renal failure and mortality
Pendrin inhibition leading to altered amphibian metamorphosis Agnes Aggy
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova b-oxidation fatty acid steatosis
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Allie Always
PPARgamma activation leading to sarcomas in rats, mice, and hamsters Brendan Ferreri-Hanberry
presynaptic neuron 1 activation to epilepsy Evgeniia Kazymova
presynaptic neuron 2 repression to epilepsy Brendan Ferreri-Hanberry
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Arthur Author Prolyl hydroxylase reproductive dysfunction
Queen egg-laying decrease leads to colony loss/failure Brendan Ferreri-Hanberry
Serotonin transporter activation to agitation Evgeniia Kazymova
Serotonin transporter activation to depression Allie Always
Serotonin transporter activation to seizure Agnes Aggy
Sodium channel (Nav1.1) inhibition leading to population decline Agnes Aggy
Sodium channel inhibition leading to congenital malformations Allie Always sodium channel congenital malformations
sodium channel inhibition leading to increased predation Agnes Aggy sodium channel increased predation
Sodium channel inhibition leading to reduced survival Arthur Author sodium channel reduced survival
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Allie Always NIS neurodevelopmental outcomes
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author
SSRI (Selective serotonin reuptake inhibitor) to hypertension Brendan Ferreri-Hanberry
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry unclear colony loss/failure
Suppression of immune system contributes to impaired development and leads to colony loss/failure Evgeniia Kazymova unclear colony loss/failure
Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Arthur Author
unknown MIE leading to renal failure and mortality Arthur Author
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Agnes Aggy Unknown reproductive dysfunction
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Brendan Ferreri-Hanberry unclear urothelial papillomas and carcinomas
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Brendan Ferreri-Hanberry
Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Arthur Author
Weather event contributes abnormal foraging leading to colony loss/failure Agnes Aggy
Weather event contributes to colony loss/failure Arthur Author
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Arthur Author DBH reduced fecundity