Stressor: 318

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Carbon nanotubes

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis	High
Substance interaction with lung resident cell membrane components leading to atherosclerosis	Not Specified
Frustrated phagocytosis leads to malignant mesothelioma

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

References

List of the literature that was cited for this prototypical stressor. More help

1. Nanotechnologies – Part 2: Guide to safe handling and disposal of manufactured nanomaterials PUBLISHED DOCUMENT. [cited 2017 Aug 9]; Available from: http://www3.imperial.ac.uk/pls/portallive/docs/1/34683696.PDF

2. Manke A, Wang L, Rojanasakul Y. Pulmonary toxicity and fibrogenic response of carbon nanotubes. Toxicol Mech Methods [Internet]. 2013 Mar [cited 2017 Aug 8];23(3):196–206. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23194015

3. Hussain S, Sangtian S, Anderson SM, Snyder RJ, Marshburn JD, Rice AB, et al. Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts. Part Fibre Toxicol [Internet]. 2014 Jun 10 [cited 2017 Aug 9];11:28. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24915862

4. Sinha N, Yeow JTW. Carbon nanotubes for biomedical applications. IEEE Trans Nanobioscience [Internet]. 2005 Jun [cited 2017 Aug 9];4(2):180–95. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16117026

5. Dong J, Ma Q. Myofibroblasts and lung fibrosis induced by carbon nanotube exposure. Part Fibre Toxicol [Internet]. 2016 [cited 2017 Aug 8];13(1):60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27814727

6. Labib S, Williams A, Yauk CL, Nikota JK, Wallin H, Vogel U, et al. Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes. Part Fibre Toxicol [Internet]. 2016 Mar 15 [cited 2017 Aug 8];13:15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26979667

7. Vietti G, Ibouraadaten S, Palmai-Pallag M, Yakoub Y, Bailly C, Fenoglio I, et al. Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay. Part Fibre Toxicol [Internet]. 2013 Jun 10 [cited 2017 Aug 8];10(1):52. Available from: http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/1743-8977-10-52

8. Oberdörster G, Castranova V, Asgharian B, Sayre P, Wallin H, Vogel U, et al. Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry. J Toxicol Environ Heal Part B [Internet]. 2015 May 19 [cited 2017 Aug 8];18(3–4):121–212. Available from: http://www.tandfonline.com/doi/full/10.1080/10937404.2015.1051611

9. Ali A, Suhail M, Mathew S, Shah MA, Harakeh SM, Ahmad S, et al. Nanomaterial Induced Immune Responses and Cytotoxicity. J Nanosci Nanotechnol [Internet]. 2016 Jan [cited 2017 Aug 9];16(1):40–57. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27398432