AOP-Wiki

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All Key Events

Showing 976 to 1000 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1408	Reduced, PTGS2 function Short Name Reduced, PTGS2 function	0	Cellular	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1409	Decreased, angiogenesis Short Name Decreased, angiogenesis	0	Tissue	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1410	Increased, leukocyte adherence Short Name Increased, leukocyte adherence	0	Tissue	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1411	Increased, leukocyte activation Short Name Increased, leukocyte activation	0	Tissue	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1412	Helicobacter pylori infection Short Name Helicobacter pylori infection	0	Tissue	Jun 2, 2017	Jun 2, 2017	229: Helicobacter pylori to gastric ulcer
1413	Reduced, presynaptic neuron 2 activity Short Name Reduced, presynaptic neuron 2 activity	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1414	Decreased, GABA Short Name Decreased, GABA	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1415	Reduced, GABA-A receptor activation Short Name Reduced, GABA-A receptor activation	0	Molecular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1416	Decreased, intracellular chloride Short Name Decreased, intracellular chloride	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1417	NFE2/Nrf2 repression Short Name NFE2/Nrf2 repression	0	Molecular	Jun 2, 2017	Jun 2, 2017	4 AOPs 232: NFE2/Nrf2 repression to steatosis 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
1419	Reduced, FXR activity Short Name Reduced, FXR activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1420	Reduced, SHP activity Short Name Reduced, SHP activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1421	Activated, LXR Short Name Activated, LXR	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1422	Reduced, PPARalpha Short Name Reduced, PPARalpha	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1423	Reduced, HSD17B4 activity Short Name Reduced, HSD17B4 activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1424	Reduced, fatty acid beta oxidation Short Name Reduced, fatty acid beta oxidation	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1425	Mu Opioid Receptor Agonism Short Name Mu Opioid Receptor Agonism	0	Molecular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1426	Release of G Proteins Short Name Release of G Proteins	0	Cellular	Jun 8, 2017	Jun 8, 2017	4 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1427	Opening of G protein gated inward rectifying K channels Short Name Opening of GIRK channels	0	Cellular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
1428	Analgesia Short Name Analgesia	0	Individual	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1429	Inhibition of N-type Ca ion channels Short Name Inhibition of Ca Channels	0	Cellular	Jun 23, 2017	Jun 23, 2017	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1430	Inhibition of neurotransmitter vesicle release Short Name Inhibition of neurotransmitter release	0	Cellular	Jun 23, 2017	Jun 27, 2023	2 AOPs 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1431	Serotonin 1A Receptor Agonism Short Name Serotonin 1A Receptor Agonism	0	Molecular	Jun 23, 2017	Jun 23, 2017	2 AOPs 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1432	Anti-depressant Activity Short Name Anti-depressant Activity	0	Individual	Jun 23, 2017	Jun 23, 2017	2 AOPs 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1433	Increased CGRP, neuronal release of CGRP Short Name Increased CGRP	1	Cellular	Jun 23, 2017	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation