AOPs

ID	Title	Point of Contact	License	MIE	AO	OECD Status	OECD Project
443	DNA damage and mutations leading to Metastatic Breast Cancer	Agnes Aggy	BY-SA	Increased, DNA damage and mutation	metastatic breast cancer	Under Development	1.103
450	Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality	Allie Always	BY-SA	Acetylcholinesterase (AchE) Inhibition	Sensory axonal peripheral neuropathy Increased Mortality
202	Inhibitor binding to topoisomerase II leading to infant leukaemia	Agnes Aggy	BY-SA	Binding to (interferes with) topoisomerase II enzyme	Infant leukaemia	WPHA/WNT Endorsed	1.53
389	Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis	Evgeniia Kazymova	BY-SA	Increase, Oxygen-evolving complex damage	Decrease, Reproduction Decrease, Population growth rate
423	Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway	Brendan Ferreri-Hanberry	BY-SA	Activation, PARP1 ROS formation	Apoptotic cell death
98	5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation	Allie Always	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, predation		1.29
97	5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline	Agnes Aggy	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increase, predation Decrease, Population growth rate		1.29
195	5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase	Agnes Aggy	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, Population		1.29
203	5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline	Allie Always	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Decreased, Reproductive Success Decrease, Population growth rate		1.29
204	5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase	Evgeniia Kazymova	BY-SA	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)	Increased, Reproductive Success Increased, Population		1.29
305	5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring	Allie Always	BY-SA	Inhibition, 5α-reductase	anogenital distance (AGD), decreased	Under Development	1.90
429	A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants	Brendan Ferreri-Hanberry	BY-SA		Memory Loss
82	Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure	Arthur Author	BY-SA		impaired, Larval development Death/Failure, Colony		1.29
427	ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.	Evgeniia Kazymova	BY-SA	Binding to ACE2	Heart failure
16	Acetylcholinesterase inhibition leading to acute mortality	Cataia Ives	BY-SA	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate	Under Development	1.3
312	Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement	Allie Always	BY-SA	Acetylcholinesterase (AchE) Inhibition	Increased Mortality Decrease, Population growth rate
281	Acetylcholinesterase Inhibition Leading to Neurodegeneration	Allie Always	BY-SA	Acetylcholinesterase (AchE) Inhibition	N/A, Neurodegeneration
210	Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building	Evgeniia Kazymova	All rights reserved		Reproductive failure
499	Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release	Evgeniia Kazymova	All rights reserved	Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2	Impairment, Learning and memory
500	Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis	Cataia Ives	All rights reserved	Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2	Impairment, Learning and memory
534	Activation of Protein kinase C leads to Kidney Failure	Arthur Author	BY-SA	Activation, Protein Kinase C (PKC)	Increased, Kidney Failure
462	Activation of reactive oxygen species leading the atherosclerosis	Allie Always	BY-SA
439	Activation of the AhR leading to metastatic breast cancer	Evgeniia Kazymova	BY-SA	Activation, AhR	metastatic breast cancer	Under Development	1.105
503	Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation	Agnes Aggy	BY-SA	Activation, estrogen receptor alpha	Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
452	Adverse outcome pathway of PM-induced respiratory toxicity	Cataia Ives	BY-SA	Non-coding RNA expression profile alteration	Chronic obstructive pulmonary disease
282	Adverse outcome pathway on photochemical toxicity initiated by light exposure	Evgeniia Kazymova	BY-SA	ROS generation from photoactivated chemicals	Inflamatory events in light-exposed tissues	Under Review	1.49
476	Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity	Cataia Ives	All rights reserved	Increased, Reactive oxygen species Disruption, Estrogen receptor Antagonism, Androgen receptor	Decreased sperm quantity or quality in the adult, Decreased fertility anogenital distance (AGD), decreased Malformation, cryptorchidism - maldescended testis Decrease, Reproduction
46	AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)	Agnes Aggy	BY-SA	Formation, Pro-mutagenic DNA Adducts	Tumorigenesis, Hepatocellular carcinoma	Under Review	1.8
458	AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Cataia Ives	Open for adoption	Activation, AhR	Cognitive Function, Decreased
459	AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Brendan Ferreri-Hanberry	Open for adoption	Activation, AhR	Cognitive Function, Decreased
57	AhR activation leading to hepatic steatosis	Agnes Aggy	BY-SA	Activation, AhR	Increased, Liver Steatosis		1.29
494	AhR activation leading to liver fibrosis	Cataia Ives	All rights reserved	Activation, AhR	N/A, Liver fibrosis
151	AhR activation leading to preeclampsia	Agnes Aggy	All rights reserved	Activation, AhR	increase, Preeclampsia	Under Development	1.42
62	AKT2 activation leading to hepatic steatosis	Arthur Author	BY-SA	systemic inflammation leading to hepatic steatosis	Increased, Liver Steatosis		1.29
465	Alcohol dehydrogenase leading to reproductive dysfunction	Brendan Ferreri-Hanberry	BY-SA	Increase, Alcohol dehydrogenase
15	Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations	Evgeniia Kazymova	BY-SA	Alkylation, DNA	Increase, Heritable mutations in offspring	WPHA/WNT Endorsed	1.11
139	Alkylation of DNA leading to cancer 1	Arthur Author	Open for adoption	Alkylation, DNA	Increase, Cancer
322	Alkylation of DNA leading to reduced sperm count	Brendan Ferreri-Hanberry	BY-SA	Alkylation, DNA	Reduce, Sperm count
126	Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Antgonism of NE receptor	Decreased, Decreased fecundity		1.29
105	Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Evgeniia Kazymova	BY-SA	Increased, Binding of chemicals to 2u (serum)	Increase, Adenomas/carcinomas (renal tubular)		1.29
104	Altered ion channel activity leading impaired heart function	Allie Always	BY-SA	impaired, ion channels	Increased Mortality		1.29
515	An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects	Agnes Aggy	All rights reserved
345	Androgen receptor (AR) antagonism leading to decreased fertility in females	Cataia Ives	BY-SA	Antagonism, Androgen receptor	irregularities, ovarian cycle impaired, Fertility	Under Development	1.109
477	Androgen receptor (AR) antagonism leading to hypospadias in male offspring	Brendan Ferreri-Hanberry	BY-SA	Antagonism, Androgen receptor	Hypospadias, increased
344	Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring	Evgeniia Kazymova	BY-SA	Antagonism, Androgen receptor	Nipple retention (NR), increased	Under Development	1.108
306	Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring	Evgeniia Kazymova	BY-SA	Antagonism, Androgen receptor	anogenital distance (AGD), decreased	Under Development	1.90
117	Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Evgeniia Kazymova	Open for adoption	Activation, Androgen receptor	Increase, hepatocellular adenomas and carcinomas	Under Development	1.26
495	Androgen receptor activation leading to prostate cancer	Brendan Ferreri-Hanberry	All rights reserved	Activation, Androgen receptor	Prostate cancer
376	Androgen receptor agonism leading to male-biased sex ratio	Evgeniia Kazymova	BY-SA	Agonism, Androgen receptor	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
496	Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）	Arthur Author	BY-SA	Agonism, Androgen receptor Increased, gene expression of AR	Decreased, Population trajectory
23	Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)	Evgeniia Kazymova	BY-SA	Agonism, Androgen receptor	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
19	Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)	Agnes Aggy	Open for adoption	N/A, Androgen receptor, Antagonism	N/A, Impairment of reproductive capacity
372	Androgen receptor antagonism leading to testicular cancer	Brendan Ferreri-Hanberry	BY-SA	Antagonism, Androgen receptor	Testicular Cancer
382	Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis	Allie Always	BY-SA	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	Lung fibrosis	Under Development	1.96
460	Antagonism of Smoothened receptor leading to orofacial clefting	Arthur Author	All rights reserved	Antagonism, Smoothened receptor	Orofacial clefting	Under Development	1.101
6	Antagonist binding to PPARα leading to body-weight loss	Agnes Aggy	BY-SA	Binding of antagonist, PPAR alpha	Decreased, Body Weight	WPHA/WNT Endorsed	2.3
170	Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat	Allie Always	BY-SA		Increased, Adenomas/carcinomas (mammary)		1.29
187	Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage	Brendan Ferreri-Hanberry	BY-SA	Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin	Impaired recruitment , Population trajectory	Under Development	1.31
165	Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse	Evgeniia Kazymova	BY-SA		Promotion, ovarian adenomas Promotion, ovarian granular cell tumors		1.29
393	AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation	Brendan Ferreri-Hanberry	BY-SA	Increased, Hepatic thyroid hormone uptake/transport
335	AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment	Arthur Author	BY-SA	Mitochondrial dysfunction	Urothelial Tumor
205	AOP from chemical insult to cell death	Cataia Ives	BY-SA	Decompartmentalization Direct mitochondrial inhibition narcosis	Apoptosis Necrosis
481	AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.	Evgeniia Kazymova	BY-SA	Increase, Reactive oxygen species	Increased incidence of respiratory disease Dysfunction of respiratory system
7	Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female	Allie Always	BY-SA	reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	impaired, Fertility irregularities, ovarian cycle	Under Review	1.21
153	Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats	Evgeniia Kazymova	BY-SA	Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol	Decreased fertility, Reduced number of oocytes ovulated		1.29
25	Aromatase inhibition leading to reproductive dysfunction	Cataia Ives	BY-SA	Inhibition, Aromatase	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
346	Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Aromatase	Decrease, Population growth rate	WPHA/WNT Endorsed	1.12
456	Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity	Allie Always	BY-SA	Activation, AhR	Increase, Early Life Stage Mortality	Under Review
455	Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development	Agnes Aggy	BY-SA	Activation, AhR	Increase, Early Life Stage Mortality Facial cartilage structures are reduced in size and morphologically distorted	Under Review
21	Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2	Allie Always	BY-SA	Activation, AhR		WPHA/WNT Endorsed	1.27
150	Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF	Arthur Author	BY-SA	Activation, AhR	Increase, Early Life Stage Mortality	WPHA/WNT Endorsed	1.7
418	Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway	Arthur Author	All rights reserved
419	Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway	Agnes Aggy	All rights reserved		Decrease, Lung function
417	Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway	Brendan Ferreri-Hanberry	All rights reserved	Activation, AhR	Lung cancer
416	Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway	Cataia Ives	All rights reserved	Activation, AhR	Lung cancer
420	Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway	Allie Always	All rights reserved	Activation, AhR
415	Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway	Evgeniia Kazymova	All rights reserved	Activation, AhR	Lung fibrosis
414	Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway	Allie Always	All rights reserved	Activation, AhR
131	Aryl hydrocarbon receptor activation leading to uroporphyria	Allie Always	BY-SA	Activation, AhR	Uroporphyria	WPHA/WNT Endorsed	1.7
96	Axonal sodium channel modulation leading to acute mortality	Arthur Author	BY-SA	modulation, sodium channel	Increased Mortality		1.29
164	Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse	Allie Always	BY-SA	Activation, beta-2 adrenergic receptor	Promotion, mesovarian leiomyomas		1.29
48	Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.	Allie Always	BY-SA	Binding of agonist, Ionotropic glutamate receptors	Impairment, Learning and memory	WPHA/WNT Endorsed	1.23
475	Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons	Evgeniia Kazymova	All rights reserved	Binding of agonist, Ionotropic glutamate receptors	Impairment, Learning and memory	Under Development	1.107
17	Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory	Brendan Ferreri-Hanberry	BY-SA	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Impairment, Learning and memory	WPHA/WNT Endorsed	1.13
284	Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease	Brendan Ferreri-Hanberry	BY-SA	Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Chronic kidney disease
506	Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation	Cataia Ives	All rights reserved	Influenza A Virus (IAV) binds sialic acid glycan receptor	Influenza A Virus (IAV) shedding and transmission
428	Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis	Cataia Ives	BY-SA	Binding to ACE2		Under Development	1.96
374	Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis	Agnes Aggy	All rights reserved	Binding to ACE2	Encephalitis	Under Development	1.96
395	Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)	Agnes Aggy	BY-SA	Binding to ACE2	Cerebrovascular disease (stroke)	Under Development	1.96
422	Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption	Cataia Ives	BY-SA	Binding to ACE2		Under Development	1.96
468	Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)	Allie Always	BY-SA	Binding to ACE2	Hyperinflammation
430	Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation	Arthur Author	All rights reserved	Binding to ACE2	Viral infection and host-to-host transmission, proliferated	Under Development	1.96
320	Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality	Evgeniia Kazymova	BY-SA	Binding to ACE2	Increased Mortality	Under Development	1.96
381	Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia	Agnes Aggy	BY-SA	Binding to ACE2	dysgeusia	Under Development	1.96
319	Binding to ACE2 leading to lung fibrosis	Allie Always	BY-SA	Induced dysregulation of ACE2	Lung fibrosis	Under Development	1.96
379	Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation	Arthur Author	All rights reserved	Binding to ACE2	Thrombosis and Disseminated Intravascular Coagulation	Under Development	1.96
314	Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)	Cataia Ives	BY-SA	Binding to estrogen receptor (ER)-α in immune cells	Exacerbation of systemic lupus erythematosus (SLE)	Under Development	1.73
486	Binding to the extracellular protein laminin leading to decreased cognitive function	Allie Always	BY-SA	Binding, extracellular matrix protein laminin	Cognitive Function, Decreased
10	Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain	Cataia Ives	BY-SA	Binding at picrotoxin site, iGABAR chloride channel	Occurrence, Epileptic seizure	WPHA/WNT Endorsed	1.15
442	Binding to voltage gate sodium channels during development leads to cognitive impairment	Arthur Author	BY-SA	Binding to voltage-gated sodium channel	Impairment, Learning and memory	Under Development	1.91
484	Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses	Arthur Author	BY-SA
397	Bulky DNA adducts leading to mutations	Evgeniia Kazymova	BY-SA	Bulky DNA adducts, increase	Increase, Mutations	Under Development	1.11
533	C6R-Derived Protein K7 following Monkeypox infection leads to heart failure	Arthur Author	All rights reserved	Binding of C6R-Derived Protein K7	Cardiac Heart Failure
464	Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits	Cataia Ives	All rights reserved	Activation of metabotropic glutamate receptor Inositol triphosphate receptor activation Overactivation, NMDARs Inhibition GABAA receptor Opening, voltage-gated calcium channels	Parkinsonian motor deficits
26	Calcium-mediated neuronal ROS production and energy imbalance	Brendan Ferreri-Hanberry	Open for adoption	Inhibition, Ca++ ATPase	Increased, Oxidative damage
519	Cardiac ion channels blockade leading to arrhythmia associated sudden cardiac death	Brendan Ferreri-Hanberry	Open for adoption
449	Ceramide synthase inhibition leading to neural tube defects	Agnes Aggy	BY-SA	Inhibition of Ceramide Synthase	Neural tube defects
106	Chemical binding to tubulin in oocytes leading to aneuploid offspring	Cataia Ives	BY-SA	Binding, Tubulin	Increase, Aneuploid offspring	Under Review	1.11
360	Chitin synthase 1 inhibition leading to mortality	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Chitin synthase 1	Increase, Mortality	WPHA/WNT Endorsed	1.94
358	Chitinase inhibition leading to mortality	Evgeniia Kazymova	All rights reserved	Inhibition, Chitinase	Increase, Mortality	Under Development	1.94
359	Chitobiase inhibition leading to mortality	Cataia Ives	All rights reserved	Inhibition, Chitobiase	Increase, Mortality	Under Development	1.94
27	Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)	Arthur Author	BY-SA	Inhibition, Bile Salt Export Pump (ABCB11)	Cholestasis, Pathology	Under Development	1.19
13	Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities	Agnes Aggy	BY-SA	Binding of antagonist, NMDA receptors	Impairment, Learning and memory	WPHA/WNT Endorsed	1.22
12	Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging	Arthur Author	BY-SA	Binding of antagonist, NMDA receptors	N/A, Neurodegeneration Impairment, Learning and memory	WPHA/WNT Endorsed	1.13
118	Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Cataia Ives	BY-SA	Increase, Cytotoxicity (hepatocytes)	Increase, hepatocellular adenomas and carcinomas		1.29
171	Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.	Evgeniia Kazymova	BY-SA		Increased, mesotheliomas		1.29
490	Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms	Arthur Author	All rights reserved	Ryanodine receptor activation Inositol triphosphate receptor activation	Impairment, Learning and memory decreased, Intellectual Quotient increased, socio-economic burden
403	combined unhealthy lifestyle factors leading to metabolic syndrome	Evgeniia Kazymova	BY-SA
367	Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis	Arthur Author	BY-SA	Binding, Thyroid binding globulin in serum	Altered, Amphibian metamorphosis
366	Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis	Brendan Ferreri-Hanberry	BY-SA	Binding, Transthyretin in serum	Altered, Amphibian metamorphosis
107	Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat	Brendan Ferreri-Hanberry	BY-SA	Activation, Constitutive androstane receptor	Increase, hepatocellular adenomas and carcinomas	Under Review	1.17
39	Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response	Arthur Author	BY-SA	Covalent Binding, Protein	Increase, Allergic Respiratory Hypersensitivity Response	Under Development	1.20
40	Covalent Protein binding leading to Skin Sensitisation	Agnes Aggy	BY-SA	Covalent Binding, Protein	sensitisation, skin	WPHA/WNT Endorsed	1.1
177	Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality	Agnes Aggy	BY-SA	Inhibition, Cyclooxygenase 1 activity	Increased Mortality Decrease, Population growth rate		1.29
28	Cyclooxygenase inhibition leading reproductive failure	Agnes Aggy	BY-SA	Inhibition, Cyclooxygenase activity	N/A, Reproductive failure		1.29
63	Cyclooxygenase inhibition leading to reproductive dysfunction	Agnes Aggy	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
100	Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior	Cataia Ives	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
101	Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
102	Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition	Arthur Author	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
103	Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint	Agnes Aggy	BY-SA	Inhibition, Cyclooxygenase activity	Reduced, Reproductive Success Decrease, Population growth rate		1.29
434	CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects	Cataia Ives	All rights reserved
260	CYP2E1 activation and formation of protein adducts leading to neurodegeneration	Brendan Ferreri-Hanberry	BY-SA	CYP2E1 Activation Protein Adduct Formation	Neurodegeneration
220	Cyp2E1 Activation Leading to Liver Cancer	Agnes Aggy	BY-SA	Activation of Cyp2E1	Liver Cancer	WPHA/WNT Endorsed	1.24
532	CYP450 upregulation leads to Chronic kidney disease	Arthur Author	BY-SA	CYP450 Upregulation	Chronic kidney disease
368	Cytochrome oxidase inhibition leading to olfactory nasal lesions	Agnes Aggy	BY-SA	Inhibition, cytochrome oxidase	Increase, Site of Contact Nasal Tumors
109	Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)	Agnes Aggy	BY-SA	Increase, Cytotoxicity (club cells)	Increase, Adenomas/carcinomas (bronchioloalveolar)		1.29
116	Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)	Allie Always	BY-SA	Increase, Cytotoxicity (tubular epithelial cells)	Increase, Adenomas/carcinomas (renal tubular)		1.29
86	Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure	Evgeniia Kazymova	BY-SA		impaired, Larval development Death/Failure, Colony		1.29
111	Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)	Evgeniia Kazymova	BY-SA	Decreased, Androgen receptor activity	Increase, Leydig cell tumors		1.29
502	Decrease, cholesterol synthesis leads to orofacial clefting	Arthur Author	All rights reserved		Orofacial clefting	Under Development	1.101
491	Decrease, GLI1/2 target gene expression leads to orofacial clefting	Agnes Aggy	All rights reserved	Decrease, GLI1/2 target gene expression	Orofacial clefting	Under Development	1.101
392	Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation	Cataia Ives	BY-SA	Fibrinolysis, decreased Bradykinin system, hyperactivated	Hyperinflammation	Under Development	1.96
528	Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis	Allie Always	BY-SA		Malformation, cryptorchidism - maldescended testis
307	Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring	Cataia Ives	BY-SA		anogenital distance (AGD), decreased	Under Development	1.90
527	Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased	Agnes Aggy	BY-SA		Hypospadias, increased
526	Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis	Arthur Author	BY-SA		Impaired, Spermatogenesis
158	Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation	Allie Always	BY-SA	Inhibition, Deiodinase 1	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
157	Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation	Agnes Aggy	BY-SA	Inhibition, Deiodinase 1	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
156	Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation	Arthur Author	BY-SA	Inhibition, Deiodinase 2	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
155	Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Deiodinase 2	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
510	Demethylation of PPAR promotor leading to vascular disrupting effects	Allie Always	All rights reserved	peroxisome proliferator activated receptor promoter demethylation	Increase, Vascular disrupting effects
432	Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia	Allie Always	All rights reserved	Deposition of Energy	Acute Myeloid Leukemia
483	Deposition of Energy Leading to Learning and Memory Impairment	Brendan Ferreri-Hanberry	All rights reserved	Deposition of Energy	Impairment, Learning and memory
272	Deposition of energy leading to lung cancer	Brendan Ferreri-Hanberry	BY-SA	Deposition of Energy	Increase, lung cancer	WPHA/WNT Endorsed	1.56
482	Deposition of energy leading to occurrence of bone loss	Cataia Ives	All rights reserved	Deposition of Energy	Occurrence, Bone Loss
478	Deposition of energy leading to occurrence of cataracts	Arthur Author	All rights reserved	Deposition of Energy	Occurrence of Cataracts
299	Deposition of energy leading to population decline via DNA oxidation and follicular atresia	Allie Always	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
311	Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis	Agnes Aggy	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
216	Deposition of energy leading to population decline via DNA strand breaks and follicular atresia	Evgeniia Kazymova	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
238	Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis	Agnes Aggy	BY-SA	Deposition of Energy	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
470	Deposition of energy leads to vascular remodeling	Cataia Ives	All rights reserved	Deposition of Energy	Occurrence, Vascular Remodeling
388	Deposition of ionising energy leading to population decline via programmed cell death	Allie Always	BY-SA	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
387	Deposition of ionising energy leading to population decline via mitochondrial dysfunction	Agnes Aggy	BY-SA	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
461	Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis	Agnes Aggy	BY-SA
435	Deposition of ionising energy leads to population decline via pollen abnormal	Brendan Ferreri-Hanberry	BY-SA	Deposition of Energy	Decrease, Reproduction Decreased, Population trajectory
386	Deposition of ionizing energy leading to population decline via inhibition of photosynthesis	Arthur Author	BY-SA	Deposition of Energy	Decrease, Reproduction Decrease, Population growth rate
396	Deposition of ionizing energy leads to population decline via impaired meiosis	Allie Always	All rights reserved	Deposition of Ionizing Energy	Decrease of egg production and cummulative fecundity Decrease, Reproduction Decreased, Population size
43	Disruption of VEGFR Signaling Leading to Developmental Defects	Cataia Ives	BY-SA	Inhibition, VegfR2	Increased, Developmental Defects	WPHA/WNT Endorsed	1.6
472	DNA adduct formation leading to kidney failure	Arthur Author	BY-SA
240	DNA Adducts Leading to Liver Hemangiosarcoma	Evgeniia Kazymova	BY-SA
336	DNA methyltransferase inhibition leading to population decline (1)	Agnes Aggy	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
337	DNA methyltransferase inhibition leading to population decline (2)	Allie Always	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
338	DNA methyltransferase inhibition leading to population decline (3)	Evgeniia Kazymova	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
339	DNA methyltransferase inhibition leading to population decline (4)	Cataia Ives	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity Decrease, Population growth rate
340	DNA methyltransferase inhibition leading to transgenerational effects (1)	Brendan Ferreri-Hanberry	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity (F3) Decrease, Population growth rate
341	DNA methyltransferase inhibition leading to transgenerational effects (2)	Arthur Author	BY-SA	Increase, DNA methyltransferase inhibition	Decrease, Fecundity (F3) Decrease, Population growth rate
466	Doda decarboxylase leading to mortality	Arthur Author	BY-SA	Decrease, Tyrosine
193	Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Dual oxidase	Altered, Amphibian metamorphosis		1.29
377	Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)	Cataia Ives	BY-SA	Prolonged TLR9 activation	Multi Organ Failure involving Acute Respiratory Distress Syndrome Increased Mortality
378	Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load	Brendan Ferreri-Hanberry	BY-SA	Toll Like Receptor (TLR) Dysregulation
167	Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.	Brendan Ferreri-Hanberry	BY-SA	prepubertal increase, Estrogen receptor (ER) activity	Increased, adenosquamous carcinomas of endometrium		1.29
295	Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk	Cataia Ives	BY-SA			Under Development	1.79
4	Ecdysone receptor agonism leading to incomplete ecdysis associated mortality	Brendan Ferreri-Hanberry	BY-SA	Increase, Ecdysone receptor agonism	Increase, Mortality
148	EGFR Activation Leading to Decreased Lung Function	Cataia Ives	BY-SA	Activation, EGFR	Decrease, Lung function	Under Development	1.51
269	Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development	Allie Always	BY-SA
270	Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity	Evgeniia Kazymova	All rights reserved
310	Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR	Arthur Author	BY-SA	Activation, AhR	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate
144	Endocytic lysosomal uptake leading to liver fibrosis	Allie Always	BY-SA	Endocytotic lysosomal uptake	N/A, Liver fibrosis	Under Review	1.47
530	Endocytotic lysosomal uptake leads to intestinal barrier disruption	Cataia Ives	All rights reserved	Endocytotic lysosomal uptake	Intestinal barrier, disruption
412	Endothelial cell dysfunction leading to thromboinflammation	Arthur Author	All rights reserved		Thromboinflammation, Increased	Under Development	1.96
473	Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin	Agnes Aggy	BY-SA	Deposition of Energy	Decrease, Growth Decreased, Reproductive Success
162	Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse	Arthur Author	BY-SA		Increase, Adenomas/carcinomas (follicular cell)		1.29
72	Epigenetic modification of PPARG leading to adipogenesis	Cataia Ives	BY-SA	peroxisome proliferator activated receptor promoter demethylation chronic high fat diet	obesity		1.29
115	Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)	Agnes Aggy	BY-SA	Increase, Cytotoxicity (epithelial cells)	Increase, Papillomas/carcinomas (squamous cells)		1.29
53	ER agonism leading to reduced survival due to renal failure	Brendan Ferreri-Hanberry	BY-SA	Agonism, Estrogen receptor			1.29
52	ER agonism leading to skewed sex ratios due to altered sexual differentiation in males	Cataia Ives	BY-SA	Agonism, Estrogen receptor	skewed, sex ratio		1.29
199	ER mediated breast cancer AOP	Cataia Ives	BY-SA
493	ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity	Evgeniia Kazymova	All rights reserved	Estrogen receptor alpha inactivation	Metabolically unhealthy Obesity
497	ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome	Agnes Aggy	All rights reserved	Estrogen receptor alpha inactivation	Insulin resistance, increased Metabolic syndrome
521	Essential element imbalance leads to reproductive failure via oxidative stress	Agnes Aggy	BY-SA	Increased, essential element imbalance	Decreased, Viable Offspring
522	Estrogen antagonism leading to increased risk of autism-like behavior	Allie Always	Open for adoption	Antagonism, Estrogen receptor	autism-like behavior
146	Estrogen Receptor Activation and Female Precocious Puberty	Evgeniia Kazymova	BY-SA				1.29
200	Estrogen receptor activation leading to breast cancer	Brendan Ferreri-Hanberry	Open for adoption	Activation, Estrogen receptor	N/A, Breast Cancer
29	Estrogen receptor agonism leading to reproductive dysfunction	Allie Always	BY-SA	Agonism, Estrogen receptor	Decrease, Population growth rate Altered, Reproductive behaviour Altered, Larval development Impaired development of, Reproductive organs		1.29
445	Estrogen Receptor Alpha Agonism leads to Impaired Reproduction	Evgeniia Kazymova	BY-SA	Activation, estrogen receptor alpha	Impaired, Reproduction
30	Estrogen receptor antagonism leading to reproductive dysfunction	Evgeniia Kazymova	BY-SA	Antagonism, Estrogen receptor	Decrease, Population growth rate	Under Review	1.12
95	Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel	Reduced, survival		1.29
501	Excessive iron accumulation leading to neurological disorders	Brendan Ferreri-Hanberry	Open for adoption	Increased intracelluar Iron accumulation	Neurological disorder
327	Excessive reactive oxygen species production leading to mortality (1)	Cataia Ives	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
328	Excessive reactive oxygen species production leading to mortality (2)	Brendan Ferreri-Hanberry	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
329	Excessive reactive oxygen species production leading to mortality (3)	Arthur Author	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
330	Excessive reactive oxygen species production leading to mortality (4)	Agnes Aggy	BY-SA	Increase, Reactive Oxygen Species production	Increase, Mortality
331	Formation of DNA photoproducts leading to growth inhibition (1)	Allie Always	BY-SA	Increase, Formation of DNA photoproducts	Increase, Mortality
332	Formation of DNA photoproducts leading to growth inhibition (2)	Evgeniia Kazymova	BY-SA
333	Formation of DNA photoproducts leading to growth inhibition (3)	Cataia Ives	BY-SA
409	Frustrated phagocytosis leads to malignant mesothelioma	Evgeniia Kazymova	BY-SA	Frustrated phagocytosis	Increased, mesotheliomas
303	Frustrated phagocytosis-induced lung cancer	Arthur Author	BY-SA	Frustrated phagocytosis	Lung cancer	Under Development	1.86
401	G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects	Agnes Aggy	BY-SA	protein-coupled estrogen receptor 1 (GPER) activation	N/A, Steatohepatisis
217	Gastric ulcer formation	Cataia Ives	Open for adoption		Inhibit, gastric ulcer formation Activated, gastric ulcer formation
64	Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility	Allie Always	BY-SA	Glucocorticoid Receptor Agonist, Activation	impaired, Fertility		1.29
318	Glucocorticoid Receptor activation leading to hepatic steatosis	Agnes Aggy	BY-SA	Activation, Glucocorticoid Receptor	Increased, Liver Steatosis
14	Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility	Allie Always	BY-SA	Activation, Glucocorticoid Receptor	Increased, Disease susceptibility		1.29
334	Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration	Brendan Ferreri-Hanberry	BY-SA	Activation, Glucocorticoid Receptor	Decrease, Population growth rate
113	Glutamate-gated chloride channel activation leading to acute mortality	Brendan Ferreri-Hanberry	BY-SA	Activation, Glutamate-gated chloride channel	Increased Mortality Decreased, population 1		1.29
161	Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality	Brendan Ferreri-Hanberry	BY-SA	Activation, Glutamate-gated chloride channels	Increased Mortality
492	Glutathione conjugation leading to reproductive dysfunction via oxidative stress	Allie Always	All rights reserved	Conjugation, GSH	impaired, Fertility
524	Gluten intake leading to celiac disease example test - under development	Cataia Ives	All rights reserved
168	GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.	Arthur Author	BY-SA		Increased, Adenomas/carcinomas (mammary)		1.29
169	GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.	Agnes Aggy	BY-SA		Increased, adenomas (pituitary)		1.29
410	GSK3beta inactivation leading to increased mortality via defects in developing inner ear	Cataia Ives	BY-SA	GSK3beta inactivation	Increased Mortality Decrease, Population growth rate
211	Handbook development AOP	Cataia Ives	BY-SA				1.29
229	Helicobacter pylori to gastric ulcer	Cataia Ives	Open for adoption	Helicobacter pylori infection	Activated, gastric ulcer formation
194	Hepatic nuclear receptor activation leading to altered amphibian metamorphosis	Arthur Author	BY-SA	Activation, Hepatic nuclear receptor(s)	Altered, Amphibian metamorphosis		1.29
433	hERG channel blockade leading to sudden cardiac death	Evgeniia Kazymova	BY-SA	hERG channel blockade	Sudden cardiac death
99	Histamine (H2) receptor antagonism leading to reduced survival	Evgeniia Kazymova	BY-SA	Antagonism, Histamine Receptor (H2)	Decreased, survival Increased, predation		1.29
212	Histone deacetylase inhibition leading to testicular atrophy	Brendan Ferreri-Hanberry	BY-SA	Histone deacetylase inhibition	Testicular atrophy	WPHA/WNT Endorsed	1.52
274	Histone deacetylase inhibition leads to impeded craniofacial development	Agnes Aggy	BY-SA	Histone deacetylase inhibition	Facial cartilage structures are reduced in size and morphologically distorted
275	Histone deacetylase inhibition leads to neural tube defects	Allie Always	BY-SA	Histone deacetylase inhibition	Neural tube defects
124	HMG-CoA reductase inhibition leading to decreased fertility	Cataia Ives	BY-SA	Inhibition, HMG-CoA reductase	Decrease, Fertility		1.29
59	HNF4alpha suppression leading to hepatic steatosis	Evgeniia Kazymova	BY-SA	Suppression, HNF4alpha			1.29
114	HPPD inhibition leading to corneal papillomas and carcinomas (in rat)	Arthur Author	BY-SA	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme	Increase, Papillomas/carcinomas (squamous cells)		1.29
384	Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease	Cataia Ives	BY-SA	Hyperactivation of ACE/Ang-II/AT1R axis	Chronic kidney disease
440	Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia	Cataia Ives	All rights reserved	Suppression, Estrogen receptor (ER) activity	Promotion, ovarian adenomas Promotion, Ovarian Cancer	Under Development	1.104
278	IKK complex inhibition leading to liver injury	Brendan Ferreri-Hanberry	BY-SA	Inhibition, IKK complex	Necrotic Tissue Liver Injury
408	Imbalance in redox homeostasis leading to structural damage to tissues	Allie Always	BY-SA
362	Immune mediated hepatitis	Agnes Aggy	BY-SA	benzoquinone imine and acylglucuronide metabolites	Immune mediated hepatitis
277	Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response	Cataia Ives	BY-SA	Impaired IL-1R1 signaling in T cell	Impairment, T-cell dependent antibody response	WPHA/WNT Endorsed	1.48
400	Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males	Arthur Author	BY-SA	Increased (ectopic) all-trans retinoic acid concentration	Reduce, Sperm count
293	Increased DNA damage leading to increased risk of breast cancer	Allie Always	BY-SA	Increase, DNA damage	Increase, Mutations Increased, Ductal Hyperplasia N/A, Breast Cancer	Under Development	1.80
112	Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)	Cataia Ives	BY-SA	Increase, Dopaminergic activity	Increase, Endometrial adenocarcinomas		1.29
498	Increased LCN2/iron complex leading to neurological disorders	Allie Always	Open for adoption	Increased LCN2/iron complex binds to SLC22A17 receptor in neuron	Neurological disorder
81	Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure	Brendan Ferreri-Hanberry	BY-SA		Decrease, Number of worker bees Death/Failure, Colony		1.29
294	Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer	Evgeniia Kazymova	BY-SA	Increase in reactive oxygen and nitrogen species (RONS)	Increase, DNA damage Increase, Mutations Increased, Ductal Hyperplasia N/A, Breast Cancer	Under Development	1.80
488	Increased reactive oxygen species production leading to decreased cognitive function	Cataia Ives	BY-SA	Increase, Reactive Oxygen Species production	Cognitive Function, Decreased
431	Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)	Agnes Aggy	BY-SA	Increase, TNF	Gestational diabetes mellitus
298	Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer	Agnes Aggy	BY-SA	Increases in cellular reactive oxygen species Chronic reactive oxygen species	Treatment-resistant gastric cancer	Under Review	1.58
349	Inhibition of 11β-hydroxylase leading to decresed population trajectory	Allie Always	BY-SA	11β-hydroxylase inhibition	Decrease, Population growth rate	Under Development	1.93
348	Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory	Agnes Aggy	BY-SA	Inhibition of 11β-HSD	Decrease, Population growth rate	Under Development	1.93
288	Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)	Evgeniia Kazymova	BY-SA	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity	Malformation, cryptorchidism - maldescended testis
289	Inhibition of 5α-reductase leading to impaired fecundity in female fish	Cataia Ives	BY-SA	Inhibition, 5α-reductase	Decrease, Population growth rate	Under Development	1.81
120	Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)	Arthur Author	BY-SA	Inhibition, 5α-reductase activity	Increase, Leydig cell tumors		1.29
398	Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary	Cataia Ives	BY-SA	Inhibition of ALDH1A (RALDH)	impaired, Fertility	Under Development	1.97
383	Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis	Evgeniia Kazymova	BY-SA	Induced dysregulation of ACE2	N/A, Liver fibrosis	Under Development	1.96
154	Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response	Cataia Ives	BY-SA	Inhibition, Calcineurin Activity	Impairment, T-cell dependent antibody response	WPHA/WNT Endorsed	1.38
276	Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome	Evgeniia Kazymova	BY-SA	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Chemical induced Fanconi syndrome
218	Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity	Brendan Ferreri-Hanberry	BY-SA	CYP7B activity, inhibition	Decrease, Population growth rate
219	Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior	Arthur Author	BY-SA	CYP7B activity, inhibition	Decrease, Population growth rate
301	Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis	Cataia Ives	BY-SA	Inhibition of cystathionine beta-synthase	Impaired,anterior-posterior axis development
213	Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)	Arthur Author	Open for adoption	Inhibition, Fatty Acid Beta Oxidation	N/A, Steatohepatisis
399	Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)	Brendan Ferreri-Hanberry	BY-SA	Inhibition of Fyna	Increased Mortality Decrease, Population growth rate
32	Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors	Brendan Ferreri-Hanberry	BY-SA
110	Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)	Allie Always	BY-SA	Inhibition, Na+/I- symporter (NIS)	Increase, Adenomas/carcinomas (follicular cell)		1.29
315	Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response	Brendan Ferreri-Hanberry	BY-SA	Inhibition of JAK3	Impairment of T-cell dependent antibody response	Under Development	1.74
242	Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity	Brendan Ferreri-Hanberry	Open for adoption	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts	Growth, reduction Decreased, survival
256	Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity	Agnes Aggy	BY-SA	Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)	Occurrence, Kidney toxicity	Under Development	1.43
437	Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity	Agnes Aggy	BY-SA	Inhibition, Mitochondrial Electron Transport Chain Complexes	Occurrence, Kidney toxicity	Under Development	1.99
285	Inhibition of N-linked glycosylation leads to liver injury	Arthur Author	BY-SA	Inhibition of N-linked glycosylation	Liver Injury
54	Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment	Arthur Author	BY-SA	Inhibition, Na+/I- symporter (NIS)	Impairment, Learning and memory	WPHA/WNT Endorsed	1.28
536	Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation	Travis Karschnik	All rights reserved	Neuropathy target esterase, inhibited	Delayed neuropathy, increased
535	Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration	Travis Karschnik	All rights reserved	Neuropathy target esterase, inhibited	Delayed neuropathy, increased
108	Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)	Arthur Author	BY-SA	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme	Increase, hepatocellular adenomas and carcinomas		1.29
436	Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries	Arthur Author	BY-SA	Inhibition of ALDH1A (RALDH)	transposition of the great arteries
297	Inhibition of retinaldehyde dehydrogenase leads to population decline	Arthur Author	BY-SA	Retinaldehyde dehydrogenase inhibition	Decrease, Population growth rate	Under Development	1.77
3	Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits	Cataia Ives	BY-SA	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	Parkinsonian motor deficits	WPHA/WNT Endorsed	1.33
119	Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)	Brendan Ferreri-Hanberry	BY-SA	Thyroperoxidase, Inhibition	Increase, Adenomas/carcinomas (follicular cell)		1.29
271	Inhibition of thyroid peroxidase leading to impaired fertility in fish	Cataia Ives	BY-SA	Thyroperoxidase, Inhibition	Reduction, Cumulative fecundity and spawning	Under Development	1.59
42	Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Evgeniia Kazymova	BY-SA	Thyroperoxidase, Inhibition	Cognitive Function, Decreased	WPHA/WNT Endorsed	1.10
292	Inhibition of tyrosinase leads to decreased population in fish	Agnes Aggy	BY-SA	Inhibition of tyrosinase	Decrease, Population growth rate	Under Development	1.78
489	Inhibition of voltage-gated sodium channels leading to decreased cognition	Brendan Ferreri-Hanberry	BY-SA	Binding to voltage-gated sodium channel	Cognitive Function, Decreased
451	Interaction with lung resident cell membrane components leads to lung cancer	Evgeniia Kazymova	BY-SA	Substance interaction with the lung resident cell membrane components	Lung cancer
152	Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity	Allie Always	BY-SA	Binding, Transthyretin in serum	Cognitive Function, Decreased	Under Development	1.41
136	Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors	Cataia Ives	BY-SA	Decrease, Intracellular pH	Increase, Site of Contact Nasal Tumors	Under Review	2.7
188	Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis	Arthur Author	BY-SA	Inhibition, Iodotyrosine deiodinase (IYD)	Altered, Amphibian metamorphosis		1.29
444	Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability	Allie Always	BY-SA	Deposition of Energy Increase in reactive oxygen and nitrogen species (RONS) Increase, DNA damage	Decrease, Population growth rate
441	Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation	Brendan Ferreri-Hanberry	BY-SA	Deposition of Energy	Increase risk, microcephaly
160	Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality	Cataia Ives	BY-SA	Activation, ionotropic GABA Receptor chloride channel	Increased Mortality
208	Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure	Agnes Aggy	All rights reserved		Reproductive failure
201	Juvenile hormone receptor agonism leading to male offspring induction associated population decline	Arthur Author	BY-SA	Activation, Juvenile hormone receptor	Increased, Male offspring Decline, Population Alteration, Food-web structures
128	Kidney dysfunction by decreased thyroid hormone	Arthur Author	BY-SA	Thyroid hormone synthesis, Decreased	Occurrence, Kidney toxicity	Under Development	1.40
447	Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways	Brendan Ferreri-Hanberry	BY-SA		Increased, Kidney Failure
33	Kidney toxicity induced by activation of 5HT2C	Arthur Author	Open for adoption	Activation, 5HT2c	Increased, Kidney Failure
467	Knickkopf leading to mortality	Agnes Aggy	BY-SA	Decrease, 20-hydroxyecdysone
261	L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility	Arthur Author	All rights reserved	Blockade, L-Type Calcium Channels	Heart failure	Under Development	1.45
283	L-type calcium channel blockade leading to hypotension	Cataia Ives	All rights reserved			Under Development	1.45
262	L-type calcium channel blockade leading to the disruption of cardiac electrophysiology	Agnes Aggy	All rights reserved			Under Development	1.45
241	Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis	Cataia Ives	BY-SA	Activation, Latent Transforming Growth Factor Beta 1	Pulmonary fibrosis
518	Liver X Receptor (LXR) activation leads to liver steatosis	Cataia Ives	BY-SA	Activation, LXR	Increased, Liver Steatosis
302	Lung surfactant function inhibition leading to decreased lung function	Brendan Ferreri-Hanberry	BY-SA	Inhibition of lung surfactant function	Decrease, Lung function	Under Development	1.87
309	Luteinizing hormone receptor antagonism leading to reproductive dysfunction	Brendan Ferreri-Hanberry	BY-SA	Antagonism,LH receptor	Decline, Population trajectory
34	LXR activation leading to hepatic steatosis	Agnes Aggy	BY-SA	Activation, LXR peroxisome proliferator activated receptor promoter demethylation	N/A, Liver Steatosis
222	Mental stress to agitation	Evgeniia Kazymova	Open for adoption	Increased, glucocorticoid receptor activity	Increased, agitation
221	Mental stress to depression	Allie Always	Open for adoption	Increased, glucocorticoid receptor activity	Increased, depression
404	Metabolic Syndrome leading to Toll Like Receptor dysregulation	Cataia Ives	BY-SA
279	Microtubule interacting drugs lead to peripheral neuropathy	Arthur Author	BY-SA	Binding of microtubule stabilizing agents (MSA) to microtubules	Sensory axonal peripheral neuropathy
290	Mitochondrial ATP synthase antagonism leading to growth inhibition (1)	Brendan Ferreri-Hanberry	BY-SA	Increase, Mitochondrial ATP synthase antagonism	Decrease, Growth
291	Mitochondrial ATP synthase antagonism leading to growth inhibition (2)	Arthur Author	BY-SA	Increase, Mitochondrial ATP synthase antagonism	Decrease, Growth
286	Mitochondrial complex III antagonism leading to growth inhibition (1)	Agnes Aggy	BY-SA	Increase, Mitochondrial complex III antagonism	Decrease, Growth
287	Mitochondrial complex III antagonism leading to growth inhibition (2)	Allie Always	BY-SA	Increase, Mitochondrial complex III antagonism	Decrease, Growth
273	Mitochondrial complex inhibition leading to liver injury	Arthur Author	BY-SA	Increase, Mitochondrial complex III antagonism Mitochondrial Complex IV inhibition Mitochondrial Complex V inhibition Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Inhibition, NADH-ubiquinone oxidoreductase (complex I) Binding of inhibitor to mitochondrial complex III Binding of inhibitor to mitochondrial complex IV Binding of inhibitor to mitochondrial complex V	Necrotic Tissue Liver Injury
480	Mitochondrial complexes inhibition leading to heart failure via decreased ATP production	Allie Always	BY-SA	Inhibition, Mitochondrial Electron Transport Chain Complexes	Decrease Left Ventricular function	Under Development	1.102
479	Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress	Agnes Aggy	BY-SA	Inhibition, Mitochondrial Electron Transport Chain Complexes	Decrease Left Ventricular function	Under Development	1.102
373	Mitochondrial dysfunction to metabolic diseases	Arthur Author	BY-SA
66	Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis	Cataia Ives	BY-SA	Decreased testosterone by the fetal Leydig cells, Increased corticosterone Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists	Decreased sperm quantity / quality in the adult, Decreased fertility		1.29
68	Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome	Arthur Author	BY-SA	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome	Decreased sperm quantity / quality in the adult, Decreased fertility		1.29
69	Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell	Agnes Aggy	BY-SA	Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol Decreased Cholesterol, Decreased Uptake of Lipoproteins Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane	Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis		1.29
67	Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis	Brendan Ferreri-Hanberry	BY-SA	Decreased testosterone by the fetal Leydig cells, Increased estradiol Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists	Decreased sperm quantity / quality in the adult, Decreased fertility		1.29
71	Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation	Evgeniia Kazymova	BY-SA	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid	Decreased sperm quantity or quality in the adult, Decreased fertility		1.29
74	Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis	Arthur Author	BY-SA	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis		1.29
70	Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell	Allie Always	BY-SA	Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell	Decreased sperm quantity or quality in the adult, Decreased fertility		1.29
215	Molecular events lead to epilepsy	Allie Always	Open for adoption		Increase, seizure Increased, hippocampal hyperdepolarization Increased, epilepsy
234	Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition	Evgeniia Kazymova	BY-SA	Mu Opioid Receptor Agonism	Analgesia
233	Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening	Allie Always	BY-SA	Mu Opioid Receptor Agonism	Analgesia
516	Na+ /K+ -ATPase inhibition leading to hypertension	Allie Always	All rights reserved	Decreased Na/K ATPase activity	Hypertension
207	NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans	Arthur Author	All rights reserved	Activation, NADPH Oxidase	Reproductive failure
35	Narcosis leading to respiratory failure	Allie Always	BY-SA	Accumulation, Biological membranes		Under Development	1.2
214	Network of SSRIs (selective serotonin reuptake inhibitors)	Agnes Aggy	Open for adoption		Increased, seizure Increased, agitation Increased, depression Increase, hypertension
232	NFE2/Nrf2 repression to steatosis	Agnes Aggy	Open for adoption	NFE2/Nrf2 repression	Increased, Liver Steatosis
61	NFE2L2/FXR activation leading to hepatic steatosis	Brendan Ferreri-Hanberry	BY-SA	Activation, NRF2 Activation, NR1H4	Increased, Liver Steatosis		1.29
77	Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1	Agnes Aggy	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
87	Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure	Cataia Ives	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
88	Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste	Brendan Ferreri-Hanberry	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
78	Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1	Allie Always	BY-SA	Activation, Nicotinic acetylcholine receptor	impaired, Larval development Death/Failure, Colony		1.29
90	Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2	Agnes Aggy	BY-SA	Activation, Nicotinic acetylcholine receptor	impaired, Larval development Death/Failure, Colony		1.29
80	Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure	Cataia Ives	BY-SA	Activation, Nicotinic acetylcholine receptor	Decrease, Number of worker bees impaired, Hive thermoregulation Death/Failure, Colony		1.29
79	Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure	Evgeniia Kazymova	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
178	Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure	Allie Always	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
89	Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure	Arthur Author	BY-SA	Activation, Nicotinic acetylcholine receptor	Death/Failure, Colony		1.29
184	Nosema infection causes abnormal role change that leads to colony loss/failure	Allie Always	BY-SA		Death/Failure, Colony		1.29
183	Nosema infection increases energetic demands leading to colony loss/failure	Agnes Aggy	BY-SA		Death/Failure, Colony		1.29
60	NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis	Cataia Ives	BY-SA	Activation, PXR/SXR	Increased, Liver Steatosis		1.29
58	NR1I3 (CAR) suppression leading to hepatic steatosis	Allie Always	BY-SA	Suppression, Constitutive androstane receptor, NR1l3 Inhibition, PPAR alpha Activation, LXR peroxisome proliferator activated receptor promoter demethylation	Increased, Liver Steatosis		1.29
509	Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction	Agnes Aggy	All rights reserved	NFE2/Nrf2 repression	Increase, Vascular disrupting effects
508	Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway	Arthur Author	All rights reserved	NFE2/Nrf2 repression	Increase, Vascular disrupting effects
507	Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway	Brendan Ferreri-Hanberry	All rights reserved	NFE2/Nrf2 repression	Increase, Vascular disrupting effects
227	NSAID induced PTGS1 inactivation to gastric ulcer	Allie Always	Open for adoption	Reduced, PTGS1 function	Activated, gastric ulcer formation
228	NSAID induced PTGS2 inactivation to gastric ulcer	Evgeniia Kazymova	Open for adoption	Reduced, PTGS2 function	Activated, gastric ulcer formation
138	Organic anion transporter (OAT1) inhibition leading to renal failure and mortality	Brendan Ferreri-Hanberry	BY-SA	Inhibition, organic anion transporter 1 (OAT1)	Increased Mortality Decrease, Population growth rate		1.29
405	Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function	Brendan Ferreri-Hanberry	BY-SA	Acetylcholinesterase (AchE) Inhibition	Cognitive Function, Decreased
413	Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure	Agnes Aggy	BY-SA	Oxidation, Glutathione (To be considered with MIE)	Increased Mortality
31	Oxidation of iron in hemoglobin leading to hematotoxicity	Cataia Ives	Open for adoption	N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)	N/A, Cyanosis occurs	Under Development	1.16
296	Oxidative DNA damage leading to chromosomal aberrations and mutations	Brendan Ferreri-Hanberry	BY-SA	Increase, Oxidative damage to DNA	Increase, Mutations Increase, Chromosomal aberrations	WPHA/WNT Endorsed	1.76
411	Oxidative stress Leading to Decreased Lung Function	Brendan Ferreri-Hanberry	BY-SA	Oxidative Stress	Decrease, Lung function
424	Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction	Arthur Author	BY-SA	Oxidative Stress	Decrease, Lung function
425	Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1	Agnes Aggy	BY-SA	Oxidative Stress	Decrease, Lung function
239	Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling	Allie Always	BY-SA
192	Pendrin inhibition leading to altered amphibian metamorphosis	Cataia Ives	BY-SA	Inhibition, Pendrin	Altered, Amphibian metamorphosis		1.29
149	Peptide Oxidation Leading to Hypertension	Brendan Ferreri-Hanberry	BY-SA	Peptide Oxidation	Hypertension	Under Development	1.50
11	Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol	Brendan Ferreri-Hanberry	BY-SA	Activation, PXR/SXR		Under Development	2.5
529	Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis	Evgeniia Kazymova	BY-SA	Stressor binding PPAR isoforms	Increased, Liver Steatosis
36	Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis	Evgeniia Kazymova	BY-SA	Decreased, PPAR-alpha activation Decreased, PPAR-beta activation Decreased, PPAR-gamma activation	Increased, Liver Steatosis		1.29
206	Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis	Brendan Ferreri-Hanberry	All rights reserved	Inactivation of PPARγ	Lung fibrosis	Under Development	1.54
209	Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP	Allie Always	All rights reserved		Hepatotoxicity
130	Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity	Agnes Aggy	BY-SA	Inhibition, Phospholipase A	Formation, Liver fibrosis	Under Development	1.39
371	Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone	Cataia Ives	BY-SA
369	Photosystem II antagonism leading to growth inhibition via oxidative damage	Allie Always	BY-SA
370	Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis	Evgeniia Kazymova	BY-SA
514	PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV	Arthur Author	All rights reserved
446	PM-related Adverse outcome pathway frameworks on various systems	Cataia Ives	BY-SA
454	PM2.5-related AOP frameworks on liver diseases	Arthur Author	BY-SA
166	PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse	Cataia Ives	BY-SA		Increased, Pancreatic acinar tumors		1.29
323	PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone	Arthur Author	BY-SA	Activation, PPARα	Decreased, Viable Offspring Decrease, Population growth rate
421	PPARG activation leading to intrahepatic cholestasis	Evgeniia Kazymova	All rights reserved
163	PPARgamma activation leading to sarcomas in rats, mice, and hamsters	Agnes Aggy	BY-SA	Activation of specific nuclear receptors, PPAR-gamma activation			1.29
18	PPARα activation in utero leading to impaired fertility in males	Arthur Author	BY-SA	Activation, PPARα	impaired, Fertility Malformation, Male reproductive tract	Under Review	1.21
37	PPARα activation leading to hepatocellular adenomas and carcinomas in rodents	Cataia Ives	BY-SA	Activation, PPARα	Increase, hepatocellular adenomas and carcinomas	Under Development	1.17
51	PPARα activation leading to impaired fertility in adult male rodents	Evgeniia Kazymova	BY-SA	Activation, PPARα	impaired, Fertility	Under Development	1.21
517	Pregnane X Receptor (PXR) activation leads to liver steatosis	Evgeniia Kazymova	BY-SA	Activation, Pregnane-X receptor, NR1l2	Increased, Liver Steatosis
230	presynaptic neuron 1 activation to epilepsy	Brendan Ferreri-Hanberry	Open for adoption	Activated, presynaptic neuron 1	Increased, epilepsy
231	presynaptic neuron 2 repression to epilepsy	Arthur Author	Open for adoption	Reduced, presynaptic neuron 2 activity	Increased, epilepsy
122	Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation	Allie Always	BY-SA	Inhibition, Prolyl hydroxylases	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate		1.29
38	Protein Alkylation leading to Liver Fibrosis	Brendan Ferreri-Hanberry	BY-SA	Alkylation, Protein	N/A, Liver fibrosis	WPHA/WNT Endorsed	1.14
185	Queen egg-laying decrease leads to colony loss/failure	Evgeniia Kazymova	BY-SA		Death/Failure, Colony		1.29
513	Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway	Brendan Ferreri-Hanberry	BY-SA	Increased, Reactive oxygen species	Increase, Cancer
505	Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway	Evgeniia Kazymova	BY-SA	Increased, Reactive oxygen species	Increase, Cancer
453	Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population	Brendan Ferreri-Hanberry	BY-SA
438	reactive oxygen species generation leading to increased cardiovascular morbidity and mortality	Allie Always	All rights reserved
469	Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population	Evgeniia Kazymova	BY-SA
257	Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity	Allie Always	BY-SA	Binding of substrate, endocytic receptor	Occurrence, Kidney toxicity	Under Development	1.43
512	Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level	Cataia Ives	All rights reserved
321	Reduced environmental pH leading to thinner shells in Mytilus edulis	Cataia Ives	BY-SA
525	Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory	Brendan Ferreri-Hanberry	Open for adoption	Binding of antagonist to thyroid hormone receptor Binding of antagonist to glucocorticoid hormone receptor Binding of (ant)agonist to liver X receptor Binding of (ant)agonist to peroxisome proliferator–activated receptor alpha	Impairment, Learning and memory
245	Reduction in photophosphorylation leading to growth inhibition in aquatic plants	Arthur Author	BY-SA	Increase, Uncoupling of photophosphorylation	Decrease, Growth
258	Renal protein alkylation leading to kidney toxicity	Evgeniia Kazymova	BY-SA	Alkylation, Protein	Occurrence, Kidney toxicity	Under Development	1.43
520	Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory	Arthur Author	Open for adoption	Agonism, Retinoic acid receptor	Impairment, Learning and memory
523	Retinoic acid receptor agonism during neurodevelopment leading to microcephaly	Evgeniia Kazymova	Open for adoption	Agonism, Retinoic acid receptor	Increase risk, microcephaly
448	ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality	Arthur Author	BY-SA
342	S-adenosylmethionine depletion leading to population decline (1)	Agnes Aggy	BY-SA	Inhibition, Chitin synthase 1	Increase, Mortality
343	S-adenosylmethionine depletion leading to population decline (2)	Allie Always	BY-SA	Increase, Sulfonylurea receptor binding	Increase, Mortality
406	SARS-CoV-2 infection leading to hyperinflammation	Arthur Author	All rights reserved	Binding to ACE2	Hyperinflammation
407	SARS-CoV-2 infection leading to pyroptosis	Agnes Aggy	All rights reserved	Binding to ACE2	Pyroptosis
394	SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)	Arthur Author	BY-SA	Binding to ACE2	impaired olfactory function (anosmia)	Under Development	1.96
426	SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.	Allie Always	BY-SA	Binding to ACE2	Myocardial Infarction
259	Sensitization induction of the intestinal tract by food proteins	Cataia Ives	BY-SA
236	Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition	Brendan Ferreri-Hanberry	BY-SA	Serotonin 1A Receptor Agonism	Anti-depressant Activity
235	Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening	Cataia Ives	BY-SA	Serotonin 1A Receptor Agonism	Anti-depressant Activity
225	Serotonin transporter activation to agitation	Arthur Author	Open for adoption		Increased, agitation
224	Serotonin transporter activation to depression	Brendan Ferreri-Hanberry	Open for adoption	Increased, serotonin transporter activity	Increased, depression
223	Serotonin transporter activation to seizure	Cataia Ives	Open for adoption	Increased, serotonin transporter activity	Increased, seizure
197	Sodium channel (Nav1.1) inhibition leading to population decline	Evgeniia Kazymova	BY-SA	Inhibition, sodium channel			1.29
94	Sodium channel inhibition leading to congenital malformations	Cataia Ives	BY-SA	Inhibition, sodium channel	Increased, amputations		1.29
93	sodium channel inhibition leading to increased predation	Evgeniia Kazymova	BY-SA	Inhibition, sodium channel	Increased, predation		1.29
91	Sodium channel inhibition leading to reduced survival	Allie Always	BY-SA	Inhibition, sodium channel	Reduced, feeding 1 Increased, predation Reduced, survival		1.29
134	Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Evgeniia Kazymova	BY-SA	Inhibition, Na+/I- symporter (NIS)	Cognitive Function, Decreased		1.29
176	Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis	Arthur Author	BY-SA	Inhibition, Na+/I- symporter (NIS)	Altered, Amphibian metamorphosis		1.29
226	SSRI (Selective serotonin reuptake inhibitor) to hypertension	Agnes Aggy	Open for adoption	Decreased, serotonin transporter activity	Increase, hypertension
313	Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease	Evgeniia Kazymova	BY-SA	Stimulation, TLR7/8	Psoriatic skin disease	Under Development	1.75
237	Substance interaction with lung resident cell membrane components leading to atherosclerosis	Arthur Author	BY-SA	Substance interaction with the lung resident cell membrane components	Atherosclerosis	Under Development	1.55
173	Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis	Cataia Ives	All rights reserved	Substance interaction with the lung resident cell membrane components	Pulmonary fibrosis	WPHA/WNT Endorsed	1.32
474	Succinate dehydrogenase inactivation leading to cancer	Allie Always	BY-SA			Under Development	1.106
457	Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine	Evgeniia Kazymova	Open for adoption	Succinate dehydrogenase, inhibited	Insulin resistance, increased
361	Sulfonylureareceptor binding leading to mortality	Arthur Author	All rights reserved	Increase, Sulfonylurea receptor binding	Increase, Mortality	Under Development	1.94
504	SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level	Allie Always	All rights reserved	Inhibition of Sulfotransferase E1 (SULT1E1)
85	Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure	Allie Always	BY-SA		Decrease, Number of worker bees Death/Failure, Colony		1.29
84	Suppression of immune system contributes to impaired development and leads to colony loss/failure	Agnes Aggy	BY-SA		Decrease, Number of worker bees impaired, Hive thermoregulation Death/Failure, Colony		1.29
41	Sustained AhR Activation leading to Rodent Liver Tumours	Allie Always	BY-SA	Activation, Long term AHR receptor driven direct and indirect gene expression changes	Formation, Hepatocellular and Bile duct tumors	Under Review	1.7
304	TBX1 inhibition leading to congenital cardiac conotruncal anomalies	Agnes Aggy	All rights reserved	Inhibition, TBX1	Anomalies, Congenital cardiac conotruncal
375	test AOP	Allie Always	BY-SA
511	The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects	Evgeniia Kazymova	All rights reserved	Increase, Reactive Oxygen Species production	Increase, Vascular disrupting effects
463	The AOP framwork on silica nanopariticles induced hepatoxicity	Evgeniia Kazymova	BY-SA
324	Thermal stress leading to population decline (1)	Agnes Aggy	BY-SA	Mitochondrial dysfunction	Decrease, Fecundity Decrease, Population growth rate
325	Thermal stress leading to population decline (2)	Allie Always	BY-SA	Mitochondrial dysfunction	Decrease, Fecundity Decrease, Population growth rate
326	Thermal stress leading to population decline (3)	Evgeniia Kazymova	BY-SA	Mitochondrial dysfunction	Decrease, Fecundity Decrease, Population growth rate
485	Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition	Agnes Aggy	BY-SA	Antagonism, Thyroid Receptor	Cognitive Function, Decreased
402	Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain	Allie Always	BY-SA	Thyroperoxidase, Inhibition	Periventricular heterotopia formation Increase, seizure
300	Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Evgeniia Kazymova	BY-SA	Antagonism, Thyroid Receptor	Cognitive Function, Decreased	Under Development	1.84
175	Thyroperoxidase inhibition leading to altered amphibian metamorphosis	Brendan Ferreri-Hanberry	BY-SA	Thyroperoxidase, Inhibition	Altered, Amphibian metamorphosis		1.29
365	Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning	Cataia Ives	All rights reserved	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	Under Development	1.35
363	Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure	Allie Always	BY-SA	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	Under Review	1.35
364	Thyroperoxidase inhibition leading to altered visual function via decreased eye size	Evgeniia Kazymova	All rights reserved	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	Under Development	1.35
159	Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation	Evgeniia Kazymova	BY-SA	Thyroperoxidase, Inhibition	Increased Mortality Decrease, Population growth rate	WPHA/WNT Endorsed	1.35
347	Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis	Arthur Author	BY-SA	Toll-like receptor 4 activation Inactivation of PPARγ	Pulmonary fibrosis
316	Trypsin inhibition leading to pancreatic acinar cell tumors	Arthur Author	BY-SA	Trypsin inhibition	Pancreatic acinar cell tumors	Under Development	1.60
189	Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis	Agnes Aggy	BY-SA	Inhibition, Deiodinase 1	Altered, Amphibian metamorphosis		1.29
190	Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis	Allie Always	BY-SA	Inhibition, Deiodinase 2	Altered, Amphibian metamorphosis		1.29
191	Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis	Evgeniia Kazymova	BY-SA	Inhibition, Deiodinase 3	Altered, Amphibian metamorphosis		1.29
263	Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation	Allie Always	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	WPHA/WNT Endorsed	1.92
264	Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death	Evgeniia Kazymova	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
266	Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity	Brendan Ferreri-Hanberry	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
267	Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion	Arthur Author	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
265	Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium	Cataia Ives	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
268	Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling	Agnes Aggy	BY-SA	Decrease, Coupling of oxidative phosphorylation	Decrease, Growth	Under Development	1.92
487	Unknown MIE altering cholesterol metabolism leading to decreased cognition	Evgeniia Kazymova	BY-SA	Unknown, MIE	Cognitive Function, Decreased
186	unknown MIE leading to renal failure and mortality	Cataia Ives	BY-SA	Unknown, MIE	Increased Mortality		1.29
123	Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription	Evgeniia Kazymova	BY-SA	modulation, Unknown	Reduction, Cumulative fecundity and spawning Decrease, Population growth rate		1.29
8	Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals	Evgeniia Kazymova	Open for adoption	Activation, Pregnane-X receptor, NR1l2	Loss, Cochlear function	Under Development	1.9
121	Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)	Agnes Aggy	BY-SA	Increase, Urinary bladder calculi	Increase, Adenomas/carcinomas (urothelial)		1.29
471	Various neuronal effects induced by elavl3, sox10, and mbp	Brendan Ferreri-Hanberry	BY-SA	Increase, CNS Neural cell death	impaired, Learning and memory Encephalitis Parkinsonian motor deficits Increase, seizure Increased, epilepsy Increase, Mortality Inhibition, Feeding
180	Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure	Cataia Ives	BY-SA		Death/Failure, Colony		1.29
179	Varroa mite infestation increases virus levels leading to colony loss/failure	Evgeniia Kazymova	BY-SA		Death/Failure, Colony		1.29
531	VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction	Brendan Ferreri-Hanberry	All rights reserved
385	Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation	Brendan Ferreri-Hanberry	BY-SA	Binding to ACE2
196	Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation	Allie Always	BY-SA	TRPA1 activation, TRPA1 Receptor	Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea Irritation of nasal mucosa inducing sneeze reflex Increased Respiratory irritability and Chronic Cough,
182	Weather event contributes abnormal foraging leading to colony loss/failure	Arthur Author	BY-SA		Death/Failure, Colony		1.29
181	Weather event contributes to colony loss/failure	Brendan Ferreri-Hanberry	BY-SA		Death/Failure, Colony		1.29
73	Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity	Brendan Ferreri-Hanberry	BY-SA	Inhibition, Inhibition of Dopamine-beta-hydroxylase	Decreased, Decreased fecundity		1.29
280	α-diketone-induced bronchiolitis obliterans	Agnes Aggy	BY-SA	Interaction of α-diketones with arginine residues	Bronchiolitis obliterans