AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
302 19.6.10 Yu Arthur Author Under development: Not open for comment. Do not cite
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Agnes Aggy Under development: Not open for comment. Do not cite Under Development 5-HTT increased predation 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Arthur Author Under development: Not open for comment. Do not cite Under Development 5-HTT increased predation 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Allie Always Under development: Not open for comment. Do not cite Under Development unk colony loss/failure 1.29
16 Acetylcholinesterase inhibition leading to acute mortality Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan AChE acute mortality Under Development 1.3
304 Activating Aryl hydrocarbon receptor (AhR) Leads to Increase Early life stage mortality 1 Arthur Author Under development: Not open for comment. Do not cite
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
306 Adverse outcome pathway Arthur Author Under development: Not open for comment. Do not cite
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
21 AhR activation leading to early life stage mortality Arthur Author Open for comment. Do not cite Included in OECD Work Plan AhR embryo toxicity EAGMST Under Review 1.27
57 AhR activation leading to hepatic steatosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development AhR hepatic steatosis 1.29
312 AhR cause early mortality Arthur Author Under development: Not open for comment. Do not cite
314 AhR cause mortality 1 Arthur Author Under development: Not open for comment. Do not cite
151 AhR signalling leading to placental vascular disruption Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
297 ahr/arnt is affected by x Arthur Author Under development: Not open for comment. Do not cite
299 AhR/ARNT, Dimerization Arthur Author Under development: Not open for comment. Do not cite
62 AKT2 activation leading to hepatic steatosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development AKT2 hepatic steatosis 1.29
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Arthur Author Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
243 Alkylation of DNA in male prebiotic germ cells leading to heritable mutations Agnes Aggy Under development: Not open for comment. Do not cite
139 Alkylation of DNA leading to cancer 1 Arthur Author Under development: Not open for comment. Do not cite Under Development DNA alkylation cancer
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development alpha Norad Receptors delayed ovulation 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development Alpha2u adenomas and carcinomas 1.29
104 Altered ion channel activity leading impaired heart function Allie Always Under development: Not open for comment. Do not cite Under Development multiple impaired heart function 1.29
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
23 Androgen receptor agonism leading to reproductive dysfunction Agnes Aggy Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction EAGMST Approved 1.12
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development AR adverse effects in the male foetus
6 Antagonist binding to PPARα leading to body-weight loss Allie Always Open for comment. Do not cite Included in OECD Work Plan PPAR starvation-like body-weight loss EAGMST Under Review 2.3
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.31
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
205 AOP from chemical insult to cell death Evgeniia Kazymova Open for comment. Do not cite Under Development
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
25 Aromatase inhibition leading to reproductive dysfunction Allie Always Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
309 Aryl hydrocarbon receptor (AhR) Activation Leads to Early life stage mortality Increase X2 Arthur Author Under development: Not open for comment. Do not cite
305 Aryl hydrocarbon receptor (AhR) leads to Early life stage mortality Arthur Author Under development: Not open for comment. Do not cite
295 Aryl hydrocarbon receptor (AhR), Activation Arthur Author Under development: Not open for comment. Do not cite
311 Aryl hydrocarbon receptor (AhR), Activation leading to Early life stage mortality Arthur Author Under development: Not open for comment. Do not cite
310 Aryl hydrocarbon receptor (AhR), Activation leads to Early life stage mortality, Increase Arthur Author Under development: Not open for comment. Do not cite
150 Aryl hydrocarbon receptor activation leading to embryolethality via cardiotoxicty Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.7
131 Aryl hydrocarbon receptor activation leading to uroporphyria Agnes Aggy Open for comment. Do not cite Included in OECD Work Plan AhR uroporphyria EAGMST Under Review 1.7
298 Aryl hydrocarbon receptor effect on Mortality Arthur Author Under development: Not open for comment. Do not cite
96 Axonal sodium channel modulation leading to acute mortality Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development sodium channel acute mortality 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Arthur Author Under development: Not open for comment. Do not cite Under Development 1.29
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins during brain development leads to impairment of learning and memory Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration Under Development 1.13
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures Arthur Author Open for comment. Do not cite Included in OECD Work Plan GABA epileptic seizures EAGMST Under Review 1.15
26 Calcium-mediated neuronal ROS production and energy imbalance Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development unclear energy imbalance
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development tubulin? aneuploid offspring
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Allie Always Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration EAGMST Approved 1.13
220 Chronic Cyp2E1 Activation Leading to Liver Cancer Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.24
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Agnes Aggy Under development: Not open for comment. Do not cite Under Development cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
301 Cognitive function, decreased Arthur Author Under development: Not open for comment. Do not cite
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Arthur Author Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.18
267 Covalent binding Arthur Author Under development: Not open for comment. Do not cite
265 covalent binding proteins leading to skin sensitization Arthur Author Under development: Not open for comment. Do not cite
263 Covalent binding to proteins leading to dermal sensitization Arthur Author Under development: Not open for comment. Do not cite
270 Covalent Binding to Proteins Leading to Skin Sens Arthur Author Under development: Not open for comment. Do not cite
264 covalent binding to proteins leading to skin sensitization Arthur Author Under development: Not open for comment. Do not cite
269 covalent binding to proteins sensitizes skin Arthur Author Under development: Not open for comment. Do not cite
40 Covalent Protein binding leading to Skin Sensitisation Allie Always Open for citation & comment Included in OECD Work Plan TFHA/WNT Endorsed 1.1
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
28 Cyclooxygenase inhibition leading reproductive failure Arthur Author Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive failure 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Arthur Author Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Arthur Author Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Agnes Aggy Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Allie Always Under development: Not open for comment. Do not cite Under Development cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development cytotox is not MIE renal tubular adenomas and carcinomas 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Arthur Author Under development: Not open for comment. Do not cite Under Development glucose oxidase colony loss/failure 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development AR leydig cell tumors 1.29
158 Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
157 Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
156 Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
155 Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
43 Disruption of VEGFR Signaling Leading to Developmental Defects Arthur Author Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
240 DNA Adducts Leading to Liver Hemangiosarcoma Evgeniia Kazymova Under development: Not open for comment. Do not cite
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1.29
4 Ecdysone receptor agonism leading to mortality Arthur Author Open for citation & comment Under Development EcR mortality
148 EGFR Activation Leading to Decreased Lung Function Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development PPARg adipogenesis 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development cytotox not MIE forestomach tumors 1.29
53 ER agonism leading to reduced survival due to renal failure Allie Always Under development: Not open for comment. Do not cite Under Development ER reduced survival 1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Agnes Aggy Under development: Not open for comment. Do not cite Under Development ER altered sexual differentiation 1.29
199 ER mediated breast cancer AOP Allie Always Under development: Not open for comment. Do not cite Under Development
315 Estrogen leads to population decrease Arthur Author Under development: Not open for comment. Do not cite
282 estrogen leads to x Arthur Author Under development: Not open for comment. Do not cite
278 estrogen leads to Y Arthur Author Under development: Not open for comment. Do not cite
317 estrogen receptor Arthur Author Under development: Not open for comment. Do not cite
300 Estrogen receptor (ER) and activation substances Arthur Author Under development: Not open for comment. Do not cite
292 Estrogen receptor (ER) leading to Population trajectory Decrease Arthur Author Under development: Not open for comment. Do not cite
279 Estrogen receptor (ER), Antagonism Arthur Author Under development: Not open for comment. Do not cite
146 Estrogen Receptor Activation and Female Precocious Puberty Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development ER 1.29
200 Estrogen receptor activation leading to breast cancer Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
29 Estrogen receptor agonism leading to reproductive dysfunction Agnes Aggy Under development: Not open for comment. Do not cite Under Development ER reproductive dysfunction 1.29
303 Estrogen receptor antagonism leading to decrease of population trajectory Arthur Author Under development: Not open for comment. Do not cite
30 Estrogen receptor antagonism leading to reproductive dysfunction Allie Always Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
307 Estrogen receptor antagonism leading to the decrease of population trajectory Arthur Author Under development: Not open for comment. Do not cite
286 Estrogen receptor leads to decreaesed fecundity Arthur Author Under development: Not open for comment. Do not cite
277 estrogen to Y Arthur Author Under development: Not open for comment. Do not cite
276 estrogenl leads to Y Arthur Author Under development: Not open for comment. Do not cite
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development ERG reduced survival 1.29
216 Excessive reactive oxygen species production leading to reproductive dysfunction Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
238 Excessive reactive oxygen species production leading to reproductive failure Agnes Aggy Under development: Not open for comment. Do not cite
285 GABA receptor leads to Y Arthur Author Under development: Not open for comment. Do not cite
217 Gastric ulcer formation Arthur Author Under development: Not open for comment. Do not cite Under Development
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Agnes Aggy Under development: Not open for comment. Do not cite Under Development GR decreased male fertitlity 1.29
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development GR increased disease susceptibility 1.29
113 Glutamate-gated chloride channel activation leading to acute mortality Agnes Aggy Under development: Not open for comment. Do not cite Under Development GluCl Channel acute mortality 1.29
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Allie Always Under development: Not open for comment. Do not cite Under Development
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Arthur Author Under development: Not open for comment. Do not cite Under Development 1.29
308 haha Arthur Author Under development: Not open for comment. Do not cite
211 Handbook development AOP Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
229 Helicobacter pylori to gastric ulcer Allie Always Under development: Not open for comment. Do not cite Under Development
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Allie Always Under development: Not open for comment. Do not cite Under Development H2 reduced survival 1.29
212 Histone deacetylase inhibition leading to testicular toxicity Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.52
124 HMG-CoA reductase inhibition leading to decreased fertility Allie Always Under development: Not open for comment. Do not cite Under Development HMG-CoA reductase decreased fertility 1.29
59 HNF4alpha suppression leading to hepatic steatosis Agnes Aggy Under development: Not open for comment. Do not cite Under Development HNF4alpha hepatic steatosis 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Allie Always Under development: Not open for comment. Do not cite Under Development HPPD corneal papillomas and carcinomas 1.29
202 In-utero DNA topoisomerase II poisons leading to infant leukaemia Arthur Author Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Arthur Author Under development: Not open for comment. Do not cite Under Development dopamine?? endometrial adenocarcinomas 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development metabolic stress is not MIE colony loss/failure 1.29
173 Increased substance interaction with the resident cell membrane components leading to lung fibrosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.32
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 5α-reductase leydig cell tumors 1.29
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Arthur Author Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.38
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Agnes Aggy Under development: Not open for comment. Do not cite Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Allie Always Under development: Not open for comment. Do not cite Under Development
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Agnes Aggy Under development: Not open for comment. Do not cite Under Development
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development nitric oxide liver tumors
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development NIS follicular cell adenomas and carcinomas 1.29
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Arthur Author Under development: Not open for comment. Do not cite
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Evgeniia Kazymova Under development: Not open for comment. Do not cite
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Evgeniia Kazymova Open for comment. Do not cite Included in OECD Work Plan NIS learning and memory deficits in children EAGMST Under Review 1.28
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Agnes Aggy Under development: Not open for comment. Do not cite Under Development pyruvate dehydrogenase hepatocellular carcinoma 1.29
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired EAGMST Approved 1.33
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Allie Always Under development: Not open for comment. Do not cite Under Development TPO follicular cell adenomas and carcinomas 1.29
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Brendan Ferreri-Hanberry Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes EAGMST Under Review 1.10
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.41
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Agnes Aggy Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
128 Kidney dysfunction by decreased thyroid hormone Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
33 Kidney toxicity induced by activation of 5HT2C Arthur Author Under development: Not open for comment. Do not cite Under Development 5-HTT2c kidney toxicity
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
294 leptin Arthur Author Under development: Not open for comment. Do not cite
287 leptin receptor Arthur Author Under development: Not open for comment. Do not cite
275 LSETAC AHR gene expression inhibition causes hepatic uroporphyria Arthur Author Under development: Not open for comment. Do not cite
274 LSETAC DNA Alkylation Arthur Author Under development: Not open for comment. Do not cite
273 LSETAC-Practice AOP Arthur Author Under development: Not open for comment. Do not cite
34 LXR activation leading to hepatic steatosis Agnes Aggy Under development: Not open for comment. Do not cite Under Development LXR liver steatosis
144 Lysosomal damage leading to liver inflammation Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation Under Development 1.47
296 maybe Arthur Author Under development: Not open for comment. Do not cite
261 McQAOP1Jan16 Morris McQ Under development: Not open for comment. Do not cite
262 McQJan19AOP Morris McQ Under development: Not open for comment. Do not cite
222 Mental stress to agitation Arthur Author Under development: Not open for comment. Do not cite Under Development
221 Mental stress to depression Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development GR modulation of leydig cell function 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Arthur Author Under development: Not open for comment. Do not cite Under Development proteins - undefined modulation of leydig cell function 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Agnes Aggy Under development: Not open for comment. Do not cite Under Development multiple modulation of leydig cell function 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development estradiol modulation of leydig cell function 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development GR modulation of leydig cell function 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Agnes Aggy Under development: Not open for comment. Do not cite Under Development unk modulation of leydig cell function 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Allie Always Under development: Not open for comment. Do not cite Under Development modulation of leydig cell function 1.29
260 MoEPA_AOP1Jan16 Mo Marikar Open for adoption Included in OECD Work Plan MoEPA_MIE1Jan16 MoAO2Jan16 TFHA/WNT Endorsed 3.0
259 MoJan16AOP1 Mo Marikar Under development: Not open for comment. Do not cite
215 Molecular events lead to epilepsy Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Allie Always Under development: Not open for comment. Do not cite
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Agnes Aggy Under development: Not open for comment. Do not cite Under Development
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Arthur Author Under development: Not open for comment. Do not cite Under Development
35 Narcosis leading to respiratory failure Allie Always Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
214 Network of SSRIs (selective serotonin reuptake inhibitors) Allie Always Under development: Not open for comment. Do not cite Under Development
232 NFE2/Nrf2 repression to steatosis Arthur Author Under development: Not open for comment. Do not cite Under Development
61 NFE2L2/FXR activation leading to hepatic steatosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development multiple hepatic steatosis 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Allie Always Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Allie Always Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Arthur Author Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Allie Always Under development: Not open for comment. Do not cite Under Development PXR hepatic steatosis 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Arthur Author Under development: Not open for comment. Do not cite Under Development CAR hepatic steatosis 1.29
227 NSAID induced PTGS1 inactivation to gastric ulcer Arthur Author Under development: Not open for comment. Do not cite Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Agnes Aggy Under development: Not open for comment. Do not cite Under Development
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development p-amino hippuric acid renal failure and mortality 1.29
31 Oxidation of iron in hemoglobin leading to hematotoxicity Evgeniia Kazymova Under development: Not open for comment. Do not cite Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Allie Always Under development: Not open for comment. Do not cite
192 Pendrin inhibition leading to altered amphibian metamorphosis Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
149 Peptide Oxidation Leading to Hypertension Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.50
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan case study Under Development 2.5
280 Perkinsus makes manila clam die Arthur Author Under development: Not open for comment. Do not cite
316 Perkinsus olseni, Mortality Arthur Author Under development: Not open for comment. Do not cite
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development b-oxidation fatty acid steatosis 1.29
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Proposed for OECD Work Plan Proposal submitted - for discussion in June 2017
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Allie Always Under development: Not open for comment. Do not cite Under Development
283 phagocytosis capacity Arthur Author Under development: Not open for comment. Do not cite
130 Phospholipase A inhibitors lead to hepatotoxicity Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
289 Population trajectory, decreased Arthur Author Under development: Not open for comment. Do not cite
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Allie Always Under development: Not open for comment. Do not cite Under Development 1.29
37 PPARalpha-dependent liver cancer Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
18 PPARα activation in utero leading to impaired fertility in males Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
51 PPARα activation leading to impaired fertility in adult male rodents Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
230 presynaptic neuron 1 activation to epilepsy Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
231 presynaptic neuron 2 repression to epilepsy Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Arthur Author Under development: Not open for comment. Do not cite Under Development Prolyl hydroxylase reproductive dysfunction 1.29
38 Protein Alkylation leading to Liver Fibrosis Arthur Author Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
185 Queen egg-laying decrease leads to colony loss/failure Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
258 Renal protein alkylation leading to kidney toxicity Arthur Author Under development: Not open for comment. Do not cite
284 ROS leading to apoptosis Arthur Author Under development: Not open for comment. Do not cite
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Arthur Author Under development: Not open for comment. Do not cite
39 Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Agnes Aggy Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Evgeniia Kazymova Under development: Not open for comment. Do not cite
225 Serotonin transporter activation to agitation Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development
224 Serotonin transporter activation to depression Allie Always Under development: Not open for comment. Do not cite Under Development
223 Serotonin transporter activation to seizure Agnes Aggy Under development: Not open for comment. Do not cite Under Development
197 Sodium channel (Nav1.1) inhibition leading to population decline Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
94 Sodium channel inhibition leading to congenital malformations Allie Always Under development: Not open for comment. Do not cite Under Development sodium channel congenital malformations 1.29
93 sodium channel inhibition leading to increased predation Agnes Aggy Under development: Not open for comment. Do not cite Under Development sodium channel increased predation 1.29
91 Sodium channel inhibition leading to reduced survival Arthur Author Under development: Not open for comment. Do not cite Under Development sodium channel reduced survival 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Allie Always Under development: Not open for comment. Do not cite Under Development NIS neurodevelopmental outcomes 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Arthur Author Under development: Not open for comment. Do not cite Under Development 1.29
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development
281 stupid kid aop Arthur Author Under development: Not open for comment. Do not cite
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development unclear colony loss/failure 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development unclear colony loss/failure 1.29
41 Sustained AhR Activation leading to Rodent Liver Tumours Evgeniia Kazymova Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
266 Terbinafine Metabolism resulting in a Reactive Aldehyde and Consequent Hepatotoxicity Arthur Author Under development: Not open for comment. Do not cite
293 thyroperoxidase inhibition Arthur Author Under development: Not open for comment. Do not cite
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
159 Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Arthur Author Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
313 Thyroperoxidase, Inhibition Arthur Author Under development: Not open for comment. Do not cite
288 Thyroperoxidase, Inhibition leads to Cognitive function, decreased Arthur Author Under development: Not open for comment. Do not cite
290 Train Arthur Author Under development: Not open for comment. Do not cite
291 Train-Gui Arthur Author Under development: Not open for comment. Do not cite
271 Training AOP Arthur Author Under development: Not open for comment. Do not cite
272 Training AOP2 Arthur Author Under development: Not open for comment. Do not cite
268 Try Arthur Author Under development: Not open for comment. Do not cite
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Arthur Author Under development: Not open for comment. Do not cite Under Development 1.29
245 Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Allie Always Under development: Not open for comment. Do not cite
186 unknown MIE leading to renal failure and mortality Arthur Author Under development: Not open for comment. Do not cite Under Development 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Agnes Aggy Under development: Not open for comment. Do not cite Under Development Unknown reproductive dysfunction 1.29
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development unclear urothelial papillomas and carcinomas 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Brendan Ferreri-Hanberry Under development: Not open for comment. Do not cite Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Evgeniia Kazymova Under development: Not open for comment. Do not cite Under Development 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Arthur Author Under development: Not open for comment. Do not cite Under Development
182 Weather event contributes abnormal foraging leading to colony loss/failure Agnes Aggy Under development: Not open for comment. Do not cite Under Development 1.29
181 Weather event contributes to colony loss/failure Arthur Author Under development: Not open for comment. Do not cite Under Development 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Arthur Author Under development: Not open for comment. Do not cite Under Development DBH reduced fecundity 1.29