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KE Relationships

ID Upstream Event Downstream Event Creation Date Last Updated AOPs
5 Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Reduction, Plasma 17beta-estradiol concentrations Nov 29, 2016 Mar 20, 2017
  • Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
  • Aromatase inhibition leading to reproductive dysfunction
  • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
  • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
  • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
  • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
9 Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity Decreased, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
  • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
750 Activation, 5HT2c N/A, Unknown Nov 29, 2016 Dec 3, 2016
  • Kidney toxicity induced by activation of 5HT2C
454 ACh Synaptic Accumulation Increased, Atrioventricular block and bradycardia Nov 29, 2016 Nov 29, 2016
    456 ACh Synaptic Accumulation Increased Cholinergic Signaling Nov 29, 2016 Dec 20, 2019
    • Acetylcholinesterase inhibition leading to acute mortality
    • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
    • Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
    459 ACh Synaptic Accumulation AchE Inhibition Nov 29, 2016 Dec 3, 2016
    • Various neuronal effects induced by elavl3, sox10, and mbp
    1857 ACh Synaptic Accumulation Activation, Muscarinic Acetylcholine Receptors Feb 13, 2019 Sep 3, 2023
    • Acetylcholinesterase Inhibition Leading to Neurodegeneration
    452 AchE Inhibition Increased Mortality Nov 29, 2016 Dec 20, 2019
    • Acetylcholinesterase inhibition leading to acute mortality
    453 AchE Inhibition Decreased, Population trajectory Nov 29, 2016 Dec 20, 2019
      11 AchE Inhibition ACh Synaptic Accumulation Nov 29, 2016 Sep 10, 2023
      • Acetylcholinesterase inhibition leading to acute mortality
      • Acetylcholinesterase Inhibition Leading to Neurodegeneration
      • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
      • Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
      449 AchE Inhibition Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016
        450 AchE Inhibition Respiratory distress/arrest Nov 29, 2016 Dec 20, 2019
        • Acetylcholinesterase inhibition leading to acute mortality
        451 AchE Inhibition Increased Cholinergic Signaling Nov 29, 2016 Dec 20, 2019
        • Acetylcholinesterase inhibition leading to acute mortality
        • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
        2653 AchE Inhibition Activation of Cyp2E1 May 16, 2022 May 16, 2022
        • Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
        3063 AchE Inhibition Increase, CNS Neural cell death Oct 17, 2023 Oct 17, 2023
        • Various neuronal effects induced by elavl3, sox10, and mbp
        3064 AchE Inhibition Dysfunctional synapses Oct 17, 2023 Oct 17, 2023
        • Various neuronal effects induced by elavl3, sox10, and mbp
        2014 AchE Inhibition Impaired coordination and movement Dec 20, 2019 Dec 20, 2019
        • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
        2016 AchE Inhibition Decrease, Population growth rate Dec 20, 2019 Dec 20, 2019
        • Acetylcholinesterase inhibition leading to acute mortality
        2007 AchE Inhibition Cardiovascular dysregulation Nov 25, 2019 Dec 20, 2019
        • Acetylcholinesterase inhibition leading to acute mortality
        16 Altered expression of AHR/ARNT pathway-dependent genes Altered, Cardiovascular development/function Nov 29, 2016 Dec 3, 2016
          17 Altered expression of AHR/ARNT pathway-dependent genes Up Regulation, CYP1A1 Nov 29, 2016 Dec 3, 2016
            18 Activation, AhR Altered expression of AHR/ARNT pathway-dependent genes Nov 29, 2016 Dec 3, 2016
              19 Activation, AhR Up Regulation, CYP1A1 Nov 29, 2016 Dec 3, 2016
              • AhR activation leading to hepatic steatosis
              • AhR activation leading to liver fibrosis
              1992 Activation, AhR Increase, DNMT expression Oct 30, 2019 Oct 30, 2019
                473 Activation, AhR Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
                • AhR activation leading to hepatic steatosis
                495 Activation, AhR Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
                • AhR activation leading to hepatic steatosis
                496 Activation, AhR Increased, FA Influx Nov 29, 2016 Dec 3, 2016
                  499 Activation, AhR Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Nov 29, 2016 Dec 3, 2016
                  • AhR activation leading to hepatic steatosis
                  506 Activation, AhR Up Regulation, LDLR (low density lipoprotein receptor) Nov 29, 2016 Dec 3, 2016
                  • AhR activation leading to hepatic steatosis
                  509 Activation, AhR Suppression, VLDL secretion Nov 29, 2016 Dec 3, 2016
                  • AhR activation leading to hepatic steatosis
                  984 Activation, AhR Increase, Early Life Stage Mortality Nov 29, 2016 Apr 14, 2019
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
                  869 Activation, AhR Induction, CYP1A2/CYP1A5 Nov 29, 2016 May 7, 2018
                  • Aryl hydrocarbon receptor activation leading to uroporphyria
                  • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                  972 Activation, AhR dimerization, AHR/ARNT Nov 29, 2016 Mar 22, 2018
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
                  • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                  • AhR activation leading to preeclampsia
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
                  • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
                  3219 Activation, AhR Increased, Liver Steatosis May 14, 2024 May 14, 2024
                  • AhR activation leading to liver fibrosis
                  2888 Activation, AhR N/A, Liver Steatosis Apr 13, 2023 Apr 13, 2023
                    2883 Activation, AhR Induction, Upregulation of glucuronyltransferase activity Apr 12, 2023 Apr 12, 2023
                    • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                    2687 Activation, AhR Increase, slincR expression Jun 30, 2022 Jun 30, 2022
                      2688 Activation, AhR Decrease, sox9 expression Jun 30, 2022 Apr 13, 2023
                      • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
                      • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
                      2689 Activation, AhR Smaller and morphologically distorted facial cartilage structures Jun 30, 2022 Apr 13, 2023
                      • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
                      2765 Activation, AhR Altered, Cardiovascular development/function Sep 27, 2022 Oct 21, 2022
                      • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
                      2571 Activation, AhR Increased, Migration (Endothelial Cells) Feb 15, 2022 Feb 29, 2024
                      • Activation of the AhR leading to metastatic breast cancer
                      2572 Activation, AhR Increased, Invasion Feb 15, 2022 Mar 5, 2024
                      • Activation of the AhR leading to metastatic breast cancer
                      2570 Activation, AhR Increased, Motility Feb 15, 2022 Feb 29, 2024
                      • Activation of the AhR leading to metastatic breast cancer
                      2569 Activation, AhR Apoptosis Feb 15, 2022 Dec 20, 2022
                      • Activation of the AhR leading to metastatic breast cancer
                      2568 Activation, AhR Increase, Inflammation Feb 15, 2022 Mar 5, 2024
                      • Activation of the AhR leading to metastatic breast cancer
                      1656 Activation, AhR Up Regulation, SCD-1 Aug 31, 2017 Aug 31, 2017
                      • AhR activation leading to hepatic steatosis
                      1384 Agonism, Androgen receptor Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Mar 17, 2017 Mar 20, 2017
                      • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                      1385 Agonism, Androgen receptor Reduction, Vitellogenin synthesis in liver Mar 17, 2017 Mar 20, 2017
                      • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                      2926 Agonism, Androgen receptor Reduction, the ratio of E2/11-KT in plasma May 22, 2023 May 22, 2023
                      • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                      2918 Agonism, Androgen receptor Increased, gene expression of AR May 22, 2023 May 22, 2023
                      • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                      31 Agonism, Androgen receptor Reduction, Gonadotropins, circulating concentrations Nov 29, 2016 Mar 20, 2017
                      • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                      32 Agonism, Androgen receptor Reduction, Testosterone synthesis by ovarian theca cells Nov 29, 2016 Mar 20, 2017
                      • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                      2349 Agonism, Androgen receptor Increased, Male Biased Sex Ratio Apr 12, 2021 Jan 3, 2023
                      • Androgen receptor agonism leading to male-biased sex ratio
                      2260 Agonism, Androgen receptor Increased, Differentiation to Testis Jan 12, 2021 Jan 3, 2023
                      • Androgen receptor agonism leading to male-biased sex ratio
                      2201 Antagonism, Androgen receptor Altered, Transcription of genes by the AR Nov 2, 2020 Feb 2, 2021
                        2123 Antagonism, Androgen receptor AGD, decreased May 11, 2020 Aug 7, 2020
                        • Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
                        2133 Antagonism, Androgen receptor nipple retention, increased May 11, 2020 Jan 11, 2023
                        • Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
                        2130 Antagonism, Androgen receptor Decrease, AR activation May 11, 2020 Apr 5, 2024
                        • Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
                        • Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
                        • Androgen receptor (AR) antagonism leading to hypospadias in male offspring
                        • Androgen receptor (AR) antagonism leading to decreased fertility in females
                        35 N/A, Androgen receptor, Antagonism Alteration, Wnt pathway Nov 29, 2016 Dec 3, 2016
                        • Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
                        33 N/A, Androgen receptor, Antagonism Altered, Transcription of genes by the AR Nov 29, 2016 Dec 3, 2016
                        • Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
                        36 Reduction, Angiogenesis Impairment, Endothelial network Nov 29, 2016 Jan 18, 2022
                        • Disruption of VEGFR Signaling Leading to Developmental Defects
                        43 Decrease, Aromatase (Cyp19a1) Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Dec 3, 2016
                          45 Inhibition, Aromatase Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Nov 30, 2016
                          • Aromatase inhibition leading to reproductive dysfunction
                          2167 Inhibition, Aromatase Increased, Differentiation to Testis Jul 28, 2020 Dec 28, 2022
                          • Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
                          2350 Inhibition, Aromatase Increased, Male Biased Sex Ratio Apr 13, 2021 Jan 10, 2023
                          • Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
                          1767 Inhibition, Aromatase Altered regulation, Alpha hemoglobin Sep 13, 2018 Sep 13, 2018
                            2144 Inhibition, Aromatase Reduction, E2 Synthesis by the undifferentiated gonad Jun 15, 2020 Jul 11, 2022
                            • Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
                            2011 Increased Cholinergic Signaling Impaired coordination and movement Dec 20, 2019 Dec 20, 2019
                            • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
                            2005 Increased Cholinergic Signaling Cardiovascular dysregulation Nov 25, 2019 Dec 20, 2019
                            • Acetylcholinesterase inhibition leading to acute mortality
                            2412 Increased Cholinergic Signaling Cognitive Function, Decreased Jun 24, 2021 Sep 1, 2021
                            • Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
                            2410 Increased Cholinergic Signaling Neuronal network function, Decreased Jun 24, 2021 Sep 1, 2021
                            • Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
                            51 Increased Cholinergic Signaling Decrease, Population growth rate Nov 29, 2016 Dec 3, 2016
                              434 Increased Cholinergic Signaling Increased Mortality Nov 29, 2016 Dec 3, 2016
                                457 Increased Cholinergic Signaling Respiratory distress/arrest Nov 29, 2016 Dec 20, 2019
                                • Acetylcholinesterase inhibition leading to acute mortality
                                1601 Decrease, Mitochondrial ATP production Decrease, Oogenesis Jun 29, 2017 Jun 29, 2017
                                  1670 Decrease, Mitochondrial ATP production Decrease, Leaf cell mitosis Oct 10, 2017 Oct 10, 2017
                                  • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                  1682 Decrease, Mitochondrial ATP production Increase, Cytotoxicity (renal tubular cell) Oct 25, 2017 Oct 25, 2017
                                  • Renal protein alkylation leading to kidney toxicity
                                  1739 Decrease, Mitochondrial ATP production Decrease, Growth May 24, 2018 May 24, 2018
                                    1750 Decrease, Mitochondrial ATP production Increase, Apoptosis Jun 12, 2018 Jun 12, 2018
                                      2823 Decrease, Mitochondrial ATP production Decrease, Cardiac contractility Jan 5, 2023 Jan 5, 2023
                                      • Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
                                      1873 Decrease, Mitochondrial ATP production Increase, Necrosis Mar 19, 2019 Mar 19, 2019
                                        2551 Decrease, Mitochondrial ATP production Decrease, Reproduction Jan 21, 2022 Jan 21, 2022
                                        • Deposition of ionising energy leading to population decline via mitochondrial dysfunction
                                        927 Inhibition, Bile Salt Export Pump (ABCB11) Bile accumulation, Pathological condition Nov 29, 2016 Dec 3, 2016
                                        • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                        59 Reduction, Ca and HCO3 transport to shell gland Reduction, Eggshell thickness Nov 29, 2016 Dec 3, 2016
                                        • Cyclooxygenase inhibition leading reproductive failure
                                        60 Increase, Ca++ (intracellular) Disruption, Mitochondrial electron transport chain Nov 29, 2016 Dec 3, 2016
                                        • Calcium-mediated neuronal ROS production and energy imbalance
                                        61 Inhibition, Ca++ ATPase Increase, Ca++ (intracellular) Nov 29, 2016 Dec 3, 2016
                                        • Calcium-mediated neuronal ROS production and energy imbalance
                                        62 Decreased, Calcium influx Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016
                                          347 Decreased, Calcium influx BDNF, Reduced Nov 29, 2016 Jun 13, 2018
                                          • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                          • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                          66 Up Regulation, CD36 Increase, FA Influx Nov 29, 2016 Mar 27, 2024
                                          • LXR activation leading to hepatic steatosis
                                          • Pregnane X Receptor (PXR) activation leads to liver steatosis
                                          501 Up Regulation, CD36 Increased, FA Influx Nov 29, 2016 Dec 3, 2016
                                          • AhR activation leading to hepatic steatosis
                                          • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                          • NR1I3 (CAR) suppression leading to hepatic steatosis
                                          2262 Up Regulation, CD36 Increased, Fatty acid uptake Jan 15, 2021 Jan 15, 2021
                                            924 Cell injury/death Release, Cytokine Nov 29, 2016 Nov 9, 2018
                                              1718 Cell injury/death Tissue resident cell activation Feb 1, 2018 Aug 2, 2018
                                              • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                              • Protein Alkylation leading to Liver Fibrosis
                                              1688 Cell injury/death Neuronal network function, Decreased Nov 9, 2017 Feb 5, 2020
                                              • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                              67 Cell injury/death Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) Nov 29, 2016 Nov 29, 2016
                                                68 Cell injury/death Activation, Stellate cells Nov 29, 2016 Nov 29, 2016
                                                • Protein Alkylation leading to Liver Fibrosis
                                                • AhR activation leading to liver fibrosis
                                                355 Cell injury/death Synaptogenesis, Decreased Nov 29, 2016 Nov 29, 2016
                                                • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                364 Cell injury/death N/A, Neurodegeneration Nov 29, 2016 Sep 10, 2023
                                                • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                365 Cell injury/death Neuroinflammation Nov 29, 2016 Jul 15, 2022
                                                • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                2875 Cell injury/death Hippocampal Physiology, Altered Apr 5, 2023 Apr 5, 2023
                                                • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                2890 Cell injury/death Leukocyte recruitment/activation Apr 13, 2023 Apr 13, 2023
                                                • AhR activation leading to liver fibrosis
                                                3198 Cell injury/death Mitochondrial dysfunction Apr 17, 2024 Apr 17, 2024
                                                  3197 Cell injury/death Disruption of the intestinal barrier Apr 17, 2024 Apr 17, 2024
                                                  • Endocytotic lysosomal uptake leads to intestinal barrier disruption
                                                  1863 Cell injury/death Neurodegeneration Feb 19, 2019 Feb 19, 2019
                                                    1831 Cell injury/death Activation, Tissue resident cells (Kuppfer cells) Jan 7, 2019 Jan 7, 2019
                                                    • IKK complex inhibition leading to liver injury
                                                    1830 Cell injury/death Necrotic Tissue Jan 7, 2019 Mar 7, 2019
                                                    • IKK complex inhibition leading to liver injury
                                                    • Mitochondrial complex inhibition leading to liver injury
                                                    1776 Cell injury/death Increased pro-inflammatory mediators Nov 12, 2018 Nov 12, 2018
                                                    • Endocytic lysosomal uptake leading to liver fibrosis
                                                    2767 Cell injury/death Decrease, Growth Sep 27, 2022 Sep 27, 2022
                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
                                                    69 Proliferation, Cell proliferation in the absence of cytotoxicity Hyperplasia, Hyperplasia Nov 29, 2016 Dec 3, 2016
                                                    • Uncharacterized liver damage leading to hepatocellular carcinoma
                                                    70 Induction, Chitin degradation and resorption Induction, Pre-mature molting Nov 29, 2016 Dec 3, 2016
                                                      667 Reduction, Ionotropic GABA receptor chloride channel conductance Reduction, Neuronal synaptic inhibition Nov 29, 2016 Apr 29, 2019
                                                      • Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
                                                      483 Activation, ChREBP Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
                                                      • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                      77 Activation, ChREBP Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
                                                      • LXR activation leading to hepatic steatosis
                                                      82 Accumulation, Collagen N/A, Liver fibrosis Nov 29, 2016 Dec 5, 2018
                                                      • Protein Alkylation leading to Liver Fibrosis
                                                      • Endocytic lysosomal uptake leading to liver fibrosis
                                                      2139 Accumulation, Collagen Lung fibrosis May 15, 2020 May 15, 2020
                                                      • Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
                                                      • Binding to ACE2 leading to lung fibrosis
                                                      1629 Accumulation, Collagen Pulmonary fibrosis Jul 26, 2017 May 18, 2023
                                                      • Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
                                                      • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                      1700 N/A, Covalent binding to protein, possibly lysine residue Activation, Dendritic Cells Dec 7, 2017 Sep 24, 2020
                                                        88 N/A, Covalent binding to protein, possibly lysine residue Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Nov 29, 2016 Sep 24, 2020
                                                          93 Production, Critical Metabolites (CGA 330050 and CGA 265307) Induction, Liver “Dysfunctional” Changes by CGA 330050 Nov 29, 2016 Dec 3, 2016
                                                          • Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
                                                          94 Reduction, Cumulative fecundity and spawning Decrease, Population growth rate Nov 29, 2016 Mar 20, 2017
                                                          • Aromatase inhibition leading to reproductive dysfunction
                                                          • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                          • Estrogen receptor antagonism leading to reproductive dysfunction
                                                          • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                          • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                          • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                          • Inhibition of 5α-reductase leading to impaired fecundity in female fish
                                                          • Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
                                                          • Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
                                                          • Deposition of energy leading to population decline via DNA oxidation and follicular atresia
                                                          • Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
                                                          2142 Reduction, Cumulative fecundity and spawning Decline, Population May 25, 2020 May 25, 2020
                                                            2924 Reduction, Cumulative fecundity and spawning Decreased, Population trajectory May 22, 2023 May 22, 2023
                                                            • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                            95 Inhibition, Cyclooxygenase activity Reduction, Prostaglandin E2 concentration Nov 29, 2016 Dec 3, 2016
                                                            • Cyclooxygenase inhibition leading reproductive failure
                                                            670 Inhibition, Cyclooxygenase activity Reduced, Prostaglandin F2alpha synthesis, ovary Nov 29, 2016 Dec 3, 2016
                                                            • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
                                                            681 Inhibition, Cyclooxygenase activity Decreased, Prostaglandin F2alpha synthesis, ovary Nov 29, 2016 Dec 3, 2016
                                                            • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
                                                            686 Inhibition, Cyclooxygenase activity Reduced, Prostaglandins, ovary Nov 29, 2016 Dec 3, 2016
                                                            • Cyclooxygenase inhibition leading to reproductive dysfunction
                                                            689 Inhibition, Cyclooxygenase activity Reduced, Prostaglandin E2 concentration, hypothalamus Nov 29, 2016 Dec 3, 2016
                                                            • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                            • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                            96 Up Regulation, CYP1A1 Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                              2887 Up Regulation, CYP1A1 Increase, ROS Apr 13, 2023 Apr 13, 2023
                                                              • AhR activation leading to liver fibrosis
                                                              104 Up Regulation, CYP1B1 Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Dec 3, 2016
                                                                108 Release, Cytokine Increase, Inflammation Nov 29, 2016 Dec 3, 2016
                                                                • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                925 Release, Cytokine Infiltration, Inflammatory cytokines Nov 29, 2016 Dec 3, 2016
                                                                  994 Release, Cytokine Infiltration, Inflammatory cells Nov 29, 2016 Nov 29, 2016
                                                                    2455 Release, Cytokine Neutrophil activation, Increased Aug 4, 2021 Aug 4, 2021
                                                                    • Endothelial cell dysfunction leading to thromboinflammation
                                                                    2454 Release, Cytokine Platelet activation, Increased Aug 4, 2021 Aug 4, 2021
                                                                    • Endothelial cell dysfunction leading to thromboinflammation
                                                                    1963 Release, Cytokine Recruitment of inflammatory cells Jul 3, 2019 Jul 3, 2019
                                                                    • Frustrated phagocytosis-induced lung cancer
                                                                    • Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
                                                                    110 Synthesis, De Novo Fatty Acid (FA) Accumulation, Triglyceride Nov 29, 2016 Mar 29, 2024
                                                                    • LXR activation leading to hepatic steatosis
                                                                    • Liver X Receptor (LXR) activation leads to liver steatosis
                                                                    23 Alkylation, DNA Increase, Heritable mutations in offspring Nov 29, 2016 Nov 29, 2016
                                                                    • Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
                                                                    24 Alkylation, DNA Inadequate DNA repair Nov 29, 2016 Dec 10, 2019
                                                                    • Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
                                                                    • Alkylation of DNA leading to cancer 1
                                                                    • Alkylation of DNA leading to reduced sperm count
                                                                    25 Alkylation, DNA Increase, Mutations Nov 29, 2016 Nov 29, 2016
                                                                    • Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
                                                                    • Alkylation of DNA leading to cancer 1
                                                                    901 Alkylation, DNA Increase, Cancer Nov 29, 2016 Dec 3, 2016
                                                                    • Alkylation of DNA leading to cancer 1
                                                                    999 Increase, EcR agonism Decreased, synthesis and secretion of molting fluid proteases Nov 29, 2016 Dec 3, 2016
                                                                      998 Increase, EcR agonism Decrease, Circulating ETH Nov 29, 2016 Dec 3, 2016
                                                                        1007 Increase, EcR agonism Decreased, Synthesis of molting fluid proteases Nov 29, 2016 Dec 3, 2016
                                                                          116 Increase, EcR agonism Induction, Chitin degradation and resorption Nov 29, 2016 Dec 3, 2016
                                                                            1343 Increase, EcR agonism Increase, E75b expression Feb 9, 2017 Feb 9, 2017
                                                                            • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                            2565 Inhibition, ETC complexes of the respiratory chain Increase, Oxidative Stress Feb 8, 2022 Mar 7, 2022
                                                                            • Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
                                                                            2636 Inhibition, ETC complexes of the respiratory chain Decrease, MMP Apr 8, 2022 Apr 8, 2022
                                                                            • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                            2821 Inhibition, ETC complexes of the respiratory chain Mitochondrial dysfunction Jan 5, 2023 Jan 5, 2023
                                                                            • Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
                                                                            123 Reduction, Eggshell thickness N/A, Reproductive failure Nov 29, 2016 Dec 3, 2016
                                                                            • Cyclooxygenase inhibition leading reproductive failure
                                                                            125 Impairment, Endothelial network Insufficiency, Vascular Nov 29, 2016 Jan 18, 2022
                                                                            • Disruption of VEGFR Signaling Leading to Developmental Defects
                                                                            976 Impairment, Endothelial network Altered, Cardiovascular development/function Nov 29, 2016 Jun 9, 2017
                                                                            • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                                                                            126 Agonism, Estrogen receptor Altered, Reproductive behaviour Nov 29, 2016 Dec 3, 2016
                                                                            • Estrogen receptor agonism leading to reproductive dysfunction
                                                                            127 Agonism, Estrogen receptor Impaired development of, Reproductive organs Nov 29, 2016 Dec 3, 2016
                                                                            • Estrogen receptor agonism leading to reproductive dysfunction
                                                                            128 Agonism, Estrogen receptor Increase, Vitellogenin synthesis in liver Nov 29, 2016 Dec 3, 2016
                                                                            • Estrogen receptor agonism leading to reproductive dysfunction
                                                                            129 Antagonism, Estrogen receptor Reduction, Vitellogenin synthesis in liver Nov 29, 2016 Nov 30, 2016
                                                                            • Estrogen receptor antagonism leading to reproductive dysfunction
                                                                            2613 Antagonism, Estrogen receptor EMT Mar 22, 2022 Aug 27, 2023
                                                                            • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                            3120 Antagonism, Estrogen receptor inhibition, EKR1/2 signaling pathway Jan 25, 2024 Jan 25, 2024
                                                                            • Estrogen antagonism leading to increased risk of autism-like behavior
                                                                            132 Increase, FA Influx Accumulation, Triglyceride Nov 29, 2016 Mar 29, 2024
                                                                            • LXR activation leading to hepatic steatosis
                                                                            • Pregnane X Receptor (PXR) activation leads to liver steatosis
                                                                            133 Activation, FAS Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
                                                                            • LXR activation leading to hepatic steatosis
                                                                            1422 Activation, FAS Increased, lipogenesis Apr 13, 2017 Apr 13, 2017
                                                                              136 N/A, Gap Reduction, Ca and HCO3 transport to shell gland Nov 29, 2016 Dec 3, 2016
                                                                              • Cyclooxygenase inhibition leading reproductive failure
                                                                              385 Activation, Glucocorticoid Receptor Induction, IKB inhibitory protein Nov 29, 2016 Dec 3, 2016
                                                                              • Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
                                                                              1451 Activation, Glucocorticoid Receptor Reduced, BDNF Apr 14, 2017 Apr 14, 2017
                                                                              • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                              2261 Activation, Glucocorticoid Receptor Up Regulation, CD36 Jan 15, 2021 Jan 15, 2021
                                                                                2266 Activation, Glucocorticoid Receptor Decrease, ACAD Jan 15, 2021 Jan 15, 2021
                                                                                • Glucocorticoid Receptor activation leading to hepatic steatosis
                                                                                2039 Activation, Glucocorticoid Receptor Decreased, Mitochondrial Fatty Acid Beta Oxidation Feb 22, 2020 Feb 22, 2020
                                                                                  2041 Activation, Glucocorticoid Receptor Decreased, PPAR-alpha activation Feb 22, 2020 Feb 22, 2020
                                                                                    2077 Activation, Glucocorticoid Receptor Increase, Cripto-1 expression Apr 20, 2020 Jul 10, 2020
                                                                                    • Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
                                                                                    143 Reduction, Gonadotropins, circulating concentrations Reduction, Testosterone synthesis by ovarian theca cells Nov 29, 2016 Mar 20, 2017
                                                                                    • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                    2878 Depletion, GSH Increased, Reactive oxygen species Apr 5, 2023 Sep 14, 2023
                                                                                    • Glutathione conjugation leading to reproductive dysfunction via oxidative stress
                                                                                    146 Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                      147 Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) Up Regulation, TGFbeta1 expression Nov 29, 2016 Nov 29, 2016
                                                                                        996 N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Dec 2, 2016
                                                                                        • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                        154 Decreased, HSD17B10 expression Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity Nov 29, 2016 Dec 3, 2016
                                                                                        • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
                                                                                        158 Hyperplasia, Hyperplasia Promotion, Hepatocelluar carcinoma Nov 29, 2016 Dec 3, 2016
                                                                                        • Uncharacterized liver damage leading to hepatocellular carcinoma
                                                                                        386 Induction, IKB inhibitory protein Inhibition, Nuclear factor kappa B (NF-kB) Nov 29, 2016 Dec 3, 2016
                                                                                        • Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
                                                                                        159 Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Induction, Sustained Hepatotoxicity Nov 29, 2016 Dec 3, 2016
                                                                                        • Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
                                                                                        781 Increase, Inflammation Increase, Regenerative cell proliferation (forestomach epithelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                        • Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
                                                                                        929 Increase, Inflammation Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
                                                                                        • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                        2976 Increase, Inflammation General Apoptosis Jul 31, 2023 Oct 19, 2023
                                                                                        • Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
                                                                                        2573 Increase, Inflammation Increased, Invasion Feb 15, 2022 Mar 5, 2024
                                                                                        • Activation of the AhR leading to metastatic breast cancer
                                                                                        2574 Increase, Inflammation Increase, angiogenesis Feb 15, 2022 Dec 20, 2022
                                                                                        • Activation of the AhR leading to metastatic breast cancer
                                                                                        1839 Increase, Inflammation Fibroproliferative airway lesions Jan 30, 2019 Jan 30, 2019
                                                                                        • α-diketone-induced bronchiolitis obliterans
                                                                                        1724 Increase, Inflammation EMT Mar 18, 2018 Jan 30, 2019
                                                                                        • Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
                                                                                        • α-diketone-induced bronchiolitis obliterans
                                                                                        1722 Increase, Inflammation Expression of Collagen Mar 18, 2018 Mar 18, 2018
                                                                                          1699 Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Activation, Dendritic Cells Dec 7, 2017 Dec 3, 2020
                                                                                            388 Suppression, Inflammatory cytokines Decreased, Lymphocytes Nov 29, 2016 Dec 3, 2016
                                                                                            • Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
                                                                                            164 Inadequate DNA repair Increase, Mutations Nov 29, 2016 Mar 8, 2024
                                                                                            • Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
                                                                                            • Alkylation of DNA leading to cancer 2
                                                                                            • Alkylation of DNA leading to cancer 1
                                                                                            • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                            • Deposition of energy leading to lung cancer
                                                                                            • Bulky DNA adducts leading to mutations
                                                                                            • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                            • Deposition of energy leading to occurrence of cataracts
                                                                                            2817 Inadequate DNA repair Cataracts Dec 18, 2022 Mar 11, 2024
                                                                                            • Deposition of energy leading to occurrence of cataracts
                                                                                            1910 Inadequate DNA repair Increase, DNA strand breaks May 19, 2019 Jan 9, 2023
                                                                                            • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                            • Alkylation of DNA leading to reduced sperm count
                                                                                            1912 Inadequate DNA repair Increase, Chromosomal aberrations May 19, 2019 Mar 8, 2024
                                                                                            • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                            • Deposition of energy leading to lung cancer
                                                                                            • Deposition of energy leading to occurrence of cataracts
                                                                                            168 N/A, Interferences with SH-/selen-proteins Depletion, GSH Nov 29, 2016 Dec 3, 2016
                                                                                              169 Increase, Liver and splenic hemosiderosis N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Nov 29, 2016 Dec 3, 2016
                                                                                              • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                              170 Induction, Liver “Dysfunctional” Changes by CGA 330050 Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Nov 29, 2016 Dec 3, 2016
                                                                                              • Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
                                                                                              172 Activation, Long term AHR receptor driven direct and indirect gene expression changes N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Nov 29, 2016
                                                                                              • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                              874 Activation, Long term AHR receptor driven direct and indirect gene expression changes Changes/Inhibition, Cellular Homeostasis and Apoptosis Nov 29, 2016 Nov 29, 2016
                                                                                              • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                              875 Activation, Long term AHR receptor driven direct and indirect gene expression changes Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Nov 29, 2016
                                                                                              • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                              876 Activation, Long term AHR receptor driven direct and indirect gene expression changes Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Nov 29, 2016
                                                                                              • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                              479 Activation, LXR Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              490 Activation, LXR Up Regulation, FAS Nov 29, 2016 Dec 3, 2016
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              491 Activation, LXR Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              510 Activation, LXR Inhibition, PPAR alpha Nov 29, 2016 Dec 3, 2016
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              516 Activation, LXR Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Nov 29, 2016 Dec 3, 2016
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              177 Activation, LXR Activation, SREBP-1c Nov 29, 2016 Dec 3, 2016
                                                                                              • LXR activation leading to hepatic steatosis
                                                                                              176 Activation, LXR Activation, SCD-1 Nov 29, 2016 Dec 3, 2016
                                                                                              • LXR activation leading to hepatic steatosis
                                                                                              175 Activation, LXR Activation, FAS Nov 29, 2016 Dec 3, 2016
                                                                                              • LXR activation leading to hepatic steatosis
                                                                                              173 Activation, LXR Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
                                                                                              • LXR activation leading to hepatic steatosis
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              174 Activation, LXR Activation, ChREBP Nov 29, 2016 Dec 3, 2016
                                                                                              • LXR activation leading to hepatic steatosis
                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                              3103 Activation, LXR Increased, Expression of LXR activated genes Dec 7, 2023 Mar 29, 2024
                                                                                              • Liver X Receptor (LXR) activation leads to liver steatosis
                                                                                              390 Decreased, Lymphocytes Suppression, Immune system Nov 29, 2016 Dec 3, 2016
                                                                                              • Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
                                                                                              389 Decreased, Lymphocytes Increased, Disease susceptibility Nov 29, 2016 Dec 3, 2016
                                                                                                182 N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number N/A, Cyanosis occurs Nov 29, 2016 Dec 3, 2016
                                                                                                • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                363 Mitochondrial dysfunction Cell injury/death Nov 29, 2016 Nov 29, 2016
                                                                                                • Endocytic lysosomal uptake leading to liver fibrosis
                                                                                                • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                • Endocytotic lysosomal uptake leads to intestinal barrier disruption
                                                                                                3131 Mitochondrial dysfunction Increase, Apoptosis Feb 21, 2024 Feb 21, 2024
                                                                                                • Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
                                                                                                • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                3132 Mitochondrial dysfunction increased,Vascular endothelial dysfunction Feb 21, 2024 Feb 21, 2024
                                                                                                • Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
                                                                                                • The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
                                                                                                3134 Mitochondrial dysfunction Increase, Cytotoxicity (renal tubular cell) Feb 28, 2024 Mar 6, 2024
                                                                                                • Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
                                                                                                • Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
                                                                                                3152 Mitochondrial dysfunction Apoptotic cell death Mar 13, 2024 Mar 13, 2024
                                                                                                • Immune mediated hepatitis
                                                                                                3153 Mitochondrial dysfunction ER stress Mar 13, 2024 Mar 13, 2024
                                                                                                • Immune mediated hepatitis
                                                                                                3150 Mitochondrial dysfunction cell injury Mar 13, 2024 Mar 13, 2024
                                                                                                • AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
                                                                                                3149 Mitochondrial dysfunction Necrosis Mar 13, 2024 Mar 13, 2024
                                                                                                • AOP from chemical insult to cell death
                                                                                                3155 Mitochondrial dysfunction Occurrence, Cytoplasmic vacuolization (hepatocyte) Mar 13, 2024 Mar 13, 2024
                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                3156 Mitochondrial dysfunction Occurrence, Ballooning degeneration (hepatocyte) Mar 13, 2024 Mar 13, 2024
                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                3146 Mitochondrial dysfunction Apoptosis Mar 13, 2024 Mar 13, 2024
                                                                                                • AOP from chemical insult to cell death
                                                                                                • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                3157 Mitochondrial dysfunction Occurrence, Cytoplasmic vacuolization (kupffer cell) Mar 13, 2024 Mar 13, 2024
                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                3158 Mitochondrial dysfunction Occurrence, Cytoplasmic vacuolization (Bile duct cell) Mar 13, 2024 Mar 13, 2024
                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                3161 Mitochondrial dysfunction Impaired insulin signaling Mar 13, 2024 Mar 13, 2024
                                                                                                • ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
                                                                                                3141 Mitochondrial dysfunction Increased, Reactive oxygen species Mar 6, 2024 Apr 11, 2024
                                                                                                • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
                                                                                                3164 Mitochondrial dysfunction Altered expression of NRF2 pathway-dependent genes Mar 14, 2024 Mar 14, 2024
                                                                                                • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                3165 Mitochondrial dysfunction Inhibition, Nuclear factor kappa B (NF-kB) Mar 14, 2024 Mar 14, 2024
                                                                                                • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                3136 Mitochondrial dysfunction Proteasomal dysfunction Feb 29, 2024 Feb 29, 2024
                                                                                                • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                582 Mitochondrial dysfunction Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                660 Mitochondrial dysfunction Overwhelmed, Mitochondrial DNA repair mechanisms Nov 29, 2016 Dec 3, 2016
                                                                                                • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                664 Mitochondrial dysfunction impaired, Thoracic shivering Nov 29, 2016 Dec 3, 2016
                                                                                                  904 Mitochondrial dysfunction Impaired, Proteostasis Nov 29, 2016 Aug 25, 2017
                                                                                                  • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                  • Mitochondrial complex inhibition leading to liver injury
                                                                                                  908 Mitochondrial dysfunction Degeneration of dopaminergic neurons of the nigrostriatal pathway Nov 29, 2016 Aug 25, 2017
                                                                                                  • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                  1958 Mitochondrial dysfunction Increased reactive oxygen species (in the mitochondria) Jun 15, 2019 Jun 15, 2019
                                                                                                  • Mitochondrial complex inhibition leading to liver injury
                                                                                                  1684 Mitochondrial dysfunction Oxidative Stress Nov 9, 2017 Nov 9, 2017
                                                                                                  • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                  1152 Mitochondrial dysfunction impaired, Hive thermoregulation Nov 29, 2016 Dec 3, 2016
                                                                                                  • Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
                                                                                                  1154 Mitochondrial dysfunction Weakened, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                  • Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
                                                                                                  1311 Mitochondrial dysfunction Altered, Ca2+-calmodulin activated signal transduction Nov 29, 2016 Dec 3, 2016
                                                                                                  • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                  • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                  2822 Mitochondrial dysfunction Decrease, Mitochondrial ATP production Jan 5, 2023 Jan 5, 2023
                                                                                                  • Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
                                                                                                  • Renal protein alkylation leading to kidney toxicity
                                                                                                  2224 Mitochondrial dysfunction Increase, ROS production Dec 4, 2020 Dec 4, 2020
                                                                                                  • Thermal stress leading to population decline (3)
                                                                                                  2227 Mitochondrial dysfunction Increase, ROS Dec 4, 2020 Dec 4, 2020
                                                                                                  • Thermal stress leading to population decline (2)
                                                                                                  2228 Mitochondrial dysfunction Decrease, ATP pool Dec 4, 2020 Dec 4, 2020
                                                                                                  • Thermal stress leading to population decline (1)
                                                                                                  188 Disruption, Mitochondrial electron transport chain Decrease, Mitochondrial ATP production Nov 29, 2016 Dec 3, 2016
                                                                                                  • Calcium-mediated neuronal ROS production and energy imbalance
                                                                                                  189 Disruption, Mitochondrial electron transport chain Increase, ROS production Nov 29, 2016 Dec 3, 2016
                                                                                                  • Calcium-mediated neuronal ROS production and energy imbalance
                                                                                                  190 Decreased, Mitochondrial fatty acid beta-oxidation Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
                                                                                                  • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
                                                                                                  • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                  3159 Decreased, Mitochondrial fatty acid beta-oxidation Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                  • ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
                                                                                                  2931 Decreased, Mitochondrial fatty acid beta-oxidation Mitochondrial dysfunction EMPTY May 25, 2023 May 25, 2023
                                                                                                    3209 Decreased, Mitochondrial fatty acid beta-oxidation Disrupted Lipid Storage May 8, 2024 May 24, 2024
                                                                                                    • Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
                                                                                                    617 Decreased, Mitochondrial fatty acid beta-oxidation Increased, Liver Steatosis Nov 29, 2016 Dec 3, 2016
                                                                                                      1025 Abnormal, Morphogenesis Increased, Developmental Defects Nov 29, 2016 Dec 3, 2016
                                                                                                        196 Abnormal, Morphogenesis Increased, Lethality Nov 29, 2016 Dec 3, 2016
                                                                                                          197 Abnormal, Morphogenesis Increased, Structural malformations Nov 29, 2016 Dec 3, 2016
                                                                                                            202 Increase, Mutations Increase, Heritable mutations in offspring Nov 29, 2016 Nov 29, 2016
                                                                                                            • Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
                                                                                                            899 Increase, Mutations Increase, Cancer Nov 29, 2016 Dec 3, 2016
                                                                                                            • Alkylation of DNA leading to cancer 2
                                                                                                            • Alkylation of DNA leading to cancer 1
                                                                                                            1978 Increase, Mutations Increase, Cell Proliferation Aug 29, 2019 Mar 8, 2024
                                                                                                            • Deposition of energy leading to lung cancer
                                                                                                            • Deposition of energy leading to occurrence of cataracts
                                                                                                            1896 Increase, Mutations Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 8, 2019
                                                                                                            • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                            • Increased DNA damage leading to increased risk of breast cancer
                                                                                                            2609 Increase, Mutations Increase,miRNA levels Mar 22, 2022 Aug 27, 2023
                                                                                                            • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                                            1984 Increase, Mutations Increase, lung cancer Aug 29, 2019 Jan 10, 2023
                                                                                                            • Deposition of energy leading to lung cancer
                                                                                                            203 Altered, Neuroanatomy Altered, Neurophysiology Nov 29, 2016 Nov 29, 2016
                                                                                                            • XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                            208 Neuroinflammation N/A, Neurodegeneration Nov 29, 2016 Feb 23, 2021
                                                                                                            • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                            • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                                                                            • Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
                                                                                                            • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                            2500 Neuroinflammation Neuronal network function, Decreased Oct 26, 2021 Oct 26, 2021
                                                                                                            • A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
                                                                                                            2288 Neuroinflammation Encephalitis Feb 23, 2021 Feb 23, 2021
                                                                                                            • Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
                                                                                                            906 Neuroinflammation Degeneration of dopaminergic neurons of the nigrostriatal pathway Nov 29, 2016 Aug 25, 2017
                                                                                                            • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                            • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                            759 Neuroinflammation Synaptogenesis, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                              2717 Neuroinflammation Increase, Cell death Jul 25, 2022 Jul 25, 2022
                                                                                                                1687 Neuroinflammation Cell injury/death Nov 9, 2017 Nov 7, 2019
                                                                                                                • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                                                                                210 Neuronal dysfunction Neuroinflammation Nov 29, 2016 Nov 29, 2016
                                                                                                                  2941 Neuronal dysfunction Neurological disorder Jun 15, 2023 Jun 15, 2023
                                                                                                                  • Increased LCN2/iron complex leading to neurological disorders
                                                                                                                  • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                  384 Altered, Neurophysiology Cognitive Function, Decreased Nov 29, 2016 Nov 29, 2016
                                                                                                                  • XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                  212 Decreased, Nitric Oxide Decreased, Long-term potentiation (LTP) Nov 29, 2016 Dec 3, 2016
                                                                                                                  • Calcium-mediated neuronal ROS production and energy imbalance
                                                                                                                  213 Inhibition, NMDARs Decreased, Calcium influx Nov 29, 2016 Apr 7, 2018
                                                                                                                  • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                  • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                                                                                  214 Inhibition, NMDARs Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016
                                                                                                                    215 Inhibition, NMDARs Neuronal dysfunction Nov 29, 2016 Dec 3, 2016
                                                                                                                      3124 Inhibition, NMDARs Aberrant, synaptic formation and plasticity Jan 25, 2024 Jan 25, 2024
                                                                                                                      • Estrogen antagonism leading to increased risk of autism-like behavior
                                                                                                                      228 Binding of antagonist, NMDA receptors Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016
                                                                                                                        229 Binding of antagonist, NMDA receptors Inhibition, NMDARs Nov 29, 2016 Jun 13, 2018
                                                                                                                        • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                        • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                                                                                        387 Inhibition, Nuclear factor kappa B (NF-kB) Suppression, Inflammatory cytokines Nov 29, 2016 Dec 3, 2016
                                                                                                                        • Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
                                                                                                                        2306 Inhibition, Nuclear factor kappa B (NF-kB) Increased proinflammatory mediators Mar 30, 2021 Mar 30, 2021
                                                                                                                          2003 Inhibition, Nuclear factor kappa B (NF-kB) Suppression of T cell activation Nov 17, 2019 Mar 2, 2023
                                                                                                                          • Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                          1871 Inhibition, Nuclear factor kappa B (NF-kB) Impairment of TDAR Mar 12, 2019 Mar 12, 2019
                                                                                                                            1828 Inhibition, Nuclear factor kappa B (NF-kB) Activation, Caspase 8 pathway Jan 7, 2019 Mar 7, 2019
                                                                                                                            • IKK complex inhibition leading to liver injury
                                                                                                                            1921 Inhibition, Nuclear factor kappa B (NF-kB) Impaired T cell activation May 23, 2019 Jun 25, 2019
                                                                                                                              2644 Inhibition, Nuclear factor kappa B (NF-kB) Increase in inflammation Apr 8, 2022 Apr 8, 2022
                                                                                                                              • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                              236 Peptide Oxidation Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                1698 Peptide Oxidation S-Glutathionylation, eNOS Nov 16, 2017 Nov 20, 2017
                                                                                                                                • Peptide Oxidation Leading to Hypertension
                                                                                                                                1379 Peptide Oxidation Activation, JNK Feb 15, 2017 Feb 15, 2017
                                                                                                                                • Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
                                                                                                                                1467 Peptide Oxidation Increase, DNA Damage Apr 15, 2017 Apr 15, 2017
                                                                                                                                  1237 Peptide Oxidation Increased activation, Nuclear factor kappa B (NF-kB) Nov 29, 2016 Dec 3, 2016
                                                                                                                                    764 Peptide Oxidation Increase, hepatocellular adenomas and carcinomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                      765 Peptide Oxidation Increase, Cytotoxicity Nov 29, 2016 Dec 3, 2016
                                                                                                                                      • Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                      980 Peptide Oxidation Decrease, GTPCH-1 Nov 29, 2016 Sep 28, 2017
                                                                                                                                      • Peptide Oxidation Leading to Hypertension
                                                                                                                                      992 Peptide Oxidation Decrease, AKT/eNOS activity Nov 29, 2016 Oct 16, 2017
                                                                                                                                      • Peptide Oxidation Leading to Hypertension
                                                                                                                                      932 Peptide Oxidation Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
                                                                                                                                      • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                                                                      922 Peptide Oxidation Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016
                                                                                                                                        923 Peptide Oxidation Release, Cytokine Nov 29, 2016 Dec 3, 2016
                                                                                                                                          948 Peptide Oxidation Oxidation, Glutathione Nov 29, 2016 Nov 29, 2016
                                                                                                                                            240 Propagation, Oxidative stress Down Regulation, Gulcose-6-phosphate dehydrogenase Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                            241 Propagation, Oxidative stress Damaging, Red blood cells; hemolysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                            245 N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin Damaging, Red blood cells; hemolysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                            244 N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin Propagation, Oxidative stress Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                            243 N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin Formation, Formation of hemoglobin adducts Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                            242 N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin Altered regulation, Alpha hemoglobin Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                            248 Bile accumulation, Pathological condition Activation of specific nuclear receptors, Transcriptional change Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                                                                            930 Bile accumulation, Pathological condition Production, Reactive oxygen species Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                                                                            928 Bile accumulation, Pathological condition Release, Cytokine Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                                                                            503 Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • AhR activation leading to hepatic steatosis
                                                                                                                                            392 Reduction, Plasma 17beta-estradiol concentrations irregularities, ovarian cycle Nov 29, 2016 Dec 3, 2016
                                                                                                                                            • Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
                                                                                                                                            253 Reduction, Plasma 17beta-estradiol concentrations Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Nov 29, 2016 Nov 29, 2016
                                                                                                                                              252 Reduction, Plasma 17beta-estradiol concentrations Reduction, Vitellogenin synthesis in liver Nov 29, 2016 Mar 20, 2017
                                                                                                                                              • Aromatase inhibition leading to reproductive dysfunction
                                                                                                                                              • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                                                                              • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                              • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                              • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                              2922 Reduction, Plasma 17beta-estradiol concentrations Reduction, the ratio of E2/11-KT in plasma May 22, 2023 May 22, 2023
                                                                                                                                              • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                                                                                                              1386 Reduction, Plasma 17beta-estradiol concentrations Reduction, Plasma vitellogenin concentrations Mar 17, 2017 Oct 18, 2018
                                                                                                                                              • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                                                                              • Aromatase inhibition leading to reproductive dysfunction
                                                                                                                                              • Inhibition of thyroid peroxidase leading to impaired fertility in fish
                                                                                                                                              • Inhibition of 5α-reductase leading to impaired fecundity in female fish
                                                                                                                                              • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                              • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                                                                                                              254 Increase, Plasma vitellogenin concentrations Increase, Renal pathology due to VTG deposition Nov 29, 2016 Nov 29, 2016
                                                                                                                                              • Estrogen receptor agonism leading to reproductive dysfunction
                                                                                                                                              255 Reduction, Plasma vitellogenin concentrations Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Nov 29, 2016 Mar 20, 2017
                                                                                                                                              • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                                                                              • Aromatase inhibition leading to reproductive dysfunction
                                                                                                                                              • Estrogen receptor antagonism leading to reproductive dysfunction
                                                                                                                                              • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                              • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                              • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                              • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                                                                                                              1882 Reduction, Plasma vitellogenin concentrations Reduction, egg production and spawning Apr 18, 2019 Apr 18, 2019
                                                                                                                                                1769 Reduction, Plasma vitellogenin concentrations Reduction, Cumulative fecundity and spawning Sep 18, 2018 Sep 18, 2018
                                                                                                                                                • Inhibition of thyroid peroxidase leading to impaired fertility in fish
                                                                                                                                                • Inhibition of 5α-reductase leading to impaired fecundity in female fish
                                                                                                                                                1410 Activation, PPARα Activation, HSD17B4 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                  1229 Activation, PPARα Increase, Phenotypic enzyme activity Nov 29, 2016 Dec 31, 2020
                                                                                                                                                  • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                  1233 Activation, PPARα Increase, Genes involved in fatty acid oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                    1236 Activation, PPARα Activation, NADPH Oxidase Nov 29, 2016 Dec 3, 2016
                                                                                                                                                      535 Activation, PPARα Activation, LXR alpha Nov 29, 2016 Dec 3, 2016
                                                                                                                                                      • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                      2134 Activation, PPARα Decreased, 11KT May 11, 2020 May 11, 2020
                                                                                                                                                        2073 Activation, PPARα Decreased, cholesterol Apr 6, 2020 May 1, 2020
                                                                                                                                                        • PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
                                                                                                                                                        2252 Activation, PPARα Increase, cell proliferation (hepatocytes) Dec 31, 2020 Dec 31, 2020
                                                                                                                                                        • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                        2253 Activation, PPARα Increase, hepatocellular adenomas and carcinomas Dec 31, 2020 Dec 31, 2020
                                                                                                                                                        • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                        369 Activation, PPARα Decrease, Steroidogenic acute regulatory protein (STAR) Nov 29, 2016 Dec 2, 2016
                                                                                                                                                        • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                        370 Activation, PPARα Decrease, Translocator protein (TSPO) Nov 29, 2016 Dec 2, 2016
                                                                                                                                                        • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                        395 demethylation, PPARg promoter reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                          411 demethylation, PPARg promoter Up Regulation, CD36 Nov 29, 2016 Nov 29, 2016
                                                                                                                                                          • LXR activation leading to hepatic steatosis
                                                                                                                                                          256 demethylation, PPARg promoter Decrease, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                            1402 demethylation, PPARg promoter Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                              1424 demethylation, PPARg promoter Activation, FAS Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                1608 demethylation, PPARg promoter Activation of specific nuclear receptors, PPAR-gamma activation Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                1659 demethylation, PPARg promoter Increased, FA Influx Aug 31, 2017 Aug 31, 2017
                                                                                                                                                                • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                487 demethylation, PPARg promoter Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                2988 demethylation, PPARg promoter Activation of PPAR Aug 20, 2023 Aug 20, 2023
                                                                                                                                                                • Demethylation of PPAR promotor leading to vascular disrupting effects
                                                                                                                                                                2042 Decreased, PPAR-alpha activation Increased, Liver Steatosis Feb 22, 2020 Feb 22, 2020
                                                                                                                                                                  257 Decreased, PPAR-alpha activation Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                  • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
                                                                                                                                                                  259 Decreased, PPAR-beta activation Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                  • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
                                                                                                                                                                  260 Decreased, PPAR-gamma activation Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                  • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
                                                                                                                                                                  3093 Decreased, PPAR-gamma activation Alteration, lipid metabolism Oct 18, 2023 Oct 19, 2023
                                                                                                                                                                  • Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
                                                                                                                                                                  261 Induction, Pre-mature molting Decrease, Fecundity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                    262 Induction, Pre-mature molting Increase, Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                      263 Induction, Pre-mature molting Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                        3100 Activation, Pregnane-X receptor, NR1l2 Up Regulation, CD36 Nov 30, 2023 Mar 27, 2024
                                                                                                                                                                        • Pregnane X Receptor (PXR) activation leads to liver steatosis
                                                                                                                                                                        2482 Activation, Pregnane-X receptor, NR1l2 Induction, Upregulation of glucuronyltransferase activity Sep 14, 2021 Sep 14, 2021
                                                                                                                                                                        • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                        266 Feminisation or incomplete development, Primary and accessory male sex organs N/A, Impairment of reproductive capacity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                        • Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
                                                                                                                                                                        268 Reduction, Prostaglandin E2 concentration N/A, Gap Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                        • Cyclooxygenase inhibition leading reproductive failure
                                                                                                                                                                        271 Alkylation, Protein Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                          269 Alkylation, Protein Cell injury/death Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                          • Protein Alkylation leading to Liver Fibrosis
                                                                                                                                                                          3135 Alkylation, Protein Mitochondrial dysfunction Feb 28, 2024 Feb 28, 2024
                                                                                                                                                                          • Renal protein alkylation leading to kidney toxicity
                                                                                                                                                                          518 Activation, PXR/SXR Inhibition, FoxA2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                          • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                          526 Activation, PXR/SXR Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                          • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                          529 Activation, PXR/SXR Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                          • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                          272 Increase, RBC congestion in liver N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                          • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                                                          276 Production, Reactive oxygen species Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                          • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                                                                                                          931 Production, Reactive oxygen species Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            277 Damaging, Red blood cells; hemolysis Increase, Liver and splenic hemosiderosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                                                            278 Damaging, Red blood cells; hemolysis N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                                                            279 Damaging, Red blood cells; hemolysis Increase, RBC congestion in liver Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            • Oxidation of iron in hemoglobin leading to hematotoxicity
                                                                                                                                                                            280 Increase, Renal pathology due to VTG deposition Altered, Larval development Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            • Estrogen receptor agonism leading to reproductive dysfunction
                                                                                                                                                                            282 Increase, ROS production Decreased, Nitric Oxide Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            • Calcium-mediated neuronal ROS production and energy imbalance
                                                                                                                                                                            283 Increase, ROS production Increased, Oxidative damage Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                            • Calcium-mediated neuronal ROS production and energy imbalance
                                                                                                                                                                            912 Increase, ROS production Mitochondrial dysfunction Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                              2590 Increase, ROS production Increase, Oxidative DNA damage Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                              • Deposition of energy leading to population decline via DNA oxidation and follicular atresia
                                                                                                                                                                              • Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
                                                                                                                                                                              1602 Increase, ROS production Increase, DNA Damage Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                1603 Increase, ROS production Increased, LPO Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                • Excessive reactive oxygen species production leading to mortality (3)
                                                                                                                                                                                1623 Increase, ROS production Increased, secretion of local growth factors Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                  1754 Increase, ROS production Decrease, Coupling of OXPHOS Jun 12, 2018 Jun 12, 2018
                                                                                                                                                                                    2099 Increase, ROS production Increase,Oxidative DNA damage Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                    • Excessive reactive oxygen species production leading to mortality (4)
                                                                                                                                                                                    2093 Increase, ROS production Decrease, MMP Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                    • Excessive reactive oxygen species production leading to mortality (2)
                                                                                                                                                                                    2089 Increase, ROS production Increase, Protein oxidation Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                    • Excessive reactive oxygen species production leading to mortality (1)
                                                                                                                                                                                    2998 Increase, ROS production Increase, Oxidative Stress Aug 21, 2023 Aug 21, 2023
                                                                                                                                                                                    • The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
                                                                                                                                                                                    2187 Increase, ROS production Increase, Apoptosis Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                      2225 Increase, ROS production Increase, Global methylation Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                      • Thermal stress leading to population decline (3)
                                                                                                                                                                                      2305 Increase, ROS production Inhibition, Nuclear factor kappa B (NF-kB) Mar 30, 2021 Mar 30, 2021
                                                                                                                                                                                        2308 Increase, ROS production Increased activation, Nuclear factor kappa B (NF-kB) Mar 30, 2021 Mar 30, 2021
                                                                                                                                                                                          2348 Increase, ROS production D1 protein deactivation Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                            1404 Activation, SCD-1 Increased, lipogenesis Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                              284 Activation, SCD-1 Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                              • LXR activation leading to hepatic steatosis
                                                                                                                                                                                              287 Binding, SH-/selen-proteins N/A, Interferences with SH-/selen-proteins Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                294 Activation, SREBP-1c Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                • LXR activation leading to hepatic steatosis
                                                                                                                                                                                                295 Activation, Stellate cells Accumulation, Collagen Nov 29, 2016 Dec 5, 2018
                                                                                                                                                                                                • Protein Alkylation leading to Liver Fibrosis
                                                                                                                                                                                                • Endocytic lysosomal uptake leading to liver fibrosis
                                                                                                                                                                                                3217 Activation, Stellate cells Increased, Liver Steatosis May 14, 2024 May 14, 2024
                                                                                                                                                                                                  2892 Activation, Stellate cells Increased extracellular matrix deposition Apr 13, 2023 Apr 13, 2023
                                                                                                                                                                                                  • AhR activation leading to liver fibrosis
                                                                                                                                                                                                  436 Decrease, Steroidogenic acute regulatory protein (STAR) Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                  • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                                                                  298 Induction, Sustained Cell Proliferation Formation, Liver tumor Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                  • Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
                                                                                                                                                                                                  299 Induction, Sustained Hepatotoxicity Induction, Sustained Cell Proliferation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                  • Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
                                                                                                                                                                                                  301 Activation/Proliferation, T-cells N/A, Allergic contact dermatitis on challenge Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                    1701 Activation/Proliferation, T-cells Increase, Allergic Respiratory Hypersensitivity Response Dec 7, 2017 Aug 1, 2022
                                                                                                                                                                                                    • Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
                                                                                                                                                                                                    835 Activation/Proliferation, T-cells sensitisation, skin Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                    • Covalent Protein binding leading to Skin Sensitisation
                                                                                                                                                                                                    302 Reduction, Testosterone synthesis by ovarian theca cells Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Mar 20, 2017
                                                                                                                                                                                                    • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                                                                                                                                    303 Up Regulation, TGFbeta1 expression Accumulation, Collagen Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                      304 Up Regulation, TGFbeta1 expression Activation, Stellate cells Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                        305 TH synthesis, Decreased T4 in serum, Decreased Nov 29, 2016 Oct 10, 2022
                                                                                                                                                                                                        • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                        • XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                        • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                        • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                        • Thyroperoxidase inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                        • Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                        • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                        • Thyroperoxidase inhibition leading to altered visual function via decreased eye size
                                                                                                                                                                                                        • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                        • Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                        • Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                        • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                        • Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                        • Pendrin inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                        • Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                        • Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
                                                                                                                                                                                                        • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                        810 TH synthesis, Decreased Increased, Serum creatinine Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                        • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                        1504 TH synthesis, Decreased BDNF, Reduced May 10, 2017 Apr 4, 2019
                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                        1505 TH synthesis, Decreased GABAergic interneurons, Decreased May 10, 2017 May 29, 2018
                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                        1506 TH synthesis, Decreased Impairment, Learning and memory May 10, 2017 May 29, 2018
                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                        1768 TH synthesis, Decreased Reduction, Plasma 17beta-estradiol concentrations Sep 18, 2018 Sep 18, 2018
                                                                                                                                                                                                        • Inhibition of thyroid peroxidase leading to impaired fertility in fish
                                                                                                                                                                                                        1040 Thyroperoxidase, Inhibition Reduced, Anterior swim bladder inflation Nov 29, 2016 Feb 22, 2019
                                                                                                                                                                                                          790 Thyroperoxidase, Inhibition Decrease, Incorporation of active iodide into iodotyrosines Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                            309 Thyroperoxidase, Inhibition TH synthesis, Decreased Nov 29, 2016 Nov 4, 2022
                                                                                                                                                                                                            • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                            • Inhibition of thyroid peroxidase leading to impaired fertility in fish
                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered visual function via decreased eye size
                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                            • Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                            383 Thyroperoxidase, Inhibition Cognitive Function, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                              366 Thyroperoxidase, Inhibition T4 in serum, Decreased Nov 29, 2016 Jul 8, 2022
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                              • Thyroperoxidase inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                              • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                              444 T4 in neuronal tissue, Decreased BDNF, Reduced Nov 29, 2016 Apr 4, 2019
                                                                                                                                                                                                              • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                              746 T4 in neuronal tissue, Decreased Hippocampal gene expression, Altered Nov 29, 2016 Aug 11, 2018
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              403 T4 in serum, Decreased Cognitive Function, Decreased Nov 29, 2016 Aug 11, 2018
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              312 T4 in serum, Decreased T4 in neuronal tissue, Decreased Nov 29, 2016 Apr 4, 2019
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                              • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              1039 T4 in serum, Decreased Reduced, Anterior swim bladder inflation Nov 29, 2016 Oct 10, 2022
                                                                                                                                                                                                              • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                              1387 T4 in serum, Decreased Hippocampal gene expression, Altered Mar 24, 2017 Aug 11, 2018
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              1388 T4 in serum, Decreased Hippocampal anatomy, Altered Mar 24, 2017 Aug 11, 2018
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              1389 T4 in serum, Decreased Hippocampal Physiology, Altered Mar 24, 2017 Aug 11, 2018
                                                                                                                                                                                                              • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                              1143 T4 in serum, Decreased Decreased, Thyroxine (T4) in tissues Nov 29, 2016 Sep 3, 2020
                                                                                                                                                                                                                2420 T4 in serum, Decreased Increase, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                  2422 T4 in serum, Decreased Increased, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                  • Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
                                                                                                                                                                                                                  • Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                  • Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                  2168 T4 in serum, Decreased Altered, Amphibian metamorphosis Aug 25, 2020 Aug 25, 2020
                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Pendrin inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  • Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                  2473 T4 in serum, Decreased Occurrence, Cytoplasmic vacuolization (Renal tubule) Sep 9, 2021 Sep 9, 2021
                                                                                                                                                                                                                  • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                  2474 T4 in serum, Decreased Occurrence, Cystic dilatation (renal tubule) Sep 9, 2021 Sep 9, 2021
                                                                                                                                                                                                                  • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                  2475 T4 in serum, Decreased Occurrence, Cytoplasmic vacuolization (podocyte) Sep 9, 2021 Sep 9, 2021
                                                                                                                                                                                                                  • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                  2865 T4 in serum, Decreased Insulin resistance, increased Apr 3, 2023 Apr 20, 2023
                                                                                                                                                                                                                  • Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
                                                                                                                                                                                                                  2038 T4 in serum, Decreased Decreased, Triiodothyronine (T3) Feb 19, 2020 Oct 10, 2022
                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered visual function via decreased eye size
                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                                  315 Reduction, Vitellogenin synthesis in liver Reduction, Plasma vitellogenin concentrations Nov 29, 2016 Mar 20, 2017
                                                                                                                                                                                                                  • Aromatase inhibition leading to reproductive dysfunction
                                                                                                                                                                                                                  • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                                                                                                                                                  • Estrogen receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                  • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                                                                                                  • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                                                                                                  • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                                                                                                  316 Altered, Transcription of genes by the AR Feminisation or incomplete development, Primary and accessory male sex organs Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                  • Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
                                                                                                                                                                                                                  317 Altered, Transcription of genes by the AR Alteration, Wnt pathway Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                  • Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
                                                                                                                                                                                                                  2132 Altered, Transcription of genes by the AR nipple retention, increased May 11, 2020 May 11, 2020
                                                                                                                                                                                                                  • Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
                                                                                                                                                                                                                  2127 Altered, Transcription of genes by the AR AGD, decreased May 11, 2020 May 11, 2020
                                                                                                                                                                                                                  • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                  2273 Altered, Transcription of genes by the AR Reduced granulosa cell proliferation Jan 28, 2021 Apr 20, 2022
                                                                                                                                                                                                                  • Androgen receptor (AR) antagonism leading to decreased fertility in females
                                                                                                                                                                                                                  2909 Altered, Transcription of genes by the AR Increase, Androgen receptor May 11, 2023 May 11, 2023
                                                                                                                                                                                                                  • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                  319 Activation of specific nuclear receptors, Transcriptional change Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                  • Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
                                                                                                                                                                                                                  437 Decrease, Translocator protein (TSPO) Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                  • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                                                                                  399 Decrease, Translocator protein (TSPO) Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                    3162 Accumulation, Triglyceride Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                    • LXR activation leading to hepatic steatosis
                                                                                                                                                                                                                    2265 Accumulation, Triglyceride Increased, Liver Steatosis Jan 15, 2021 Mar 27, 2024
                                                                                                                                                                                                                    • Glucocorticoid Receptor activation leading to hepatic steatosis
                                                                                                                                                                                                                    • Pregnane X Receptor (PXR) activation leads to liver steatosis
                                                                                                                                                                                                                    • Liver X Receptor (LXR) activation leads to liver steatosis
                                                                                                                                                                                                                    • Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
                                                                                                                                                                                                                    • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                    324 N/A, Unknown Proliferation, Cell proliferation in the absence of cytotoxicity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                    • Uncharacterized liver damage leading to hepatocellular carcinoma
                                                                                                                                                                                                                    751 N/A, Unknown Increased, Kidney Failure Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                    • Kidney toxicity induced by activation of 5HT2C
                                                                                                                                                                                                                    2235 Induction, Upregulation of glucuronyltransferase activity Increase, Biliary excretion TH glucuronide Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                      2428 Induction, Upregulation of glucuronyltransferase activity Increased, T4/T3 catabolism Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                        2884 Induction, Upregulation of glucuronyltransferase activity Increase, Glucuronidation of T4 Apr 12, 2023 Apr 12, 2023
                                                                                                                                                                                                                          2483 Induction, Upregulation of glucuronyltransferase activity T4 in serum, Decreased Sep 14, 2021 Sep 14, 2021
                                                                                                                                                                                                                            2478 Induction, Upregulation of glucuronyltransferase activity Increased, Clearance of thyroxine from serum Sep 10, 2021 Sep 10, 2021
                                                                                                                                                                                                                            • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                            • Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
                                                                                                                                                                                                                            • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                            • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                            329 Insufficiency, Vascular Abnormal, Morphogenesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                              1036 Insufficiency, Vascular Increased, Developmental Defects Nov 29, 2016 Jan 18, 2022
                                                                                                                                                                                                                              • Disruption of VEGFR Signaling Leading to Developmental Defects
                                                                                                                                                                                                                              330 Binding, VEGF-A Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                331 Binding, VEGF-A Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                  332 Production, VEGF-A Binding, VEGF-A Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                    333 Production, VEGF-A Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                      334 Decreased, VegfR2 Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                        335 Inhibition, VegfR2 Reduction, Angiogenesis Nov 29, 2016 Jul 20, 2022
                                                                                                                                                                                                                                        • Disruption of VEGFR Signaling Leading to Developmental Defects
                                                                                                                                                                                                                                        336 Increase, Vitellogenin synthesis in liver Increase, Plasma vitellogenin concentrations Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                        • Estrogen receptor agonism leading to reproductive dysfunction
                                                                                                                                                                                                                                        337 Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Reduction, Cumulative fecundity and spawning Nov 29, 2016 Mar 20, 2017
                                                                                                                                                                                                                                        • Aromatase inhibition leading to reproductive dysfunction
                                                                                                                                                                                                                                        • Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
                                                                                                                                                                                                                                        • Estrogen receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                        • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                                                                                                                        • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                                                                                                                        • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                                                                                                                        • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                                                                                                                                                                                                        338 Alteration, Wnt pathway Feminisation or incomplete development, Primary and accessory male sex organs Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                        • Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
                                                                                                                                                                                                                                        1567 Altered, Cardiovascular development/function Increase, Early Life Stage Mortality Jun 9, 2017 Mar 23, 2018
                                                                                                                                                                                                                                        • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                                                                                                                                                                                                                                        • Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
                                                                                                                                                                                                                                        • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
                                                                                                                                                                                                                                        1352 Altered, Cardiovascular development/function Increase, Mortality Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                          977 Altered, Cardiovascular development/function Increase, Pericardial edema Nov 29, 2016 Jun 9, 2017
                                                                                                                                                                                                                                            472 Accumulation, Fatty acid Accumulation, Triglyceride Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                            • Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis
                                                                                                                                                                                                                                            514 Accumulation, Fatty acid Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                            • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                            515 Accumulation, Fatty acid Increased, Liver Steatosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                            • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                            • Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
                                                                                                                                                                                                                                            • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                            • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                            135 Decrease, Fecundity Decline, Population Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                              1886 Decrease, Fecundity Decrease, Population growth rate Apr 22, 2019 Apr 22, 2019
                                                                                                                                                                                                                                              • DNA methyltransferase inhibition leading to population decline (1)
                                                                                                                                                                                                                                              • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                              • DNA methyltransferase inhibition leading to population decline (3)
                                                                                                                                                                                                                                              • Thermal stress leading to population decline (3)
                                                                                                                                                                                                                                              • Thermal stress leading to population decline (2)
                                                                                                                                                                                                                                              • Thermal stress leading to population decline (1)
                                                                                                                                                                                                                                              • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                              2621 Decrease, Fecundity Decrease, Reproduction Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                              • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                              1472 Decrease, Fertility Decrease, Population growth rate Apr 15, 2017 Apr 15, 2017
                                                                                                                                                                                                                                                1644 Impairment, Learning and memory Decreased, locomotion Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                564 Impairment, Learning and memory Abnormal, Roll change within caste Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                                                                                                                                                                583 Impairment, Learning and memory Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                2872 Impairment, Learning and memory decreased, IQ Apr 4, 2023 Apr 4, 2023
                                                                                                                                                                                                                                                • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                                                                                                                                                                                                                2889 N/A, Liver Steatosis Cell injury/death Apr 13, 2023 Apr 13, 2023
                                                                                                                                                                                                                                                  405 Malformation, Male reproductive tract impaired, Fertility Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                                                  • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                                                                                                                  198 Increase, Mortality Decrease, Fecundity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                    199 Increase, Mortality Decline, Population Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                      1004 Increase, Mortality Decreased, population 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                        1013 Increase, Mortality Decreased, Population size Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                          2463 Increase, Mortality Decrease, Population growth rate Aug 5, 2021 Aug 5, 2021
                                                                                                                                                                                                                                                            2013 Increased Mortality Decrease, Population growth rate Dec 20, 2019 Jul 8, 2022
                                                                                                                                                                                                                                                            • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
                                                                                                                                                                                                                                                            • Acetylcholinesterase inhibition leading to acute mortality
                                                                                                                                                                                                                                                            • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                            • Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                            • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                            • Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered visual function via decreased eye size
                                                                                                                                                                                                                                                            • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                                                                            • Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
                                                                                                                                                                                                                                                            • GSK3beta inactivation leading to increased mortality via defects in developing inner ear
                                                                                                                                                                                                                                                            1191 Increased Mortality Decreased, Population size Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                              2486 Increased Mortality Decline, Population trajectory Oct 8, 2021 Oct 8, 2021
                                                                                                                                                                                                                                                                756 Increased Mortality Decreased, population 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                • Glutamate-gated chloride channel activation leading to acute mortality
                                                                                                                                                                                                                                                                200 Increased Mortality Decline, Population Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                  428 Increased Mortality Decreased, Population trajectory Nov 29, 2016 Dec 20, 2019
                                                                                                                                                                                                                                                                    368 N/A, Neurodegeneration Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                      207 N/A, Neurodegeneration Neuroinflammation Nov 29, 2016 Jun 13, 2018
                                                                                                                                                                                                                                                                      • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                                                                                                                                                                                      • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                                                                                                                                                                                                                                      1069 N/A, Neurodegeneration Impairment, Learning and memory Nov 29, 2016 Apr 11, 2024
                                                                                                                                                                                                                                                                      • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                                                                                                                                                                                                                                      • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
                                                                                                                                                                                                                                                                      3070 N/A, Neurodegeneration Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                      3075 N/A, Neurodegeneration impaired, Learning and memory Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                      3081 N/A, Neurodegeneration Increase, seizure Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                      2287 N/A, Neurodegeneration Encephalitis Feb 23, 2021 Feb 23, 2021
                                                                                                                                                                                                                                                                      • Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                      647 N/A, Neurodegeneration Decreased, Neuronal network function in adult brain Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                      • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                                                                                                                                                                                      • Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
                                                                                                                                                                                                                                                                      1265 Decline, Population Alteration, Food-web structures Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                      • Juvenile hormone receptor agonism leading to male offspring induction associated population decline
                                                                                                                                                                                                                                                                      296 Increased, Structural malformations Increased, Lethality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                        344 Formation, Pro-mutagenic DNA Adducts Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                          345 Formation, Pro-mutagenic DNA Adducts Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                          • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                          352 Formation, Pro-mutagenic DNA Adducts Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                            548 Formation, Pro-mutagenic DNA Adducts Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                            • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                            551 Formation, Pro-mutagenic DNA Adducts Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                            • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                            549 Increased, Induced Mutations in Critical Genes Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                            • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                            891 Increased, Induced Mutations in Critical Genes Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                              342 Increased, Induced Mutations in Critical Genes Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                346 Increased, Induced Mutations in Critical Genes Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 30, 2016
                                                                                                                                                                                                                                                                                • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                                351 Increased, Induced Mutations in Critical Genes Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                  343 Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                    340 Activation, Pre-MIE: Metabolism of AFB1 Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                      348 BDNF, Reduced Aberrant, Dendritic morphology Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                      • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                      353 BDNF, Reduced Cell injury/death Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                      • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
                                                                                                                                                                                                                                                                                      • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                      354 BDNF, Reduced Reduced, Presynaptic release of glutamate Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                      • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                      445 BDNF, Reduced Down Regulation, K-Cl co-transporter 2 (KCC2) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                        448 BDNF, Reduced Synaptogenesis, Decreased Nov 29, 2016 Apr 4, 2019
                                                                                                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                        870 BDNF, Reduced GABAergic interneurons, Decreased Nov 29, 2016 Jan 19, 2018
                                                                                                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                        1507 BDNF, Reduced Impairment, Learning and memory May 10, 2017 May 29, 2018
                                                                                                                                                                                                                                                                                        • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                        356 Aberrant, Dendritic morphology Synaptogenesis, Decreased Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                        • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                        357 Reduced, Presynaptic release of glutamate Synaptogenesis, Decreased Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                        • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                        350 Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                          358 Synaptogenesis, Decreased Neuronal network function, Decreased Nov 29, 2016 May 25, 2018
                                                                                                                                                                                                                                                                                          • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                          • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                          656 Synaptogenesis, Decreased Neuroinflammation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                            359 Neuronal network function, Decreased Impairment, Learning and memory Nov 29, 2016 Jul 15, 2022
                                                                                                                                                                                                                                                                                            • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                                                            • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                                                                                                                                                                                                            • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                            • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                            • Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
                                                                                                                                                                                                                                                                                            • Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
                                                                                                                                                                                                                                                                                            3123 Neuronal network function, Decreased autism-like behavior Jan 25, 2024 Jan 25, 2024
                                                                                                                                                                                                                                                                                            • Estrogen antagonism leading to increased risk of autism-like behavior
                                                                                                                                                                                                                                                                                            2953 Neuronal network function, Decreased Neurological disorder Jun 21, 2023 Jun 21, 2023
                                                                                                                                                                                                                                                                                            • Excessive iron accumulation leading to neurological disorders
                                                                                                                                                                                                                                                                                            2411 Neuronal network function, Decreased Cognitive Function, Decreased Jun 24, 2021 Aug 27, 2021
                                                                                                                                                                                                                                                                                            • Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
                                                                                                                                                                                                                                                                                            2501 Neuronal network function, Decreased Memory Loss Oct 26, 2021 Oct 26, 2021
                                                                                                                                                                                                                                                                                            • A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
                                                                                                                                                                                                                                                                                            360 Binding of agonist, NMDARs Overactivation, NMDARs Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                              361 Overactivation, NMDARs Increased, Intracellular Calcium overload Nov 29, 2016 Sep 10, 2023
                                                                                                                                                                                                                                                                                              • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                                                                                                                                                                                                              • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                              • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                              • Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
                                                                                                                                                                                                                                                                                              2781 Overactivation, NMDARs Status epilepticus Oct 12, 2022 Sep 3, 2023
                                                                                                                                                                                                                                                                                              • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                              2806 Overactivation, NMDARs Loss of drebrin Dec 11, 2022 Dec 11, 2022
                                                                                                                                                                                                                                                                                              • Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
                                                                                                                                                                                                                                                                                              3038 Overactivation, NMDARs Increase, Cell membrane depolarization Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                              • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                              3068 Overactivation, NMDARs AchE Inhibition Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                              3069 Overactivation, NMDARs Decreased, Neuronal network function in adult brain Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                              3071 Overactivation, NMDARs Neuroinflammation Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                              3042 Increased, Intracellular Calcium overload Mitochondrial dysfunction EMPTY Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                3091 Increased, Intracellular Calcium overload Loss of drebrin Oct 18, 2023 Oct 18, 2023
                                                                                                                                                                                                                                                                                                • Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
                                                                                                                                                                                                                                                                                                362 Increased, Intracellular Calcium overload Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                                                                                                                                                                                                                • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                1862 Increased, Intracellular Calcium overload Cell injury/death Feb 19, 2019 Sep 3, 2023
                                                                                                                                                                                                                                                                                                • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                                1860 Increased, Intracellular Calcium overload Occurrence, Epileptic seizure Feb 13, 2019 Feb 13, 2019
                                                                                                                                                                                                                                                                                                  892 Increased, Intracellular Calcium overload Decreased, Neuronal network function in adult brain Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                    2140 Increased, Intracellular Calcium overload Status epilepticus May 21, 2020 May 21, 2020
                                                                                                                                                                                                                                                                                                      2709 Increased, Intracellular Calcium overload Decrease, OXPHOS Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                        2710 Increased, Intracellular Calcium overload Endoplasmic reticulum stress Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                        • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                        2704 Increased, Intracellular Calcium overload Activation, calpain Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                        • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                        2650 Covalent Binding, Protein Increase, Allergic Respiratory Hypersensitivity Response Apr 28, 2022 Aug 1, 2022
                                                                                                                                                                                                                                                                                                        • Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
                                                                                                                                                                                                                                                                                                        2649 Covalent Binding, Protein Increased proinflammatory mediators Apr 28, 2022 Sep 8, 2022
                                                                                                                                                                                                                                                                                                        • Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
                                                                                                                                                                                                                                                                                                        833 Covalent Binding, Protein Activation, Keratinocytes Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                        • Covalent Protein binding leading to Skin Sensitisation
                                                                                                                                                                                                                                                                                                        377 Covalent Binding, Protein Activation, Dendritic Cells Nov 29, 2016 Nov 5, 2020
                                                                                                                                                                                                                                                                                                        • Covalent Protein binding leading to Skin Sensitisation
                                                                                                                                                                                                                                                                                                        • Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
                                                                                                                                                                                                                                                                                                        376 Covalent Binding, Protein Response, Keratinocytes Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                          2202 Covalent Binding, Protein Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Nov 5, 2020 Feb 11, 2021
                                                                                                                                                                                                                                                                                                            380 Response, Keratinocytes Activation/Proliferation, T-cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                              378 Response, Keratinocytes Activation, Dendritic Cells Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                379 Activation, Dendritic Cells Activation/Proliferation, T-cells Nov 29, 2016 Aug 22, 2022
                                                                                                                                                                                                                                                                                                                • Covalent Protein binding leading to Skin Sensitisation
                                                                                                                                                                                                                                                                                                                • Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
                                                                                                                                                                                                                                                                                                                2236 Increase, Biliary excretion TH glucuronide T4 in serum, Decreased Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                  570 Suppression, Immune system Increased, Viral susceptibility Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                  • Suppression of immune system contributes to impaired development and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                  • Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                  394 irregularities, ovarian cycle impaired, Fertility Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                  • Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
                                                                                                                                                                                                                                                                                                                  • Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
                                                                                                                                                                                                                                                                                                                  • Androgen receptor (AR) antagonism leading to decreased fertility in females
                                                                                                                                                                                                                                                                                                                  393 irregularities, ovarian cycle Decrease, Fertility Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                    2387 impaired, Fertility Decrease of egg production and cummulative fecundity May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                    • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                    2292 impaired, Fertility Decrease, Population growth rate Mar 26, 2021 Mar 26, 2021
                                                                                                                                                                                                                                                                                                                    • Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
                                                                                                                                                                                                                                                                                                                    • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                    396 reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                    • Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
                                                                                                                                                                                                                                                                                                                    402 Metabolism of AFB1, Production of Reactive Electrophiles Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                    • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                                                                    439 Reduction, Testosterone synthesis in Leydig cells Reduction of testosterone Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                                                                                                                      2125 Reduction, Testosterone synthesis in Leydig cells Decrease, testosterone levels May 11, 2020 May 1, 2024
                                                                                                                                                                                                                                                                                                                      • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                      • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                                                                                                                                                                                      • PPARα activation leading to impaired fertility in adult male rodents
                                                                                                                                                                                                                                                                                                                      • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                      461 Increase, Luteinizing hormone (LH) Increase proliferation, Leydig cell Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                      • PPARα activation leading to impaired fertility in adult male rodents
                                                                                                                                                                                                                                                                                                                      462 Hyperplasia, Leydig cell impaired, Fertility Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                      • PPARα activation leading to impaired fertility in adult male rodents
                                                                                                                                                                                                                                                                                                                      398 Increase proliferation, Leydig cell Hyperplasia, Leydig cell Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                      • PPARα activation leading to impaired fertility in adult male rodents
                                                                                                                                                                                                                                                                                                                      442 Inhibition, Na+/I- symporter (NIS) Thyroidal Iodide, Decreased Nov 29, 2016 May 29, 2018
                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                      • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                      2232 Inhibition, Na+/I- symporter (NIS) T4 in serum, Decreased Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                      1503 Inhibition, Na+/I- symporter (NIS) Impairment, Learning and memory May 10, 2017 Apr 4, 2019
                                                                                                                                                                                                                                                                                                                      • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                                                      552 Inhibition, Na+/I- symporter (NIS) TH synthesis, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                      • XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                      • Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                      872 Thyroidal Iodide, Decreased TH synthesis, Decreased Nov 29, 2016 Jun 4, 2018
                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                      • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                      • Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                      443 Thyroidal Iodide, Decreased T4 in serum, Decreased Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                        446 Down Regulation, K-Cl co-transporter 2 (KCC2) Delay, Developmental GABA shift Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                          447 Delay, Developmental GABA shift Synaptogenesis, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                            1491 Decreased, Population trajectory Increased Mortality Apr 18, 2017 Apr 18, 2017
                                                                                                                                                                                                                                                                                                                              591 Increased, Atrioventricular block and bradycardia Respiratory distress/arrest Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                              • Sodium channel inhibition leading to congenital malformations
                                                                                                                                                                                                                                                                                                                              432 Increased, Atrioventricular block and bradycardia Increased Mortality Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                433 Respiratory distress/arrest Increased Mortality Nov 29, 2016 Dec 20, 2019
                                                                                                                                                                                                                                                                                                                                • Acetylcholinesterase inhibition leading to acute mortality
                                                                                                                                                                                                                                                                                                                                592 Respiratory distress/arrest N/A, hypoxia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                • Sodium channel inhibition leading to congenital malformations
                                                                                                                                                                                                                                                                                                                                460 Reduction of testosterone Increase, Luteinizing hormone (LH) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                  608 Reduction of testosterone Malformation, Male reproductive tract Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                                                                                                                                    1649 Reduction of testosterone Decreased sperm quantity or quality in the adult, Decreased fertility Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                      438 Reduction, Cholesterol transport in mitochondria Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                                                                                                                                      • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                                                                                                                                                                                                      • PPARα activation leading to impaired fertility in adult male rodents
                                                                                                                                                                                                                                                                                                                                      3216 Suppression, VLDL secretion Increased, Liver Steatosis May 9, 2024 May 9, 2024
                                                                                                                                                                                                                                                                                                                                      • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      475 Inhibition, Mitochondrial fatty acid beta-oxidation Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                      • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      538 Inhibition, Mitochondrial fatty acid beta-oxidation Increased, Liver Steatosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                      • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      486 Increased, Triglyceride formation Increased, Liver Steatosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                      • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      476 Suppression, Constitutive androstane receptor, NR1l3 Activation, LXR Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                      • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      477 Suppression, Constitutive androstane receptor, NR1l3 demethylation, PPARg promoter Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                      • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                      482 Activation, SREBF1 Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                        489 Activation, SREBF1 Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                        • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                        1662 Activation, SREBF1 Increased, Liver Steatosis Aug 31, 2017 Aug 31, 2017
                                                                                                                                                                                                                                                                                                                                        • AKT2 activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                        1607 Increased, De Novo FA synthesis Increased, Liver Steatosis Jul 18, 2017 Jul 18, 2017
                                                                                                                                                                                                                                                                                                                                        • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                        484 Increased, De Novo FA synthesis Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                          512 Increased, De Novo FA synthesis Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                          • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                          3218 Increased, Liver Steatosis Cell injury/death May 14, 2024 May 14, 2024
                                                                                                                                                                                                                                                                                                                                          • AhR activation leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                          1695 Increased, Liver Steatosis Increased, Reactive oxygen species Nov 14, 2017 Nov 14, 2017
                                                                                                                                                                                                                                                                                                                                          • Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
                                                                                                                                                                                                                                                                                                                                          2263 Increased, Fatty acid uptake Increased, Liver Steatosis Jan 15, 2021 Jan 15, 2021
                                                                                                                                                                                                                                                                                                                                            1657 Up Regulation, SCD-1 Accumulation, Triglyceride Aug 31, 2017 Aug 31, 2017
                                                                                                                                                                                                                                                                                                                                            • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                            493 Up Regulation, SCD-1 Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                            • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                            • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                            492 Up Regulation, FAS Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                            • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                            504 Increased, FA Influx Accumulation, Triglyceride Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              505 Increased, FA Influx Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              1658 Increased, FA Influx Increased, Triglyceride formation Aug 31, 2017 Aug 31, 2017
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              507 Up Regulation, LDLR (low density lipoprotein receptor) Increased, LDL uptake Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              508 Increased, LDL uptake Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • AhR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              511 Inhibition, PPAR alpha Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              517 Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • NR1I3 (CAR) suppression leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              519 Inhibition, FoxA2 Down Regulation, CPT1A Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              523 Inhibition, FoxA2 Down Regulation, HMGCS2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              520 Down Regulation, CPT1A Decreased, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              524 Down Regulation, HMGCS2 Decreased, Ketogenesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              1660 Decreased, Ketogenesis Accumulation, Fatty acid Aug 31, 2017 Aug 31, 2017
                                                                                                                                                                                                                                                                                                                                              • NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                              1406 Activation, NRF2 Activation, FXR Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                532 Activation, NRF2 Activation, NR1H4 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                533 Activation, NR1H4 Activation, SHP Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                534 Activation, NR1H4 Activation, PPARα Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                896 Activation, SHP Inhibition, SREBP1c Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                1409 Activation, SHP Activation, PPARα Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                  1412 Activation, SHP Inhibition, LXR Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                    1414 Activation, SHP Inhibition, LRH-1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                      537 Decreased, DHB4/HSD17B4 Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                      • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                      1606 Activation, LXR alpha Increased, De Novo FA synthesis Jul 18, 2017 Jul 18, 2017
                                                                                                                                                                                                                                                                                                                                                      • NFE2L2/FXR activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                      1661 Activation, AKT2 Activation, SREBF1 Aug 31, 2017 Aug 31, 2017
                                                                                                                                                                                                                                                                                                                                                      • AKT2 activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                      541 inflammation Activation, AKT2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                      • AKT2 activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                      544 Decrease, Ovulation Reduction, Cumulative fecundity and spawning Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                        687 Decrease, Ovulation Reduced, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase inhibition leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                        1471 Decrease, Ovulation Decrease, Fertility Apr 15, 2017 Apr 15, 2017
                                                                                                                                                                                                                                                                                                                                                          1753 Decrease, Ovulation Decrease, Fecundity Jun 12, 2018 Jun 12, 2018
                                                                                                                                                                                                                                                                                                                                                            550 Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                            • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                                                                                                            547 Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Increased, Induced Mutations in Critical Genes Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                            • AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
                                                                                                                                                                                                                                                                                                                                                            1645 GR Agonist, Activation Decreased Leydig Cells Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                                            • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                                                            1646 GR Agonist, Activation Repressed expression of steroidogenic enzymes Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                                            • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                                                            1648 Repressed expression of steroidogenic enzymes Reduction, Testosterone synthesis in Leydig cells Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                                            • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                                                            1647 Decreased Leydig Cells Reduction, Testosterone synthesis in Leydig cells Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                                            • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                                                            1650 Decreased sperm quantity or quality in the adult, Decreased fertility impaired, Fertility Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                                            • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                                                            1146 Activation, Nicotinic acetylcholine receptor Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                            • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                                                                                                                                                                                                                                                                            • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                            • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                                                                                                                            • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                            1147 Activation, Nicotinic acetylcholine receptor Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                              581 Activation, Nicotinic acetylcholine receptor Mitochondrial dysfunction Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                                                                                                                                                                                                                                                                              658 Activation, Nicotinic acetylcholine receptor Desensitization, Nicotinic acetylcholine receptor Nov 29, 2016 Jun 7, 2018
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                                                                                                                              • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                                                                                                                              569 Abnormal, Foraging activity and behavior Decrease, Number of worker bees Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                              • Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                              • Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                              584 Abnormal, Foraging activity and behavior Reduced, Food storage Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                1144 Abnormal, Foraging activity and behavior Weakened, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                                                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                                                                                                                                • Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                • Weather event contributes abnormal foraging leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                • Nosema infection increases energetic demands leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                1148 Abnormal, Foraging activity and behavior Abnormal, Roll change within caste Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                  1150 Abnormal, Foraging activity and behavior Abnormal, Role change within caste Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                  • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                  • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                  558 Reduced, Food storage Decrease, Number of worker bees Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                    562 Reduced, Food storage impaired, Larval development Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                    • Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                    565 Abnormal, Roll change within caste Reduced, Brood care Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                    • Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                    • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                                                                                                                                    • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                                                                                                                                                                                                                                                                                    579 Abnormal, Roll change within caste Reduced, Food storage Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                    • Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                    580 Abnormal, Roll change within caste Decrease, Number of worker bees Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                      1149 Abnormal, Roll change within caste Weakened, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        566 Reduced, Brood care impaired, Larval development Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                                                                                                                                                                                                                                                                                        563 impaired, Larval development Death/Failure, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        • Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
                                                                                                                                                                                                                                                                                                                                                                        574 impaired, Hive thermoregulation Death/Failure, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Suppression of immune system contributes to impaired development and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        1153 impaired, Hive thermoregulation Weakened, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        662 Accumulation, Damaged mitochondrial DNA Accelerated, Aging Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        663 Accelerated, Aging Decrease, Number of worker bees Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        559 Decrease, Number of worker bees Death/Failure, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        • Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        573 Decrease, Number of worker bees impaired, Hive thermoregulation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Suppression of immune system contributes to impaired development and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        567 Increase, Energetic demands and therefore metabolic stress Increased, Appetite and hunger Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        568 Increased, Appetite and hunger Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        571 Increased, Viral susceptibility impaired, Development Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Suppression of immune system contributes to impaired development and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        575 Increased, Viral susceptibility Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        572 impaired, Development Decrease, Number of worker bees Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Suppression of immune system contributes to impaired development and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        576 Decreased, Glucose oxidase enzyme activity Decreased, Hydrogen peroxide production Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        577 Decreased, Hydrogen peroxide production Reduced, Antiseptic incorporated in food Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        578 Reduced, Antiseptic incorporated in food Abnormal, Roll change within caste Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                        • Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                        665 impaired, Thoracic shivering impaired, Hive thermoregulation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                          585 Inhibition, sodium channel Decreased, Sodium conductance 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                          • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                          • sodium channel inhibition leading to increased predation
                                                                                                                                                                                                                                                                                                                                                                          • Sodium channel inhibition leading to congenital malformations
                                                                                                                                                                                                                                                                                                                                                                          590 Inhibition, sodium channel Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            1242 Inhibition, sodium channel Decreased, sodium conductance 2 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel (Nav1.1) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                            586 Decreased, Sodium conductance 1 Reduced, swimming speed Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            • sodium channel inhibition leading to increased predation
                                                                                                                                                                                                                                                                                                                                                                            • Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            594 Decreased, Sodium conductance 1 Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to congenital malformations
                                                                                                                                                                                                                                                                                                                                                                            587 Reduced, swimming speed Reduced, feeding 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            • Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            588 Reduced, swimming speed Increased, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            • Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            • sodium channel inhibition leading to increased predation
                                                                                                                                                                                                                                                                                                                                                                            589 Reduced, feeding 1 Increased, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            • Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            596 Reduced, feeding 1 Reduced, survival Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            595 Increased, predation Reduced, survival Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            • Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            654 Increased, predation Decreased, survival Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            593 N/A, hypoxia Increased, amputations Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Sodium channel inhibition leading to congenital malformations
                                                                                                                                                                                                                                                                                                                                                                            597 Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel Decreased, Sodium conductance 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                            603 modulation, sodium channel prolonged, Depolarization of neuronal membrane Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Axonal sodium channel modulation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                            604 prolonged, Depolarization of neuronal membrane Overactivation, Neuronotransmitter release Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Axonal sodium channel modulation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                            605 Overactivation, Neuronotransmitter release Overactivation, muscle contraction Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Axonal sodium channel modulation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                            606 Overactivation, muscle contraction Increased, Ataxia, paralysis, or hyperactivity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Axonal sodium channel modulation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                            607 Increased, Ataxia, paralysis, or hyperactivity Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                            • Axonal sodium channel modulation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                            1861 Occurrence, Epileptic seizure Increased, glutamate Feb 13, 2019 Feb 13, 2019
                                                                                                                                                                                                                                                                                                                                                                              1999 Occurrence, Epileptic seizure Overactivation, NMDARs Nov 13, 2019 Nov 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                630 Occurrence, A paroxysmal depolarizing shift Occurrence, Epileptic seizure Nov 29, 2016 May 22, 2018
                                                                                                                                                                                                                                                                                                                                                                                • Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
                                                                                                                                                                                                                                                                                                                                                                                634 Decreased, Neuronal network function in adult brain Impairment, Learning and memory Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                                                                                                                                                                                                                                                                                                2656 Decreased, Neuronal network function in adult brain Sensory axonal peripheral neuropathy May 16, 2022 May 16, 2022
                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
                                                                                                                                                                                                                                                                                                                                                                                3072 Decreased, Neuronal network function in adult brain Neurological disorder Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                3073 Decreased, Neuronal network function in adult brain Neuroinflammation Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                3074 Decreased, Neuronal network function in adult brain Degeneration of dopaminergic neurons of the nigrostriatal pathway Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                  3076 Decreased, Neuronal network function in adult brain impaired, Learning and memory Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                  • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                  635 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increased, serotonin (5-HT) 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                    643 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increased, serotonin (5-HT) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                    1208 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increased, cilia movement Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                      1316 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increased, muscular waves in foot Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                      1317 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increased, valve movement Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                      1318 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increase, cilia movement Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                      1319 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) increased mantel display Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                      1337 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Increased, oocyte maturation Jan 30, 2017 Jan 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                      1172 Increased, serotonin (5-HT) 1 Increased, valve movement Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                        1186 Increased, serotonin (5-HT) 1 Decreased, gametogenesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                          1189 Increased, serotonin (5-HT) 1 Increased, locomotion Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                            1192 Increased, serotonin (5-HT) 1 increased or inappropriate, mantel display Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                              636 Increased, serotonin (5-HT) 1 Increase, cilia movement Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                640 Increased, serotonin (5-HT) 1 Increased, muscular waves in foot Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                  637 Increase, cilia movement Increased, locomotion Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                    639 Increase, cilia movement Increased, foot detachment Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                      1178 Increase, cilia movement premature, spawning 1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                        1187 Increase, cilia movement premature, Spawning Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                          1217 Increase, cilia movement Increased, water pumping Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                            1218 Increase, cilia movement Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                              1321 Increase, cilia movement induced spawning Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                              1335 Increase, cilia movement Induced parturition Jan 30, 2017 Jan 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                              1177 Increased, locomotion Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                              638 Increased, locomotion Increase, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                              2634 Increase, predation Decrease, Population growth rate Apr 6, 2022 Apr 6, 2022
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                              1176 Increased, foot detachment Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                              • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                              1183 Increased, foot detachment Increase, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                1228 Increased, muscular waves in foot Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                  641 Increased, muscular waves in foot Increased, locomotion Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                  • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                  642 Increased, muscular waves in foot Increased, foot detachment Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                  • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                  644 Increased, serotonin (5-HT) Decreased, anxiety Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                  • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
                                                                                                                                                                                                                                                                                                                                                                                                                  1207 Increased, serotonin (5-HT) Increased, mantel display Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                    1209 Increased, serotonin (5-HT) Increased, cilia movement Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      1212 Increased, serotonin (5-HT) Increased, oocyte maturation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                      1327 Increased, serotonin (5-HT) Increased, valve movement Jan 17, 2017 Jan 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                      1332 Increased, serotonin (5-HT) Increased, muscular waves in foot Jan 30, 2017 Jan 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                      1333 Increased, serotonin (5-HT) Increase, cilia movement Jan 30, 2017 Jan 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                      1336 Increased, serotonin (5-HT) increased mantel display Jan 30, 2017 Jan 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                      645 Decreased, anxiety Decreased, sheltering Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
                                                                                                                                                                                                                                                                                                                                                                                                                      646 Decreased, sheltering Increased, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
                                                                                                                                                                                                                                                                                                                                                                                                                      649 Decrease, histaminergic neuron excitation N/A, sedation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                                                                      1643 Decrease, histaminergic neuron excitation Impairment, Learning and memory Aug 11, 2017 Aug 11, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                      • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                                                                      650 N/A, sedation Decreased, locomotion Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                                                                      651 Decreased, locomotion Increased, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                                                                      3079 impaired, Learning and memory Parkinsonian motor deficits Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                      1061 Antagonism, Histamine Receptor (H2) Decrease, histaminergic neuron excitation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Histamine (H2) receptor antagonism leading to reduced survival
                                                                                                                                                                                                                                                                                                                                                                                                                      3171 Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes Decrease, DHT level Mar 20, 2024 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                      • Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
                                                                                                                                                                                                                                                                                                                                                                                                                      3168 Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes Decrease, testosterone levels Mar 20, 2024 Apr 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                      • Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                      3167 Decreased COUP-TFII in Leydig cells Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes Mar 20, 2024 Apr 16, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                      • Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                      • Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
                                                                                                                                                                                                                                                                                                                                                                                                                      659 Desensitization, Nicotinic acetylcholine receptor Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
                                                                                                                                                                                                                                                                                                                                                                                                                      1309 Desensitization, Nicotinic acetylcholine receptor Altered, Ca2+-calmodulin activated signal transduction Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                      • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                                                                                                                                                                                      661 Overwhelmed, Mitochondrial DNA repair mechanisms Accumulation, Damaged mitochondrial DNA Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                      666 Binding at picrotoxin site, iGABAR chloride channel Reduction, Ionotropic GABA receptor chloride channel conductance Nov 29, 2016 Apr 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
                                                                                                                                                                                                                                                                                                                                                                                                                      683 Reduction, Neuronal synaptic inhibition Generation, Amplified excitatory postsynaptic potential (EPSP) Nov 29, 2016 May 15, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
                                                                                                                                                                                                                                                                                                                                                                                                                      672 Reduced, Prostaglandin F2alpha concentration, plasma Reduced, Spawning behavior Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
                                                                                                                                                                                                                                                                                                                                                                                                                      678 Reduced, Prostaglandin F2alpha concentration, plasma Reduced, Pheromone release Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
                                                                                                                                                                                                                                                                                                                                                                                                                      671 Reduced, Prostaglandin F2alpha synthesis, ovary Reduced, Prostaglandin F2alpha concentration, plasma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
                                                                                                                                                                                                                                                                                                                                                                                                                      673 Reduced, Spawning behavior Reduced, Ability to attract spawning mates Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
                                                                                                                                                                                                                                                                                                                                                                                                                      674 Reduced, Ability to attract spawning mates Reduced, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
                                                                                                                                                                                                                                                                                                                                                                                                                      675 Reduced, Reproductive Success Decrease, Population growth rate Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                      679 Reduced, Pheromone release Reduced, Ability to attract spawning mates Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
                                                                                                                                                                                                                                                                                                                                                                                                                      682 Decreased, Prostaglandin F2alpha synthesis, ovary Reduced, Prostaglandin F2alpha concentration, plasma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
                                                                                                                                                                                                                                                                                                                                                                                                                      684 Generation, Amplified excitatory postsynaptic potential (EPSP) Occurrence, A paroxysmal depolarizing shift Nov 29, 2016 May 15, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
                                                                                                                                                                                                                                                                                                                                                                                                                      685 Reduced, Prostaglandins, ovary Decrease, Ovulation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                      690 Reduced, Prostaglandin E2 concentration, hypothalamus Reduced, Gonadotropin releasing hormone, hypothalamus Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                      691 Reduced, Gonadotropin releasing hormone, hypothalamus Reduced, Luteinizing hormone (LH), plasma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                      692 Reduced, Luteinizing hormone (LH), plasma Reduced, Maturation inducing steroid, plasma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                      693 Reduced, Maturation inducing steroid, plasma Reduced, Maturation inducing steroid receptor signalling, oocyte Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                      694 Reduced, Maturation inducing steroid receptor signalling, oocyte Increased, cyclic adenosine monophosphate Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                      698 Reduced, Maturation inducing steroid receptor signalling, oocyte Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                      695 Increased, cyclic adenosine monophosphate Reduced, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        696 Increased, cyclic adenosine monophosphate Reduced, Meiotic prophase I/metaphase I transition, oocyte Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                        697 Reduced, Meiotic prophase I/metaphase I transition, oocyte Reduced, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
                                                                                                                                                                                                                                                                                                                                                                                                                        699 Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Increased, Chromosome misseggregation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                        700 Increased, Chromosome misseggregation Reduced, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
                                                                                                                                                                                                                                                                                                                                                                                                                        701 impaired, ion channels Altered, Action Potential Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Altered ion channel activity leading impaired heart function
                                                                                                                                                                                                                                                                                                                                                                                                                        702 Altered, Action Potential Increased, cardiac arrthymia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Altered ion channel activity leading impaired heart function
                                                                                                                                                                                                                                                                                                                                                                                                                        703 Increased, cardiac arrthymia Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Altered ion channel activity leading impaired heart function
                                                                                                                                                                                                                                                                                                                                                                                                                        707 Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Increase, Cytotoxicity (renal tubular cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                        708 Increase, Cytotoxicity (renal tubular cell) Increase, Regenerative cell proliferation (tubular epithelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                        1676 Increase, Cytotoxicity (renal tubular cell) Occurrence, Kidney toxicity Oct 25, 2017 Mar 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                        • Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                        • Renal protein alkylation leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                        760 Increase, Regenerative cell proliferation (tubular epithelial cells) Increase, Hyperplasia (renal tubular cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                        785 Increase, Regenerative cell proliferation (tubular epithelial cells) Increase, Hyperplasia (tubular epithelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                        706 Increased, Binding of chemicals to 2u (serum) Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                        • Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                        711 Activation, Constitutive androstane receptor Increase, cell proliferation (hepatocytes) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          1268 Activation, Constitutive androstane receptor Altered expression of hepatic CAR-dependent genes Nov 29, 2016 Dec 21, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                          • Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
                                                                                                                                                                                                                                                                                                                                                                                                                          1239 Increase, cell proliferation (hepatocytes) Increase, Clonal Expansion of Altered Hepatic Foci Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                                                                                                                                                                                                                                                                                          2254 Increase, cell proliferation (hepatocytes) Increase, hepatocellular adenomas and carcinomas Dec 31, 2020 Dec 31, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                                                                                                                                                                                                                                                                                          773 Increase, cell proliferation (hepatocytes) Increase, Preneoplastic foci (hepatocytes) Nov 29, 2016 Feb 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                          • Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                          714 Binding, Tubulin Disruption, Microtubule dynamics Nov 29, 2016 May 27, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                          • Chemical binding to tubulin in oocytes leading to aneuploid offspring
                                                                                                                                                                                                                                                                                                                                                                                                                          724 Binding, Tubulin Altered, Chromosome number Nov 29, 2016 Dec 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                          • Chemical binding to tubulin in oocytes leading to aneuploid offspring
                                                                                                                                                                                                                                                                                                                                                                                                                          715 Disruption, Microtubule dynamics Disorganization, Meiotic Spindle Nov 29, 2016 Dec 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                          • Chemical binding to tubulin in oocytes leading to aneuploid offspring
                                                                                                                                                                                                                                                                                                                                                                                                                          737 Disorganization, Meiotic Spindle Altered, Meiotic chromosome dynamics Nov 29, 2016 Dec 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                          • Chemical binding to tubulin in oocytes leading to aneuploid offspring
                                                                                                                                                                                                                                                                                                                                                                                                                          723 Altered, Chromosome number Increase, Aneuploid offspring Nov 29, 2016 Dec 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                          • Chemical binding to tubulin in oocytes leading to aneuploid offspring
                                                                                                                                                                                                                                                                                                                                                                                                                          716 Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme Increased, Induction of pyruvate dehydrogenase (PDH) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                          762 Increased, Induction of pyruvate dehydrogenase (PDH) Increase, Oxidative metabolism Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                          726 Increase, Necrosis (terminal bronchiolar cells) Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          • Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                          727 Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Increase, Hyperplasia (terminal bronchiolar cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          • Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                          728 Increase, Hyperplasia (terminal bronchiolar cells) Increase, Adenomas/carcinomas (bronchioloalveolar) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                          • Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                          768 Decreased, Uptake of inorganic iodide Decrease, Serum thyroid hormone (T4/T3) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                            2421 Decreased, Uptake of inorganic iodide TH synthesis, Decreased Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                              742 Increase, Hypertrophy and proliferation (follicular cell) Increase, Hyperplasia (follicular cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                              • Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                              743 Increase, Hyperplasia (follicular cells) Increase, Adenomas/carcinomas (follicular cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                              • Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                              729 Decreased, Androgen receptor activity Decreased, Testosterone binding to androgen receptor (hypothalamus) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                              • Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                              730 Decreased, Testosterone binding to androgen receptor (hypothalamus) Increase, Hyperplasia (Leydig cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                744 Decreased, Testosterone binding to androgen receptor (hypothalamus) Increased, Luteinizing hormone (LH) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                • Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                731 Increase, Hyperplasia (Leydig cells) Increase, Leydig cell tumors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                • Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                732 Increase, Dopaminergic activity Decreased, Prolactin Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                770 Increase, Dopaminergic activity Increase, Endometrial adenocarcinomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                  733 Decreased, Prolactin Increased, Estrogen receptor (ER) activity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                  734 Increased, Estrogen receptor (ER) activity Decreased, Progesterone from corpus luteum Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                  2737 Increased, Estrogen receptor (ER) activity Increase, Vitellogenin mRNA Aug 28, 2022 Aug 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Alcohol dehydrogenase leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                  772 Decreased, Progesterone from corpus luteum Increase, Hyperplasia (glandular epithelial cells of endometrium) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                  738 Altered, Meiotic chromosome dynamics Altered, Chromosome number Nov 29, 2016 Dec 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Chemical binding to tubulin in oocytes leading to aneuploid offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                  2554 Altered, Meiotic chromosome dynamics Increase, Pollen abnormal Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionising energy leads to population decline via pollen abnormal
                                                                                                                                                                                                                                                                                                                                                                                                                                  2384 Altered, Meiotic chromosome dynamics Decreased spermatogenesis May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                  2383 Altered, Meiotic chromosome dynamics Increase, Oocyte apoptosis May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                  2391 Altered, Meiotic chromosome dynamics Ionizing Energy May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                    741 Increase, Thyroid-stimulating hormone (TSH) Increase, Hypertrophy and proliferation (follicular cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                      745 Increased, Luteinizing hormone (LH) Increase, Hyperplasia (Leydig cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                      747 Hippocampal gene expression, Altered Hippocampal anatomy, Altered Nov 29, 2016 Aug 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      2886 Hippocampal gene expression, Altered Hippocampal Physiology, Altered Apr 12, 2023 Apr 12, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                      • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      749 Hippocampal anatomy, Altered Hippocampal Physiology, Altered Nov 29, 2016 Aug 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      748 Hippocampal Physiology, Altered Cognitive Function, Decreased Nov 29, 2016 Aug 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      2484 Hippocampal Physiology, Altered Loss, Cochlear function Sep 14, 2021 Sep 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                      2864 Hippocampal Physiology, Altered Impairment, Learning and memory Apr 3, 2023 Apr 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                      2466 Increased, Kidney Failure Increased Mortality Aug 11, 2021 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                      • Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
                                                                                                                                                                                                                                                                                                                                                                                                                                      2462 Increased, Kidney Failure Increase, Mortality Aug 5, 2021 Aug 5, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                        752 Activation, Glutamate-gated chloride channel Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glutamate-gated chloride channel activation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        758 Increased, Chloride conductance hyperpolarisation, neuron Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glutamate-gated chloride channel activation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        1052 Increased, Chloride conductance Increased, Neuronal synaptic inhibition Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        1051 Activation, ionotropic GABA Receptor chloride channel Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        1566 hyperpolarisation, neuron Analgesia Jun 8, 2017 Jun 8, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                        1572 hyperpolarisation, neuron Anti-depressant Activity Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                        755 hyperpolarisation, neuron N/A, Ataxia, paralysis, or hyperactivity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glutamate-gated chloride channel activation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        757 N/A, Ataxia, paralysis, or hyperactivity Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glutamate-gated chloride channel activation leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                        775 Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme Increased, Plasma tyrosine Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                        761 Increase, Hyperplasia (renal tubular cells) Increase, Adenomas/carcinomas (renal tubular) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                        766 Increase, Cytotoxicity Increase, hepatocellular adenomas and carcinomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                        887 Increase, Cytotoxicity Increase, Tissue Degeneration, Necrosis & Atrophy Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                        763 Increase, Oxidative metabolism Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                        767 Increase, Cytotoxicity (club cells) Increase, Necrosis (terminal bronchiolar cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                        • Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                                        769 Decrease, Serum thyroid hormone (T4/T3) Increase, Thyroid-stimulating hormone (TSH) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          771 Increase, Hyperplasia (glandular epithelial cells of endometrium) Increase, Endometrial adenocarcinomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          2972 Increase, Hyperplasia (glandular epithelial cells of endometrium) Genomic instability Jul 27, 2023 Jul 27, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
                                                                                                                                                                                                                                                                                                                                                                                                                                          774 Increase, Preneoplastic foci (hepatocytes) Increase, hepatocellular adenomas and carcinomas Nov 29, 2016 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          776 Increased, Plasma tyrosine Increase, Cytotoxicity (corneal cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          777 Increase, Cytotoxicity (corneal cells) Increase, Inflammation (corneal cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          778 Increase, Inflammation (corneal cells) Increase, Regenerative cell proliferation (corneal cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          779 Increase, Regenerative cell proliferation (corneal cells) Increase, Papillomas/carcinomas (squamous cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          780 Increase, Cytotoxicity (epithelial cells) Increase, Inflammation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          2664 Increase, Cytotoxicity (epithelial cells) Secondary genotoxicity May 25, 2022 May 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                          2659 Increase, Cytotoxicity (epithelial cells) Increased, Reactive oxygen species May 25, 2022 May 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                          782 Increase, Regenerative cell proliferation (forestomach epithelial cells) Increase, Hyperplasia (forestomach epithelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          783 Increase, Hyperplasia (forestomach epithelial cells) Increase, Papillomas/carcinomas (squamous cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          784 Increase, Cytotoxicity (tubular epithelial cells) Increase, Regenerative cell proliferation (tubular epithelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          786 Increase, Hyperplasia (tubular epithelial cells) Increase, Adenomas/carcinomas (renal tubular) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          787 Activation, Androgen receptor Increase, cell proliferation (hepatocytes) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          2915 Activation, Androgen receptor Inflammatory events May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                          2913 Activation, Androgen receptor Decreased, Apoptosis (Epithelial Cells) May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                          2908 Activation, Androgen receptor Altered, Transcription of genes by the AR May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                          788 Increase, Cytotoxicity (hepatocytes) Increase, Regenerative cell proliferation (hepatocytes) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          789 Increase, Regenerative cell proliferation (hepatocytes) Increase, Preneoplastic foci (hepatocytes) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                          • Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                          791 Decrease, Incorporation of active iodide into iodotyrosines Decrease, Serum thyroid hormone (T4/T3) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                            792 Inhibition, 5α-reductase activity Decrease, Bioactivation of testosterone Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                              3226 Inhibition, 5α-reductase activity Decrease, testosterone levels May 24, 2024 May 24, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                              794 Increased, Leutinizing hormone (LH) Increase, Hyperplasia (Leydig cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                              793 Decrease, Bioactivation of testosterone Increased, Leutinizing hormone (LH) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                795 Increase, Urinary bladder calculi Increase, Cytotoxicity (urothelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                                796 Increase, Cytotoxicity (urothelial cells) Increase, Regenerative cell proliferation (urothelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                                797 Increase, Regenerative cell proliferation (urothelial cells) Increase, Hyperplasia (urothelial) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                                • AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                798 Increase, Hyperplasia (urothelial) Increase, Adenomas/carcinomas (urothelial) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                                2085 Increase, Hyperplasia (urothelial) carcinogenicity Apr 21, 2020 Apr 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                • AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                799 Inhibition, Prolyl hydroxylases Increased, HIF-1 heterodimer Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                800 Increased, HIF-1 heterodimer Decreased, Aromatase (Cyp19a1) mRNA Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                                                                                                                                                                                                                                                                                                                                801 Decreased, Aromatase (Cyp19a1) mRNA Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                                                                                                                                                                                                                                                                                                                                802 modulation, Unknown Increased, HIF-1 alpha transcription Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                                                                                                                                                                                                                                                                                                                                803 Increased, HIF-1 alpha transcription Increased, HIF-1 heterodimer Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
                                                                                                                                                                                                                                                                                                                                                                                                                                                804 Inhibition, HMG-CoA reductase Decreased, mevalonate Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • HMG-CoA reductase inhibition leading to decreased fertility
                                                                                                                                                                                                                                                                                                                                                                                                                                                805 Decreased, mevalonate Decreased, cholesterol Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • HMG-CoA reductase inhibition leading to decreased fertility
                                                                                                                                                                                                                                                                                                                                                                                                                                                2072 Decreased, cholesterol Decreased, 11KT Mar 23, 2020 May 6, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                • PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
                                                                                                                                                                                                                                                                                                                                                                                                                                                3201 Decreased, cholesterol Decrease, testosterone levels Apr 25, 2024 Apr 25, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                • HMG-CoA reductase inhibition leading to decreased fertility
                                                                                                                                                                                                                                                                                                                                                                                                                                                808 malformed, Male reproductive tract Decrease, Fertility Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • HMG-CoA reductase inhibition leading to decreased fertility
                                                                                                                                                                                                                                                                                                                                                                                                                                                813 Increased, Serum creatinine Occurrence, Cytoplasmic vacuolization (Renal tubule) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                814 Increased, Serum creatinine Occurrence, Cystic dilatation (renal tubule) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                816 Increased, Serum creatinine Occurrence, Cytoplasmic vacuolization (podocyte) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                2648 Occurrence, Kidney toxicity Increased, Kidney Failure Apr 8, 2022 Apr 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                817 Occurrence, Cytoplasmic vacuolization (Renal tubule) Decreased, Glomerular filtration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                818 Occurrence, Cytoplasmic vacuolization (Renal tubule) Decreased, Renal plasma flow Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                819 Occurrence, Cytoplasmic vacuolization (Renal tubule) Decreased, Sodium reabsorption Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                820 Occurrence, Cytoplasmic vacuolization (Renal tubule) Decreased, Renal ability to dilute urine Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                829 Decreased, Glomerular filtration Occurrence, Kidney toxicity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                3234 Decreased, Glomerular filtration Increased, Kidney Failure Jun 6, 2024 Jun 6, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Activation of Protein kinase C leads to Kidney Failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                830 Decreased, Renal plasma flow Occurrence, Kidney toxicity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                831 Decreased, Sodium reabsorption Occurrence, Kidney toxicity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                821 Occurrence, Cystic dilatation (renal tubule) Decreased, Glomerular filtration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                822 Occurrence, Cystic dilatation (renal tubule) Decreased, Renal plasma flow Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                823 Occurrence, Cystic dilatation (renal tubule) Decreased, Sodium reabsorption Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                824 Occurrence, Cystic dilatation (renal tubule) Decreased, Renal ability to dilute urine Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                825 Occurrence, Cytoplasmic vacuolization (podocyte) Decreased, Glomerular filtration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                826 Occurrence, Cytoplasmic vacuolization (podocyte) Decreased, Renal plasma flow Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                827 Occurrence, Cytoplasmic vacuolization (podocyte) Decreased, Sodium reabsorption Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                828 Occurrence, Cytoplasmic vacuolization (podocyte) Decreased, Renal ability to dilute urine Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                832 Decreased, Renal ability to dilute urine Occurrence, Kidney toxicity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Kidney dysfunction by decreased thyroid hormone
                                                                                                                                                                                                                                                                                                                                                                                                                                                834 Activation, Keratinocytes Activation, Dendritic Cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Covalent Protein binding leading to Skin Sensitisation
                                                                                                                                                                                                                                                                                                                                                                                                                                                836 Inhibition, Phospholipase A Damage, Lipid bilayer Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                837 Inhibition, Phospholipase A Disturbance, Lysosomal function Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                3154 Inhibition, Phospholipase A Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                839 Damage, Lipid bilayer Occurrence, Cytoplasmic vacuolization (hepatocyte) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                840 Damage, Lipid bilayer Occurrence, Ballooning degeneration (hepatocyte) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                841 Damage, Lipid bilayer Occurrence, Cytoplasmic vacuolization (Bile duct cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                842 Damage, Lipid bilayer Occurrence, Cytoplasmic vacuolization (kupffer cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                843 Disturbance, Lysosomal function Occurrence, Cytoplasmic vacuolization (hepatocyte) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                844 Disturbance, Lysosomal function Occurrence, Ballooning degeneration (hepatocyte) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                845 Disturbance, Lysosomal function Occurrence, Cytoplasmic vacuolization (Bile duct cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                846 Disturbance, Lysosomal function Occurrence, Cytoplasmic vacuolization (kupffer cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                1678 Disturbance, Lysosomal function Disruption, Lysosome Oct 25, 2017 Oct 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                851 Occurrence, Cytoplasmic vacuolization (hepatocyte) Induction, Microvesicular fat Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                852 Occurrence, Cytoplasmic vacuolization (hepatocyte) Formation, Mallory body Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                853 Occurrence, Ballooning degeneration (hepatocyte) Induction, Microvesicular fat Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                854 Occurrence, Ballooning degeneration (hepatocyte) Formation, Mallory body Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                855 Occurrence, Cytoplasmic vacuolization (Bile duct cell) Induction, Microvesicular fat Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                856 Occurrence, Cytoplasmic vacuolization (Bile duct cell) Formation, Mallory body Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                857 Occurrence, Cytoplasmic vacuolization (kupffer cell) Induction, Microvesicular fat Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                858 Occurrence, Cytoplasmic vacuolization (kupffer cell) Formation, Mallory body Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                859 Induction, Microvesicular fat Formation, Liver fibrosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                860 Formation, Mallory body Formation, Liver fibrosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                • Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                864 Oxidation, Uroporphyrinogen Accumulation, Highly carboxylated porphyrins Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                  865 Oxidation, Uroporphyrinogen Inhibition, UROD Nov 29, 2016 May 30, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Aryl hydrocarbon receptor activation leading to uroporphyria
                                                                                                                                                                                                                                                                                                                                                                                                                                                  867 Inhibition, UROD Oxidation, Uroporphyrinogen Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                    1070 Inhibition, UROD Accumulation, Highly carboxylated porphyrins Nov 29, 2016 May 30, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Aryl hydrocarbon receptor activation leading to uroporphyria
                                                                                                                                                                                                                                                                                                                                                                                                                                                    866 Accumulation, Highly carboxylated porphyrins Uroporphyria Nov 29, 2016 May 7, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Aryl hydrocarbon receptor activation leading to uroporphyria
                                                                                                                                                                                                                                                                                                                                                                                                                                                    868 Induction, CYP1A2/CYP1A5 Oxidation, Uroporphyrinogen Nov 29, 2016 May 31, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Aryl hydrocarbon receptor activation leading to uroporphyria
                                                                                                                                                                                                                                                                                                                                                                                                                                                    2893 Induction, CYP1A2/CYP1A5 Increase, ROS production Apr 13, 2023 Apr 13, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                      2907 Induction, CYP1A2/CYP1A5 Increase, Oxidative Stress May 4, 2023 May 4, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                                      871 GABAergic interneurons, Decreased Synaptogenesis, Decreased Nov 29, 2016 Jan 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                      995 Changes/Inhibition, Cellular Homeostasis and Apoptosis N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                                                                                                                                                                                                                                                                                                                                                                                      997 Alterations, Cellular proliferation / hyperplasia Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Dec 2, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Sustained AhR Activation leading to Rodent Liver Tumours
                                                                                                                                                                                                                                                                                                                                                                                                                                                      2911 Alterations, Cellular proliferation / hyperplasia prostatic intraepithelial neoplasia May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                      877 Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain Decreased, PPARalpha transactivation of gene expression Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                        879 Decreased, PPARalpha transactivation of gene expression Decreased, Mitochondrial Fatty Acid Beta Oxidation Nov 29, 2016 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                          880 Decreased, PPARalpha transactivation of gene expression Decreased, Ketogenesis (production of ketone bodies) Nov 29, 2016 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                          878 Decreased, PPARalpha transactivation of gene expression Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Nov 29, 2016 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                            1748 Decreased, PPARalpha transactivation of gene expression Fatty Acid Beta Oxidation, Decreased Jun 11, 2018 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                            881 Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Decreased, Mitochondrial Fatty Acid Beta Oxidation Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                              882 Decreased, Mitochondrial Fatty Acid Beta Oxidation Decreased, Ketogenesis (production of ketone bodies) Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                2040 Decreased, Mitochondrial Fatty Acid Beta Oxidation Increased, Liver Steatosis Feb 22, 2020 Feb 22, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2264 Decreased, Mitochondrial Fatty Acid Beta Oxidation Accumulation, Triglyceride Jan 15, 2021 Jan 15, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Glucocorticoid Receptor activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  883 Decreased, Ketogenesis (production of ketone bodies) Not Increased, Circulating Ketone Bodies Nov 29, 2016 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  884 Not Increased, Circulating Ketone Bodies Increased, Catabolism of Muscle Protein Nov 29, 2016 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  885 Increased, Catabolism of Muscle Protein Decreased, Body Weight Nov 29, 2016 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  886 Decrease, Intracellular pH Increase, Cytotoxicity Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  888 Increase, Tissue Degeneration, Necrosis & Atrophy Increase, Respiratory or Squamous Metaplasia Nov 29, 2016 Dec 1, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  889 Increase, Respiratory or Squamous Metaplasia Increase, Cell Proliferation Nov 29, 2016 Dec 1, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                  890 Increase, Cell Proliferation Increased, Induced Mutations in Critical Genes Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    893 Increase, Cell Proliferation Increase, Mutations in Critical Genes Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    895 Increase, Cell Proliferation Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 1, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2419 Increase, Cell Proliferation Increased, mesotheliomas Jul 6, 2021 Jul 6, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2819 Increase, Cell Proliferation Cataracts Dec 18, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1967 Increase, Cell Proliferation Lung cancer Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Frustrated phagocytosis-induced lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1980 Increase, Cell Proliferation Increase, lung cancer Aug 29, 2019 Jan 10, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    919 Binding of agonist, Ionotropic glutamate receptors Overactivation, NMDARs Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    894 Increase, Mutations in Critical Genes Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 1, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1131 Inhibition, organic anion transporter 1 (OAT1) Increased, blood uric acid concentration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    934 Inhibition, NADH-ubiquinone oxidoreductase (complex I) Mitochondrial dysfunction Nov 29, 2016 Aug 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1940 Inhibition, NADH-ubiquinone oxidoreductase (complex I) Decrease in mitochondrial oxidative phosphorylation Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1809 Inhibition, NADH-ubiquinone oxidoreductase (complex I) Decrease, OXPHOS Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    933 Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Inhibition, NADH-ubiquinone oxidoreductase (complex I) Nov 29, 2016 Aug 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    905 Impaired, Proteostasis Degeneration of dopaminergic neurons of the nigrostriatal pathway Nov 29, 2016 Aug 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1943 Impaired, Proteostasis Cell injury/death Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    907 Degeneration of dopaminergic neurons of the nigrostriatal pathway Neuroinflammation Nov 29, 2016 Oct 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    910 Degeneration of dopaminergic neurons of the nigrostriatal pathway Parkinsonian motor deficits Nov 29, 2016 Aug 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3077 Degeneration of dopaminergic neurons of the nigrostriatal pathway impaired, Learning and memory Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3083 Parkinsonian motor deficits Increase, Mortality Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                    921 Disruption, Lysosome Peptide Oxidation Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                      911 Disruption, Lysosome Increase, ROS production Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        993 Disruption, Lysosome Mitochondrial dysfunction Nov 29, 2016 Nov 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Endocytic lysosomal uptake leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Endocytotic lysosomal uptake leads to intestinal barrier disruption
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1679 Disruption, Lysosome Increase, Cytotoxicity (renal tubular cell) Oct 25, 2017 Oct 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                        916 Infiltration, Inflammatory cells Inflammation, Liver Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                          926 Infiltration, Inflammatory cytokines Inflammation, Liver Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                            936 Activation, Epidermal Growth Factor Receptor Decreased ciliated cell apoptosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                              946 Activation, Epidermal Growth Factor Receptor Activation, Sp1 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                939 Activation, Epidermal Growth Factor Receptor Increased goblet cell proliferation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  942 Activation, Epidermal Growth Factor Receptor Occurrence, Transdifferentiation of ciliated epithelial cells Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    961 Decreased ciliated cell apoptosis Occurrence, Transdifferentiation of ciliated epithelial cells Nov 29, 2016 Aug 25, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2470 Decreased ciliated cell apoptosis Goblet cell metaplasia Aug 25, 2021 Aug 25, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        943 Occurrence, Transdifferentiation of ciliated epithelial cells Goblet cell metaplasia Nov 29, 2016 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          990 Goblet cell metaplasia Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1313 Goblet cell metaplasia Increase, Mucin production Nov 29, 2016 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2471 Goblet cell metaplasia Chronic, Mucus hypersecretion Aug 26, 2021 Aug 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2472 Goblet cell hyperplasia Chronic, Mucus hypersecretion Aug 26, 2021 Aug 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  989 Goblet cell hyperplasia Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1312 Goblet cell hyperplasia Increase, Mucin production Nov 29, 2016 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      944 Increased goblet cell proliferation Goblet cell hyperplasia Nov 29, 2016 Aug 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        987 Activation, Sp1 Increase, Mucin production Nov 29, 2016 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          954 Oxidation, Glutathione S-Glutathionylation, eNOS Nov 29, 2016 Sep 28, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2459 Oxidation, Glutathione Increased, Reactive oxygen species Aug 5, 2021 Aug 5, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            955 S-Glutathionylation, eNOS Uncoupling, eNOS Nov 29, 2016 Oct 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            956 Uncoupling, eNOS Depletion, Nitric Oxide Nov 29, 2016 Oct 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3014 Uncoupling, eNOS Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3023 Uncoupling, eNOS increased,Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              958 Depletion, Nitric Oxide Impaired, Vasodilation Nov 29, 2016 Oct 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              953 Decrease, Tetrahydrobiopterin Uncoupling, eNOS Nov 29, 2016 Oct 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              952 Decrease, GTPCH-1 Decrease, Tetrahydrobiopterin Nov 29, 2016 Oct 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              982 Impaired, Vasodilation Increase, Vascular Resistance Nov 29, 2016 Oct 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              986 Activation, EGFR Increase, Mucin production Nov 29, 2016 Mar 9, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • EGFR Activation Leading to Decreased Lung Function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              962 Activation, EGFR Decreased ciliated cell apoptosis Nov 29, 2016 Aug 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                964 Activation, EGFR Activation, Sp1 Nov 29, 2016 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  965 Activation, EGFR Occurrence, Transdifferentiation of ciliated epithelial cells Nov 29, 2016 Aug 25, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    970 Activation, EGFR Increased goblet cell proliferation Nov 29, 2016 Aug 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2469 Activation, EGFR Goblet cell metaplasia Aug 25, 2021 Aug 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2857 Activation, EGFR Increase, goblet cell number Mar 15, 2023 Mar 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • EGFR Activation Leading to Decreased Lung Function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        973 dimerization, AHR/ARNT reduced dimerization, ARNT/HIF1-alpha Nov 29, 2016 Mar 23, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • AhR activation leading to preeclampsia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2683 dimerization, AHR/ARNT Increase, slincR expression Jun 30, 2022 Sep 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2682 dimerization, AHR/ARNT Decrease, sox9 expression Jun 30, 2022 Jun 30, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1350 dimerization, AHR/ARNT Increase, COX-2 expression Feb 9, 2017 May 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1996 dimerization, AHR/ARNT Increase, DNMT expression Oct 30, 2019 Oct 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          974 reduced dimerization, ARNT/HIF1-alpha reduced production, VEGF Nov 29, 2016 Mar 23, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • AhR activation leading to preeclampsia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          975 reduced production, VEGF Impairment, Endothelial network Nov 29, 2016 Mar 23, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2407 reduced production, VEGF abnormal, placental labyrinth vasculature morphology May 31, 2021 May 31, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • AhR activation leading to preeclampsia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          983 Increase, Vascular Resistance Hypertension Nov 29, 2016 Oct 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2245 Binding, Transthyretin in serum Displacement, Serum thyroxine (T4) from transthyretin Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2248 Binding, Transthyretin in serum Displacement, Serum thyroxine (T4) from carrier protein Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2269 Binding, Transthyretin in serum Increased, Clearance of thyroxine from serum Jan 26, 2021 Jan 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2271 Binding, Transthyretin in serum Increased, Free serum thyroxine (T4) Jan 26, 2021 Jan 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2246 Displacement, Serum thyroxine (T4) from transthyretin Increased, Free serum thyroxine (T4) Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2247 Increased, Free serum thyroxine (T4) Increased, Hepatic thyroid hormone uptake/transport Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2268 Increased, Free serum thyroxine (T4) Increased, Uptake of thyroxine into tissue Jan 26, 2021 Jan 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2272 Increased, Free serum thyroxine (T4) Increased, Clearance of thyroxine from serum Jan 26, 2021 Jan 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2270 Increased, Clearance of thyroxine from serum T4 in serum, Decreased Jan 26, 2021 Jan 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                991 Increase, Mucin production Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2859 Increase, Mucin production Decreased lung function Mar 15, 2023 Mar 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • EGFR Activation Leading to Decreased Lung Function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1315 Increase, Mucin production Chronic, Mucus hypersecretion Nov 29, 2016 Aug 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    988 Decrease, AKT/eNOS activity Depletion, Nitric Oxide Nov 29, 2016 Oct 16, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Peptide Oxidation Leading to Hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1062 Formation, The binding of FK506 with FKBP12 Inhibition, Calcineurin Activity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1016 Activation, Suppression of NFAT activation and hindrance of nuclear localization Interference, nuclear localization of NFAT Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1017 Interference, nuclear localization of NFAT Reduction, NFAT/AP-1 complex formation Nov 29, 2016 Jul 2, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1015 Inhibition, Calcineurin Activity Activation, Suppression of NFAT activation and hindrance of nuclear localization Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1508 Inhibition, Calcineurin Activity Interference, nuclear localization of NFAT May 19, 2017 Jun 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1254 Inhibition, Calcineurin Activity Suppression, IL-2 and IL-4 production Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3248 Inhibition, Calcineurin Activity Disrupted calcium-dependent signalling pathway Jun 19, 2024 Jun 19, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3237 Inhibition, Calcineurin Activity Increased, activation of RAAS Jun 6, 2024 Jun 6, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3238 Inhibition, Calcineurin Activity Inhibition, COX-2 activity Jun 7, 2024 Jun 7, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3240 Inhibition, Calcineurin Activity Inhibition, NFAT Jun 7, 2024 Jun 7, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1256 Reduction, NFAT/AP-1 complex formation Suppression, Suppression of production of cytotoxic T-cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1257 Reduction, NFAT/AP-1 complex formation Suppression, Suppression of T-cell dependent antibody production Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1509 Reduction, NFAT/AP-1 complex formation Suppression, IL-2 and IL-4 production May 19, 2017 Jun 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1018 Reduction, NFAT/AP-1 complex formation Suppression, Suppression in mixed lymphocyte reaction (MLR) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1019 Reduction, NFAT/AP-1 complex formation Suppression, Suppression of T-cell dependent antibody response (TDAR) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1020 Reduction, NFAT/AP-1 complex formation Impairment, T-cell dependent antibody response Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1021 Reduction, NFAT/AP-1 complex formation Relief, Relief of atopic dermatitis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1022 Reduction, NFAT/AP-1 complex formation Impairment of TDAR Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1823 Suppression, Suppression of T-cell dependent antibody response (TDAR) Impairment of TDAR Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1000 Decrease, Circulating ETH Increase, Incomplete ecdysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1008 Decrease, Circulating ETH Decrease, Abdominal muscle contraction Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1346 Decrease, Circulating ETH Decrease, Circulating CCAP Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1001 Decreased, synthesis and secretion of molting fluid proteases Increase, Incomplete ecdysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1002 Increase, Incomplete ecdysis Increase, Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Doda decarboxylase leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1190 Increase, Incomplete ecdysis Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2759 Increase, Incomplete ecdysis Increase, developmental abnormalities Aug 28, 2022 Aug 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Knickkopf leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2751 Increase, Incomplete ecdysis Decrease, hatching of egg Aug 28, 2022 Aug 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Doda decarboxylase leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2750 Increase, Incomplete ecdysis Increase, delay in oviposition Aug 28, 2022 Aug 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Doda decarboxylase leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1010 Decrease, Abdominal muscle contraction Increase, Incomplete ecdysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1009 Decreased, Synthesis of molting fluid proteases Decrease, Digestion of old cuticle Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1011 Decrease, Digestion of old cuticle Increase, Incomplete ecdysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2171 Decrease, Digestion of old cuticle Increase, Premature molting Oct 21, 2020 Oct 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Chitinase inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Chitobiase inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1023 Binding of antagonist, PPAR alpha stabilization, PPAR alpha co-repressor Nov 29, 2016 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1024 stabilization, PPAR alpha co-repressor Decreased, PPARalpha transactivation of gene expression Nov 29, 2016 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1199 Inhibition, Deiodinase 2 Decreased, Triiodothyronine (T3) in tissues Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1026 Inhibition, Deiodinase 2 Decreased, Triiodothyronine (T3) Nov 29, 2016 Oct 7, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1042 Inhibition, Deiodinase 2 Reduced, Posterior swim bladder inflation Nov 29, 2016 Oct 7, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1043 Inhibition, Deiodinase 2 Reduced, Anterior swim bladder inflation Nov 29, 2016 Mar 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1027 Decreased, Triiodothyronine (T3) Reduced, Posterior swim bladder inflation Nov 29, 2016 Oct 7, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1035 Decreased, Triiodothyronine (T3) Reduced, Anterior swim bladder inflation Nov 29, 2016 Oct 7, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2378 Decreased, Triiodothyronine (T3) Altered, Photoreceptor patterning May 11, 2021 Oct 17, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2376 Decreased, Triiodothyronine (T3) Decreased, Eye size May 11, 2021 Jun 16, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered visual function via decreased eye size
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2373 Decreased, Triiodothyronine (T3) Altered, retinal layer structure May 11, 2021 Jul 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2213 Reduced, Posterior swim bladder inflation Increased Mortality Nov 30, 2020 Sep 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1031 Reduced, Posterior swim bladder inflation Reduced, Anterior swim bladder inflation Nov 29, 2016 Nov 20, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1028 Reduced, Posterior swim bladder inflation Reduced, Swimming performance Nov 29, 2016 Sep 3, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1641 Reduced, Swimming performance Growth, reduction Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1642 Reduced, Swimming performance Decreased, survival Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2212 Reduced, Swimming performance Increased Mortality Nov 30, 2020 Sep 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2081 Reduced, Swimming performance Decrease, Population growth rate Apr 21, 2020 Jun 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1032 Reduced, Anterior swim bladder inflation Reduced, Hearing Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1034 Reduced, Anterior swim bladder inflation Reduced, Swimming performance Nov 29, 2016 Oct 7, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2231 Reduced, Hearing Increased Mortality Dec 8, 2020 Dec 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • GSK3beta inactivation leading to increased mortality via defects in developing inner ear
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1045 Inhibition, Deiodinase 1 Reduced, Anterior swim bladder inflation Nov 29, 2016 Mar 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1044 Inhibition, Deiodinase 1 Reduced, Posterior swim bladder inflation Nov 29, 2016 Oct 10, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1037 Inhibition, Deiodinase 1 Decreased, Triiodothyronine (T3) Nov 29, 2016 Oct 10, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1198 Inhibition, Deiodinase 1 Decreased, Triiodothyronine (T3) in tissues Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1047 Increased, Chloride influx Increased, Inhibitory postsynaptic potential Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1054 Increased, Inhibitory postsynaptic potential Induction, Somatic muscle paralysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1048 Increased, Inhibitory postsynaptic potential Inhibition, Motor neuron activity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1058 Increased, Inhibitory postsynaptic potential Induction, pharyngeal muscle paralysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1049 Inhibition, Motor neuron activity Induction, Somatic muscle paralysis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1055 Induction, Somatic muscle paralysis Inhibition, Feeding Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1050 Induction, Somatic muscle paralysis Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3089 Induction, Somatic muscle paralysis Increased, Neuronal synaptic inhibition Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3090 Increased, Neuronal synaptic inhibition Inhibition, Feeding Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1053 Increased, Neuronal synaptic inhibition Increased, Inhibitory postsynaptic potential Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1056 Inhibition, Feeding Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3087 Inhibition, Feeding Increase, Mortality Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3084 Activation, Glutamate-gated chloride channels Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3085 Activation, Glutamate-gated chloride channels Increase, CNS Neural cell death Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1057 Activation, Glutamate-gated chloride channels Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1059 Induction, pharyngeal muscle paralysis Inhibition, Feeding Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1063 Increased, induction of UDPGT's in liver Increased, T4/T3 catabolism Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1064 Increased, T4/T3 catabolism Decreased, serum T4/T3 Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2423 Increased, T4/T3 catabolism T4 in serum, Decreased Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1065 Decreased, serum T4/T3 Increased, Thyroid-stimulating hormone (TSH) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1066 Increased, Thyroid-stimulating hormone (TSH) Increased, Hypertrophy and proliferation (follicular cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2425 Increased, Thyroid-stimulating hormone (TSH) Increase, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2424 Increased, Thyroid-stimulating hormone (TSH) Increase, Hypertrophy and proliferation (follicular cell) Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2240 Increased, Thyroid-stimulating hormone (TSH) Increased, Thyroxine (T4) in serum Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2427 Increased, Hypertrophy and proliferation (follicular cell) Increase, Hyperplasia (follicular cells) Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1067 Increased, Hypertrophy and proliferation (follicular cell) Increased, Hyperplasia (follicular cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1068 Increased, Hyperplasia (follicular cells) Increased Apoptosis, Adenomas/carcinomas (follicular cell) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2426 Increased, Hyperplasia (follicular cells) Increase, Adenomas/carcinomas (follicular cell) Jul 7, 2021 Jul 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1071 Activation of specific nuclear receptors, PPAR-gamma activation Increased, adipogenesis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1072 Activation of specific nuclear receptors, PPAR-gamma activation Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1609 Activation of specific nuclear receptors, PPAR-gamma activation increased adipogenesis Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1073 Increased, adipogenesis Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1074 Increased, secretion of local growth factors Increased, proliferation of mesenchymal cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1075 Increased, secretion of local growth factors Increased, IGF-1 (mouse) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1624 Increased, secretion of local growth factors Differentiation of fibroblasts Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1625 Increased, secretion of local growth factors EMT Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1129 Increased, secretion of local growth factors Increased, Cell Proliferation (mesothelium) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1076 Increased, proliferation of mesenchymal cells Increased, Firbrosarcoma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1077 Increased, proliferation of mesenchymal cells Increased, liposarcoma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1078 Increased, proliferation of mesenchymal cells Increased, hemagiosarcoma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • PPARgamma activation leading to sarcomas in rats, mice, and hamsters
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1079 Activation, beta-2 adrenergic receptor Increased activity, beta-2 adrenergic receptor Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1080 Increased activity, beta-2 adrenergic receptor relaxation, smooth muscle Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1081 relaxation, smooth muscle Proliferation/Clonal Expansion, smooth muscle Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1082 Proliferation/Clonal Expansion, smooth muscle Hypertrophy/hyperplasia, smooth muscle Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1083 Hypertrophy/hyperplasia, smooth muscle Promotion, mesovarian leiomyomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1084 Decreased, Ovarian E2 Increased, secretion of GnRH from hypothalamus Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1085 Decreased, Ovarian E2 Decrease, E2 blood concentrations at hypothalamus Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1086 Suppression, Estrogen receptor (ER) activity Decrease, E2 blood concentrations at hypothalamus Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2580 Suppression, Estrogen receptor (ER) activity Increased, secretion of GnRH from hypothalamus Feb 26, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1088 Increased, secretion of GnRH from hypothalamus Increased, secrection of FSH from anterior pituitary Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1089 Increased, secretion of GnRH from hypothalamus Increased, secretion of LH from anterior pituitary Nov 29, 2016 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1090 Increased, secrection of FSH from anterior pituitary Hyperplasia, ovarian stromal cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1091 Increased, secrection of FSH from anterior pituitary Hyperplasia, ovarian epithelium Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1092 Increased, secretion of LH from anterior pituitary Hyperplasia, ovarian stromal cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2581 Increased, secretion of LH from anterior pituitary Increased, Steroidogenic acute regulatory protein (StAR) Feb 26, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1094 Hyperplasia, ovarian stromal cells Promotion, ovarian granular cell tumors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1093 Hyperplasia, ovarian epithelium Promotion, ovarian adenomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2829 Promotion, ovarian adenomas Promotion, Ovarian Cancer Jan 13, 2023 Mar 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2830 Promotion, ovarian granular cell tumors Promotion, Ovarian Cancer Jan 13, 2023 Jan 13, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1087 Decrease, E2 blood concentrations at hypothalamus Increased, secretion of GnRH from hypothalamus Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1095 Increased, PPAR-alpha activation Decreased, bile flow Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1096 Increased, PPAR-alpha activation Increased, cholestasis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1097 Increased, PPAR-alpha activation Alteration, lipid metabolism Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1101 Decreased, bile flow Increased, cholestasis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1100 Increased, cholestasis prolonged, elevation of serun CCK Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3094 Alteration, lipid metabolism General Apoptosis Oct 18, 2023 Oct 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1098 prolonged, elevation of serun CCK Increased, Cellular proliferation / hyperplasia of acinar cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1099 Increased, Cellular proliferation / hyperplasia of acinar cells Increased, Pancreatic acinar tumors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1102 prepubertal increase, Estrogen receptor (ER) activity Activation, estrogen receptor alpha Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1103 Activation, estrogen receptor alpha Promotion, SIX-1 postive basal-type progenitor cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2969 Activation, estrogen receptor alpha Epigenetic modification process Jul 27, 2023 Jul 27, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2730 Activation, estrogen receptor alpha Impaired, Reproduction Aug 15, 2022 Aug 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2666 Activation, estrogen receptor alpha Decreased, Gonadotropins Jun 6, 2022 Aug 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2665 Activation, estrogen receptor alpha Increased, Kisspeptin signalling Jun 6, 2022 Aug 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1104 Promotion, SIX-1 postive basal-type progenitor cells Proliferation/Clonal Expansion, aberrant basal cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1105 Proliferation/Clonal Expansion, aberrant basal cells squamous metaplasia, aberrant basal cells Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1106 squamous metaplasia, aberrant basal cells Increased, Hyperplasia (glandular epithelial cells of endometrium) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1107 Increased, Hyperplasia (glandular epithelial cells of endometrium) Increased, adenosquamous carcinomas of endometrium Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1108 Decreased, GnRH pulsatility/release in hypothalamus Decreased, LH Surge from anterior pituitary Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1109 Decreased, LH Surge from anterior pituitary interruption, Ovulation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1110 Decreased, LH Surge from anterior pituitary prolonged, estrus Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1118 interruption, Ovulation Increased, circulating estrogen levels Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1111 prolonged, estrus Increased, circulating estrogen levels Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1112 prolonged, estrus Increased, prolactin exposure Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1113 Increased, circulating estrogen levels Hyperplasia, Mammary gland Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1119 Increased, circulating estrogen levels Increased, lactotroph hyperplasia and hypertrophy Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2584 Increased, circulating estrogen levels Hyperplasia, ovarian stromal cells Feb 26, 2022 Mar 2, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2585 Increased, circulating estrogen levels Hyperplasia, ovarian epithelium Feb 26, 2022 Mar 2, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1114 Increased, prolactin exposure Hyperplasia, Mammary gland Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1115 Hyperplasia, Mammary gland Increased, latency period Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1116 Hyperplasia, Mammary gland Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1117 Increased, latency period Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1120 Increased, lactotroph hyperplasia and hypertrophy Increased, adenomas (pituitary) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1121 Decreased, Dopaminergic activity Increased, prolactin secretion Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1122 Increased, prolactin secretion Increased, hyperplasia (mammary gland) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1123 Increased, hyperplasia (mammary gland) Increased, latency period Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1124 Increased, hyperplasia (mammary gland) Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1125 persistent, cytotoxicity (pleura or peritoneum) Increased, inflammation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1126 persistent, cytotoxicity (pleura or peritoneum) Increased, Oxidative Stress Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1127 Increased, inflammation Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1128 Increased, Oxidative Stress Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1160 Increased, Oxidative Stress Occurrence, renal proximal tubular necrosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • unknown MIE leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1300 Increased, Oxidative Stress Increase, DNA Damage Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2618 Increased, Oxidative Stress Increase, Apoptosis Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2936 Increased, Oxidative Stress Mitochondrial dysfunction EMPTY May 26, 2023 May 26, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2933 Increased, Oxidative Stress Impaired insulin signaling May 25, 2023 May 25, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3160 Increased, Oxidative Stress Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2385 Increased, Oxidative Stress Increase, Oocyte apoptosis May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1130 Increased, Cell Proliferation (mesothelium) Increased, mesotheliomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1142 Decreased, Thyroxine (T4) in tissues Altered, Amphibian metamorphosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1163 Decreased, Thyroxine (T4) in tissues Decreased, Triiodothyronine (T3) in tissues Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1132 Increased, blood uric acid concentration Occurrence, tophi (urate) deposition Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1158 Increased, blood uric acid concentration Increased, Oxidative Stress Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1134 Occurrence, renal proximal tubular necrosis Increased, blood potassium concentration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • unknown MIE leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1156 Occurrence, renal proximal tubular necrosis Increased, blood uric acid concentration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2647 Occurrence, renal proximal tubular necrosis Occurrence, Kidney toxicity Apr 8, 2022 Apr 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1135 Increased, blood potassium concentration Occurrence, cardiac arrthymia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1140 Increased, blood potassium concentration Occurrence, cardiac arrhythmia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • unknown MIE leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1136 Occurrence, cardiac arrthymia Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1133 Occurrence, tophi (urate) deposition Occurrence, renal proximal tubular necrosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1137 Inhibition, Cyclooxygenase 1 activity Decreased, Prostaglandin F2alpha concentration, plasma Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1138 Decreased, Prostaglandin F2alpha concentration, plasma Occurrence, renal ischemia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1139 Occurrence, renal ischemia Occurrence, renal proximal tubular necrosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1159 Occurrence, renal ischemia Increased, Oxidative Stress Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1141 Occurrence, cardiac arrhythmia Increased Mortality Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • unknown MIE leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2854 Occurrence, cardiac arrhythmia Increased,Cardiac dysfunction Jan 29, 2023 Jan 29, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1145 Weakened, Colony Death/Failure, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Varroa mite infestation increases virus levels leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Weather event contributes to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Weather event contributes abnormal foraging leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nosema infection increases energetic demands leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nosema infection causes abnormal role change that leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Queen egg-laying decrease leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1151 Abnormal, Role change within caste Weakened, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nosema infection causes abnormal role change that leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1155 Increased, Deformed Wing Virus levels Weakened, Colony Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Varroa mite infestation increases virus levels leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1157 Increased, Energetic demands and therefore metabolic stress Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Nosema infection increases energetic demands leading to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1161 Unknown, MIE Increased, Reactive oxygen species Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • unknown MIE leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2035 Unknown, MIE Unknown, Jan 26, 2020 Jan 26, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2036 Unknown, MIE N/A, Unknown Jan 26, 2020 Jan 26, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2033 Increased, Reactive oxygen species β-catenin activation Jan 19, 2020 Jan 19, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2009 Increased, Reactive oxygen species Oxidative Stress Dec 3, 2019 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Essential element imbalance leads to reproductive failure via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1162 Increased, Reactive oxygen species Increased, Oxidative Stress Nov 29, 2016 Jul 31, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • unknown MIE leading to renal failure and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1696 Increased, Reactive oxygen species increased, oncotic necrosis Nov 14, 2017 Nov 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2660 Increased, Reactive oxygen species Secondary genotoxicity May 25, 2022 May 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2966 Increased, Reactive oxygen species Apoptosis Jul 18, 2023 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3092 Increased, Reactive oxygen species Decreased, PPAR-gamma activation Oct 18, 2023 Oct 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2328 Increased, Reactive oxygen species Increased Sodium-sensitive hypertension Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2324 Increased, Reactive oxygen species Increased extracellular matrix deposition Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2320 Increased, Reactive oxygen species Increased activation, Nuclear factor kappa B (NF-kB) Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding to ACE2 leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2460 Increased, Reactive oxygen species Increased, LPO Aug 5, 2021 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Glutathione conjugation leading to reproductive dysfunction via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Essential element imbalance leads to reproductive failure via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1965 Increased, Reactive oxygen species Increased, DNA damage and mutation Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis-induced lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2594 Increased, Reactive oxygen species Accumulation, Collagen Mar 3, 2022 Mar 3, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2550 Increased, Reactive oxygen species Decrease, MMP Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionising energy leading to population decline via mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2549 Increased, Reactive oxygen species D1 protein deactivation Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1164 Decreased, Triiodothyronine (T3) in tissues Altered, Amphibian metamorphosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2238 Decreased, Triiodothyronine (T3) in tissues Increased, Thyroid-stimulating hormone (TSH) Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2239 Decreased, Triiodothyronine (T3) in tissues Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1168 Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1169 Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1165 Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo Hemostasis, Depletion from blood of fully functional carboxylated clotting factors Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1170 Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1166 Hemostasis, Depletion from blood of fully functional carboxylated clotting factors Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1167 Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carbo Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1171 Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction Impaired recruitment , Population trajectory Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1175 Increased, water retention in foot Increased, foot detachment Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1223 Increased, water retention in foot Increased, valve movement Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1182 Delayed, Sexual maturity Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2635 Decreased, Reproductive Success Decrease, Population growth rate Apr 6, 2022 Apr 6, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1173 Increased, valve movement Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1174 Increased, valve movement Increased, water retention in foot Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1216 Increased, valve movement Increased, water pumping Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1227 Increased, valve movement Increase, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1320 Increased, valve movement induced spawning Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1334 Increased, valve movement Induced parturition Jan 30, 2017 Jan 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1181 Depletion, energy reserves Delayed, Sexual maturity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1185 Depletion, energy reserves Increase, predation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1179 premature, spawning 1 Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1188 Decreased, gametogenesis Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1211 premature, Spawning Increased, Population Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1222 premature, Spawning Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1193 increased or inappropriate, mantel display Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1219 increased or inappropriate, mantel display Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1220 increased or inappropriate, mantel display induced, parturition Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1194 Anticoagulant rodenticide interferes with gamma-carboxyglutamate formation, Inhibition of p Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1195 Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1196 Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp Osteoporosis and vascular calcification, Bone deterioration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1197 Inhibition, Iodotyrosine deiodinase (IYD) Thyroidal Iodide, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2476 Inhibition, Iodotyrosine deiodinase (IYD) T4 in serum, Decreased Sep 9, 2021 Sep 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1200 Inhibition, Deiodinase 3 Increased, Triiodothyronine (T3) in tissues Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1201 Increased, Triiodothyronine (T3) in tissues Altered, Amphibian metamorphosis Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2243 Increased, Triiodothyronine (T3) in tissues Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1202 Inhibition, Pendrin TH synthesis, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Pendrin inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1203 Inhibition, Dual oxidase TH synthesis, Decreased Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1204 Activation, Hepatic nuclear receptor(s) Increased, Hepatic thyroid hormone uptake/transport Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1205 Activation, Hepatic nuclear receptor(s) Induction, Upregulation of glucuronyltransferase activity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1206 Increased, Hepatic thyroid hormone uptake/transport Increase, Biliary excretion TH glucuronide Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2479 Increased, Hepatic thyroid hormone uptake/transport Increased, Clearance of thyroxine from serum Sep 10, 2021 Sep 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2237 Increased, Hepatic thyroid hormone uptake/transport T4 in serum, Decreased Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1214 Increased, mantel display Increased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1213 Increased, oocyte maturation Increased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1328 Increased, oocyte maturation induced spawning Jan 17, 2017 Jan 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1210 Increased, cilia movement premature, Spawning Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1329 Increased, cilia movement induced spawning Jan 17, 2017 Jan 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1215 Increased, Reproductive Success Increased, Population Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1224 Increased, water pumping Increased, water retention in foot Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1225 Increased, water pumping premature, Spawning Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1226 Increased, water pumping induced, parturition Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1221 induced, parturition Decreased, Reproductive Success Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1230 Increase, Phenotypic enzyme activity Increase, cell proliferation (hepatocytes) Nov 29, 2016 Dec 31, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1231 Increase, Phenotypic enzyme activity Increase, Clonal Expansion of Altered Hepatic Foci Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1232 Increase, Clonal Expansion of Altered Hepatic Foci Increase, hepatocellular adenomas and carcinomas Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1238 Increased activation, Nuclear factor kappa B (NF-kB) Increase, Phenotypic enzyme activity Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2432 Increased activation, Nuclear factor kappa B (NF-kB) Increased pro-inflammatory mediators Jul 8, 2021 Jul 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2431 Increased activation, Nuclear factor kappa B (NF-kB) Release, Cytokine Jul 8, 2021 Jul 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2309 Increased activation, Nuclear factor kappa B (NF-kB) Increased proinflammatory mediators Mar 30, 2021 Mar 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding to ACE2 leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2612 Increased activation, Nuclear factor kappa B (NF-kB) Antagonism, Estrogen receptor Mar 22, 2022 Aug 27, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1241 Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1235 Activation, NADPH Oxidase Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1360 Activation, NADPH Oxidase ROS formation Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1234 Increase, Genes involved in fatty acid oxidation Peptide Oxidation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1240 Increase, Genes involved in fatty acid oxidation Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1243 Decreased, sodium conductance 2 Decreased, Ionotropic GABA receptor chloride channel conductance Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1244 Decreased, sodium conductance 2 Decreased, GABA release Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Sodium channel (Nav1.1) inhibition leading to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1245 Decreased, GABA release Decreased, Chloride conductance Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1246 Activation, Estrogen receptor Increased, ER binding to DNA (classical pathway) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1249 Activation, Estrogen receptor Increased, ER binding to T.F. to DNA (non-classical pathway) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1294 Activation, Estrogen receptor Increased, Non-genomic signaling Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1307 Activation, Estrogen receptor Increased, Second Messenger Production Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1247 Increase, Cell Proliferation (Epithelial Cells) Increased, Ductal Hyperplasia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1907 Increase, Cell Proliferation (Epithelial Cells) Increase, Mutations May 8, 2019 May 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2914 Decreased, Apoptosis (Epithelial Cells) Alterations, Cellular proliferation / hyperplasia May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1248 Decreased, Apoptosis (Epithelial Cells) Increased, Ductal Hyperplasia Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1250 Increased, ER binding to DNA (classical pathway) Increase, Cell Proliferation (Epithelial Cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1296 Increased, ER binding to DNA (classical pathway) Altered, Gene Expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1251 Increased, ER binding to T.F. to DNA (non-classical pathway) Increase, Cell Proliferation (Epithelial Cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1297 Increased, ER binding to T.F. to DNA (non-classical pathway) Altered, Gene Expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1266 Increased, Proliferation (Endothelial cells) Increased, Angiogenesis Nov 29, 2016 Dec 20, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1267 Increased, Migration (Endothelial Cells) Increased, Angiogenesis Nov 29, 2016 Dec 20, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2575 Increased, Migration (Endothelial Cells) Increase, angiogenesis Feb 15, 2022 Mar 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Activation of the AhR leading to metastatic breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1295 Increased, Non-genomic signaling Increased, ER binding to T.F. to DNA (non-classical pathway) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1302 Increased, Non-genomic signaling Altered, Gene Expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1252 Increased, Ductal Hyperplasia N/A, Breast Cancer Nov 29, 2016 May 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1301 Increase, DNA Damage Altered, Gene Expression Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1468 Increase, DNA Damage Increase, Apoptosis Apr 15, 2017 Apr 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2595 Increase, DNA Damage Activation of TP53 Mar 9, 2022 Mar 9, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1899 Increase, DNA Damage Increase mutations May 7, 2019 May 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1898 Increase, DNA Damage Tissue resident cell activation May 7, 2019 May 10, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1897 Increase, DNA Damage Increase, Mutations May 7, 2019 May 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2622 Increase, DNA Damage Decreased spermatogenesis Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2790 Increase, DNA Damage Cell cycle, disrupted Oct 25, 2022 Oct 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2338 Increase, DNA Damage Increase, Programmed cell death Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionising energy leading to population decline via programmed cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2381 Increase, DNA Damage Altered, Meiotic chromosome dynamics May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionising energy leads to population decline via pollen abnormal
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2382 Increase, DNA Damage Increase, Oocyte apoptosis May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2576 Increased, Invasion N/A, Breast Cancer Feb 15, 2022 Feb 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3138 Increased, Invasion Metastasis, Breast Cancer Mar 5, 2024 Mar 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Activation of the AhR leading to metastatic breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1253 Binding, Immunophilins Inhibition, Calcineurin Activity Nov 29, 2016 Oct 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1255 Suppression, IL-2 and IL-4 production Interference, nuclear localization of NFAT Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1510 Suppression, IL-2 and IL-4 production Impairment, T-cell dependent antibody response May 19, 2017 Jun 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1258 Suppression, Suppression of production of cytotoxic T-cells Impairment, T-cell dependent antibody response Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1260 Suppression, Suppression of production of cytotoxic T-cells Impairment of TDAR Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1259 Suppression, Suppression of T-cell dependent antibody production Impairment of TDAR Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1261 Activation, Juvenile hormone receptor Induction, Doublesex1 gene Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Juvenile hormone receptor agonism leading to male offspring induction associated population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1262 Induction, Doublesex1 gene Induction, Male reproductive tract Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Juvenile hormone receptor agonism leading to male offspring induction associated population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1264 Increased, Male offspring Decline, Population Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Juvenile hormone receptor agonism leading to male offspring induction associated population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1263 Induction, Male reproductive tract Increased, Male offspring Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Juvenile hormone receptor agonism leading to male offspring induction associated population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1269 Altered expression of hepatic CAR-dependent genes Increase, cell proliferation (hepatocytes) Nov 29, 2016 Dec 21, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1271 TRPA1 activation, TRPA1 Receptor Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1284 TRPA1 activation, TRPA1 Receptor Non-neuronal production of IL-8/CXCL1, Epithelial irritation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1576 TRPA1 activation, TRPA1 Receptor Generation of novel epitopes , Antigen presentation Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1273 Sensory Airway Irritation Cough, Dyspnea, Sneezing, Acute respiratory effect Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1272 Opening of calcium channel, Calcium influx Sensory Airway Irritation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1274 Opening of calcium channel, Calcium influx Excitation, Trigeminal nerve excitation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1280 Opening of calcium channel, Calcium influx SP (Substance P) release, Local increase of SP Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1275 Excitation, Trigeminal nerve excitation Cough, Dyspnea, Sneezing, Acute respiratory effect Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1276 Excitation, Trigeminal nerve excitation Increased Airway Hyper-responsiveness,Cough, Dyspnea Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1575 Excitation, Trigeminal nerve excitation SP (Substance P) release, Local increase of SP Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1578 Excitation, Trigeminal nerve excitation Increased CGRP Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1582 Excitation, Trigeminal nerve excitation Irritation induced sneezing Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1583 Excitation, Trigeminal nerve excitation Increased NKA Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1574 SP (Substance P) release, Local increase of SP Increased Airway Hyper-responsiveness,Cough, Dyspnea Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1577 SP (Substance P) release, Local increase of SP Leukocyte infiltration Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1279 SP (Substance P) release, Local increase of SP Non-neuronal production of TNF, Epithelial irritation Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1772 SP (Substance P) release, Local increase of SP Respiratory irritability Sep 24, 2018 Sep 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1771 Increased Airway Hyper-responsiveness,Cough, Dyspnea Respiratory irritability Sep 24, 2018 Sep 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1277 Non-neuronal production of TNF, Epithelial irritation Leukocyte infiltration Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1288 Non-neuronal production of TNF, Epithelial irritation Opening of calcium channel, Calcium influx Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1278 Leukocyte infiltration Respiratory irritability Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1290 Leukocyte infiltration Sensitization, Immune system Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1770 Respiratory irritability Increased Airway Hyper-responsiveness,Cough, Dyspnea Sep 24, 2018 Sep 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1281 TRPV1 activation, TRPV1 Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1282 Oxidization of biomolecules, Lipid bilayer and cellular proteins TRPA1 activation, TRPA1 Receptor Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1285 Oxidization of biomolecules, Lipid bilayer and cellular proteins Generation of novel epitopes , Antigen presentation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1286 Oxidization of biomolecules, Lipid bilayer and cellular proteins Production of nerve growth factor , Epithelial irritation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1283 Production of nerve growth factor , Epithelial irritation SP (Substance P) release, Local increase of SP Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1287 Non-neuronal production of IL-8/CXCL1, Epithelial irritation Opening of calcium channel, Calcium influx Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1289 Generation of novel epitopes , Antigen presentation Sensitization, Immune system Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1291 Oxidation Generation of novel epitopes , Antigen presentation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1292 Oxidation TRPA1 activation, TRPA1 Receptor Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1293 Oxidation Production of nerve growth factor , Epithelial irritation Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1298 Altered, Gene Expression Altered, Protein Production Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1807 Altered, Gene Expression Altered differentiation Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Histone deacetylase inhibition leads to neural tube defects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1299 Altered, Protein Production Increased, Oxidative Stress Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1303 Altered, Protein Production Increased, Proliferation (Endothelial cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1304 Altered, Protein Production Decreased, Apoptosis (Epithelial Cells) Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1305 Altered, Protein Production Increased, Motility Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1306 Increased, Motility Increased, Invasion Nov 29, 2016 Feb 29, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Activation of the AhR leading to metastatic breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1308 Increased, Second Messenger Production Increased, Non-genomic signaling Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Estrogen receptor activation leading to breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1310 Altered, Ca2+-calmodulin activated signal transduction Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1314 Chronic, Mucus hypersecretion Decreased lung function Nov 29, 2016 Aug 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1330 Binding, topoisomerase II MLL translocation Jan 20, 2017 Apr 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1634 Binding, topoisomerase II Increase, DSB Aug 2, 2017 Aug 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibitor binding to topoisomerase II leading to infant leukaemia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1331 MLL translocation IFL Jan 20, 2017 Aug 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibitor binding to topoisomerase II leading to infant leukaemia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1324 induced spawning Decreased, Reproductive Success Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1325 induced spawning Increased, Reproductive Success Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1322 increased mantel display Induced parturition Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1323 Induced parturition Decreased, Reproductive Success Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1326 Induced parturition Increased, Reproductive Success Jan 13, 2017 Jan 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3147 Decompartmentalization Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • AOP from chemical insult to cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3148 narcosis Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • AOP from chemical insult to cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3145 Direct mitochondrial inhibition Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • AOP from chemical insult to cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2967 Apoptosis N/A, Neurodegeneration Jul 18, 2023 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3106 Apoptosis decline, neural progenitor cells Jan 10, 2024 Jan 10, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1368 Apoptosis Reproductive failure Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1735 Apoptosis Spermatocyte depletion May 22, 2018 Jul 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1713 Apoptosis Testicular atrophy Jan 21, 2018 Jan 21, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2191 Apoptosis Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1867 Apoptosis Activation, hepatic stellate cells Mar 6, 2019 Mar 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of N-linked glycosylation leads to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1869 Apoptosis Liver Injury Mar 6, 2019 Mar 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of N-linked glycosylation leads to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2577 Apoptosis tumor growth Feb 15, 2022 Mar 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Activation of the AhR leading to metastatic breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2792 Apoptosis Decrease, outgrowth Oct 27, 2022 Apr 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Antagonism of Smoothened receptor leading to orofacial clefting
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Decrease, GLI1/2 target gene expression leads to orofacial clefting
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2675 Apoptosis Emphysema Jun 17, 2022 Jun 17, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Adverse outcome pathway of PM-induced respiratory toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1344 Increase, E75b expression Increase, Ftz-f1 expression Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1345 Increase, Ftz-f1 expression Decrease, Circulating ETH Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1347 Decrease, Circulating CCAP Decrease, Ecdysis motoneuron bursts Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1348 Decrease, Ecdysis motoneuron bursts Decrease, Excitatory postsynaptic potential Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1349 Decrease, Excitatory postsynaptic potential Decrease, Abdominal muscle contraction Feb 9, 2017 Feb 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1351 Increase, COX-2 expression Altered, Cardiovascular development/function Feb 9, 2017 Mar 28, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1353 Inactivation of PPARγ Activation of TGF-β signaling Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2156 Inactivation of PPARγ Activation, TGF-beta pathway Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1354 Activation of TGF-β signaling Differentiation of Myofibroblast Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1355 Activation of TGF-β signaling Expression of Collagen Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1721 Activation of TGF-β signaling Increase, Inflammation Mar 18, 2018 Mar 18, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1723 Activation of TGF-β signaling EMT Mar 18, 2018 Mar 18, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1356 Differentiation of Myofibroblast Production of α-smooth muscle actin Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1357 Expression of Collagen Collagen Deposition Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1358 Production of α-smooth muscle actin Lung fibrosis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1359 Collagen Deposition Lung fibrosis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1628 Collagen Deposition Accumulation, Collagen Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1361 ROS formation Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1362 Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Increased, DNA Damage-Repair Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1364 Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Activation, HIF-1 Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        3166 Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Mitochondrial dysfunction Mar 14, 2024 Mar 14, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1365 Activation, HIF-1 Apoptosis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1366 Increased, DNA Damage-Repair Apoptosis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1369 Activation, JAK/STAT pathway Activation, TGF-beta pathway Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1370 Activation, TGF-beta pathway Reproductive failure Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2153 Activation, TGF-beta pathway EMT Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1371 Up Regulation, SREBF2 Up Regulation, Unsaturated fatty acid Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1372 Up Regulation, Unsaturated fatty acid Perturbation of cholesterol Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1373 Down Regulation, GSS and GSTs gene Glutathione synthesis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1376 Down Regulation, GSS and GSTs gene Glutathione homeostasis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1374 Glutathione synthesis Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1375 Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Perturbation of cholesterol Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1377 Perturbation of cholesterol Hepatotoxicity Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1378 Glutathione homeostasis Hepatotoxicity Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1380 Activation, JNK Activation, FOXO Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2149 Activation, JNK AP-1 activation Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2150 Activation, JNK Pin-1 activation Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1381 Activation, FOXO Inhibition, Wnt pathway Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1382 Inhibition, Wnt pathway Defect of Embryogenesis Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1383 Defect of Embryogenesis Reproductive failure Feb 15, 2017 Feb 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1390 Increase, insulin Activation, insulin receptor Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1391 Activation, insulin receptor Activation, mTORC2 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1392 Activation, mTORC2 Activation, AKT Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1393 Activation, mTORC2 Activation, mTORC1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1394 Activation, AKT Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1398 Activation, AKT Activation, mTORC1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1400 Activation, AKT Activation, L-FABP Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1395 Activation, mTORC1 Activation, L-FABP Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1396 Activation, mTORC1 Activation, HSD17B4 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1399 Activation, mTORC1 Activation, SREBP-1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1397 Activation, SREBP-1 Activation, FXR Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1403 Activation, SREBP-1 Activation, SCD-1 Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1401 Activation, L-FABP Increase, cytosolic fatty acid Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1423 Activation, L-FABP demethylation, PPARg promoter Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1411 Activation, HSD17B4 Inhibition, Mitochondrial fatty acid beta-oxidation Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1415 Activation, HSD17B4 Increase, Fatty acid β-oxidation Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1407 Activation, FXR Activation, SHP Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1408 Activation, FXR Activation, PPARα Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1693 Increase, cytosolic fatty acid steatohepatitis Nov 13, 2017 Nov 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1694 Increase, cytosolic fatty acid Increased, Liver Steatosis Nov 14, 2017 Nov 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1405 Increased, lipogenesis Increase, cytosolic fatty acid Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1413 Inhibition, LXR Inhibition, PPAR alpha Apr 12, 2017 Apr 12, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1421 Activation, aPKC Activation, SREBP-1 Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1418 Activation, PI3K Activation, AKT Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1419 Activation, PI3K Activation, L-FABP Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1420 Activation, PI3K Activation, aPKC Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1417 Increase, Fatty acid β-oxidation Decrease, cytosolic fatty acid Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1425 Activation, LRH-1 Activation, FAS Apr 13, 2017 Apr 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1520 Inhibit, serotonin transporter activity Decreased, serotonin transporter activity May 30, 2017 May 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1426 Decreased, serotonin transporter activity Increased, intracellular sodium (Na+) Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1427 Decreased, serotonin transporter activity Increased, intracellular chloride (Cl-) Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1428 Decreased, serotonin transporter activity Decreased, extracellular Na+ Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1429 Decreased, serotonin transporter activity Decreased, extracellular chloride (Cl-) Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1430 Decreased, serotonin transporter activity Increased, extracellular serotonin Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1431 Decreased, serotonin transporter activity Decreased, intracellular serotonin Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1521 Increased, extracellular serotonin Decreased, extracellular serotonin May 30, 2017 May 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1529 Increased, extracellular serotonin Decreased, 5-HT3 Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1531 Increased, extracellular serotonin Activation, 5-HT2A Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1455 Increased, intracellular sodium (Na+) Activated, voltage-gated sodium channel Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1465 Increased, intracellular chloride (Cl-) Inactive, membrane depolarization Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1432 Decreased, intracellular serotonin Decreased, packaged serotonin Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1433 Decreased, packaged serotonin Decreased, synaptic release Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1434 Decreased, synaptic release Decreased, extracellular serotonin Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1445 Increased, 5-HT3 Increased, seizure Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1446 Inactivated, 5-HTR Reduce expression, BDNF Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1511 Inactivated, 5-HTR Reduced, BDNF May 30, 2017 May 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1447 Reduce expression, BDNF Decreased, neuroplasticity Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1448 Decreased, neuroplasticity Increased, agitation Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1449 Decreased, neuroplasticity Increased, depression Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1450 Increase, cortisone Activation, Glucocorticoid Receptor Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1523 Reduced, BDNF Decreased, neuroplasticity May 31, 2017 May 31, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1438 Activation, 5-HT2A Activate, PLC Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1439 Activate, PLC Increase, inositol triphosphate Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1440 Increase, inositol triphosphate Increase, intracellular calcium Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1441 Increase, intracellular calcium Activate, calmodulin Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3140 Increase, intracellular calcium Mitochondrial dysfunction Mar 6, 2024 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2954 Increase, intracellular calcium Disruption, neurotransmitter release Jun 27, 2023 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2968 Increase, intracellular calcium Apoptosis Jul 18, 2023 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1442 Activate, calmodulin Increase, myosin light chain phosphorylation Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1443 Increase, myosin light chain phosphorylation Increase, vascular smooth muscle contraction Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1444 Increase, vascular smooth muscle contraction Increase, hypertension Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • SSRI (Selective serotonin reuptake inhibitor) to hypertension
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1581 Increase, hypertension Respiratory irritability Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1550 Increased, seizure Increased, epilepsy Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1519 Decreased, extracellular serotonin Decreased, synaptic release May 30, 2017 May 30, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1435 Decreased, extracellular serotonin Increased, 5-HT3 Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1436 Decreased, extracellular serotonin Inactivated, 5-HTR Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1437 Decreased, extracellular serotonin Activation, 5-HT2A Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Network of SSRIs (selective serotonin reuptake inhibitors)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1460 Increase, seizure Increased, epilepsy Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1452 Activated, presynaptic neuron 1 Increased, glutamate Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3086 Activated, presynaptic neuron 1 Activation, Glutamate-gated chloride channels Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3088 Activated, presynaptic neuron 1 Decreased, Ionotropic GABA receptor chloride channel conductance Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2868 Increased, glutamate decreased, Bcl-2 Apr 4, 2023 Apr 4, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2869 Increased, glutamate increased, Bax Apr 4, 2023 Apr 4, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1453 Increased, glutamate Activated, NMDA receptor Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2861 Increased, glutamate Microglia activation Apr 3, 2023 Apr 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1859 Increased, glutamate Overactivation, NMDARs Feb 13, 2019 Sep 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1454 Activated, NMDA receptor Increased, intracellular sodium (Na+) Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1457 Activated, voltage-gated sodium channel Activated, membrane depolarization Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2605 Binding to VGSC Altered kinetics of sodium channel Mar 21, 2022 Mar 31, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to voltage gate sodium channels during development leads to cognitive impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1456 Treat, carbamazepine Binding to VGSC Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1458 Activated, membrane depolarization Increased, hippocampal hyperdepolarization Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1463 Increased, RDX dose Activate, GABA-A receptor Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1555 Increased, RDX dose Reduced, GABA-A receptor activation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1464 Activate, GABA-A receptor Increased, intracellular chloride (Cl-) Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1461 Activate, presynaptic neuron 2 Increase, GABA Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1462 Increase, GABA Activate, GABA-A receptor Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1459 Increased, hippocampal hyperdepolarization Increase, seizure Apr 14, 2017 Apr 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Molecular events lead to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1549 Increased, hippocampal hyperdepolarization Increased, seizure Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 1 activation to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3082 Increased, epilepsy Increase, Mortality Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1595 Increase, ROS Increase, DNA Damage Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1598 Increase, ROS Increased, LPO Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1466 Increase, ROS Peptide Oxidation Apr 15, 2017 Apr 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2342 Increase, ROS D1 protein deactivation Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2345 Increase, ROS Decrease, MMP Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1876 Increase, ROS Increase,Oxidative DNA damage Mar 19, 2019 Mar 19, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2826 Increase, ROS Oxidative Stress Jan 9, 2023 Jan 9, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1469 Increase, Apoptosis Decrease, Oogenesis Apr 15, 2017 Apr 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1751 Increase, Apoptosis Increase, Mortality Jun 12, 2018 Jun 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Formation of DNA photoproducts leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Excessive reactive oxygen species production leading to mortality (4)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1741 Increase, Apoptosis Decrease, Growth May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1596 Increase, Apoptosis Increase, Follicular atresia Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3034 Increase, Apoptosis increased,Vascular endothelial dysfunction Aug 28, 2023 Aug 28, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2948 Increase, Apoptosis Inhibition of neurotransmitter release Jun 20, 2023 Jun 20, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2075 Increase, Apoptosis Reduce, Sperm count Apr 6, 2020 Apr 6, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Alkylation of DNA leading to reduced sperm count
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2645 Increase, Apoptosis Occurrence, renal proximal tubular necrosis Apr 8, 2022 Apr 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2619 Increase, Apoptosis Decreased spermatogenesis Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2725 Increase, Apoptosis Decrease, outgrowth Jul 28, 2022 Jul 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2602 Increase, Apoptosis Microcephaly Mar 17, 2022 Mar 17, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2185 Increase, Apoptosis Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2461 Increase, Apoptosis Increased, Kidney Failure Aug 5, 2021 Aug 5, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1470 Decrease, Oogenesis Decrease, Ovulation Apr 15, 2017 Apr 15, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1752 Decrease, Oogenesis Decrease, Fecundity Jun 12, 2018 Jun 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA methyltransferase inhibition leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA methyltransferase inhibition leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2588 Decrease, Oogenesis Reduction, Cumulative fecundity and spawning Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deposition of energy leading to population decline via DNA oxidation and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2586 Decrease, Oogenesis Decrease, Reproduction Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1480 Activation, PTGS-1 Increase, platelet aggregation Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1481 Activation, PTGS-1 Increase, mucosal blood flow Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1482 Activation, PTGS-1 Increase, mucous Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1483 Activation, PTGS-1 Increase, bicarbonate Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1478 Activation, PTGS-2 Decrease, leukocyte adherence Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1479 Activation, PTGS-2 Increase, angiogenesis Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1484 Increase, bicarbonate Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1485 Increase, mucous Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1486 Increase, mucosal blood flow Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1474 Increase, platelet aggregation Inhibit, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1473 Increase, angiogenesis Inhibit, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3137 Increase, angiogenesis Metastasis, Breast Cancer Mar 5, 2024 Mar 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Activation of the AhR leading to metastatic breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2578 Increase, angiogenesis N/A, Breast Cancer Feb 15, 2022 Feb 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1477 Increase, leukocyte adherence Activate, leukocyte Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1476 Activate, leukocyte Activated, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1475 Activate, mucosal defense Inhibit, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1489 Increase, surfactant Activate, mucosal defense Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1547 Decrease, surfactant Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Helicobacter pylori to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1488 Activate, phospholipase Decrease, surfactant Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Helicobacter pylori to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1487 Increase, ammonium (NH4+) Decrease, surfactant Apr 17, 2017 Apr 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Gastric ulcer formation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Helicobacter pylori to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1493 CYP7B activity, inhibition 7α-hydroxypregnenolone synthesis in the brain, decreased May 2, 2017 May 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1494 CYP7B activity, inhibition Locomotor activity, decreased May 2, 2017 May 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1495 7α-hydroxypregnenolone synthesis in the brain, decreased Locomotor activity, decreased May 2, 2017 May 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1496 7α-hydroxypregnenolone synthesis in the brain, decreased Dopamine release in the brain, decreased May 2, 2017 May 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1498 7α-hydroxypregnenolone synthesis in the brain, decreased Sexual behavior, decreased May 3, 2017 May 17, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1497 Dopamine release in the brain, decreased Locomotor activity, decreased May 2, 2017 May 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1502 Dopamine release in the brain, decreased Sexual behavior, decreased May 9, 2017 May 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1500 Locomotor activity, decreased Decreased, Reproductive Success May 8, 2017 Jun 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1499 Sexual behavior, decreased Decreased, Reproductive Success May 8, 2017 May 8, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1512 Activation of Cyp2E1 Oxidative Stress May 30, 2017 Jul 1, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1515 Activation of Cyp2E1 Hepatocytotoxicity May 30, 2017 Dec 6, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2654 Activation of Cyp2E1 Oxidative Stress in Brain May 16, 2022 May 16, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2714 Oxidative Stress Mitochondrial Injury Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2674 Oxidative Stress Pulmonary inflammation Jun 17, 2022 Jun 17, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Adverse outcome pathway of PM-induced respiratory toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2716 Oxidative Stress Increase, Cell death Jul 25, 2022 Mar 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2771 Oxidative Stress Altered Signaling Sep 28, 2022 Feb 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2772 Oxidative Stress Increased pro-inflammatory mediators Sep 28, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2774 Oxidative Stress Altered, Nitric Oxide Levels Sep 28, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2776 Oxidative Stress Increase, Endothelial Dysfunction Sep 28, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2505 Oxidative Stress p-Tau Oct 26, 2021 Oct 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2008 Oxidative Stress Wnt ligand stimulation Dec 3, 2019 Dec 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2818 Oxidative Stress Cataracts Dec 18, 2022 Mar 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2827 Oxidative Stress Mitochondrial dysfunction EMPTY Jan 9, 2023 Jan 9, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2810 Oxidative Stress Increase, Oxidative DNA damage Dec 16, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2811 Oxidative Stress Increase, DNA strand breaks Dec 16, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2812 Oxidative Stress Modified Proteins Dec 16, 2022 Mar 30, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2833 Oxidative Stress Tissue resident cell activation Jan 25, 2023 Feb 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2846 Oxidative Stress Altered Bone Cell Homeostasis Jan 25, 2023 Mar 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2451 Oxidative Stress CBF, Decreased Aug 2, 2021 Mar 24, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Oxidative stress Leading to Decreased Lung Function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2450 Oxidative Stress FOXJ1 Protein, Decreased Aug 2, 2021 Sep 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2449 Oxidative Stress CFTR Function, Decreased Jul 30, 2021 Sep 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2289 Oxidative Stress Coagulation Mar 25, 2021 Mar 25, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1513 Oxidative Stress Hepatocytotoxicity May 30, 2017 Jun 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1516 Oxidative Stress Liver Cancer May 30, 2017 Jun 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1685 Oxidative Stress Glutamate dyshomeostasis Nov 9, 2017 Feb 6, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1690 Oxidative Stress Cell injury/death Nov 9, 2017 Feb 7, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2975 Oxidative Stress Increase, Inflammation Jul 31, 2023 Oct 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3047 Oxidative Stress Accumulation, misfolded proteins Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3048 Oxidative Stress Proteasomal dysfunction Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3116 Oxidative Stress Increased, LPO Jan 24, 2024 Jun 20, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Essential element imbalance leads to reproductive failure via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CYP450 upregulation leads to Chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3129 Oxidative Stress Mitochondrial dysfunction Feb 17, 2024 Feb 17, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3233 Oxidative Stress Chronic kidney disease Jun 4, 2024 Jun 4, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • CYP450 upregulation leads to Chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1514 Hepatocytotoxicity Sustained proliferation May 30, 2017 Jun 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1517 Hepatocytotoxicity Liver Cancer May 30, 2017 May 1, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1518 Sustained proliferation Liver Cancer May 30, 2017 Oct 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Cyp2E1 Activation Leading to Liver Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1522 Increased, glucocorticoid receptor activity Reduced, BDNF May 31, 2017 May 31, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Mental stress to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Mental stress to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1524 Increased, serotonin transporter activity Increased, intracellular serotonin Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1528 Increased, serotonin transporter activity Decreased, extracellular serotonin Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1525 Increased, intracellular serotonin Increased, packaged serotonin Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1526 Increased, packaged serotonin Increased, synaptic release Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1527 Increased, synaptic release Increased, extracellular serotonin Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to depression
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to agitation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1530 Decreased, 5-HT3 Increased, seizure Jun 1, 2017 Jun 1, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Serotonin transporter activation to seizure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1532 Reduced, PTGS1 function Reduced, platelet aggregation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1534 Reduced, PTGS1 function Decreased, mucosal blood flow Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1537 Reduced, PTGS1 function Decreased, mucous Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1539 Reduced, PTGS1 function Decreased, bicarbonate Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1533 Reduced, platelet aggregation Activated, gastric ulcer formation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1535 Decreased, mucosal blood flow Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1536 Reduced, mucosal defense Activated, gastric ulcer formation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Helicobacter pylori to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1548 Reduced, mucosal defense Helicobacter pylori infection Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1538 Decreased, mucous Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1540 Decreased, bicarbonate Reduced, mucosal defense Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS1 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1541 Reduced, PTGS2 function Decreased, angiogenesis Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS2 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1543 Reduced, PTGS2 function Increased, leukocyte adherence Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS2 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1542 Decreased, angiogenesis Activated, gastric ulcer formation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS2 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1544 Increased, leukocyte adherence Increased, leukocyte activation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS2 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1545 Increased, leukocyte activation Activated, gastric ulcer formation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NSAID induced PTGS2 inactivation to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1546 Helicobacter pylori infection Increase, ammonium (NH4+) Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Helicobacter pylori to gastric ulcer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1551 Reduced, presynaptic neuron 2 activity Decreased, GABA Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1552 Decreased, GABA Reduced, GABA-A receptor activation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1553 Reduced, GABA-A receptor activation Decreased, intracellular chloride Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1554 Decreased, intracellular chloride Activated, membrane depolarization Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • presynaptic neuron 2 repression to epilepsy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1556 NFE2/Nrf2 repression Reduced, FXR activity Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2979 NFE2/Nrf2 repression Increase, Oxidative Stress Aug 19, 2023 Aug 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2984 NFE2/Nrf2 repression Activation, HIF1α Aug 20, 2023 Aug 20, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3035 NFE2/Nrf2 repression Activation, inflammation pathway Aug 28, 2023 Aug 28, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1557 Reduced, FXR activity Reduced, SHP activity Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1558 Reduced, SHP activity Activated, LXR Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1559 Activated, LXR Reduced, PPARalpha Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1560 Reduced, PPARalpha Reduced, HSD17B4 activity Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1561 Reduced, HSD17B4 activity Reduced, fatty acid beta oxidation Jun 2, 2017 Jun 2, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3215 Reduced, fatty acid beta oxidation Increased, Liver Steatosis May 9, 2024 May 9, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • NFE2/Nrf2 repression to steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1563 Mu Opioid Receptor Agonism Release of G Proteins Jun 8, 2017 Jun 8, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1564 Release of G Proteins Opening of GIRK channels Jun 8, 2017 Jun 8, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1568 Release of G Proteins Inhibition of Ca Channels Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1565 Opening of GIRK channels hyperpolarisation, neuron Jun 8, 2017 Jun 8, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1569 Inhibition of Ca Channels Inhibition of neurotransmitter release Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1570 Inhibition of neurotransmitter release Analgesia Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1573 Inhibition of neurotransmitter release Anti-depressant Activity Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1571 Serotonin 1A Receptor Agonism Release of G Proteins Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1579 Increased CGRP Increased Airway Hyper-responsiveness,Cough, Dyspnea Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1580 Increased CGRP Increase, hypertension Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1586 Increased CGRP Leukocyte infiltration Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1587 Increased CGRP Respiratory irritability Jun 27, 2017 Jun 27, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1774 Irritation induced sneezing Increased Airway Hyper-responsiveness,Cough, Dyspnea Sep 24, 2018 Sep 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1773 Increased NKA Respiratory irritability Sep 24, 2018 Sep 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1584 Increased NKA Increased Airway Hyper-responsiveness,Cough, Dyspnea Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1585 Increased NKA Leukocyte infiltration Jun 23, 2017 Jun 23, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1588 Sensing of the stressor Increased transcription of genes encoding acute phase proteins Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1589 Increased transcription of genes encoding acute phase proteins Systemic acute phase response Jun 29, 2017 Dec 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1590 Systemic acute phase response HDL-SAA formation Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2860 Systemic acute phase response Atherosclerosis Mar 28, 2023 Dec 18, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1591 HDL-SAA formation Systemic cholesterol increased Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1593 HDL-SAA formation Foam cell formation Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1592 Systemic cholesterol increased Foam cell formation Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1594 Foam cell formation Atherosclerosis Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1597 Increase, Follicular atresia Decrease, Oogenesis Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to population decline via DNA oxidation and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2211 Increase, Follicular atresia Decrease, Fecundity Nov 25, 2020 Nov 25, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2210 Increased, LPO Increase, Apoptosis Nov 25, 2020 Nov 25, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2222 Increased, LPO Increase, Cell death Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2464 Increased, LPO Increase, Necrosis Aug 11, 2021 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2097 Increased, LPO Decrease, Neutral lipids Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Excessive reactive oxygen species production leading to mortality (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1599 Increased, LPO Decrease, Coupling of OXPHOS Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3231 Increased, LPO Acrolein accumulation Jun 4, 2024 Jun 4, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • CYP450 upregulation leads to Chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3117 Increased, LPO Increased, histomorphological alteration of testis Jan 24, 2024 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Essential element imbalance leads to reproductive failure via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2879 Increased, LPO impaired, Fertility Apr 5, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Glutathione conjugation leading to reproductive dysfunction via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2175 Decrease, Coupling of OXPHOS Decrease, ATP synthase activity Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2182 Decrease, Coupling of OXPHOS Increase, Complex III dysfunction Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2188 Decrease, Coupling of OXPHOS Increase, Complex I dysfunction Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2203 Decrease, Coupling of OXPHOS Decrease, ATP pool Nov 12, 2020 Jul 6, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2219 Decrease, Coupling of OXPHOS Increase, Oxygen consumption Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2763 Decrease, Coupling of OXPHOS Increase, Cytosolic Ca Sep 13, 2022 Sep 13, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2796 Decrease, Coupling of OXPHOS Increase, Mitochondrial swelling Nov 1, 2022 Nov 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2793 Decrease, Coupling of OXPHOS Increase, Glycolysis Nov 1, 2022 Nov 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1600 Decrease, Coupling of OXPHOS Decrease, Mitochondrial ATP production Jun 29, 2017 Jun 29, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1610 activation of CEBPA Activation of specific nuclear receptors, PPAR-gamma activation Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1611 activation of CEBPA increased adipogenesis Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1612 increased adipogenesis obesity Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1614 decreased dopamine decreased reward Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1615 decreased reward decreased DNA methylation of tyrosine hydroxylase Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1616 decreased reward decreased methylation of dopamine transporter promoter Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1617 decreased reward decreased dopamine Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1618 decreased DNA methylation of tyrosine hydroxylase obesity Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1620 decreased DNA methylation of tyrosine hydroxylase decreased dopamine Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1619 decreased methylation of dopamine transporter promoter obesity Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1621 decreased methylation of dopamine transporter promoter decreased dopamine Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1613 chronic high fat diet decreased dopamine Jul 24, 2017 Jul 24, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Epigenetic modification of PPARG leading to adipogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1622 Sustained inflammatory cytokine release Increased, secretion of local growth factors Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1633 Sustained inflammatory cytokine release Differentiation of fibroblasts Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1626 Differentiation of fibroblasts Expression of Collagen Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1654 Differentiation of fibroblasts Accumulation, Collagen Aug 16, 2017 Aug 16, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1627 EMT Expression of Collagen Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1655 EMT Accumulation, Collagen Aug 16, 2017 Aug 16, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1725 EMT Lung fibrosis Mar 18, 2018 Mar 18, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2154 EMT Pulmonary fibrosis Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3204 EMT Airway remodeling May 1, 2024 May 1, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Adverse outcome pathway of PM-induced respiratory toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3200 EMT Resistant gastric cancer Apr 23, 2024 Apr 23, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2614 EMT Metastasis, Breast Cancer Mar 22, 2022 Sep 26, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1779 EMT Collagen Deposition Nov 20, 2018 Nov 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1840 EMT Fibroproliferative airway lesions Jan 30, 2019 Jan 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • α-diketone-induced bronchiolitis obliterans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1630 Cell damage sensing Sustained inflammatory cytokine release Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1631 Cell damage sensing Increase, ROS production Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1632 Cell damage sensing Increased, secretion of local growth factors Jul 26, 2017 Jul 26, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1635 Increase, DSB MLL translocation Aug 2, 2017 Aug 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibitor binding to topoisomerase II leading to infant leukaemia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3096 Increase, DSB Increase, Apoptosis Nov 16, 2023 Nov 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Excessive reactive oxygen species production leading to mortality (4)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Formation of DNA photoproducts leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3099 Increase, DSB Increase, Casp transcription Nov 16, 2023 Nov 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1636 Thiol protein adducts Inhibition of lysyl oxidase Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1637 Inhibition of lysyl oxidase Reduction of collagen crosslinking Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1638 Reduction of collagen crosslinking Weak collagen matrix Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1639 Weak collagen matrix Notochord malformation Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1640 Notochord malformation Reduced, Swimming performance Aug 3, 2017 Aug 3, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1651 TGFbeta1 activation TGFbeta pathway activation Aug 16, 2017 Aug 16, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1652 TGFbeta pathway activation Differentiation of fibroblasts Aug 16, 2017 Aug 16, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1653 TGFbeta pathway activation EMT Aug 16, 2017 Aug 16, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1663 Increase, Uncoupling of photophosphorylation Decrease, ATP production Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1664 Decrease, ATP production Decrease, Chlorophyll synthesis Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2341 Decrease, ATP production Decrease, Leaf development Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2547 Decrease, ATP production Decrease, Reproduction Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1665 Decrease, Chlorophyll synthesis Decrease, Light harvest capacity Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1666 Decrease, Light harvest capacity Decrease, Photosynthesis Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1667 Decrease, Photosynthesis Decrease, Glycolysis Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2334 Decrease, Photosynthesis Decrease, ATP production Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2343 Decrease, Photosynthesis Decrease, ATP synthase activity Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1668 Decrease, Glycolysis Decrease, OXPHOS Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1738 Decrease, Glycolysis Decrease, Mitochondrial ATP production May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1669 Decrease, OXPHOS Decrease, Mitochondrial ATP production Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Deposition of ionising energy leading to population decline via mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1810 Decrease, OXPHOS Decreased Na/K ATPase activity Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2346 Decrease, OXPHOS Decrease, ATP synthase activity Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2095 Decrease, OXPHOS Decrease, ATP pool Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Excessive reactive oxygen species production leading to mortality (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2713 Decrease, OXPHOS Oxidative Stress Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1671 Decrease, Leaf cell mitosis Decrease, Leaf development Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1672 Decrease, Leaf development Increase, Growth hormone Oct 10, 2017 Oct 10, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2335 Decrease, Leaf development Decrease, Reproduction Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2283 Decrease, Leaf development Decrease, Growth Feb 16, 2021 Feb 16, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Reduction in photophosphorylation leading to growth inhibition in aquatic plants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1673 Inhibition, mitochondrial DNA polymerase gamma (Pol gamma) Depletion, mtDNA Oct 25, 2017 Oct 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3133 Depletion, mtDNA Mitochondrial dysfunction Feb 28, 2024 Feb 28, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1677 Binding of substrate, endocytic receptor Disturbance, Lysosomal function Oct 25, 2017 Oct 25, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1683 Binding, SH/SeH proteins involved in protection against oxidative stress Mitochondrial dysfunction Nov 9, 2017 Nov 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1689 Binding, SH/SeH proteins involved in protection against oxidative stress Oxidative Stress Nov 9, 2017 Feb 7, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1765 Binding, SH/SeH proteins involved in protection against oxidative stress Protection against oxidative stress, decreased Sep 13, 2018 Feb 10, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1686 Glutamate dyshomeostasis Cell injury/death Nov 9, 2017 Feb 6, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1691 Glutamate dyshomeostasis Neuronal network function, Decreased Nov 9, 2017 Nov 9, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1692 Inhibition of fatty acid beta oxidation Increase, cytosolic fatty acid Nov 13, 2017 Nov 13, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1697 increased, oncotic necrosis steatohepatitis Nov 14, 2017 Nov 14, 2017
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1763 Tissue resident cell activation Increased pro-inflammatory mediators Aug 2, 2018 Aug 2, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Protein Alkylation leading to Liver Fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2834 Tissue resident cell activation Increase, Pro-Inflammatory Mediators Jan 25, 2023 Feb 16, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1764 Increased pro-inflammatory mediators Activation, Stellate cells Aug 2, 2018 Aug 2, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Protein Alkylation leading to Liver Fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1719 Increased pro-inflammatory mediators Cell injury/death Feb 1, 2018 Feb 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2777 Increased pro-inflammatory mediators Increase, Endothelial Dysfunction Sep 28, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1777 Increased pro-inflammatory mediators Leukocyte recruitment/activation Nov 12, 2018 Nov 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Endocytic lysosomal uptake leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1903 Increased pro-inflammatory mediators Increase in RONS May 7, 2019 May 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1902 Increased pro-inflammatory mediators N/A, Breast Cancer May 7, 2019 May 10, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1908 Increased pro-inflammatory mediators Increase, Cell Proliferation (Epithelial Cells) May 10, 2019 May 10, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1905 Leukocyte recruitment/activation Increase in RONS May 7, 2019 May 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1901 Leukocyte recruitment/activation Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1778 Leukocyte recruitment/activation Activation, Stellate cells Nov 12, 2018 Nov 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Endocytic lysosomal uptake leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2891 Leukocyte recruitment/activation Increased extracellular matrix deposition Apr 13, 2023 Apr 13, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • AhR activation leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2958 Interaction with the lung cell membrane Increased transcription of genes encoding acute phase proteins Jul 4, 2023 Dec 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2959 Interaction with the lung cell membrane Systemic acute phase response Jul 4, 2023 Dec 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2960 Interaction with the lung cell membrane Atherosclerosis Jul 4, 2023 Dec 18, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1702 Interaction with the lung cell membrane Increased proinflammatory mediators Jan 5, 2018 Aug 29, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2663 Interaction with the lung cell membrane Increased, DNA damage and mutation May 25, 2022 May 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2662 Interaction with the lung cell membrane Increased, Reactive oxygen species May 25, 2022 May 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2651 Increased proinflammatory mediators Activation, Dendritic Cells Apr 28, 2022 Aug 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        3052 Increased proinflammatory mediators Systemic acute phase response Sep 19, 2023 Dec 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1703 Increased proinflammatory mediators Recruitment of inflammatory cells Jan 5, 2018 May 18, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2301 Increased proinflammatory mediators Impaired gustatory nerve Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2307 Increased proinflammatory mediators Accumulation, Collagen Mar 30, 2021 Mar 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding to ACE2 leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2061 Increased proinflammatory mediators Increased inflammatory immune responses Mar 10, 2020 Mar 10, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2053 Increased proinflammatory mediators Increased transcription of genes encoding acute phase proteins Mar 1, 2020 Dec 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Substance interaction with lung resident cell membrane components leading to atherosclerosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2658 Recruitment of inflammatory cells Increase, Cytotoxicity (epithelial cells) May 25, 2022 May 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2761 Recruitment of inflammatory cells Increased proinflammatory mediators Sep 1, 2022 Sep 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2543 Recruitment of inflammatory cells Gut dysbiosis Dec 15, 2021 Dec 15, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2492 Recruitment of inflammatory cells GI disorders Oct 19, 2021 Oct 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2491 Recruitment of inflammatory cells Disruption of the intestinal barrier Oct 19, 2021 Oct 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1964 Recruitment of inflammatory cells Increased, Reactive oxygen species Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis-induced lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2354 Recruitment of inflammatory cells Hyperinflammation Apr 20, 2021 Feb 8, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                3246 Recruitment of inflammatory cells Cardiac Heart Failure Jun 10, 2024 Jun 29, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • C6R-Derived Protein K7 following Monkeypox infection leads to heart failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2903 Recruitment of inflammatory cells Increase in inflammation May 4, 2023 May 4, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1704 Recruitment of inflammatory cells Loss of alveolar capillary membrane integrity Jan 5, 2018 May 18, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1705 Loss of alveolar capillary membrane integrity Activation of Th2 cells Jan 5, 2018 May 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2368 Loss of alveolar capillary membrane integrity Inhibition of LS function. Apr 27, 2021 Apr 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2369 Loss of alveolar capillary membrane integrity Reduced tidal volume Apr 27, 2021 Apr 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2372 Loss of alveolar capillary membrane integrity Decreased lung function Apr 27, 2021 Apr 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2174 Loss of alveolar capillary membrane integrity Blood extravasation into the lungs Oct 22, 2020 Oct 22, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2258 Loss of alveolar capillary membrane integrity Impaired lung function Jan 8, 2021 Jan 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2259 Loss of alveolar capillary membrane integrity Substance - LS interaction Jan 8, 2021 Jan 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1706 Activation of Th2 cells Increased cellular proliferation and differentiation Jan 5, 2018 May 18, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1707 Increased cellular proliferation and differentiation Increased extracellular matrix deposition Jan 5, 2018 Dec 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2652 Increased cellular proliferation and differentiation Accumulation, Collagen May 4, 2022 May 18, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1708 Increased extracellular matrix deposition Pulmonary fibrosis Jan 16, 2018 Dec 6, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2325 Increased extracellular matrix deposition N/A, Liver fibrosis Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • AhR activation leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2699 Histone deacetylase inhibition Neural tube defects Jul 19, 2022 Jul 19, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ceramide synthase inhibition leading to neural tube defects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2010 Histone deacetylase inhibition Spermatocyte depletion Dec 11, 2019 Jul 1, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1709 Histone deacetylase inhibition Histone acetylation, increase Jan 21, 2018 Aug 5, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Histone deacetylase inhibition leads to neural tube defects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1714 Histone deacetylase inhibition p21 (CDKN1A) expression, increase Jan 21, 2018 Jul 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1715 Histone deacetylase inhibition Cell cycle, disrupted Jan 21, 2018 Jul 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1716 Histone deacetylase inhibition Apoptosis Jan 21, 2018 Jul 1, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1717 Histone deacetylase inhibition Testicular atrophy Jan 21, 2018 Jul 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1805 Histone deacetylase inhibition Reduced collagen production Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Histone deacetylase inhibition leads to impeded craniofacial development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1802 Histone deacetylase inhibition Reduced neural crest cell migration Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Histone deacetylase inhibition leads to impeded craniofacial development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1806 Histone acetylation, increase Altered, Gene Expression Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Histone deacetylase inhibition leads to neural tube defects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1710 Histone acetylation, increase p21 (CDKN1A) expression, increase Jan 21, 2018 Jul 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1997 Histone acetylation, increase Cell cycle, disrupted Nov 11, 2019 Jul 1, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3244 Histone acetylation, increase Inhibition of E4 (Uracil-DNA Glycosylase) Jun 10, 2024 Jun 10, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • C6R-Derived Protein K7 following Monkeypox infection leads to heart failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3247 Histone acetylation, increase Recruitment of inflammatory cells Jun 10, 2024 Jun 10, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • C6R-Derived Protein K7 following Monkeypox infection leads to heart failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1711 p21 (CDKN1A) expression, increase Cell cycle, disrupted Jan 21, 2018 Jul 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1712 Cell cycle, disrupted Apoptosis Jan 21, 2018 Jul 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2791 Cell cycle, disrupted Altered, Meiotic chromosome dynamics Oct 25, 2022 Oct 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1720 Activation of PPARγ Increase, Inflammation Mar 18, 2018 Mar 18, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1726 CYP2E1 Activation Oxidative Stress in Brain Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1729 Protein Adduct Formation Unfolded Protein Response Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1730 Oxidative Stress in Brain Unfolded Protein Response Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1727 Oxidative Stress in Brain Lipid Peroxidation Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2655 Oxidative Stress in Brain N/A, Neurodegeneration May 16, 2022 May 16, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3062 Oxidative Stress in Brain Decreased, Neuronal network function in adult brain Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2952 Oxidative Stress in Brain Neuronal network function, Decreased Jun 21, 2023 Jun 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Excessive iron accumulation leading to neurological disorders
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1731 Lipid Peroxidation General Apoptosis Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1728 Lipid Peroxidation Protein Adduct Formation Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1732 Unfolded Protein Response General Apoptosis Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3041 Unfolded Protein Response Caspase activation Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2712 Unfolded Protein Response Increase, Cell death Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1866 Unfolded Protein Response Apoptosis Mar 6, 2019 Mar 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of N-linked glycosylation leads to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1733 General Apoptosis Neurodegeneration Apr 4, 2018 Apr 5, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • CYP2E1 activation and formation of protein adducts leading to neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2977 General Apoptosis Increase, Cancer Jul 31, 2023 Oct 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1734 Spermatocyte depletion Testicular atrophy May 22, 2018 Jul 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Histone deacetylase inhibition leading to testicular atrophy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1736 Increase, D1 protein antagonism Decrease, PSII activity May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1740 Decrease, PSII activity Increase, ROS May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1737 Decrease, PSII activity Decrease, Photosynthesis May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2169 Decrease, Growth Decrease, Population growth rate Oct 8, 2020 Oct 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2804 Decrease, Growth Decreased, Reproductive Success Nov 16, 2022 Nov 16, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1742 Inhibition, CHS-1 Decrease, Cuticular chitin content May 24, 2018 Feb 17, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chitin synthase 1 inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1743 Decrease, Cuticular chitin content Increase, Premature molting May 24, 2018 Feb 17, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chitin synthase 1 inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Sulfonylureareceptor binding leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1744 Increase, Premature molting Increase, Mortality May 24, 2018 Feb 17, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chitinase inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chitobiase inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Chitin synthase 1 inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Sulfonylureareceptor binding leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1745 Increase, SUR binding Increase, Cell membrane depolarization May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Sulfonylureareceptor binding leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1747 Increase, Opening of voltage-dependent calcium channel Decrease, Cuticular chitin content May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Sulfonylureareceptor binding leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1746 Increase, Cell membrane depolarization Increase, Opening of voltage-dependent calcium channel May 24, 2018 May 24, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • S-adenosylmethionine depletion leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Sulfonylureareceptor binding leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2788 Increase, Cell membrane depolarization Cell injury/death Oct 19, 2022 Oct 19, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2708 Increase, Cell membrane depolarization Increased, Intracellular Calcium overload Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3039 Increase, Cell membrane depolarization Opening VGCCs Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1749 Fatty Acid Beta Oxidation, Decreased Decreased, Ketogenesis (production of ketone bodies) Jun 11, 2018 Jun 11, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Antagonist binding to PPARα leading to body-weight loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1755 Blockade, L-Type Calcium Channels Decrease, Calcium currents Jun 19, 2018 Jun 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1756 Decrease, Calcium currents Decrease, Calcium binding to Troponin C Jun 19, 2018 Jun 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1760 Decrease, Calcium currents Disruption, Intracellular calcium mobilization Jun 21, 2018 Jun 21, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1757 Decrease, Calcium binding to Troponin C Decrease, Cardiac contractility Jun 19, 2018 Jun 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1758 Decrease, Cardiac contractility Decrease, Cardiac ejection fraction Jun 19, 2018 Jun 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3176 Decrease, Cardiac contractility Decrease LV function Apr 3, 2024 Apr 3, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2824 Decrease, Cardiac contractility Heart failure Jan 5, 2023 Jan 5, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1759 Decrease, Cardiac ejection fraction Heart failure Jun 19, 2018 Jun 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2825 Heart failure Increase, Mortality Jan 5, 2023 Jan 5, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2514 Heart failure Altered mechanotransduction properties of pericytes Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2508 Heart failure Upregulation of ACE2 Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1761 Disruption, Intracellular calcium mobilization Disruption, Sarcomere assembly Jun 21, 2018 Jun 21, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1762 Disruption, Sarcomere assembly Decrease, Cardiac contractility Jun 21, 2018 Jun 21, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1766 Protection against oxidative stress, decreased Oxidative Stress Sep 13, 2018 Feb 7, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1775 Endocytosis Disruption, Lysosome Nov 12, 2018 Nov 12, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Endocytic lysosomal uptake leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Endocytotic lysosomal uptake leads to intestinal barrier disruption
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1790 Mitochondrial Complex I inhibition Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1780 Mitochondrial Complex I inhibition Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1784 Increase, Mitochondrial complex III antagonism Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1781 Increase, Mitochondrial complex III antagonism Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1872 Increase, Mitochondrial complex III antagonism Decrease, OXPHOS Mar 19, 2019 Mar 19, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1875 Increase, Mitochondrial complex III antagonism Increase, ROS Mar 19, 2019 Mar 19, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2230 Increase, Mitochondrial complex III antagonism Decrease, ATP pool Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mitochondrial complex III antagonism leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1785 Mitochondrial Complex IV inhibition Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1782 Mitochondrial Complex IV inhibition Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1786 Mitochondrial Complex V inhibition Increased reactive oxygen species (in the mitochondria) Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1783 Mitochondrial Complex V inhibition Decrease in mitochondrial oxidative phosphorylation Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1787 Decrease in mitochondrial oxidative phosphorylation Mitochondrial Injury Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1956 Decrease in mitochondrial oxidative phosphorylation Mitochondrial dysfunction Jun 15, 2019 Jun 15, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1957 Increased reactive oxygen species (in the mitochondria) Mitochondrial dysfunction Jun 15, 2019 Jun 15, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1788 Increased reactive oxygen species (in the mitochondria) Mitochondrial Injury Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1941 Mitochondrial Injury Increased reactive oxygen species (in the mitochondria) Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1942 Mitochondrial Injury Impaired, Proteostasis Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            3049 Mitochondrial Injury Increase, Cyt c release Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2715 Mitochondrial Injury Increase, Cell death Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1789 Necrotic Tissue Liver Injury Dec 19, 2018 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • IKK complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1798 Ionizing Energy Increase mutations Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1799 Ionizing Energy Increase chromosomal aberrations Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2392 Ionizing Energy Altered, Meiotic chromosome dynamics May 14, 2021 May 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2393 Ionizing Energy Decreased spermatogenesis May 14, 2021 May 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2394 Ionizing Energy impaired, Fertility May 14, 2021 May 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2395 Ionizing Energy Decrease of egg production and cummulative fecundity May 14, 2021 May 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2396 Ionizing Energy Decreased, Population size May 14, 2021 May 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2390 Ionizing Energy Increased, Oxidative Stress May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2397 Ionizing Energy Increase, Oocyte apoptosis May 14, 2021 May 14, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2380 Ionizing Energy Increase, DNA Damage May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2379 Ionizing Energy Increased, Reactive oxygen species May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1794 DNA repair Increase chromosomal aberrations Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1793 DNA repair Increase mutations Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1800 Increase mutations Increase, lung cancer Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1795 Increase mutations Increase cell proliferation Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1900 Increase mutations Increase, Cell Proliferation (Epithelial Cells) May 7, 2019 May 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1801 Increase chromosomal aberrations Increase, lung cancer Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1796 Increase chromosomal aberrations Increase cell proliferation Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2729 Increase chromosomal aberrations Increase,miRNA levels Aug 14, 2022 Aug 27, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1797 Increase cell proliferation Increase, lung cancer Dec 19, 2018 Dec 19, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1803 Reduced neural crest cell migration Reduced collagen production Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Histone deacetylase inhibition leads to impeded craniofacial development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2563 Reduced neural crest cell migration Transposition of the great arteries Feb 8, 2022 Feb 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1804 Reduced collagen production Smaller and morphologically distorted facial cartilage structures Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Histone deacetylase inhibition leads to impeded craniofacial development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2686 Smaller and morphologically distorted facial cartilage structures Increase, Early Life Stage Mortality Jun 30, 2022 Apr 13, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1808 Altered differentiation Neural tube defects Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Histone deacetylase inhibition leads to neural tube defects
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2603 Altered differentiation Microcephaly Mar 17, 2022 Mar 17, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1811 Decreased Na/K ATPase activity Decreased proximal tubular vectorial transport Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2787 Decreased Na/K ATPase activity Increase, Cell membrane depolarization Oct 19, 2022 Oct 19, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1812 Decreased proximal tubular vectorial transport Chemical induced Fanconi syndrome Dec 20, 2018 Dec 20, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1817 Suppressed AP-1 Suppressed DC activation Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1818 Suppressed NF-kB Suppressed DC activation Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1819 Suppressed DC activation Impaired antigen presentation Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1820 Impaired antigen presentation Impaired T cell activation Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1822 Impaired T cell activation Impairment of TDAR Dec 25, 2018 Jun 1, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1821 Impaired T cell activation Suppression, Suppression of T-cell dependent antibody response (TDAR) Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1922 Impaired T cell activation Impaired Ab production May 23, 2019 Jun 25, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1813 Blocking of IL-1R Impaired IL-1 signaling Dec 24, 2018 Jun 25, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1814 Decreased IL-1 production Impaired IL-1 signaling Dec 25, 2018 Jun 25, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1824 Decreased IL-1 production Suppressed MyD88 Jan 6, 2019 Jan 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1825 Impaired IL-1 signaling Suppressed MyD88 Jan 6, 2019 Mar 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1816 Impaired IL-1 signaling Suppressed NF-kB Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1815 Impaired IL-1 signaling Suppressed AP-1 Dec 25, 2018 Dec 25, 2018
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1920 Impaired IL-1 signaling Inhibition, Nuclear factor kappa B (NF-kB) May 23, 2019 Jun 25, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1826 Suppressed MyD88 Impairment of TDAR Jan 6, 2019 Jan 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1870 Suppressed MyD88 Inhibition, Nuclear factor kappa B (NF-kB) Mar 12, 2019 Mar 12, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1827 Inhibition, IKK complex Inhibition, Nuclear factor kappa B (NF-kB) Jan 7, 2019 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • IKK complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1829 Activation, Caspase 8 pathway Cell injury/death Jan 7, 2019 Mar 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • IKK complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1832 Activation, Tissue resident cells (Kuppfer cells) Increase, proinflammatory mediators (TNFalpha) Jan 7, 2019 Jan 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • IKK complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1833 Binding of MSAs to microtubules Disturbance in microtubule dynamic instability Jan 29, 2019 Jan 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Microtubule interacting drugs lead to peripheral neuropathy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1834 Disturbance in microtubule dynamic instability Impaired axonial transport Jan 29, 2019 Jan 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Microtubule interacting drugs lead to peripheral neuropathy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1835 Impaired axonial transport Sensory axonal peripheral neuropathy Jan 29, 2019 Jan 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Microtubule interacting drugs lead to peripheral neuropathy
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2506 Impaired axonial transport Dysfunctional synapses Oct 26, 2021 Oct 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2657 Sensory axonal peripheral neuropathy Increased Mortality May 16, 2022 May 16, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3066 Sensory axonal peripheral neuropathy Decreased, Neuronal network function in adult brain Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Various neuronal effects induced by elavl3, sox10, and mbp
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3067 Sensory axonal peripheral neuropathy Overactivation, NMDARs Oct 17, 2023 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1836 Interaction of α-diketones with arginine residues Proteasomal dysfunction Jan 30, 2019 Jan 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • α-diketone-induced bronchiolitis obliterans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1837 Proteasomal dysfunction Airway epithelial injury Jan 30, 2019 Jan 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • α-diketone-induced bronchiolitis obliterans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3044 Proteasomal dysfunction Accumulation, misfolded proteins Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1838 Airway epithelial injury Increase, Inflammation Jan 30, 2019 Jan 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • α-diketone-induced bronchiolitis obliterans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1841 Fibroproliferative airway lesions Bronchiolitis obliterans Jan 30, 2019 Jan 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • α-diketone-induced bronchiolitis obliterans
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1842 Distribution of chemicals Absorption of photon energy Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1843 Absorption of photon energy ROS generation Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1844 Absorption of photon energy Radical generation Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1845 ROS generation Oxidation of membrane lipids Feb 4, 2019 Jul 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Adverse outcome pathway on photochemical toxicity initiated by light exposure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1846 ROS generation Oxidation/denatuation of membrane proteins Feb 4, 2019 Jul 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Adverse outcome pathway on photochemical toxicity initiated by light exposure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1847 ROS generation Oxidation of DNA Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1849 Radical generation Protein photo-adducts Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1848 Radical generation DNA photo-adducts Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1850 Oxidation of membrane lipids Inflammatory events Feb 4, 2019 Jul 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Adverse outcome pathway on photochemical toxicity initiated by light exposure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1851 Oxidation/denatuation of membrane proteins Inflammatory events Feb 4, 2019 Jul 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Adverse outcome pathway on photochemical toxicity initiated by light exposure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1852 Oxidation of DNA Inflammatory events Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1853 DNA photo-adducts Inflammatory events Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1854 Protein photo-adducts Inflammatory events Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1855 Inflammatory events Eczematous eruption Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2917 Inflammatory events prostatic intraepithelial neoplasia May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2916 Inflammatory events Increased, Invasion May 11, 2023 May 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor activation leading to prostate cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1856 Eczematous eruption Scaling, Lichenification Feb 4, 2019 Feb 4, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1858 Activation, Muscarinic Acetylcholine Receptors Increased, glutamate Feb 13, 2019 Feb 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1889 Activation, Muscarinic Acetylcholine Receptors Occurrence, Focal Seizure Apr 22, 2019 Sep 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1864 Inhibition of N-linked glycosylation Accumulation, misfolded proteins Mar 6, 2019 Mar 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of N-linked glycosylation leads to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1865 Accumulation, misfolded proteins Unfolded Protein Response Mar 6, 2019 Mar 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of N-linked glycosylation leads to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3045 Accumulation, misfolded proteins Endoplasmic reticulum stress Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3046 Accumulation, misfolded proteins Caspase activation Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1868 Activation, hepatic stellate cells Liver Injury Mar 6, 2019 Mar 6, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of N-linked glycosylation leads to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1874 Increase, Necrosis Increase, Mortality Mar 19, 2019 Mar 19, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2177 Increase, Necrosis Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2465 Increase, Necrosis Increased, Kidney Failure Aug 11, 2021 Aug 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2122 Increase, Necrosis Increase, Ovarian follicle breakdown May 8, 2020 May 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3095 Increase,Oxidative DNA damage Increase, DSB Nov 16, 2023 Nov 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Excessive reactive oxygen species production leading to mortality (4)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2559 Increase,Oxidative DNA damage Increase, Ovarian somatic cell apoptosis Feb 4, 2022 Feb 4, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2558 Increase,Oxidative DNA damage Increase, Oocyte apoptosis Feb 4, 2022 Feb 4, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2190 Increase,Oxidative DNA damage Apoptosis Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2221 Increase,Oxidative DNA damage Increase, Cell death Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1877 Increase,Oxidative DNA damage Increase, Apoptosis Mar 19, 2019 Mar 19, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Thermal stress leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1879 Inhibition of Cyp17A1 activity Reduction, androstenedione Apr 10, 2019 Apr 10, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1878 Inhibition of Cyp17A1 activity Reduction, DHEA Apr 10, 2019 Apr 10, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1932 Reduction, DHEA Decrease, testosterone level Jun 3, 2019 Jun 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3228 Reduction, DHEA Decrease, testosterone levels May 24, 2024 May 24, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3229 Reduction, androstenedione Decrease, testosterone levels May 24, 2024 May 24, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1933 Reduction, androstenedione Decrease, testosterone level Jun 3, 2019 Jun 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1936 Decrease, testosterone level Decrease, AR activation Jun 3, 2019 Jun 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1934 Decrease, testosterone level Decrease, DHT level Jun 3, 2019 Jun 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1935 Decrease, DHT level Decrease, AR activation Jun 3, 2019 Apr 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1881 Decrease, DHT level Reduction, Plasma 17beta-estradiol concentrations Apr 18, 2019 Apr 18, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 5α-reductase leading to impaired fecundity in female fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3172 Decrease, DHT level Impaired, urethral tube closure Mar 20, 2024 Apr 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1937 Decrease, AR activation Impaired inguinoscrotal phase Jun 3, 2019 Jun 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2128 Decrease, AR activation decrease, transcription of genes by AR May 11, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2124 Decrease, AR activation Altered, Transcription of genes by the AR May 11, 2020 Apr 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Androgen receptor (AR) antagonism leading to decreased fertility in females
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2820 Decrease, AR activation AGD, decreased Dec 22, 2022 Dec 22, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2828 Decrease, AR activation Hypospadias Jan 11, 2023 Jan 11, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Androgen receptor (AR) antagonism leading to hypospadias in male offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1938 Impaired inguinoscrotal phase Malformation, cryptorchidism Jun 3, 2019 Apr 12, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1880 Inhibition, 5α-reductase Decrease, DHT level Apr 18, 2019 Apr 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 5α-reductase leading to impaired fecundity in female fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1883 Increase, DNMT inhibition Increase, DNA hypomethylation Apr 22, 2019 Apr 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3098 Increase, DNMT inhibition Increase, DSB Nov 16, 2023 Nov 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2101 Increase, DNMT inhibition Decrease, Global DNA methylation Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1887 Increase, DNA hypomethylation Decrease, Transgenerational DNA methylation Apr 22, 2019 Apr 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1884 Increase, DNA hypomethylation Increase, Gene expression Apr 22, 2019 Apr 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1885 Increase, Gene expression Decrease, Fecundity Apr 22, 2019 Apr 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1888 Decrease, Transgenerational DNA methylation Increase, Gene expression Apr 22, 2019 Apr 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1890 Occurrence, Focal Seizure Increased, glutamate Apr 22, 2019 Sep 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1998 Occurrence, Focal Seizure Overactivation, NMDARs Nov 13, 2019 Nov 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1891 tyrosinase Reduction of L-Dopaquinone May 3, 2019 May 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of tyrosinase leads to decreased population in fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1892 Reduction of L-Dopaquinone Reduction in melanin level May 3, 2019 May 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of tyrosinase leads to decreased population in fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1893 Reduction in melanin level Reduction of melanosome level May 3, 2019 May 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of tyrosinase leads to decreased population in fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1894 Reduction of melanosome level Reduction fo Pigmentation pattern May 3, 2019 May 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of tyrosinase leads to decreased population in fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1895 Reduction fo Pigmentation pattern Decrease, Population growth rate May 3, 2019 May 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of tyrosinase leads to decreased population in fish
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1904 Increase in RONS Increase, DNA Damage May 7, 2019 May 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1906 Increase in RONS Tissue resident cell activation May 7, 2019 May 9, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Increased DNA damage leading to increased risk of breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2337 Increase in RONS Decrease, MMP Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2331 Increase in RONS D1 protein deactivation Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2617 Increase in RONS Increased, Oxidative Stress Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2798 Increase in RONS methemocyanin formation (decrease overall oxygen binding capacity) Nov 16, 2022 Nov 16, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2646 Increase in inflammation Occurrence, renal proximal tubular necrosis Apr 8, 2022 Apr 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3177 Increase in inflammation Insulin resistance, increased Apr 9, 2024 Apr 9, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2199 Increase in inflammation hepatitis Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1909 Increase, Oxidative DNA damage Inadequate DNA repair May 19, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1913 Increase, Oxidative DNA damage Increase, DNA strand breaks May 19, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1914 Increase, Oxidative DNA damage Increase, Mutations May 19, 2019 Jan 9, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2591 Increase, Oxidative DNA damage Increase, Follicular atresia Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to population decline via DNA oxidation and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2592 Increase, Oxidative DNA damage Increase, Oocyte apoptosis Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2589 Increase, DNA strand breaks Increase, Oocyte apoptosis Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2587 Increase, DNA strand breaks Increase, Follicular atresia Mar 1, 2022 Mar 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2841 Increase, DNA strand breaks Abnormal Neural Remodeling Jan 25, 2023 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2856 Increase, DNA strand breaks Altered Signaling Mar 10, 2023 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2074 Increase, DNA strand breaks Increase, Apoptosis Apr 6, 2020 Apr 6, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Alkylation of DNA leading to reduced sperm count
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1931 Increase, DNA strand breaks Increase, Mutations Jun 2, 2019 Jan 9, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1911 Increase, DNA strand breaks Inadequate DNA repair May 19, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1939 Increase, DNA strand breaks Increase, Chromosomal aberrations Jun 3, 2019 Jan 9, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Oxidative DNA damage leading to chromosomal aberrations and mutations
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1979 Increase, Chromosomal aberrations Increase, Cell Proliferation Aug 29, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1985 Increase, Chromosomal aberrations Increase, lung cancer Aug 29, 2019 Jan 10, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1915 Retinaldehyde dehydrogenase retinoic acid May 22, 2019 May 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of retinaldehyde dehydrogenase leads to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1918 Altered, Photoreceptor patterning Altered, Visual function May 22, 2019 Jun 16, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of retinaldehyde dehydrogenase leads to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1916 retinoic acid plasma retionic acid May 22, 2019 May 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of retinaldehyde dehydrogenase leads to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1917 plasma retionic acid Altered, Photoreceptor patterning May 22, 2019 May 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of retinaldehyde dehydrogenase leads to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1919 Altered, Visual function Decline, Population May 22, 2019 May 22, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2143 Altered, Visual function Decrease, Population growth rate May 25, 2020 May 25, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of retinaldehyde dehydrogenase leads to population decline
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2375 Altered, Visual function Increased Mortality May 11, 2021 Jul 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroperoxidase inhibition leading to altered visual function via decreased eye size
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1923 Impaired Ab production Impairment of TDAR May 23, 2019 Jun 25, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1924 Wnt ligand stimulation Frizzled activation May 29, 2019 May 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1925 Frizzled activation GSK3beta inactivation May 29, 2019 May 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1926 GSK3beta inactivation β-catenin activation May 29, 2019 May 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2485 GSK3beta inactivation Repression of Gbx2 expression Oct 3, 2021 Dec 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • GSK3beta inactivation leading to increased mortality via defects in developing inner ear
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1927 β-catenin activation Snail, Zeb, Twist activation May 29, 2019 May 29, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1930 Increase, SAM depletion Increase, DNA hypomethylation May 30, 2019 May 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1944 Binding of inhibitor, mitochondrial complex III Increase, Mitochondrial complex III antagonism Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1945 Binding of inhibitor, mitochondrial complex IV Mitochondrial Complex IV inhibition Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1946 Binding of inhibitor, mitochondrial complex V Mitochondrial Complex V inhibition Jun 7, 2019 Jun 7, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mitochondrial complex inhibition leading to liver injury
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1947 TR Antagnoism Hippocampal gene expression, Altered Jun 8, 2019 Jun 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1948 TR Antagnoism Cognitive Function, Decreased Jun 8, 2019 Jun 8, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3193 TR Antagnoism Hypomyelination Apr 12, 2024 Apr 12, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3186 TR Antagnoism Reduced number of oligodendrocytes Apr 12, 2024 Apr 12, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1949 CBS inhibition Homocysteine increases Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1951 Methionine synthase Homocysteine increases Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    1950 MTHFR inhibition Homocysteine increases Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1952 betaine-homocysteine methyltransferase inhibition Homocysteine increases Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1953 Homocysteine increases plasma homocysteine increases Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1959 Homocysteine increases Plasma HCY level Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1954 plasma homocysteine increases brain Homocysteine level increases Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            1955 brain Homocysteine level increases Neuronal dysfunctions induction Jun 14, 2019 Jun 14, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1960 Plasma HCY level dysfunction of microcirculation Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1961 dysfunction of microcirculation anterior-posterior axis development Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2512 dysfunction of microcirculation Increased inflammatory immune responses Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1962 Frustrated phagocytosis Release, Cytokine Jul 3, 2019 Aug 13, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis-induced lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2415 Frustrated phagocytosis Increased proinflammatory mediators Jul 6, 2021 Jul 6, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2416 Frustrated phagocytosis Increased, Reactive oxygen species Jul 6, 2021 Jul 6, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2417 Increased, DNA damage and mutation Genomic instability Jul 6, 2021 Jul 6, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis leads to malignant mesothelioma
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2608 Increased, DNA damage and mutation Inadequate DNA repair Mar 22, 2022 Aug 27, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2728 Increased, DNA damage and mutation Increase chromosomal aberrations Aug 14, 2022 Aug 27, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • DNA damage and mutations leading to Metastatic Breast Cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1966 Increased, DNA damage and mutation Increase, Cell Proliferation Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Frustrated phagocytosis-induced lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Interaction with lung resident cell membrane components leads to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1968 Substance - LS interaction Inhibition of LS function. Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1969 Inhibition of LS function. Alveolar collapse Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2255 Inhibition of LS function. Loss of alveolar capillary membrane integrity Jan 8, 2021 Jan 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2256 Inhibition of LS function. Reduced tidal volume Jan 8, 2021 Jan 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2370 Inhibition of LS function. Decreased lung function Apr 27, 2021 Apr 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2371 Alveolar collapse Decreased lung function Apr 27, 2021 Apr 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2284 Alveolar collapse Loss of alveolar capillary membrane integrity Feb 16, 2021 Feb 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2285 Alveolar collapse Impaired lung function Feb 16, 2021 Feb 16, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1970 Alveolar collapse Alveolar reopening Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1974 Alveolar collapse Reduced tidal volume Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1971 Alveolar reopening Loss of barrier function Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2173 Alveolar reopening Loss of alveolar capillary membrane integrity Oct 22, 2020 Oct 22, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              1972 Loss of barrier function Blood extravasation into the lungs Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                1973 Blood extravasation into the lungs Acute inhalation toxicity Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  1975 Reduced tidal volume Impaired oxygenation of the blood Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2257 Reduced tidal volume Impaired lung function Jan 8, 2021 Jan 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2367 Reduced tidal volume Decreased lung function Apr 27, 2021 Apr 27, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Lung surfactant function inhibition leading to decreased lung function
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      1976 Impaired oxygenation of the blood Acute inhalation toxicity Jul 3, 2019 Jul 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2562 Disruption, Progenitor cells of second heart field Reduced neural crest cell migration Feb 8, 2022 Feb 10, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2552 Energy Deposition Increase, DNA Damage Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of ionising energy leading to population decline via programmed cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of ionising energy leads to population decline via pollen abnormal
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2548 Energy Deposition Increased, Reactive oxygen species Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of ionising energy leading to population decline via mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2557 Energy Deposition Increase, ROS production Feb 4, 2022 Feb 4, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to population decline via DNA oxidation and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2604 Energy Deposition Microcephaly Mar 17, 2022 Mar 17, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1977 Energy Deposition Increase, DNA strand breaks Aug 26, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1981 Energy Deposition Increase, Mutations Aug 29, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1982 Energy Deposition Increase, Chromosomal aberrations Aug 29, 2019 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        1983 Energy Deposition Increase, lung cancer Aug 29, 2019 Jul 5, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to lung cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2849 Energy Deposition Bone Loss Jan 25, 2023 Mar 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2815 Energy Deposition Cataracts Dec 18, 2022 Mar 11, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2837 Energy Deposition Abnormal Neural Remodeling Jan 25, 2023 Feb 14, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2838 Energy Deposition Impairment, Learning and memory Jan 25, 2023 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2832 Energy Deposition Tissue resident cell activation Jan 25, 2023 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2847 Energy Deposition Altered Bone Cell Homeostasis Jan 25, 2023 Mar 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2848 Energy Deposition Bone Remodeling Jan 25, 2023 Mar 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2813 Energy Deposition Increase, Oxidative DNA damage Dec 18, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2814 Energy Deposition Increase, Cell Proliferation Dec 18, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2809 Energy Deposition Modified Proteins Dec 16, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2785 Energy Deposition Occurrence, Vascular Remodeling Oct 17, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2769 Energy Deposition Oxidative Stress Sep 28, 2022 Mar 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of Energy Leading to Learning and Memory Impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Deposition of energy leading to occurrence of cataracts
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2770 Energy Deposition Vascular remodeling Sep 28, 2022 Sep 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2779 Energy Deposition Altered, Nitric Oxide Levels Sep 28, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2780 Energy Deposition Increase, Endothelial Dysfunction Sep 28, 2022 Mar 21, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Deposition of energy leads to vascular remodeling
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2616 Energy Deposition Increase in RONS Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2129 decrease, transcription of genes by AR AGD, decreased May 11, 2020 May 11, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2131 Decrease, testosterone levels Decrease, AR activation May 11, 2020 Apr 5, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2126 Decrease, testosterone levels Decrease, DHT level May 11, 2020 Oct 19, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3169 Decrease, testosterone levels Epididymal agenesis Mar 20, 2024 Apr 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3202 Decrease, testosterone levels malformed, Male reproductive tract Apr 25, 2024 Apr 25, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • HMG-CoA reductase inhibition leading to decreased fertility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3225 Decrease, testosterone levels Decreased sperm quantity or quality in the adult, Decreased fertility May 24, 2024 May 24, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3214 Decrease, testosterone levels Reduction, the ratio of E2/11-KT in plasma May 8, 2024 May 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3227 Decrease, testosterone levels Increased, Leutinizing hormone (LH) May 24, 2024 May 24, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3213 Decrease, testosterone levels Reduction, Plasma 17beta-estradiol concentrations May 8, 2024 May 8, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3205 Decrease, testosterone levels Malformation, Male reproductive tract May 1, 2024 May 1, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARα activation in utero leading to impaired fertility in males
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          3206 Decrease, testosterone levels Increase, Luteinizing hormone (LH) May 1, 2024 May 1, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • PPARα activation leading to impaired fertility in adult male rodents
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1986 Antagonism,LH receptor Reduction, Progesterone synthesis Oct 3, 2019 Oct 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Luteinizing hormone receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1987 Reduction, Progesterone synthesis Reduction, Plasma progesterone concentration Oct 3, 2019 Oct 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Luteinizing hormone receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1988 Reduction, Plasma progesterone concentration Reduction, progesterone uptake, decresed maturation Oct 3, 2019 Oct 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Luteinizing hormone receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1989 Reduction, progesterone uptake, decresed maturation Impaired ovulation Oct 3, 2019 Oct 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Luteinizing hormone receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1990 Impaired ovulation Decrease of egg production and cummulative fecundity Oct 3, 2019 Oct 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Luteinizing hormone receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1991 Decrease of egg production and cummulative fecundity Decline, Population trajectory Oct 3, 2019 Oct 3, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Luteinizing hormone receptor antagonism leading to reproductive dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2389 Decrease of egg production and cummulative fecundity Decreased, Population size May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1993 Increase, DNMT expression Increase, hypermethylation of the promotor region of GnRHR Oct 30, 2019 Oct 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1994 Increase, hypermethylation of the promotor region of GnRHR Decease, expression of GnRHR Oct 30, 2019 Oct 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          1995 Decease, expression of GnRHR Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Oct 30, 2019 Oct 30, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2002 Impaired IL-1R1 signaling Inhibition, Nuclear factor kappa B (NF-kB) Nov 17, 2019 Sep 29, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2000 Impaired IL-1R1 signaling Suppression of T cell activation Nov 17, 2019 Nov 17, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2001 Suppression of T cell activation Inhibition, Nuclear factor kappa B (NF-kB) Nov 17, 2019 Nov 17, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2004 Suppression of T cell activation Impairment of TDAR Nov 17, 2019 Mar 2, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2928 Suppression of T cell activation Impairment, T-cell dependent antibody response May 24, 2023 May 25, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2927 Suppression of T cell activation Impaired IL-1R1 signaling May 24, 2023 May 24, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2006 Cardiovascular dysregulation Respiratory distress/arrest Nov 25, 2019 Dec 19, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Acetylcholinesterase inhibition leading to acute mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2034 test Unknown, MIE Jan 26, 2020 Jan 26, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2037 test N/A, Unknown Jan 26, 2020 Jan 26, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2012 Impaired coordination and movement Increased Mortality Dec 20, 2019 Dec 20, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2015 Impaired coordination and movement Decrease, Population growth rate Dec 20, 2019 Dec 20, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2017 Stimulation of TLR7/8 Increase of IL-23 Dec 27, 2019 Dec 27, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2018 Increase of IL-23 Th17 cell migration and inflammation induction Dec 27, 2019 Dec 27, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2019 Th17 cell migration and inflammation induction Skin disease Dec 27, 2019 Dec 27, 2019
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2020 Binding to estrogen receptor (ER)-α Induction of GATA3 expression Dec 29, 2019 Aug 14, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2021 Induction of GATA3 expression Increase of Th2 cells producing IL-4 Dec 29, 2019 Aug 14, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2022 Increase of Th2 cells producing IL-4 Increase of autoantibody production Dec 29, 2019 Aug 14, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2023 Increase of autoantibody production Exacerbation of SLE Dec 29, 2019 Aug 14, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2024 Inhibition of JAK3 STAT5 inhibition Jan 5, 2020 Nov 3, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2025 STAT5 inhibition Suppression of STAT5 binding to cytokine gene promoters Jan 5, 2020 Nov 3, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2026 Suppression of STAT5 binding to cytokine gene promoters Suppression of IL-4 production Jan 5, 2020 Mar 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2027 Suppression of IL-4 production Impairment, TDAR Jan 5, 2020 Apr 4, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2028 Inhibition, trypsin Increased monitor peptide Jan 8, 2020 Jan 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Trypsin inhibition leading to pancreatic acinar cell tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2029 Increased monitor peptide Increased blood CCK level Jan 8, 2020 Jan 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Trypsin inhibition leading to pancreatic acinar cell tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2030 Increased blood CCK level Increased acinar cell exocrine secretion Jan 8, 2020 Jan 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Trypsin inhibition leading to pancreatic acinar cell tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2031 Increased acinar cell exocrine secretion Acinar cell proliferation Jan 8, 2020 Jan 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Trypsin inhibition leading to pancreatic acinar cell tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2032 Acinar cell proliferation Acinar cell tumors Jan 8, 2020 Jan 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Trypsin inhibition leading to pancreatic acinar cell tumors
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2052 SARS-CoV-2 cell entry Increased proinflammatory mediators Mar 1, 2020 Mar 1, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2361 SARS-CoV-2 cell entry Sustentacular cells, decrease Apr 26, 2021 Apr 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2314 SARS-CoV-2 cell entry Increased viral transcription and replication Apr 9, 2021 Apr 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2310 SARS-CoV-2 cell entry SARS-CoV-2 production Mar 30, 2021 Feb 7, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SARS-CoV-2 infection leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2302 SARS-CoV-2 cell entry TLR Activation/Dysregulation Mar 29, 2021 Mar 29, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2510 SARS-CoV-2 cell entry Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2496 SARS-CoV-2 cell entry IFN-I response, antagonized Oct 24, 2021 Dec 12, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2522 Binding to ACE2 ADAM17 induction Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2294 Binding to ACE2 Induced, Angiotensin (Ang) II accumulation Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2297 Binding to ACE2 Increased AngII Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2286 Binding to ACE2 Neuroinflammation Feb 23, 2021 Feb 23, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2299 Binding to ACE2 ACE2 enzymatic inhibition Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2452 Binding to ACE2 Endothelial cell dysfunction Aug 4, 2021 Aug 4, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2312 Binding to ACE2 Downregulation of ACE2 Mar 31, 2021 Nov 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2311 Binding to ACE2 ACE2 dysregulation Mar 31, 2021 Feb 7, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2056 Binding to ACE2 SARS-CoV-2 cell entry Mar 2, 2020 Feb 7, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • SARS-CoV-2 infection leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2065 ACE2 enzymatic inhibition Increased AngII Mar 17, 2020 Mar 17, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding to ACE2 leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2321 ACE2 enzymatic inhibition Induced, Angiotensin (Ang) II accumulation Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2434 ACE2 enzymatic inhibition Increase plasma Ang II Jul 13, 2021 Jul 13, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2322 Induced, Angiotensin (Ang) II accumulation Increased Ang II type 1 receptor (AT1R) Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2295 Induced, Angiotensin (Ang) II accumulation Impaired gustatory nerve Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2520 Induced, Angiotensin (Ang) II accumulation Hyperactivation of ACE/Ang-II/AT1R axis Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2435 Increase plasma Ang II Increased Ang II type 1 receptor (AT1R) Jul 13, 2021 Jul 13, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2067 Increase plasma Ang II Increase,collagen synthesis Mar 17, 2020 Mar 17, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2138 Increase plasma Ang II Accumulation, Collagen May 15, 2020 May 15, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2068 Increase,collagen synthesis Induction lung fibrosis Mar 17, 2020 Mar 17, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2064 Increase, the risk of acute respiratory failure Decreased mortality Mar 17, 2020 Mar 17, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2135 Increase, the risk of acute respiratory failure Increased Mortality May 13, 2020 May 13, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2062 Increased inflammatory immune responses Increase, the risk of acute respiratory failure Mar 10, 2020 Mar 10, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2513 Increased inflammatory immune responses Heart attack Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2593 Increased AngII Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Mar 3, 2022 Mar 3, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Binding to ACE2 leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2066 Increased AngII Increase plasma Ang II Mar 17, 2020 Mar 17, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2298 Increased AngII Impaired gustatory nerve Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2300 Increased AngII Increased proinflammatory mediators Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2327 Increased AngII Increased Ang II type 1 receptor (AT1R) Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2317 Increased AngII Sodium inhibition, Sweet enhancement Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2069 Chronic ROS Porcupine-induced Wnt secretion and Wnt signaling activation Mar 23, 2020 May 13, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2070 Porcupine-induced Wnt secretion and Wnt signaling activation beta-catenin activation Mar 23, 2020 Nov 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  3199 beta-catenin activation EMT Apr 23, 2024 Apr 23, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2165 Decreased, 11KT Decrease, Fertility Jul 21, 2020 Jul 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2166 Decreased, 11KT Decreased spermatogenesis Jul 21, 2020 Jul 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2076 Decreased, 11KT Impaired, Spermatogenesis Apr 16, 2020 Apr 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2937 Impaired, Spermatogenesis Decreased, Viable Offspring Jun 2, 2023 Sep 29, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Essential element imbalance leads to reproductive failure via oxidative stress
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2692 Impaired, Spermatogenesis Viable offspring, decreased Jul 18, 2022 Jul 18, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2164 Impaired, Spermatogenesis Decrease, Fertility Jul 13, 2020 Jul 13, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2274 Impaired, Spermatogenesis impaired, Fertility Jan 29, 2021 Aug 15, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2082 Increase, Cripto-1 expression Inhibition, Fin regeneration Apr 21, 2020 Jul 10, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2078 Increase, Cripto-1 expression Inhibition, Activin signaling Apr 21, 2020 Jul 7, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2079 Inhibition, Activin signaling Inhibition, Fin regeneration Apr 21, 2020 Jul 10, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2080 Inhibition, Fin regeneration Reduced, Swimming performance Apr 21, 2020 Jul 10, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2084 cell injury Increase, Regenerative cell proliferation (urothelial cells) Apr 21, 2020 Apr 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        3097 Increase, Formation of DNA photoproducts Increase, DSB Nov 16, 2023 Nov 16, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Formation of DNA photoproducts leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2090 Increase, Protein oxidation Increase, Abnormal osmoregulation Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Excessive reactive oxygen species production leading to mortality (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2223 Increase, Protein oxidation Increase, Cell death Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2181 Increase, Abnormal osmoregulation Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2091 Increase, Abnormal osmoregulation Increase, Body fluid overload Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Excessive reactive oxygen species production leading to mortality (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2092 Increase, Body fluid overload Increase, Mortality Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Excessive reactive oxygen species production leading to mortality (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2094 Decrease, MMP Decrease, OXPHOS Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Excessive reactive oxygen species production leading to mortality (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionising energy leading to population decline via mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2347 Decrease, MMP Increase, Programmed cell death Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              3163 Decrease, MMP Mitochondrial dysfunction Mar 14, 2024 Mar 14, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2179 Decrease, ATP pool Decrease, ATPase activity Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2204 Decrease, ATP pool Decrease, Cell proliferation Nov 12, 2020 Dec 7, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mitochondrial complex III antagonism leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2209 Decrease, ATP pool Decrease, Oogenesis Nov 25, 2020 Nov 25, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Thermal stress leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2214 Decrease, ATP pool Increase, Cell death Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2216 Decrease, ATP pool Increase, Fatty acid β-oxidation Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2096 Decrease, ATP pool Increase, Mortality Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Excessive reactive oxygen species production leading to mortality (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Excessive reactive oxygen species production leading to mortality (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2121 Decrease, ATP pool Increase, Necrosis May 8, 2020 May 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2120 Decrease, ATP pool Increase, Oocyte apoptosis May 8, 2020 May 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2768 Decrease, ATP pool Cell injury/death Sep 27, 2022 Sep 27, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2786 Decrease, ATP pool Decreased Na/K ATPase activity Oct 19, 2022 Oct 19, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2098 Decrease, Neutral lipids Decrease, ATP pool Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Excessive reactive oxygen species production leading to mortality (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2102 Decrease, Global DNA methylation Increase, Casp transcription Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2110 Decrease, Global DNA methylation Decrease, Heritable DNA methylation (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2103 Increase, Casp transcription Increase, Oocyte apoptosis Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2105 Increase, Casp transcription Increase, Ovarian somatic cell apoptosis Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2104 Increase, Oocyte apoptosis Decrease, Oogenesis Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2386 Increase, Oocyte apoptosis impaired, Fertility May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2400 Increase, Oocyte apoptosis Decrease of egg production and cummulative fecundity May 18, 2021 May 18, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2106 Increase, Ovarian somatic cell apoptosis Increase, Ovarian follicle breakdown Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2107 Increase, Ovarian follicle breakdown Decrease, Oogenesis Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • DNA methyltransferase inhibition leading to population decline (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2560 Increase, Ovarian follicle breakdown Decrease, Fecundity Feb 4, 2022 Feb 4, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2111 Decrease, Heritable DNA methylation (F3) Increase, Casp transcription (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2112 Increase, Casp transcription (F3) Increase, Oocyte apoptosis (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2116 Increase, Casp transcription (F3) Increase, Ovarian somatic cell apoptosis (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2113 Increase, Oocyte apoptosis (F3) Decrease, Oogenesis (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2115 Decrease, Fecundity (F3) Decrease, Population growth rate Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2114 Decrease, Oogenesis (F3) Decrease, Fecundity (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2117 Increase, Ovarian somatic cell apoptosis (F3) Increase, Ovarian follicle breakdown (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2118 Increase, Ovarian follicle breakdown (F3) Decrease, Oogenesis (F3) Apr 30, 2020 Apr 30, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • DNA methyltransferase inhibition leading to transgenerational effects (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2119 Increase, Mitochondrial ATP synthase antagonism Decrease, OXPHOS May 8, 2020 May 8, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2229 Increase, Mitochondrial ATP synthase antagonism Decrease, ATP pool Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2137 Downregulation of ACE2 Increased AngII May 15, 2020 May 15, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2136 Downregulation of ACE2 Increase plasma Ang II May 15, 2020 May 15, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2517 Downregulation of ACE2 Ang (1-7) levels reduced Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2141 Status epilepticus Overactivation, NMDARs May 21, 2020 May 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2783 Status epilepticus Increased, Intracellular Calcium overload Oct 12, 2022 Jul 24, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2782 Status epilepticus Increased, glutamate Oct 12, 2022 Sep 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Acetylcholinesterase Inhibition Leading to Neurodegeneration
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2145 Reduction, E2 Synthesis by the undifferentiated gonad Increased, Differentiation to Testis Jun 15, 2020 Jul 11, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2146 Increased, Differentiation to Testis Increased, Male Biased Sex Ratio Jun 15, 2020 Jan 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Androgen receptor agonism leading to male-biased sex ratio
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2147 Increased, Male Biased Sex Ratio Decrease, Population growth rate Jun 15, 2020 Jan 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Androgen receptor agonism leading to male-biased sex ratio
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2148 TLR4 activation Activation, JNK Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2155 TLR4 activation Activation, TGF-beta pathway Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2251 TLR4 activation AP-1 activation Dec 23, 2020 Dec 23, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2157 AP-1 activation TGFbeta expression Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2151 Pin-1 activation TGFbeta expression Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2152 TGFbeta expression Activation, TGF-beta pathway Jul 9, 2020 Jul 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2158 11β-hydroxylase inhibition Decreased, 11KT Jul 13, 2020 Jul 13, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2275 11β-hydroxylase inhibition Cortisol and 11β-(OH) testosterone decreased Feb 9, 2021 Feb 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2161 Decreased spermatogenesis impaired, Fertility Jul 13, 2020 Jul 13, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2388 Decreased spermatogenesis Decrease of egg production and cummulative fecundity May 12, 2021 May 12, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of ionizing energy leads to population decline via impaired meiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2620 Decreased spermatogenesis Decrease, Fecundity Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2623 Decreased spermatogenesis Decrease, Reproduction Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2624 Decreased spermatogenesis Decrease, Population growth rate Mar 28, 2022 Mar 28, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2162 Inhibition of 11β-HSD Decreased, 11KT Jul 13, 2020 Jul 13, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      3142 Reduced granulosa cell proliferation irregularities, ovarian cycle Mar 7, 2024 Mar 7, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Androgen receptor (AR) antagonism leading to decreased fertility in females
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2170 Inhibition, Chitinase Decrease, Digestion of old cuticle Oct 21, 2020 Oct 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Chitinase inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2172 Inhibition, Chitobiase Decrease, Digestion of old cuticle Oct 21, 2020 Oct 21, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Chitobiase inhibition leading to mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2176 Decrease, ATP synthase activity Decrease, ATP pool Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2344 Decrease, ATP synthase activity Decrease, Leaf development Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2178 Increase, Tissue/organ damage Decrease, Growth Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2180 Decrease, ATPase activity Increase, Abnormal osmoregulation Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2183 Increase, Complex III dysfunction Increase, Cyt c release Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2186 Increase, Complex III dysfunction Increase, ROS production Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2184 Increase, Cyt c release Increase, Apoptosis Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    3050 Increase, Cyt c release Caspase activation Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2189 Increase, Complex I dysfunction Increase, ROS production Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2192 Reactive Metabolite Mitochondrial dysfunction EMPTY Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2194 Reactive Metabolite Immune cell activation Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        3151 Reactive Metabolite Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2200 ER stress Apoptotic cell death Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2643 ER stress Increase, Apoptosis Apr 8, 2022 Apr 8, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        • Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        3043 Mitochondrial dysfunction EMPTY Proteasomal dysfunction Sep 14, 2023 Sep 14, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2932 Mitochondrial dysfunction EMPTY Impaired insulin signaling May 25, 2023 May 25, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2499 Mitochondrial dysfunction EMPTY Oxidative Stress Oct 26, 2021 Oct 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2193 Mitochondrial dysfunction EMPTY Apoptotic cell death Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2195 Mitochondrial dysfunction EMPTY ER stress Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2198 Apoptotic cell death Increase in inflammation Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2196 Immune cell activation IFNγ signaling Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2197 IFNγ signaling Increase in inflammation Nov 2, 2020 Nov 2, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Immune mediated hepatitis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2205 Decrease, Cell proliferation Decrease, Growth Nov 12, 2020 Jul 6, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Mitochondrial complex III antagonism leading to growth inhibition (1)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2405 Decrease, Cell proliferation Decreased, Eye size May 28, 2021 Aug 7, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2724 Decrease, Cell proliferation Decrease, outgrowth Jul 28, 2022 May 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Antagonism of Smoothened receptor leading to orofacial clefting
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Decrease, GLI1/2 target gene expression leads to orofacial clefting
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2208 Decrease, FAO Decrease, ATP pool Nov 25, 2020 Nov 25, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2215 Increase, Cell death Decrease, Growth Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2467 Increase, Cell death Altered, inner ear development Aug 23, 2021 Aug 29, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • GSK3beta inactivation leading to increased mortality via defects in developing inner ear
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2718 Increase, Cell death Neuroinflammation Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2706 Increase, Cell death Parkinsonian motor deficits Jul 25, 2022 Jul 25, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2760 Increase, Cell death Increased proinflammatory mediators Sep 1, 2022 Sep 1, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2863 Increase, Cell death Hippocampal Physiology, Altered Apr 3, 2023 Apr 3, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2842 Increase, Cell death Altered Bone Cell Homeostasis Jan 25, 2023 Mar 22, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      • Deposition of energy leading to occurrence of bone loss
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2489 Increase, Cell death Disruption of the intestinal barrier Oct 19, 2021 Oct 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2220 Increase, Oxygen consumption Increase, ROS production Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2226 Increase, Global methylation Increase, Apoptosis Dec 4, 2020 Dec 4, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Thermal stress leading to population decline (3)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2241 Increased, Thyroxine (T4) in serum Altered, Amphibian metamorphosis Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2242 Increased, Thyroxine (T4) in serum Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2244 Altered, TH-dependent gene expression Altered, Amphibian metamorphosis Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2249 Displacement, Serum thyroxine (T4) from carrier protein Increased, Free serum thyroxine (T4) Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2250 Binding, Thyroid binding globulin in serum Displacement, Serum thyroxine (T4) from carrier protein Dec 9, 2020 Dec 9, 2020
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2267 Decrease, ACAD Decreased, Mitochondrial Fatty Acid Beta Oxidation Jan 15, 2021 Jan 15, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Glucocorticoid Receptor activation leading to hepatic steatosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2277 Cortisol and 11β-(OH) testosterone decreased Decreased, 11KT Feb 9, 2021 Feb 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2276 Cortisol and 11β-(OH) testosterone decreased Decreased plasma Cortisol level Feb 9, 2021 Feb 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2278 Decreased plasma Cortisol level decreased oocyte maturation Feb 9, 2021 Feb 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2293 decreased oocyte maturation impaired, Fertility Mar 26, 2021 Mar 26, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Inhibition of 11β-hydroxylase leading to decresed population trajectory
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2429 TLR9 activation MyD88 activation Jul 8, 2021 Jul 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2433 TLR9 activation inflammasome activity, increased Jul 8, 2021 Jul 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2290 Coagulation Thrombosis and DIC Mar 25, 2021 Feb 5, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2360 Coagulation Diminished Protective Response to ROS Apr 20, 2021 Oct 17, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          • Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2313 Coagulation Oxidative Stress Apr 8, 2021 Apr 8, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2351 SARS-CoV-2 production TLR Activation/Dysregulation Apr 16, 2021 Apr 16, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2291 SARS-CoV-2 production Oxidative Stress Mar 25, 2021 Mar 25, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2358 SARS-CoV-2 production Diminished Protective Response to ROS Apr 20, 2021 Sep 26, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SARS-CoV-2 infection leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2488 SARS-CoV-2 production Increase, Cell death Oct 19, 2021 Oct 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2498 SARS-CoV-2 production Viral infection, proliferated Oct 24, 2021 Mar 31, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2545 SARS-CoV-2 production Sustentacular cells, decrease Jan 5, 2022 Jan 5, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2546 SARS-CoV-2 production Disruption of the intestinal barrier Jan 5, 2022 Jun 14, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2303 TLR Activation/Dysregulation Increased proinflammatory mediators Mar 29, 2021 Feb 7, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2296 Impaired gustatory nerve taste impairment Mar 28, 2021 Mar 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2304 Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Increase, ROS production Mar 30, 2021 Mar 30, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2319 Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Increased, Reactive oxygen species Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Binding to ACE2 leading to lung fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2323 Increased Ang II type 1 receptor (AT1R) Increased, Reactive oxygen species Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2326 Hyperactivation of ACE/Ang-II/AT1R axis Increased AngII Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                • Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                2521 Hyperactivation of ACE/Ang-II/AT1R axis Heart failure Oct 28, 2021 Oct 28, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2532 ACE2 dysregulation Gut dysbiosis Dec 2, 2021 Dec 2, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  • Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  2493 ACE2 dysregulation Recruitment of inflammatory cells Oct 19, 2021 Oct 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2831 ACE2 dysregulation (Micro)vascular dysfunction Jan 23, 2023 Feb 28, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2329 Increased Sodium-sensitive hypertension Chronic kidney disease Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2318 Sodium inhibition, Sweet enhancement Impaired gustatory nerve Apr 10, 2021 Apr 10, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2458 Platelet-neutrophil interactions, Increased Thromboinflammation, Increased Aug 4, 2021 Aug 4, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    • Endothelial cell dysfunction leading to thromboinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    2316 Increased viral transcription and replication TLR Activation/Dysregulation Apr 9, 2021 Apr 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      2315 Increased viral transcription and replication Increased proinflammatory mediators Apr 9, 2021 Apr 9, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        2330 Excitation of intracellular water Increase in RONS Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2332 D1 protein deactivation Decrease, Photosystem II efficiency Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2333 Decrease, Photosystem II efficiency Decrease, Photosynthesis Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2336 Decrease, Reproduction Decrease, Population growth rate Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionising energy leading to population decline via mitochondrial dysfunction
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionising energy leading to population decline via programmed cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2556 Decrease, Reproduction Decreased, Population trajectory Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionising energy leads to population decline via pollen abnormal
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2553 Increase, Programmed cell death Decrease, Reproduction Jan 21, 2022 Jan 21, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            • Deposition of ionising energy leading to population decline via programmed cell death
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            2339 Increase, Programmed cell death Decrease, Leaf development Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2340 Increase, OEC damage Decrease, Photosystem II efficiency Apr 11, 2021 Apr 11, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2352 Hypofibrinolysis Bradykinin, activated Apr 20, 2021 Apr 20, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2356 Hypofibrinolysis Increased proinflammatory mediators Apr 20, 2021 Feb 7, 2023
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2355 Bradykinin, activated Hypofibrinolysis Apr 20, 2021 Jan 24, 2022
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2357 Bradykinin, activated Hyperinflammation Apr 20, 2021 Oct 19, 2021
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              • Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              2353 Bradykinin, activated Increased proinflammatory mediators Apr 20, 2021