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All Key Events

Showing 1701 to 1725 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2168	Activation of angiopoietin like protein 4 Short Name	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2169	Activation of Angiogenic cytokines Short Name Activation of Angiogenic cytokines	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2170	Activated ANG/Tie2 pathway Short Name Activated ANG/Tie2 pathway	0	Molecular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2171	Activated BMP/TGF-beta pathway Short Name Activated BMP/TGF-beta pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2172	Activated Wnt/Frizzled pathway Short Name Activated Wnt/Frizzled pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2173	Activated AKT/ERK/PI3K pathway Short Name Activated AKT/ERK/PI3K pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2174	Inhibition VEGF/VEGFR pathway Short Name Inhibition VEGF/VEGFR pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2175	Endothelial cell death Short Name Endothelial cell death	0	Cellular	Aug 21, 2023	Aug 21, 2023	None
2176	Decreased endothelial cell proliferation Short Name	0	Cellular	Aug 21, 2023	Aug 21, 2023	None
2177	Adhesion disfunction Short Name Adhesion disfunction	0	Cellular	Aug 21, 2023	Aug 21, 2023	None
2178	Vascular barrier disruption Short Name Vascular barrier disruption	0	Tissue	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2179	Impaired Platelet Aggregation Short Name Impaired Platelet Aggregation	0	Tissue	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2180	Immune mechanisms antagonized by viral proteins Short Name immune mechanisms antagonized	5	Molecular	Aug 23, 2023	Dec 13, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2181	Angiogenesis dysfunction Short Name Angiogenesis dysfunction	0	Organ	Aug 28, 2023	Aug 28, 2023	5 AOPs 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2182	Phenotype switching of vascular smooth muscle cells Short Name VSMC phenotype switching	0	Cellular	Sep 4, 2023	Sep 4, 2023	None
2183	Increased incidence of vascular calcification and atherosclerosis morbidity Short Name	0	Population	Sep 4, 2023	Nov 14, 2023	None
2184	Apoptosis of vascular smooth muscle cells Short Name VSMC apoptosis	0	Cellular	Sep 4, 2023	Sep 4, 2023	None
2185	Proliferation of vascular smooth muscle cells Short Name VSMC proliferation	0	Cellular	Sep 5, 2023	Sep 5, 2023	None
2186	Ryanodine receptor activation Short Name Activation, RyR	0	Molecular	Sep 8, 2023	Sep 8, 2023	490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2187	Opening, voltage-gated calcium channels Short Name Opening VGCCs	0	Molecular	Sep 14, 2023	Sep 14, 2023	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2188	Activation, caspases Short Name Caspase activation	0	Cellular	Sep 14, 2023	Sep 14, 2023	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2189	Development-related pathway alterations Short Name Development-related pathway alterations	0	Cellular	Sep 16, 2023	Sep 17, 2023	None
2190	Cardiomyocyte differentiation inhibition Short Name	0	Cellular	Sep 16, 2023	Sep 16, 2023	None
2191	Inhibition of the Wnt/β-catenin pathway Short Name	0	Cellular	Sep 18, 2023	Sep 18, 2023	None
2192	Influenza A Virus production increased Short Name IAV production increased	4	Molecular	Oct 2, 2023	Jan 29, 2024	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation