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Showing 776 to 800 of 1781 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
1205 Activation, Juvenile hormone receptor
1 Molecular Nov 29, 2016 Sep 16, 2017 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1206 Induction, Doublesex1 gene
1 Molecular Nov 29, 2016 Sep 16, 2017 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1207 Induction, Male traits formation in embryos
0 Nov 29, 2016 Nov 29, 2016 None
1208 Increased, Male offspring
2 Population Nov 29, 2016 Dec 3, 2016 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1209 Induction, Male reproductive tract
1 Organ Nov 29, 2016 Sep 16, 2017 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1210 Alteration, Food-web structures
1 Population Nov 29, 2016 Dec 3, 2016 201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
1211 Altered, food-web structures
0 Population Nov 29, 2016 Dec 3, 2016 None
1212 Reduced, Neuronal synaptic inhibition
0 Cellular Nov 29, 2016 Dec 3, 2016 None
1213 Increased, Angiogenesis
1 Cellular Nov 29, 2016 Dec 20, 2022 200: Estrogen receptor activation leading to breast cancer
1214 Altered gene expression specific to CAR activation, Hepatocytes
1 Cellular Nov 29, 2016 Dec 19, 2018 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
1215 TRPA1 activation, TRPA1 Receptor
1 Molecular Nov 29, 2016 Sep 16, 2017 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1216 Influx of Ca2+, Excitation of trigeminal nerves
0 Nov 29, 2016 Nov 29, 2016 None
1217 Excitation of trigeminal nerves induces Sensory Airway Irritation,
0 Organ Nov 29, 2016 Sep 24, 2018 None
1218 Opening of calcium channel, Calcium influx
1 Cellular Nov 29, 2016 Oct 25, 2017 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1219 Release of Substance P (SP), Substance P increase in circulation
0 Nov 29, 2016 Nov 29, 2016 None
1220 Trigeminal nerve activation
1 Tissue Nov 29, 2016 Sep 24, 2018 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1221 Cough, Dyspnea, Sneezing, Acute respiratory effect
0 Nov 29, 2016 Nov 29, 2016 None
1222 SP (Substance P) release, Local increase of SP
1 Cellular Nov 29, 2016 Sep 16, 2017 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1223 Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
4 Tissue Nov 29, 2016 Sep 24, 2018 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1224 Non-neuronal production of TNF, Epithelial irritation
2 Individual Nov 29, 2016 Dec 3, 2016 None
1225 Immune system inflammation
2 Tissue Nov 29, 2016 Sep 16, 2017 None
1226 Increased Respiratory irritability and Chronic Cough,
2 Organ Nov 29, 2016 Sep 24, 2018 196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1227 TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/NEK293 fibroblast cells
0 Nov 29, 2016 Nov 29, 2016 None
1228 TRPA1 activation, Classic receptor binding / HEK 293 cells (fibroclast), cho cells (ovary), noncovalently linkked)
0 Nov 29, 2016 Nov 29, 2016 None
1229 TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/ HEK293 fibroblast cells
0 Nov 29, 2016 Nov 29, 2016 None