AOP-Wiki

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All Key Events

Showing 926 to 950 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1358	Repress, GABA-A receptor Short Name Repress, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1359	Activate, GABA-A receptor Short Name Activate, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1360	Activate, presynaptic neuron 2 Short Name Activate, presynaptic neuron 2	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1361	Increase, GABA Short Name Increase, GABA	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1362	Increased, hippocampal hyperdepolarization Short Name	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1363	Increased, epilepsy Short Name Increased, epilepsy	0	Individual	Apr 14, 2017	Jun 2, 2017	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy 471: Various neuronal effects induced by elavl3, sox10, and mbp
1364	Increase, Reactive oxygen species Short Name Increase, ROS	0	Molecular	Apr 15, 2017	Mar 19, 2019	4 AOPs 325: Thermal stress leading to population decline (2) 396: Deposition of ionizing energy leads to population decline via impaired meiosis 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 494: AhR activation leading to liver fibrosis
1365	Increase, Apoptosis Short Name Increase, Apoptosis	0	Cellular	Apr 15, 2017	Apr 15, 2017	8 AOPs 322: Alkylation of DNA leading to reduced sperm count 331: Formation of DNA photoproducts leading to growth inhibition (1) 330: Excessive reactive oxygen species production leading to mortality (4) 326: Thermal stress leading to population decline (3) 325: Thermal stress leading to population decline (2) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
1366	Decrease, Oogenesis Short Name Decrease, Oogenesis	0	Organ	Apr 15, 2017	Apr 30, 2020	12 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 326: Thermal stress leading to population decline (3) 325: Thermal stress leading to population decline (2) 324: Thermal stress leading to population decline (1) 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1367	Inhibit, gastric ulcer formation Short Name Inhibit, gastric ulcer formation	0	Organ	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1368	Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Short Name Inhibition, PTGS-1	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1369	Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Short Name Activation, PTGS-1	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1370	Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Short Name Activation, PTGS-2	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1371	Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Short Name	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1372	Increase, bicarbonate Short Name Increase, bicarbonate	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1373	Increase, mucous Short Name Increase, mucous	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1374	Increase, mucosal blood flow Short Name Increase, mucosal blood flow	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1375	Increase, platelet aggregation Short Name Increase, platelet aggregation	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1376	Increase, angiogenesis Short Name Increase, angiogenesis	1	Tissue	Apr 17, 2017	Feb 29, 2024	2 AOPs 217: Gastric ulcer formation 439: Activation of the AhR leading to metastatic breast cancer
1377	Decrease, leukocyte adherence Short Name Decrease, leukocyte adherence	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1378	Increase, leukocyte adherence Short Name Increase, leukocyte adherence	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1379	Activate, leukocyte Short Name Activate, leukocyte	0	Cellular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1380	Activate, mucosal defense Short Name Activate, mucosal defense	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1381	Increase, surfactant Short Name Increase, surfactant	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1382	Decrease, surfactant Short Name Decrease, surfactant	0	Molecular	Apr 17, 2017	Apr 17, 2017	2 AOPs 217: Gastric ulcer formation 229: Helicobacter pylori to gastric ulcer