AOP-Wiki

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All Key Events

Showing 1576 to 1600 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2043	Decrease, Sonic Hedgehog second messenger production Short Name	1	Cellular	Aug 12, 2022	Mar 22, 2023	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2044	Decrease, Smoothend relocation and activation Short Name Decrease, SMO relocation	1	Cellular	Aug 23, 2022	Oct 27, 2022	460: Antagonism of Smoothened receptor leading to orofacial clefting
2045	Increase, Alcohol dehydrogenase Short Name Increase, Alcohol dehydrogenase	0	Molecular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2046	Increase, Vitellogenin mRNA Short Name Increase, Vitellogenin mRNA	0	Molecular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2047	Delay, Ovarian maturation Short Name Delay, Ovarian maturation	0	Cellular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2048	Increase, Body volume of female adults Short Name Increase, Body volume of female adults	0	Individual	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2049	Increase, sex ratio (F/M) Short Name Increase, sex ratio (F/M)	0	Individual	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2050	Increase, developmental abnormalities Short Name Increase, developmental abnormalities	0	Individual	Aug 28, 2022	Aug 28, 2022	2 AOPs 465: Alcohol dehydrogenase leading to reproductive dysfunction 467: Knickkopf leading to mortality
2051	Decrease, Tyrosine Short Name Decrease, Tyrosine	0	Molecular	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2052	Decrease, dopa decarboxylase Short Name Decrease, dopa decarboxylase	0	Cellular	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2053	Increase, Defects in tanning of new cuticle Short Name	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2054	Increase, impairment of cuticle sclerotization Short Name	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2055	Increase, pigmentation Short Name Increase, pigmentation	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2056	Increase, delay in oviposition Short Name Increase, delay in oviposition	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2057	Decrease, hatching of egg Short Name Decrease, hatching of egg	0	Individual	Aug 28, 2022	Aug 28, 2022	466: Doda decarboxylase leading to mortality
2058	Decrease, 20-hydroxyecdysone Short Name Decrease, 20-hydroxyecdysone	0	Molecular	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2059	Decrease, knickkopf gene Short Name Decrease, knickkopf gene	0	Cellular	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2060	Decrease, Chitin laminar organization Short Name Decrease, Chitin laminar organization	0	Tissue	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2061	Decrease, Prevent chitin degradation by chitinases Short Name	0	Tissue	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2062	Weak, Procuticle protection Short Name Weak, Procuticle protection	0	Organ	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2063	Decrease, New cuticle secretion Short Name Decrease, New cuticle secretion	0	Organ	Aug 28, 2022	Aug 28, 2022	467: Knickkopf leading to mortality
2064	Increase, Cytosolic calcium Short Name Increase, Cytosolic Ca	0	Cellular	Sep 13, 2022	Sep 13, 2022	265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
2065	Inhibition, Fatty acid oxidation Short Name Inhibition, Fatty acid oxidation	0	Cellular	Sep 19, 2022	Sep 28, 2022	454: PM2.5-related AOP frameworks on liver diseases
2066	Altered Signaling Pathways Short Name Altered Signaling	0	Molecular	Sep 28, 2022	Feb 13, 2024	3 AOPs 470: Deposition of energy leads to vascular remodeling 482: Deposition of energy leading to occurrence of bone loss 483: Deposition of Energy Leading to Learning and Memory Impairment
2067	Altered, Nitric Oxide Levels Short Name Altered, Nitric Oxide Levels	1	Cellular	Sep 28, 2022	Apr 13, 2023	470: Deposition of energy leads to vascular remodeling