AOP-Wiki

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All Key Events

Showing 1651 to 1675 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2118	Succinate dehydrogenase, inhibited Short Name SDH, inhibited	3	Molecular	Apr 3, 2023	May 4, 2023	457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
2119	Insulin resistance, increased Short Name Insulin resistance, increased	1	Individual	Apr 3, 2023	May 26, 2023	4 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 454: PM2.5-related AOP frameworks on liver diseases 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2120	Superoxide generation, increased Short Name Superoxide generation, increased	1	Cellular	Apr 3, 2023	Apr 17, 2023	457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
2121	decreased, Intellectual Quotient Short Name decreased, IQ	0	Population	Apr 4, 2023	Apr 4, 2023	490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2122	increased, socio-economic burden Short Name increased, Economic Burden	0	Population	Apr 4, 2023	Feb 5, 2024	490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2123	decreased, Bcl-2 expression Short Name decreased, Bcl-2	0	Molecular	Apr 4, 2023	Sep 7, 2023	490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2124	increased, Bax expression Short Name increased, Bax	0	Molecular	Apr 4, 2023	Sep 7, 2023	490: Co-activation of IP3R and RyR leads to socio-economic burden through reduced IQ and non-cholinergic mechanisms
2125	Increased fat mass Short Name Increased fat mass	0	Organ	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2126	Estrogen receptor alpha inactivation Short Name ERa inactivation	0	Molecular	Apr 5, 2023	Apr 10, 2023	2 AOPs 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2127	Increased adipocyte size Short Name Increased adipocyte size	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2128	Increased adipocyte numbers Short Name Increased adipocyte numbers	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2129	Metabolically unhealthy Obesity Short Name Metabolically unhealthy Obesity	0	Individual	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2130	increased lipid accumulation Short Name increased lipid accumulation	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2131	Conjugation, GSH Short Name Conjugation, GSH	1	Cellular	Apr 5, 2023	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
2132	Increased pro-inflammatory cytokine expression Short Name Increased cytokine expression	0	Cellular	Apr 6, 2023	Apr 6, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2133	Increase, Glucuronidation of T4 Short Name Increase, Glucuronidation of T4	0	Molecular	Apr 12, 2023	Apr 12, 2023	None
2134	Increase, Androgen receptor Short Name Increase, Androgen receptor	0	Molecular	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2135	Prostate cancer Short Name Prostate cancer	0	Individual	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2136	prostatic intraepithelial neoplasia Short Name prostatic intraepithelial neoplasia	0	Tissue	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2137	Increase, Gonadotropins concentration in plasma Short Name	0	Tissue	May 16, 2023	May 16, 2023	496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
2138	Derease, testosterone levels Short Name Derease, testosterone levels	0	Tissue	May 16, 2023	May 8, 2024	None
2139	Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma Short Name	0	Organ	May 16, 2023	May 16, 2023	496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
2140	Decreased spawning and cumulative fecundity, decreased gonadosomatic index Short Name	0	Individual	May 16, 2023	May 16, 2023	None
2141	Disruption, Estrogen receptor Short Name Disruption of ER	0	Molecular	May 17, 2023	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
2142	Depletion, Ectoplasmic specialization (ES) Short Name Depletion of ES	0	Cellular	May 17, 2023	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity