AOP-Wiki

API

All Key Events

Showing 1676 to 1700 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2143	Increased, gene expression of AR Short Name Increased, gene expression of AR	0	Molecular	May 18, 2023	May 18, 2023	496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
2144	Impaired insulin signaling Short Name Impaired insulin signaling	0	Cellular	May 25, 2023	May 25, 2023	497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2145	Metabolic syndrome Short Name Metabolic syndrome	0	Population	May 25, 2023	May 25, 2023	497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2146	Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 Short Name Activation of MEK, ERK1/2	1	Molecular	May 25, 2023	Jul 28, 2023	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
2147	Decreased, Viable Offspring Short Name Decreased, Viable Offspring	2	Individual	Jun 2, 2023	Apr 10, 2024	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 521: Essential element imbalance leads to reproductive failure via oxidative stress
2148	Increased LCN2/iron complex binds to SLC22A17 receptor in neuron Short Name Increased LCN2/iron complex	0	Molecular	Jun 15, 2023	Jun 15, 2023	498: Increased LCN2/iron complex leading to neurological disorders
2149	Increased intracelluar Iron accumulation Short Name Increased intracelluar Iron	0	Cellular	Jun 15, 2023	Jun 15, 2023	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 501: Excessive iron accumulation leading to neurological disorders
2150	Neurological disorder Short Name Neurological disorder	0	Individual	Jun 15, 2023	Jun 15, 2023	3 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 501: Excessive iron accumulation leading to neurological disorders 471: Various neuronal effects induced by elavl3, sox10, and mbp
2151	Disruption, neurotransmitter release Short Name Disruption, neurotransmitter release	1	Molecular	Jun 27, 2023	Jul 21, 2023	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 471: Various neuronal effects induced by elavl3, sox10, and mbp
2152	Epigenetic modification process Short Name Epigenetic modification process	0	Cellular	Jul 27, 2023	Jul 27, 2023	503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
2153	Expression of factors ruling proliferation, modified Short Name	0	Cellular	Jul 27, 2023	Jul 27, 2023	503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
2154	Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Short Name endometrioid adenocarcinoma Type I	0	Organ	Jul 27, 2023	Jul 27, 2023	503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
2155	Inhibition of Sulfotransferase E1 (SULT1E1) Short Name SULT1E1 inhibition	0	Molecular	Jul 28, 2023	Aug 14, 2023	504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
2156	Increased morbidity of congenital heart defect Short Name	0	Population	Jul 31, 2023	Jul 31, 2023	None
2157	Abnormal Cardiac Structure and Function Short Name	0	Organ	Jul 31, 2023	Jul 31, 2023	None
2158	Influenza A Virus (IAV) binds sialic acid glycan receptor Short Name IAV binds receptor	1	Molecular	Jul 31, 2023	Aug 2, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2159	Influenza A virus (IAV) cell entry Short Name IAV cell entry	3	Cellular	Aug 11, 2023	Oct 3, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2160	Angiogenesis disfunction Short Name Angiogenesis disfunction	0	Organ	Aug 19, 2023	Aug 19, 2023	None
2161	Increase, Vascular disrupting effects Short Name Increase, Vascular disrupting effects	0	Individual	Aug 19, 2023	Aug 19, 2023	5 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2162	Activation, HIF1α Short Name Activation, HIF1α	0	Cellular	Aug 20, 2023	Aug 20, 2023	508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2163	Activation Sema6A Short Name Activation Sema6A	0	Cellular	Aug 20, 2023	Aug 20, 2023	508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2164	Activation, Dll4-Notch pathway Short Name Activation, Dll4-Notch pathway	0	Cellular	Aug 20, 2023	Aug 20, 2023	2 AOPs 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2165	Activation of PPAR Short Name Activation of PPAR	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2166	Abnormal expression of NO Short Name Abnormal expression of NO	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2167	Activation of MMP-2 MMP-9 Short Name Activation of MMP-2 MMP-9	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects