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All Key Events

Showing 201 to 225 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

414	Increase, Luteinizing hormone (LH) Short Name Increase, Luteinizing hormone (LH)	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
415	Hyperplasia, Leydig cell Short Name Hyperplasia, Leydig cell	1	Cellular	Nov 29, 2016	Sep 27, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
416	Increase proliferation, Leydig cell Short Name Increase proliferation, Leydig cell	1	Cellular	Nov 29, 2016	Sep 16, 2017	51: PPARα activation leading to impaired fertility in adult male rodents
417	skewed, sex ratio Short Name skewed, sex ratio	1	Population	Nov 29, 2016	Dec 3, 2016	52: ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
418	Increased, Vitellogenin synthesis Short Name Increased, Vitellogenin synthesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
419	Increased, renal vitellogenin deposition Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
421	Increased, glomerular rupture and renal hemorrhaging Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	53: ER agonism leading to reduced survival due to renal failure
422	Increased, nephropathy Short Name Increased, nephropathy	1	Individual	Nov 29, 2016	Dec 3, 2016	53: ER agonism leading to reduced survival due to renal failure
423	Increased, Clonal Expansion / Cell Proliferation to Form Pre-Neoplastic Altered Hepatic Foci Short Name	0		Nov 29, 2016	Nov 29, 2016	None
424	Inhibition, Na+/I- symporter (NIS) Short Name Inhibition, Na+/I- symporter (NIS)	1	Molecular	Nov 29, 2016	Apr 4, 2019	5 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
425	Decrease of Thyroidal iodide Short Name Thyroidal Iodide, Decreased	1	Cellular	Nov 29, 2016	Apr 4, 2019	4 AOPs 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
427	Down Regulation, K-Cl co-transporter 2 (KCC2) Short Name	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
428	Delay, Developmental GABA shift Short Name Delay, Developmental GABA shift	0	Cellular	Nov 29, 2016	Nov 29, 2016	None
429	Cellular Proliferation and Clonal Expansion of Mutant Cells (Pre-neoplastic Foci), Alteration of cellular growth homeostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None
442	Decreased, Population trajectory Short Name Decreased, Population trajectory	1	Population	Nov 29, 2016	Apr 18, 2017	2 AOPs 435: Deposition of ionising energy leads to population decline via pollen abnormal 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
444	Increased, Atrioventricular block and bradycardia Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	94: Sodium channel inhibition leading to congenital malformations
445	Respiratory distress/arrest Short Name Respiratory distress/arrest	1	Organ	Nov 29, 2016	Dec 20, 2019	2 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 94: Sodium channel inhibition leading to congenital malformations
446	Reduction, fetal/adult testosterone Short Name Reduction of testosterone	1	Tissue	Nov 29, 2016	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
447	Reduction, Cholesterol transport in mitochondria Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 51: PPARα activation leading to impaired fertility in adult male rodents 18: PPARα activation in utero leading to impaired fertility in males
450	Suppression, VLDL secretion Short Name Suppression, VLDL secretion	1	Cellular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
451	Inhibition, Mitochondrial fatty acid beta-oxidation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 57: AhR activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis
454	Increased, Triglyceride formation Short Name Increased, Triglyceride formation	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
456	Suppression, Constitutive androstane receptor, NR1l3 Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
457	Activation, SREBF1 Short Name Activation, SREBF1	2	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 62: AKT2 activation leading to hepatic steatosis
458	Increased, De Novo FA synthesis Short Name Increased, De Novo FA synthesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis