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Increased, Migration (Endothelial Cells) leads to Increased, Angiogenesis
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Estrogen receptor activation leading to breast cancer||adjacent||High||High||Brendan Ferreri-Hanberry (send email)||Open for adoption|
|Homo sapiens||Homo sapiens||High||NCBI|
Life Stage Applicability
Key Event Relationship Description
Pontillo et al. treated mice with increasing doses of hexachlorobenzene and then calculated the vessel density in mammary fat pads (Pontillo et al., 2015 Nov 19). They found that mice treated with hexachlorobenzene had a higher vessel density with a dose–response concordance. Treatment by AhR antagonists completely reversed this association (Pontillo et al., 2015 Nov 19, Zárate et al., 2020 Aug). The relationship between endothelial migration and angiogenesis was not detailed here since there is existing extensive knowledge (Lamalice et al., 2007 Mar 30, Norton and Popel, 2016 Nov 14, Ausprunk and Folkman, 1977 Jul 1). The KER 12 was considered as “strong”.