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TRPA1 activation, TRPA1 Receptor leads to Opening of calcium channel, Calcium influx
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation||adjacent||High||High||Allie Always (send email)||Under development: Not open for comment. Do not cite|
Life Stage Applicability
Key Event Relationship Description
Electrophiles (e.g. isocyanates, aldehydes) react covalently with ankyrin domains while select non-reactive irritants activate through an uncharacterized alternative mechanism. Both cause localized calcium transients and deplorarization of neuronal membrane which may lead to action potentials.
Evidence Collection Strategy
Evidence Supporting this KER
The basic function of TRPA1 is known and is concordant with existing biological knowledge.
Uncertainties and Inconsistencies
Some modes of TRPA1 activation are unclear.