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Non-neuronal production of TNF, Epithelial irritation leads to Leukocyte infiltration
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
TNF is a well-known mediator of pro-inflammatory signaling. Its local effects include leukocyte attraction, edema, and sensitivity to pain.
Evidence Collection Strategy
Evidence Supporting this KER
TNF signals through the TNF receptor family which is widespread in many tissues. TNF is a strong activator of NF-kB and MAPK pathways in cells.