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Opening of calcium channel, Calcium influx leads to SP (Substance P) release, Local increase of SP
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
Activation of TRPA1 or TRPV1 channels in nociceptive neurons produces calcium transients which signal the neuron to release substance P, among other neuropeptides. The local effects of substance P release are collectively termed neurogenic inflammation.
Evidence Collection Strategy
Evidence Supporting this KER
It is unknown how TRP-mediated calcium transients directly lead to substance P release but it does not conflict with known biology.
Uncertainties and Inconsistencies
Mechanism is not known.