Upstream eventGeneral Apoptosis
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|CYP2E1 activation and formation of protein adducts leading to neurodegeneration||adjacent||High||High|
Life Stage Applicability
Key Event Relationship Description
Neurodegeneration is the loss of neuron cells in the brain. Apoptosis is a form of cell death that can cause neurodegeneration. Neurodegeneration is linked with diseases such as Alzheimer.
Evidence Supporting this KER
Apoptosis is a form of cell death, where neurodegeneration is the loss of neuron cells in the brain.
Uncertainties and Inconsistencies
More AOPs should be developed to link other forms of cell death with neurodegeneration.
Quantitative Understanding of the Linkage
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Uttara, B., Singh, A. V, Zamboni, P. & Mahajan, R. T. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 7, 65–74 (2009).
Obulesu, M. & Lakshmi, M. J. Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues. Neurochemical Research 39, 2301–2312 (2014).