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Impaired IL-1 signaling leads to Suppressed MyD88
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
Evidence Collection Strategy
Evidence Supporting this KER
The trimeric complex consists of IL-1, IL-1R1 and IL-1R3 (a coreceptor, formerly IL-1R accessory protein) allows for the approximation of the Toll-IL-1-Receptor (TIR) domains of each receptor chain. MyD88 then binds to the TIR domains. The binding of MyD88 triggers a cascade of kinases to activation of NF-κB. (Dinaarello et al.)
Uncertainties and Inconsistencies
Known modulating factors
There is no report to quantitatively measue MyD88 activation.