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Airway epithelial injury leads to Increase, Inflammation
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
Damage of the airway epithelium leads to inflammatory reactions.
Evidence Collection Strategy
Evidence Supporting this KER
Inflammation is a biological response to harmful stimuli, including cell damage. Therefore, damage to airway epithelium will initiate inflammatory reactions.
Uncertainties and Inconsistencies
It is clear that inflammatory reactions occur after exposure to α-diketones. The exact role of inflammation in the ultimate development of bronchiolitis obliterans remains unclear.
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Anderson, S.E., Jackson, L.G., Franko, J., Wells, J.R., 2010. Evaluation of dicarbonyls generated in a simulated indoor air environment using an in vitro exposure system. Toxicol. Sci. 115, 453–461.
McGraw, M. D., Rioux, J. S., Garlick, R. B., Rancourt, R. C., White, C. W., & Veress, L. A. (2017). Impaired proliferation and differentiation of the conducting airway epithelium associated with bronchiolitis obliterans after sulfur mustard inhalation injury in rats. Toxicological Sciences, 157(2), 399–409. https://doi.org/10.1093/toxsci/kfx057