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Inhibition, Aromatase leads to Reduction, E2 Synthesis by the undifferentiated gonad
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation||adjacent||High||Brendan Ferreri-Hanberry (send email)||Under Development: Contributions and Comments Welcome|
Life Stage Applicability
Key Event Relationship Description
Evidence Supporting this KER
Uncertainties and Inconsistencies
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
The life stage applicable to this key event relationship is developing embryos and juveniles prior to or during the gonadal developmental stage. This key event relationship is not applicable to sexually differentiated adults.
Phylogenetic analysis among mammalian, amphibian, reptile, bird, and fish has shown that aromatase is well conserved among all vertebrates (Wilson JY et al., 2005)70. Additionally, CYP19 was detected in the amphioxus suggesting that it has possible origin in primitive chordates. However this key event is only applicable to to vertebrates.