The activation of the AhR can modulate cell motility in different types of breast cancers such as: ER-positive cells lines (MCF-7, T-47D, ZR-75–1), triple negative (MDA-MB-231, MDA-MB-435, HS-578-T, SUM149), and cells overexpressing the Her2 (SK-BR-3) (Goode et al., 2013 Dec 15, Regan Anderson et al., 2018, Parks et al., 2014 Nov, Pontillo et al., 2011 Apr, Qin et al., 2011 Oct 20, Nguyen et al., 2016 Nov 15, Novikov et al., 2016 Nov, Miret et al., 2016 Jul, Shan et al., 2020 Nov, Dwyer et al., 2021 Feb, Narasimhan et al., 2018 May 7, Hsieh et al., 2012 Feb). Activation of the AhR with TCDD, butyl-benzyl phthalate, di-n-butyl phthalate, hexachlorobenzene, and benzo[a]pyrene can promote cell migration in different assays (Parks et al., 2014 Nov, Pontillo et al., 2011 Apr, Qin et al., 2011 Oct 20, Novikov et al., 2016 Nov, Miret et al., 2016 Jul, Shan et al., 2020 Nov, Narasimhan et al., 2018 May 7, Hsieh et al., 2012 Feb). On the other hand, the use of AhR antagonists, AhR silencing or AhR knockout reversed this effect (Goode et al., 2013 Dec 15, Regan Anderson et al., 2018, Parks et al., 2014 Nov, Pontillo et al., 2011 Apr, Qin et al., 2011 Oct 20, Novikov et al., 2016 Nov, Shan et al., 2020 Nov, Narasimhan et al., 2018 May 7, Hsieh et al., 2012 Feb). The most frequently used assays for evaluating cell migration were the scratch wound assay and the transwell chamber assay. Only three works evaluated the dose–response concordance of AhR activation with stressors and cell migration (Pontillo et al., 2011 Apr, Miret et al., 2016 Jul, Shan et al., 2020 Nov). The evidence was therefore classified as “moderate”.