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Increase, Regenerative cell proliferation (hepatocytes) leads to Increase, Preneoplastic foci (hepatocytes)
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)||adjacent||Cataia Ives (send email)||Under Development: Contributions and Comments Welcome|
Life Stage Applicability
Key Event Relationship Description
Sustained regenerative cell proliferation of hepatocytes directly leads to preneoplastic hepatocyte foci.