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Decreased, Aromatase (Cyp19a1) mRNA leads to Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation||adjacent||High||Moderate||Allie Always (send email)||Under Development: Contributions and Comments Welcome|
|Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription||adjacent||Evgeniia Kazymova (send email)||Under Development: Contributions and Comments Welcome|