Key Event Relationships (KERs)

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Showing 76 to 100 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3232 2229: Acrolein accumulation 1603: Chronic kidney disease Jun 4, 2024 Jun 4, 2024
1442 1340: Activate, calmodulin 1341: Increase, myosin light chain phosphorylation Apr 14, 2017 Apr 14, 2017
1464 1359: Activate, GABA-A receptor 1322: Increased, intracellular chloride (Cl-) Apr 14, 2017 Apr 14, 2017
1476 1379: Activate, leukocyte 1385: Activated, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
1475 1380: Activate, mucosal defense 1367: Inhibit, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
1488 1383: Activate, phospholipase 1382: Decrease, surfactant Apr 17, 2017 Apr 17, 2017
1439 1337: Activate, PLC 1338: Increase, inositol triphosphate Apr 14, 2017 Apr 14, 2017
1461 1360: Activate, presynaptic neuron 2 1361: Increase, GABA Apr 14, 2017 Apr 14, 2017
3015 2173: Activated AKT/ERK/PI3K pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3024 2173: Activated AKT/ERK/PI3K pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
3010 2170: Activated ANG/Tie2 pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3020 2170: Activated ANG/Tie2 pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
3012 2171: Activated BMP/TGF-beta pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3021 2171: Activated BMP/TGF-beta pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
3013 2172: Activated Wnt/Frizzled pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3022 2172: Activated Wnt/Frizzled pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
1559 1421: Activated, LXR 1422: Reduced, PPARalpha Jun 2, 2017 Jun 2, 2017
1458 1355: Activated, membrane depolarization 1362: Increased, hippocampal hyperdepolarization Apr 14, 2017 Apr 14, 2017
1454 1351: Activated, NMDA receptor 1321: Increased, intracellular sodium (Na+) Apr 14, 2017 Apr 14, 2017
1452 1349: Activated, presynaptic neuron 1 1350: Increased, glutamate Apr 14, 2017 Apr 14, 2017
3086 1349: Activated, presynaptic neuron 1 1018: Activation, Glutamate-gated chloride channels Oct 17, 2023 Oct 17, 2023
3088 1349: Activated, presynaptic neuron 1 1177: Decreased, Ionotropic GABA receptor chloride channel conductance Oct 17, 2023 Oct 17, 2023
1457 1352: Activated, voltage-gated sodium channel 1355: Activated, membrane depolarization Apr 14, 2017 Apr 14, 2017
2996 2169: Activation of Angiogenic cytokines 1928: increased，Vascular endothelial dysfunction Aug 20, 2023 Aug 20, 2023
2995 2168: Activation of angiopoietin like protein 4 1928: increased，Vascular endothelial dysfunction Aug 20, 2023 Aug 20, 2023