AOPs Including This Stressor
|Chemical binding to tubulin in oocytes leading to aneuploid offspring||High|
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
Mailhes and Aardema (1992) Hyperhaploidy is significantly increased at all doses tested. The percentages of hyperhaploid oocytes were 0.3 (1/309), 3.9 (6/155), 16.6 (38/229), 35.4 (46/130), 27.9 (60/215) and 29.4 (42/143) for controls, 500, 1000, 1500, 1750 and 2000 mg/kg, respectively. A saturation of the effect is detected for doses above 1500 mg/kg, but its cause is not investigated.
There is no evidence text for this event.
Administration of benomyl ranging from 500 to 2000 mg/kg per os at the time of the induction of ovulation increased hyperhaploidy mouse oocytes at all doses tested (Mailhes and Aardema, 1992). A saturation of the effect is detected for doses above 1500 mg/kg
Benomyl (methyl-[1-[(butylamino)carbonyl]-1H-benzimidazol-2-yl]carbamate, an azole fungicide, inhibits RALDH2 in vivo (IC50 = 24 µmol/kg) (Staub et al, 1998). Same inhibitory effect is not observed in vitro, suggesting that there is a metabolite (e.g. MBT) of benomyl that is most active in vivo (Koppaka et al, 2012; Staub et al, 1998).