Stressor: 176
Title
Diethylstilbestrol
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
Diethylstilbestrol | DTXSID3020465 | Diethylstilbestrol | 56-53-1 | RGLYKWWBQGJZGM-ISLYRVAYSA-N | RGLYKWWBQGJZGM-ISLYRVAYSA-N |
AOP Evidence
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
There is no evidence text for this AOP
Event Evidence
Increase of anti-DNA antibody from autoreactive B cell
BPA as well as E2 and diethylstilbestrol (DES) enhanced anti-Br-RBC autoantibody production by B1 cells in vivo. IgM production by B1 cells in the presence of ED was more prominent on aged BWF1 mice developing lupus nephritis. (Yurino H. 2004).
To examine a direct effect of endocrine disruptors on IgM antibody production by B1 or B2 cells, B1 cells were prepared from peritoneal cells and B2 cells from spleen, B1 or B2 cells were cultured in the presence of endocrine disruptors (E2: 100 nM, DES: 100 nM, BPA: 1 μM) for 4 days (Yurino H. 2004).
In both (NZB×NZW) F1 and MRL/lpr mice, estrogen treatment exacerbates the lupus disease, with augmented levels of autoantibodies against dsDNA and phospholipids as well as formation of circulating immune complexes (Grimaldi CM. 2002, Peeva E. 2000).
Reduced size of the ovarian follicle pool
Diethylstilbestrol (DES) exposure (0.2 an 20 µg/kg, s.c., 1, 3, 5, and 7 dpp, killed 8 dpp) reduced the number of primordial follicles in rats exposed postnatally (Rodríguez et al. 2010)