Stressor: 218
Title
metofluthrin
Stressor Overview
AOPs Including This Stressor
| AOP Name | Evidence |
|---|---|
| Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat | High |
Events Including This Stressor
| Event Name |
|---|
| Activation, Constitutive androstane receptor |
Chemical Table
| User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
|---|---|---|---|---|---|
| metofluthrin | DTXSID4034738 | Metofluthrin | 240494-70-6 | KVIZNNVXXNFLMU-DUVUQDDDSA-N | KVIZNNVXXNFLMU-DUVUQDDDSA-N |
AOP Evidence
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
Metofluthrin produced increased liver tumors in male and female Wistar rats at dose levels of 900 and 1800 ppm in the diet for 2 years (Deguchi et al., 2009). As shown in Table 5 of the AOP for CAR-mediated rodent liver tumors, dose-concordant data supporting all of the Key Events and/or Associative Events in the AOP for CAR have been demonstrated with metofluthrin (Deguchi et al., 2009; Yamada et al., 2009). Therefore, there is Strong evidence for metofluthrin as an AOP stressor for the CAR-mediated formation of rat liver tumors.
Event Evidence
Activation, Constitutive androstane receptor
There is no evidence text for this event.