AOPs Including This Stressor
Events Including This Stressor
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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
Organochlorine insecticides, including DDT, dieldrin, heptachlor, lindane, and β-hexachlorocyclohexane (β-HCH), have varied targets and mechanisms of action within the central nervous system that affect the function of sodium and calcium channels and transporters. They also interfere with γ-aminobutyric acid (GABA) neurotransmission by blocking specific GABA receptors, contributing to their neurotoxic effects (Narahashi et al., 1995).