Stressor: 36
Title
Mercury
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
Mercury | DTXSID1024172 | Mercury | 7439-97-6 | QSHDDOUJBYECFT-UHFFFAOYSA-N | QSHDDOUJBYECFT-UHFFFAOYSA-N |
AOP Evidence
Event Evidence
Binding, SH-/selen-proteins
There is no evidence text for this event.
Decreased protection against oxidative stress
There is no evidence text for this event.
Increase, Oxidative Stress
Belyaeva et al. (2012) conducted a study which looked at the effects of mercury on human kidney cells, they found that mercury was the most toxic when the sample was treated with 100 μM for 30 minutes.
Buelna-Chontal et al. (2017) investigated the effects of mercury on rat kidneys and found that treated rats had higher lipid peroxidation content and reduced cytochrome c content in their kidneys.
Occurrence, Kidney toxicity
In their study investigating the effect of mercury treatment on rat kidneys, Buelna-Chontal et al. (2017) observed severe proximal tubular necrosis in the treated rats, which was not observed in the control rats. They also found that serum urea nitrogen was 5 times higher in the treated rats, serum creatinine was 3 times higher, and creatinine clearance was 52% lower (Buelna-Chontal et al., 2017).
Durante et al. (2010) conducted a study of the effect of mercury on the histological changes to rat kidneys when treated for increasing lengths of time. In their study, they found that within 24 hours of treatment the amount of necrosis shown in the kidney samples increased to 97% from 0% in the control. The LDH content after 24 hours of mercury treatment was 3 times higher than the untreated control group. Treatment with mercury for 48 hours, showed lessened histological changes in the kidney samples but LDH levels remained high, implying necrosis was still occuring. Durante et al. (2010) also investigated renal function in the rats treated with mercury. Plasma creatinine showed a time-dependant increase, as did blood urea nitrogen (Durante et al., 2010).
Oxidative Stress
Belyaeva et al. (2012) conducted a study which looked at the effects of mercury on human kidney cells, they found that mercury was the most toxic when the sample was treated with 100 μM for 30 minutes.
Buelna-Chontal et al. (2017) investigated the effects of mercury on rat kidneys and found that treated rats had higher lipid peroxidation content and reduced cytochrome c content in their kidneys.
Increase, Cytotoxicity (renal tubular cell)
Belyaeva et al. (2012) conducted a study to determine the effect of mercury treatment on rat kidney cell (PC12 cells) viability and found that treatment with 50 μM of mercury for 24 hours resulted in significant lactate dehydrogenase (LDH) release.