Stressor: 63
Title
Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors.
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Thioacetamide
Stressor Overview
A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP.
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AOPs Including This Stressor
This table is automatically generated and lists the AOPs associated with this prototypical stressor.
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| AOP Name | Evidence |
|---|---|
| Protein Alkylation leading to Liver Fibrosis | High |
Chemical Table
A list of chemicals associated with a prototypical stressor.
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| Preferred name | DTXID | Casrn | jchem_inchi_key | indigo_inchi_key | User term |
|---|---|---|---|---|---|
| Thioacetamide | DTXSID9021340 | 62-55-5 | YUKQRDCYNOVPGJ-UHFFFAOYSA-N | YUKQRDCYNOVPGJ-UHFFFAOYSA-N | Thioacetamide |
References
List of the literature that was cited for this prototypical stressor.
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Hajovsky et al, 2012, Metabolism and Toxicity of Thioacetamide and ThioacetamideS‑Oxide in Rat HepatocytesChem. Res. Toxicol. 2012, 25, 1955−19
Sarma et al. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites. Chem Res Toxicol. 2012 Sep 17;25(9):1868-77.
Akhtar and Sheikh, An overview of thioacetamide-induced hepatotoxicity. Toxin Reviews. 2013; 32,(3): 43-46.
Staňková et al, The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010 Dec;24(8):2097-103.