Stressor: 643

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Staurosporine

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)	Moderate

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
Staurosporine	DTXSID6041131	62996-74-1	HKSZLNNOFSGOKW-HMWZOHBLSA-N	HKSZLNNOFSGOKW-GKHVWRADSA-N	Staurosporine

References

List of the literature that was cited for this prototypical stressor. More help

Omura, S., Iwai, Y., Hirano, A., Nakagawa, A., Awaya, J., Tsuchya, H., Takahashi, Y. & Masuma, R. (1977). New alkaloid AM-2282 of Streptomyces origin - tax- onomy, fermentation, isolation and preliminary characterisation.

Kinoshita, T., Matsubara, M., Ishiguro, H., Okita, K., & Tada, T. (2006). Structure of human Fyn kinase domain complexed with staurosporine. Biochemical and Biophysical Research Communications, 346(3), 840–844. https://doi.org/10.1016/j.bbrc.2006.05.212

Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Loriolle, F., Duhamel, L., Charon, D., & Kirilovsky, J. (1991). The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. Journal of Biological Chemistry, 266(24), 15771–15781. https://doi.org/10.1016/s0021-9258(18)98476-0